EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I908_LEIDO

TriTrypDb:

LdBPK_110810.1 , LdCL_110013500 , LDHU3_11.1010

Length:

976

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I908

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I908

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.649
CLV_C14_Caspase3-7	492	496	PF00656	0.616
CLV_C14_Caspase3-7	630	634	PF00656	0.520
CLV_C14_Caspase3-7	702	706	PF00656	0.524
CLV_NRD_NRD_1	12	14	PF00675	0.510
CLV_NRD_NRD_1	172	174	PF00675	0.435
CLV_NRD_NRD_1	22	24	PF00675	0.395
CLV_NRD_NRD_1	390	392	PF00675	0.528
CLV_NRD_NRD_1	421	423	PF00675	0.549
CLV_NRD_NRD_1	456	458	PF00675	0.493
CLV_NRD_NRD_1	541	543	PF00675	0.482
CLV_NRD_NRD_1	754	756	PF00675	0.477
CLV_NRD_NRD_1	777	779	PF00675	0.458
CLV_NRD_NRD_1	859	861	PF00675	0.540
CLV_NRD_NRD_1	904	906	PF00675	0.416
CLV_NRD_NRD_1	918	920	PF00675	0.548
CLV_PCSK_KEX2_1	172	174	PF00082	0.436
CLV_PCSK_KEX2_1	21	23	PF00082	0.466
CLV_PCSK_KEX2_1	541	543	PF00082	0.521
CLV_PCSK_KEX2_1	754	756	PF00082	0.454
CLV_PCSK_KEX2_1	777	779	PF00082	0.581
CLV_PCSK_KEX2_1	859	861	PF00082	0.538
CLV_PCSK_KEX2_1	904	906	PF00082	0.434
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.534
CLV_PCSK_SKI1_1	137	141	PF00082	0.573
CLV_PCSK_SKI1_1	22	26	PF00082	0.540
CLV_PCSK_SKI1_1	27	31	PF00082	0.506
CLV_PCSK_SKI1_1	348	352	PF00082	0.516
CLV_PCSK_SKI1_1	48	52	PF00082	0.451
CLV_PCSK_SKI1_1	601	605	PF00082	0.523
CLV_PCSK_SKI1_1	715	719	PF00082	0.398
CLV_PCSK_SKI1_1	844	848	PF00082	0.539
CLV_PCSK_SKI1_1	899	903	PF00082	0.553
CLV_PCSK_SKI1_1	905	909	PF00082	0.497
DEG_APCC_DBOX_1	347	355	PF00400	0.513
DEG_SCF_FBW7_2	125	130	PF00400	0.507
DEG_SPOP_SBC_1	497	501	PF00917	0.613
DEG_SPOP_SBC_1	505	509	PF00917	0.532
DEG_SPOP_SBC_1	511	515	PF00917	0.465
DOC_CKS1_1	672	677	PF01111	0.517
DOC_CYCLIN_RxL_1	170	180	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	657	663	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	935	941	PF00134	0.399
DOC_MAPK_DCC_7	670	678	PF00069	0.402
DOC_MAPK_gen_1	290	298	PF00069	0.451
DOC_MAPK_gen_1	562	569	PF00069	0.473
DOC_MAPK_gen_1	646	653	PF00069	0.530
DOC_MAPK_MEF2A_6	562	569	PF00069	0.440
DOC_MAPK_RevD_3	445	458	PF00069	0.427
DOC_MAPK_RevD_3	889	905	PF00069	0.332
DOC_PP1_RVXF_1	713	720	PF00149	0.470
DOC_PP2B_LxvP_1	151	154	PF13499	0.505
DOC_PP2B_LxvP_1	503	506	PF13499	0.630
DOC_PP2B_LxvP_1	657	660	PF13499	0.480
DOC_PP2B_LxvP_1	935	938	PF13499	0.388
DOC_PP4_FxxP_1	256	259	PF00568	0.582
DOC_PP4_MxPP_1	446	449	PF00568	0.483
DOC_USP7_MATH_1	110	114	PF00917	0.561
DOC_USP7_MATH_1	364	368	PF00917	0.649
DOC_USP7_MATH_1	521	525	PF00917	0.659
DOC_USP7_MATH_1	554	558	PF00917	0.492
DOC_USP7_MATH_1	587	591	PF00917	0.485
DOC_USP7_MATH_1	740	744	PF00917	0.623
DOC_USP7_MATH_1	824	828	PF00917	0.592
DOC_USP7_MATH_1	854	858	PF00917	0.663
DOC_USP7_MATH_1	87	91	PF00917	0.690
DOC_WW_Pin1_4	117	122	PF00397	0.688
DOC_WW_Pin1_4	123	128	PF00397	0.610
DOC_WW_Pin1_4	409	414	PF00397	0.521
DOC_WW_Pin1_4	464	469	PF00397	0.543
DOC_WW_Pin1_4	55	60	PF00397	0.602
DOC_WW_Pin1_4	671	676	PF00397	0.493
DOC_WW_Pin1_4	705	710	PF00397	0.635
DOC_WW_Pin1_4	794	799	PF00397	0.553
LIG_14-3-3_CanoR_1	134	140	PF00244	0.425
LIG_14-3-3_CanoR_1	165	169	PF00244	0.602
LIG_14-3-3_CanoR_1	260	267	PF00244	0.512
LIG_14-3-3_CanoR_1	295	299	PF00244	0.445
LIG_14-3-3_CanoR_1	325	335	PF00244	0.564
LIG_14-3-3_CanoR_1	40	46	PF00244	0.374
LIG_14-3-3_CanoR_1	438	448	PF00244	0.489
LIG_14-3-3_CanoR_1	457	462	PF00244	0.495
LIG_14-3-3_CanoR_1	498	506	PF00244	0.677
LIG_14-3-3_CanoR_1	63	71	PF00244	0.533
LIG_14-3-3_CanoR_1	715	720	PF00244	0.396
LIG_14-3-3_CanoR_1	778	786	PF00244	0.471
LIG_14-3-3_CanoR_1	802	808	PF00244	0.565
LIG_14-3-3_CanoR_1	904	912	PF00244	0.423
LIG_Actin_WH2_2	599	616	PF00022	0.467
LIG_BIR_III_2	551	555	PF00653	0.460
LIG_BRCT_BRCA1_1	545	549	PF00533	0.468
LIG_BRCT_BRCA1_1	65	69	PF00533	0.465
LIG_BRCT_BRCA1_1	781	785	PF00533	0.430
LIG_FHA_1	150	156	PF00498	0.585
LIG_FHA_1	161	167	PF00498	0.602
LIG_FHA_1	242	248	PF00498	0.702
LIG_FHA_1	291	297	PF00498	0.396
LIG_FHA_1	440	446	PF00498	0.417
LIG_FHA_1	498	504	PF00498	0.787
LIG_FHA_1	597	603	PF00498	0.524
LIG_FHA_1	694	700	PF00498	0.369
LIG_FHA_1	709	715	PF00498	0.570
LIG_FHA_1	904	910	PF00498	0.482
LIG_FHA_2	124	130	PF00498	0.545
LIG_FHA_2	360	366	PF00498	0.574
LIG_FHA_2	383	389	PF00498	0.619
LIG_FHA_2	49	55	PF00498	0.543
LIG_FHA_2	490	496	PF00498	0.596
LIG_FHA_2	602	608	PF00498	0.578
LIG_FHA_2	628	634	PF00498	0.544
LIG_FHA_2	688	694	PF00498	0.516
LIG_FXI_DFP_1	30	34	PF00024	0.360
LIG_FXI_DFP_1	415	419	PF00024	0.412
LIG_FXI_DFP_1	662	666	PF00024	0.387
LIG_LIR_Apic_2	254	259	PF02991	0.550
LIG_LIR_Gen_1	28	36	PF02991	0.403
LIG_LIR_Gen_1	287	296	PF02991	0.420
LIG_LIR_Gen_1	417	426	PF02991	0.494
LIG_LIR_Gen_1	96	106	PF02991	0.392
LIG_LIR_LC3C_4	500	505	PF02991	0.587
LIG_LIR_Nem_3	28	33	PF02991	0.377
LIG_LIR_Nem_3	282	288	PF02991	0.472
LIG_LIR_Nem_3	346	350	PF02991	0.438
LIG_LIR_Nem_3	417	421	PF02991	0.473
LIG_LIR_Nem_3	471	477	PF02991	0.391
LIG_LIR_Nem_3	833	839	PF02991	0.358
LIG_LIR_Nem_3	96	102	PF02991	0.389
LIG_MAD2	63	71	PF02301	0.523
LIG_MLH1_MIPbox_1	545	549	PF16413	0.468
LIG_MLH1_MIPbox_1	781	785	PF16413	0.434
LIG_PCNA_PIPBox_1	680	689	PF02747	0.526
LIG_Pex14_2	25	29	PF04695	0.411
LIG_Pex14_2	661	665	PF04695	0.392
LIG_RPA_C_Fungi	11	23	PF08784	0.471
LIG_SH2_CRK	459	463	PF00017	0.546
LIG_SH2_GRB2like	99	102	PF00017	0.501
LIG_SH2_NCK_1	281	285	PF00017	0.486
LIG_SH2_NCK_1	459	463	PF00017	0.546
LIG_SH2_SRC	281	284	PF00017	0.511
LIG_SH2_STAP1	281	285	PF00017	0.486
LIG_SH2_STAP1	99	103	PF00017	0.514
LIG_SH2_STAT5	327	330	PF00017	0.549
LIG_SH2_STAT5	383	386	PF00017	0.614
LIG_SH2_STAT5	459	462	PF00017	0.434
LIG_SH2_STAT5	475	478	PF00017	0.434
LIG_SH2_STAT5	716	719	PF00017	0.412
LIG_SH2_STAT5	922	925	PF00017	0.429
LIG_SH2_STAT5	960	963	PF00017	0.371
LIG_SH3_3	337	343	PF00018	0.677
LIG_SH3_3	458	464	PF00018	0.567
LIG_SH3_3	669	675	PF00018	0.530
LIG_SH3_3	935	941	PF00018	0.562
LIG_SUMO_SIM_par_1	968	976	PF11976	0.601
LIG_TRAF2_1	127	130	PF00917	0.545
LIG_TRAF2_1	262	265	PF00917	0.427
LIG_TRFH_1	313	317	PF08558	0.474
LIG_WRC_WIRS_1	26	31	PF05994	0.558
LIG_WRC_WIRS_1	5	10	PF05994	0.456
LIG_WRC_WIRS_1	545	550	PF05994	0.467
LIG_WRC_WIRS_1	716	721	PF05994	0.500
MOD_CDK_SPxK_1	794	800	PF00069	0.556
MOD_CDK_SPxxK_3	409	416	PF00069	0.518
MOD_CK1_1	112	118	PF00069	0.619
MOD_CK1_1	119	125	PF00069	0.581
MOD_CK1_1	246	252	PF00069	0.643
MOD_CK1_1	3	9	PF00069	0.526
MOD_CK1_1	467	473	PF00069	0.478
MOD_CK1_1	484	490	PF00069	0.717
MOD_CK1_1	507	513	PF00069	0.715
MOD_CK1_1	708	714	PF00069	0.568
MOD_CK1_1	743	749	PF00069	0.715
MOD_CK1_1	864	870	PF00069	0.595
MOD_CK1_1	878	884	PF00069	0.646
MOD_CK1_1	92	98	PF00069	0.576
MOD_CK2_1	123	129	PF00069	0.467
MOD_CK2_1	177	183	PF00069	0.565
MOD_CK2_1	259	265	PF00069	0.529
MOD_CK2_1	382	388	PF00069	0.618
MOD_CK2_1	55	61	PF00069	0.438
MOD_CK2_1	601	607	PF00069	0.479
MOD_CK2_1	687	693	PF00069	0.411
MOD_CK2_1	816	822	PF00069	0.437
MOD_Cter_Amidation	19	22	PF01082	0.487
MOD_GlcNHglycan	112	115	PF01048	0.600
MOD_GlcNHglycan	177	180	PF01048	0.585
MOD_GlcNHglycan	261	264	PF01048	0.487
MOD_GlcNHglycan	340	343	PF01048	0.613
MOD_GlcNHglycan	365	369	PF01048	0.665
MOD_GlcNHglycan	486	489	PF01048	0.661
MOD_GlcNHglycan	509	512	PF01048	0.707
MOD_GlcNHglycan	556	559	PF01048	0.456
MOD_GlcNHglycan	585	588	PF01048	0.533
MOD_GlcNHglycan	701	704	PF01048	0.548
MOD_GlcNHglycan	738	741	PF01048	0.644
MOD_GlcNHglycan	748	752	PF01048	0.595
MOD_GlcNHglycan	818	821	PF01048	0.523
MOD_GlcNHglycan	826	829	PF01048	0.507
MOD_GlcNHglycan	863	866	PF01048	0.623
MOD_GlcNHglycan	877	880	PF01048	0.635
MOD_GlcNHglycan	89	92	PF01048	0.690
MOD_GSK3_1	112	119	PF00069	0.673
MOD_GSK3_1	160	167	PF00069	0.456
MOD_GSK3_1	175	182	PF00069	0.495
MOD_GSK3_1	241	248	PF00069	0.662
MOD_GSK3_1	290	297	PF00069	0.410
MOD_GSK3_1	364	371	PF00069	0.621
MOD_GSK3_1	379	386	PF00069	0.544
MOD_GSK3_1	427	434	PF00069	0.418
MOD_GSK3_1	506	513	PF00069	0.723
MOD_GSK3_1	526	533	PF00069	0.497
MOD_GSK3_1	583	590	PF00069	0.500
MOD_GSK3_1	689	696	PF00069	0.412
MOD_GSK3_1	736	743	PF00069	0.639
MOD_NEK2_1	1	6	PF00069	0.629
MOD_NEK2_1	177	182	PF00069	0.565
MOD_NEK2_1	25	30	PF00069	0.446
MOD_NEK2_1	373	378	PF00069	0.520
MOD_NEK2_1	403	408	PF00069	0.462
MOD_NEK2_1	543	548	PF00069	0.538
MOD_NEK2_1	588	593	PF00069	0.560
MOD_NEK2_1	613	618	PF00069	0.533
MOD_NEK2_1	65	70	PF00069	0.527
MOD_NEK2_1	699	704	PF00069	0.418
MOD_NEK2_1	749	754	PF00069	0.627
MOD_NEK2_1	839	844	PF00069	0.424
MOD_NEK2_1	861	866	PF00069	0.565
MOD_NEK2_2	219	224	PF00069	0.678
MOD_NEK2_2	890	895	PF00069	0.463
MOD_PIKK_1	354	360	PF00454	0.582
MOD_PIKK_1	395	401	PF00454	0.459
MOD_PIKK_1	439	445	PF00454	0.536
MOD_PIKK_1	481	487	PF00454	0.583
MOD_PIKK_1	596	602	PF00454	0.446
MOD_PIKK_1	687	693	PF00454	0.538
MOD_PIKK_1	854	860	PF00454	0.509
MOD_PIKK_1	878	884	PF00454	0.554
MOD_PK_1	243	249	PF00069	0.572
MOD_PKA_1	457	463	PF00069	0.497
MOD_PKA_2	164	170	PF00069	0.600
MOD_PKA_2	259	265	PF00069	0.559
MOD_PKA_2	294	300	PF00069	0.442
MOD_PKA_2	39	45	PF00069	0.377
MOD_PKA_2	497	503	PF00069	0.740
MOD_PKA_2	613	619	PF00069	0.433
MOD_PKA_2	903	909	PF00069	0.410
MOD_Plk_1	726	732	PF00069	0.576
MOD_Plk_1	968	974	PF00069	0.502
MOD_Plk_4	246	252	PF00069	0.708
MOD_Plk_4	25	31	PF00069	0.564
MOD_Plk_4	300	306	PF00069	0.581
MOD_Plk_4	379	385	PF00069	0.571
MOD_Plk_4	526	532	PF00069	0.539
MOD_Plk_4	544	550	PF00069	0.441
MOD_Plk_4	715	721	PF00069	0.373
MOD_Plk_4	968	974	PF00069	0.502
MOD_ProDKin_1	117	123	PF00069	0.677
MOD_ProDKin_1	409	415	PF00069	0.516
MOD_ProDKin_1	464	470	PF00069	0.540
MOD_ProDKin_1	55	61	PF00069	0.597
MOD_ProDKin_1	671	677	PF00069	0.493
MOD_ProDKin_1	705	711	PF00069	0.631
MOD_ProDKin_1	794	800	PF00069	0.556
TRG_DiLeu_BaEn_1	450	455	PF01217	0.404
TRG_DiLeu_BaEn_1	943	948	PF01217	0.500
TRG_DiLeu_BaEn_2	345	351	PF01217	0.436
TRG_ENDOCYTIC_2	288	291	PF00928	0.473
TRG_ENDOCYTIC_2	347	350	PF00928	0.393
TRG_ENDOCYTIC_2	474	477	PF00928	0.375
TRG_ENDOCYTIC_2	716	719	PF00928	0.380
TRG_ENDOCYTIC_2	836	839	PF00928	0.353
TRG_ENDOCYTIC_2	960	963	PF00928	0.356
TRG_ENDOCYTIC_2	99	102	PF00928	0.375
TRG_ER_diArg_1	132	135	PF00400	0.580
TRG_ER_diArg_1	171	173	PF00400	0.413
TRG_ER_diArg_1	22	24	PF00400	0.440
TRG_ER_diArg_1	277	280	PF00400	0.417
TRG_ER_diArg_1	433	436	PF00400	0.474
TRG_ER_diArg_1	541	543	PF00400	0.523
TRG_ER_diArg_1	777	779	PF00400	0.513
TRG_ER_diArg_1	859	861	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	401	405	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	438	443	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCJ9	Leptomonas seymouri	58%	100%
A0A0S4JMU3	Bodo saltans	32%	100%
A0A1X0NV98	Trypanosomatidae	38%	98%
A0A3R7KQI0	Trypanosoma rangeli	37%	100%
A4H6K5	Leishmania braziliensis	83%	99%
A4HUZ0	Leishmania infantum	99%	100%
D0A7F9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ANM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QGZ8	Leishmania major	94%	100%
V5DT33	Trypanosoma cruzi	39%	100%