Zinc finger (CCCH type) protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger (CCCH type) protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I906_LEIDO

TriTrypDb:

LdBPK_150160.1 , LdCL_150006500 , LDHU3_15.0220

Length:

839

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I906

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I906

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.711
CLV_NRD_NRD_1	167	169	PF00675	0.654
CLV_NRD_NRD_1	290	292	PF00675	0.784
CLV_NRD_NRD_1	5	7	PF00675	0.544
CLV_NRD_NRD_1	687	689	PF00675	0.618
CLV_NRD_NRD_1	709	711	PF00675	0.643
CLV_NRD_NRD_1	760	762	PF00675	0.720
CLV_NRD_NRD_1	820	822	PF00675	0.593
CLV_PCSK_FUR_1	821	825	PF00082	0.701
CLV_PCSK_KEX2_1	115	117	PF00082	0.801
CLV_PCSK_KEX2_1	167	169	PF00082	0.653
CLV_PCSK_KEX2_1	290	292	PF00082	0.763
CLV_PCSK_KEX2_1	5	7	PF00082	0.544
CLV_PCSK_KEX2_1	686	688	PF00082	0.626
CLV_PCSK_KEX2_1	709	711	PF00082	0.647
CLV_PCSK_KEX2_1	759	761	PF00082	0.726
CLV_PCSK_KEX2_1	823	825	PF00082	0.699
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.801
CLV_PCSK_PC1ET2_1	686	688	PF00082	0.604
CLV_PCSK_PC1ET2_1	823	825	PF00082	0.704
CLV_PCSK_SKI1_1	34	38	PF00082	0.431
CLV_PCSK_SKI1_1	824	828	PF00082	0.697
DEG_APCC_DBOX_1	823	831	PF00400	0.624
DEG_SCF_FBW7_1	442	449	PF00400	0.644
DEG_SCF_TRCP1_1	436	441	PF00400	0.739
DEG_SPOP_SBC_1	279	283	PF00917	0.726
DEG_SPOP_SBC_1	478	482	PF00917	0.602
DEG_SPOP_SBC_1	511	515	PF00917	0.664
DEG_SPOP_SBC_1	522	526	PF00917	0.593
DEG_SPOP_SBC_1	768	772	PF00917	0.639
DOC_CKS1_1	198	203	PF01111	0.651
DOC_CKS1_1	342	347	PF01111	0.688
DOC_CKS1_1	802	807	PF01111	0.633
DOC_PP2B_LxvP_1	171	174	PF13499	0.628
DOC_PP2B_LxvP_1	189	192	PF13499	0.812
DOC_PP2B_LxvP_1	268	271	PF13499	0.588
DOC_PP2B_LxvP_1	675	678	PF13499	0.763
DOC_PP4_FxxP_1	459	462	PF00568	0.617
DOC_USP7_MATH_1	104	108	PF00917	0.634
DOC_USP7_MATH_1	141	145	PF00917	0.746
DOC_USP7_MATH_1	181	185	PF00917	0.601
DOC_USP7_MATH_1	277	281	PF00917	0.728
DOC_USP7_MATH_1	300	304	PF00917	0.637
DOC_USP7_MATH_1	366	370	PF00917	0.633
DOC_USP7_MATH_1	371	375	PF00917	0.619
DOC_USP7_MATH_1	387	391	PF00917	0.577
DOC_USP7_MATH_1	419	423	PF00917	0.642
DOC_USP7_MATH_1	424	428	PF00917	0.593
DOC_USP7_MATH_1	432	436	PF00917	0.599
DOC_USP7_MATH_1	450	454	PF00917	0.540
DOC_USP7_MATH_1	478	482	PF00917	0.705
DOC_USP7_MATH_1	511	515	PF00917	0.642
DOC_USP7_MATH_1	517	521	PF00917	0.689
DOC_USP7_MATH_1	522	526	PF00917	0.761
DOC_USP7_MATH_1	654	658	PF00917	0.629
DOC_USP7_MATH_1	671	675	PF00917	0.516
DOC_USP7_MATH_1	678	682	PF00917	0.586
DOC_USP7_UBL2_3	115	119	PF12436	0.639
DOC_USP7_UBL2_3	715	719	PF12436	0.609
DOC_WW_Pin1_4	105	110	PF00397	0.695
DOC_WW_Pin1_4	197	202	PF00397	0.692
DOC_WW_Pin1_4	341	346	PF00397	0.600
DOC_WW_Pin1_4	359	364	PF00397	0.620
DOC_WW_Pin1_4	420	425	PF00397	0.658
DOC_WW_Pin1_4	438	443	PF00397	0.526
DOC_WW_Pin1_4	465	470	PF00397	0.582
DOC_WW_Pin1_4	604	609	PF00397	0.645
DOC_WW_Pin1_4	622	627	PF00397	0.616
DOC_WW_Pin1_4	72	77	PF00397	0.652
DOC_WW_Pin1_4	753	758	PF00397	0.643
DOC_WW_Pin1_4	801	806	PF00397	0.607
LIG_14-3-3_CanoR_1	315	323	PF00244	0.616
LIG_14-3-3_CanoR_1	425	432	PF00244	0.665
LIG_14-3-3_CanoR_1	585	595	PF00244	0.522
LIG_14-3-3_CanoR_1	821	827	PF00244	0.608
LIG_BIR_III_2	299	303	PF00653	0.675
LIG_BRCT_BRCA1_1	183	187	PF00533	0.575
LIG_BRCT_BRCA1_1	206	210	PF00533	0.640
LIG_BRCT_BRCA1_1	77	81	PF00533	0.682
LIG_deltaCOP1_diTrp_1	576	586	PF00928	0.468
LIG_EVH1_1	171	175	PF00568	0.713
LIG_EVH1_1	268	272	PF00568	0.654
LIG_EVH1_2	460	464	PF00568	0.647
LIG_FHA_1	106	112	PF00498	0.595
LIG_FHA_1	184	190	PF00498	0.581
LIG_FHA_1	290	296	PF00498	0.574
LIG_FHA_1	312	318	PF00498	0.649
LIG_FHA_1	49	55	PF00498	0.714
LIG_FHA_1	511	517	PF00498	0.654
LIG_FHA_1	551	557	PF00498	0.420
LIG_FHA_1	578	584	PF00498	0.452
LIG_FHA_1	640	646	PF00498	0.643
LIG_FHA_1	770	776	PF00498	0.649
LIG_FHA_2	335	341	PF00498	0.661
LIG_FHA_2	587	593	PF00498	0.522
LIG_FHA_2	636	642	PF00498	0.639
LIG_FHA_2	829	835	PF00498	0.615
LIG_Integrin_RGD_1	153	155	PF01839	0.753
LIG_LIR_Gen_1	411	420	PF02991	0.653
LIG_LIR_Gen_1	534	544	PF02991	0.551
LIG_LIR_Gen_1	549	559	PF02991	0.445
LIG_LIR_Gen_1	740	745	PF02991	0.420
LIG_LIR_Nem_3	207	213	PF02991	0.622
LIG_LIR_Nem_3	256	262	PF02991	0.795
LIG_LIR_Nem_3	411	415	PF02991	0.646
LIG_LIR_Nem_3	534	540	PF02991	0.558
LIG_LIR_Nem_3	549	554	PF02991	0.445
LIG_LIR_Nem_3	740	744	PF02991	0.463
LIG_LYPXL_yS_3	259	262	PF13949	0.659
LIG_PDZ_Class_2	834	839	PF00595	0.591
LIG_PROFILIN_1	269	275	PF00235	0.584
LIG_Rb_LxCxE_1	728	749	PF01857	0.440
LIG_REV1ctd_RIR_1	20	28	PF16727	0.537
LIG_SH2_CRK	537	541	PF00017	0.497
LIG_SH2_CRK	551	555	PF00017	0.442
LIG_SH2_NCK_1	551	555	PF00017	0.442
LIG_SH2_SRC	228	231	PF00017	0.674
LIG_SH2_SRC	743	746	PF00017	0.462
LIG_SH2_STAT3	643	646	PF00017	0.603
LIG_SH2_STAT5	228	231	PF00017	0.591
LIG_SH2_STAT5	347	350	PF00017	0.749
LIG_SH2_STAT5	551	554	PF00017	0.437
LIG_SH2_STAT5	734	737	PF00017	0.430
LIG_SH2_STAT5	743	746	PF00017	0.425
LIG_SH3_2	704	709	PF14604	0.587
LIG_SH3_3	169	175	PF00018	0.639
LIG_SH3_3	189	195	PF00018	0.604
LIG_SH3_3	196	202	PF00018	0.581
LIG_SH3_3	220	226	PF00018	0.564
LIG_SH3_3	266	272	PF00018	0.632
LIG_SH3_3	339	345	PF00018	0.599
LIG_SH3_3	372	378	PF00018	0.682
LIG_SH3_3	383	389	PF00018	0.559
LIG_SH3_3	701	707	PF00018	0.575
LIG_SH3_3	739	745	PF00018	0.436
LIG_SH3_3	772	778	PF00018	0.625
LIG_SUMO_SIM_par_1	280	289	PF11976	0.656
LIG_SUMO_SIM_par_1	470	475	PF11976	0.557
LIG_SUMO_SIM_par_1	657	663	PF11976	0.620
LIG_TRAF2_1	526	529	PF00917	0.688
LIG_TRAF2_1	831	834	PF00917	0.659
LIG_WRC_WIRS_1	19	24	PF05994	0.439
LIG_WW_2	174	177	PF00397	0.600
LIG_WW_2	194	197	PF00397	0.635
MOD_CDK_SPK_2	420	425	PF00069	0.619
MOD_CDK_SPxK_1	753	759	PF00069	0.716
MOD_CDK_SPxxK_3	753	760	PF00069	0.717
MOD_CK1_1	105	111	PF00069	0.678
MOD_CK1_1	122	128	PF00069	0.597
MOD_CK1_1	129	135	PF00069	0.619
MOD_CK1_1	18	24	PF00069	0.439
MOD_CK1_1	258	264	PF00069	0.706
MOD_CK1_1	280	286	PF00069	0.622
MOD_CK1_1	319	325	PF00069	0.663
MOD_CK1_1	427	433	PF00069	0.628
MOD_CK1_1	434	440	PF00069	0.657
MOD_CK1_1	480	486	PF00069	0.620
MOD_CK1_1	491	497	PF00069	0.697
MOD_CK1_1	515	521	PF00069	0.677
MOD_CK1_1	549	555	PF00069	0.460
MOD_CK1_1	564	570	PF00069	0.556
MOD_CK1_1	647	653	PF00069	0.766
MOD_CK1_1	680	686	PF00069	0.693
MOD_CK1_1	746	752	PF00069	0.658
MOD_CK1_1	75	81	PF00069	0.681
MOD_CK1_1	798	804	PF00069	0.674
MOD_CK2_1	358	364	PF00069	0.771
MOD_CK2_1	522	528	PF00069	0.723
MOD_CK2_1	563	569	PF00069	0.562
MOD_CK2_1	586	592	PF00069	0.502
MOD_CK2_1	635	641	PF00069	0.639
MOD_CK2_1	678	684	PF00069	0.665
MOD_CK2_1	822	828	PF00069	0.698
MOD_Cter_Amidation	757	760	PF01082	0.721
MOD_Cter_Amidation	819	822	PF01082	0.590
MOD_GlcNHglycan	103	107	PF01048	0.613
MOD_GlcNHglycan	126	129	PF01048	0.636
MOD_GlcNHglycan	131	134	PF01048	0.639
MOD_GlcNHglycan	143	146	PF01048	0.671
MOD_GlcNHglycan	147	150	PF01048	0.816
MOD_GlcNHglycan	206	209	PF01048	0.651
MOD_GlcNHglycan	237	240	PF01048	0.674
MOD_GlcNHglycan	282	285	PF01048	0.718
MOD_GlcNHglycan	334	337	PF01048	0.632
MOD_GlcNHglycan	389	392	PF01048	0.583
MOD_GlcNHglycan	436	439	PF01048	0.762
MOD_GlcNHglycan	452	455	PF01048	0.546
MOD_GlcNHglycan	486	489	PF01048	0.683
MOD_GlcNHglycan	519	522	PF01048	0.657
MOD_GlcNHglycan	533	536	PF01048	0.722
MOD_GlcNHglycan	541	544	PF01048	0.519
MOD_GlcNHglycan	563	566	PF01048	0.638
MOD_GlcNHglycan	646	649	PF01048	0.635
MOD_GlcNHglycan	680	683	PF01048	0.638
MOD_GlcNHglycan	727	730	PF01048	0.470
MOD_GlcNHglycan	745	748	PF01048	0.504
MOD_GlcNHglycan	86	89	PF01048	0.615
MOD_GSK3_1	10	17	PF00069	0.462
MOD_GSK3_1	115	122	PF00069	0.699
MOD_GSK3_1	123	130	PF00069	0.599
MOD_GSK3_1	141	148	PF00069	0.588
MOD_GSK3_1	18	25	PF00069	0.437
MOD_GSK3_1	183	190	PF00069	0.593
MOD_GSK3_1	200	207	PF00069	0.584
MOD_GSK3_1	254	261	PF00069	0.685
MOD_GSK3_1	275	282	PF00069	0.753
MOD_GSK3_1	319	326	PF00069	0.661
MOD_GSK3_1	396	403	PF00069	0.649
MOD_GSK3_1	404	411	PF00069	0.556
MOD_GSK3_1	420	427	PF00069	0.634
MOD_GSK3_1	434	441	PF00069	0.606
MOD_GSK3_1	442	449	PF00069	0.783
MOD_GSK3_1	480	487	PF00069	0.648
MOD_GSK3_1	511	518	PF00069	0.705
MOD_GSK3_1	546	553	PF00069	0.452
MOD_GSK3_1	614	621	PF00069	0.629
MOD_GSK3_1	622	629	PF00069	0.604
MOD_GSK3_1	635	642	PF00069	0.651
MOD_GSK3_1	66	73	PF00069	0.639
MOD_GSK3_1	767	774	PF00069	0.608
MOD_GSK3_1	80	87	PF00069	0.713
MOD_N-GLC_1	332	337	PF02516	0.698
MOD_N-GLC_1	359	364	PF02516	0.685
MOD_N-GLC_1	522	527	PF02516	0.594
MOD_N-GLC_1	671	676	PF02516	0.665
MOD_NEK2_1	123	128	PF00069	0.682
MOD_NEK2_1	187	192	PF00069	0.627
MOD_NEK2_1	253	258	PF00069	0.791
MOD_NEK2_1	286	291	PF00069	0.615
MOD_NEK2_1	323	328	PF00069	0.632
MOD_NEK2_1	358	363	PF00069	0.643
MOD_NEK2_1	479	484	PF00069	0.654
MOD_NEK2_1	497	502	PF00069	0.527
MOD_NEK2_1	512	517	PF00069	0.530
MOD_NEK2_1	577	582	PF00069	0.464
MOD_NEK2_1	718	723	PF00069	0.543
MOD_NEK2_2	785	790	PF00069	0.542
MOD_PIKK_1	366	372	PF00454	0.659
MOD_PIKK_1	702	708	PF00454	0.819
MOD_PIKK_1	795	801	PF00454	0.708
MOD_PK_1	822	828	PF00069	0.608
MOD_PKA_1	115	121	PF00069	0.672
MOD_PKA_1	822	828	PF00069	0.608
MOD_PKA_2	115	121	PF00069	0.661
MOD_PKA_2	289	295	PF00069	0.572
MOD_PKA_2	424	430	PF00069	0.671
MOD_PKA_2	491	497	PF00069	0.604
MOD_PKB_1	309	317	PF00069	0.653
MOD_Plk_1	671	677	PF00069	0.666
MOD_Plk_2-3	828	834	PF00069	0.620
MOD_Plk_4	18	24	PF00069	0.439
MOD_Plk_4	397	403	PF00069	0.592
MOD_Plk_4	497	503	PF00069	0.679
MOD_Plk_4	66	72	PF00069	0.668
MOD_Plk_4	737	743	PF00069	0.500
MOD_ProDKin_1	105	111	PF00069	0.695
MOD_ProDKin_1	197	203	PF00069	0.695
MOD_ProDKin_1	341	347	PF00069	0.600
MOD_ProDKin_1	359	365	PF00069	0.623
MOD_ProDKin_1	420	426	PF00069	0.661
MOD_ProDKin_1	438	444	PF00069	0.522
MOD_ProDKin_1	465	471	PF00069	0.575
MOD_ProDKin_1	604	610	PF00069	0.645
MOD_ProDKin_1	622	628	PF00069	0.618
MOD_ProDKin_1	72	78	PF00069	0.653
MOD_ProDKin_1	753	759	PF00069	0.644
MOD_ProDKin_1	801	807	PF00069	0.606
MOD_SUMO_rev_2	41	51	PF00179	0.632
MOD_SUMO_rev_2	780	785	PF00179	0.636
TRG_DiLeu_BaEn_2	736	742	PF01217	0.444
TRG_DiLeu_BaLyEn_6	379	384	PF01217	0.627
TRG_ENDOCYTIC_2	215	218	PF00928	0.634
TRG_ENDOCYTIC_2	259	262	PF00928	0.807
TRG_ENDOCYTIC_2	349	352	PF00928	0.593
TRG_ENDOCYTIC_2	537	540	PF00928	0.507
TRG_ENDOCYTIC_2	551	554	PF00928	0.437
TRG_ER_diArg_1	687	689	PF00400	0.706
TRG_ER_diArg_1	759	761	PF00400	0.672
TRG_NLS_MonoCore_2	820	825	PF00514	0.641
TRG_NLS_MonoExtC_3	114	119	PF00514	0.652
TRG_NLS_MonoExtN_4	115	120	PF00514	0.613
TRG_NLS_MonoExtN_4	819	826	PF00514	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y8	Leptomonas seymouri	42%	100%
A4H7Y5	Leishmania braziliensis	61%	95%
A4HWB3	Leishmania infantum	99%	100%
E9AQ13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QFG8	Leishmania major	91%	99%