Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8I8Z9_LEIDO

TriTrypDb:

LdBPK_110340.1 , LdCL_110008300 , LDHU3_11.0430

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I8Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.692
CLV_NRD_NRD_1	17	19	PF00675	0.637
CLV_NRD_NRD_1	4	6	PF00675	0.754
CLV_NRD_NRD_1	426	428	PF00675	0.733
CLV_PCSK_KEX2_1	13	15	PF00082	0.671
CLV_PCSK_KEX2_1	360	362	PF00082	0.590
CLV_PCSK_KEX2_1	4	6	PF00082	0.765
CLV_PCSK_KEX2_1	425	427	PF00082	0.784
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.590
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.765
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.717
DEG_SIAH_1	440	448	PF03145	0.712
DEG_SPOP_SBC_1	232	236	PF00917	0.769
DOC_CKS1_1	128	133	PF01111	0.786
DOC_USP7_MATH_1	109	113	PF00917	0.804
DOC_USP7_MATH_1	278	282	PF00917	0.729
DOC_USP7_MATH_1	291	295	PF00917	0.791
DOC_USP7_MATH_1	385	389	PF00917	0.655
DOC_USP7_MATH_1	404	408	PF00917	0.608
DOC_USP7_UBL2_3	100	104	PF12436	0.663
DOC_USP7_UBL2_3	6	10	PF12436	0.802
DOC_WW_Pin1_4	127	132	PF00397	0.758
DOC_WW_Pin1_4	162	167	PF00397	0.772
DOC_WW_Pin1_4	214	219	PF00397	0.671
DOC_WW_Pin1_4	220	225	PF00397	0.668
DOC_WW_Pin1_4	233	238	PF00397	0.703
DOC_WW_Pin1_4	273	278	PF00397	0.805
DOC_WW_Pin1_4	351	356	PF00397	0.788
DOC_WW_Pin1_4	362	367	PF00397	0.783
DOC_WW_Pin1_4	369	374	PF00397	0.677
DOC_WW_Pin1_4	79	84	PF00397	0.694
LIG_14-3-3_CanoR_1	136	140	PF00244	0.807
LIG_14-3-3_CanoR_1	61	70	PF00244	0.678
LIG_Actin_WH2_2	190	206	PF00022	0.702
LIG_Actin_WH2_2	305	322	PF00022	0.684
LIG_BIR_III_4	250	254	PF00653	0.590
LIG_Clathr_ClatBox_1	263	267	PF01394	0.776
LIG_FHA_1	118	124	PF00498	0.785
LIG_FHA_1	240	246	PF00498	0.755
LIG_FHA_1	346	352	PF00498	0.655
LIG_FHA_2	291	297	PF00498	0.565
LIG_GBD_Chelix_1	179	187	PF00786	0.701
LIG_HP1_1	447	451	PF01393	0.787
LIG_LIR_Apic_2	296	302	PF02991	0.720
LIG_LIR_Apic_2	410	415	PF02991	0.655
LIG_LIR_Gen_1	307	315	PF02991	0.560
LIG_LIR_Gen_1	348	357	PF02991	0.728
LIG_LIR_Nem_3	175	181	PF02991	0.719
LIG_LIR_Nem_3	196	201	PF02991	0.681
LIG_LIR_Nem_3	296	301	PF02991	0.691
LIG_LIR_Nem_3	307	313	PF02991	0.464
LIG_LIR_Nem_3	348	353	PF02991	0.713
LIG_SH2_CRK	125	129	PF00017	0.789
LIG_SH2_CRK	412	416	PF00017	0.675
LIG_SH2_NCK_1	125	129	PF00017	0.789
LIG_SH2_STAT5	178	181	PF00017	0.599
LIG_SH2_STAT5	416	419	PF00017	0.659
LIG_SH2_STAT5	47	50	PF00017	0.767
LIG_SH3_1	125	131	PF00018	0.787
LIG_SH3_3	125	131	PF00018	0.787
LIG_SH3_3	153	159	PF00018	0.776
LIG_SH3_3	321	327	PF00018	0.772
LIG_SUMO_SIM_par_1	261	267	PF11976	0.692
LIG_TRFH_1	256	260	PF08558	0.619
LIG_TRFH_1	298	302	PF08558	0.607
LIG_WW_3	322	326	PF00397	0.713
MOD_CDK_SPK_2	364	369	PF00069	0.859
MOD_CDK_SPxxK_3	351	358	PF00069	0.706
MOD_CDK_SPxxK_3	362	369	PF00069	0.779
MOD_CK1_1	118	124	PF00069	0.785
MOD_CK1_1	138	144	PF00069	0.470
MOD_CK1_1	188	194	PF00069	0.738
MOD_CK1_1	202	208	PF00069	0.470
MOD_CK1_1	233	239	PF00069	0.656
MOD_CK1_1	262	268	PF00069	0.660
MOD_CK1_1	279	285	PF00069	0.548
MOD_CK1_1	388	394	PF00069	0.718
MOD_CK1_1	407	413	PF00069	0.644
MOD_CK1_1	54	60	PF00069	0.786
MOD_CK2_1	79	85	PF00069	0.675
MOD_DYRK1A_RPxSP_1	369	373	PF00069	0.675
MOD_GlcNHglycan	111	114	PF01048	0.809
MOD_GlcNHglycan	117	120	PF01048	0.790
MOD_GlcNHglycan	140	143	PF01048	0.664
MOD_GlcNHglycan	204	207	PF01048	0.588
MOD_GlcNHglycan	293	296	PF01048	0.745
MOD_GlcNHglycan	427	430	PF01048	0.678
MOD_GlcNHglycan	89	92	PF01048	0.797
MOD_GSK3_1	123	130	PF00069	0.730
MOD_GSK3_1	181	188	PF00069	0.710
MOD_GSK3_1	189	196	PF00069	0.678
MOD_GSK3_1	258	265	PF00069	0.620
MOD_GSK3_1	279	286	PF00069	0.687
MOD_GSK3_1	388	395	PF00069	0.782
MOD_GSK3_1	50	57	PF00069	0.787
MOD_GSK3_1	66	73	PF00069	0.492
MOD_N-GLC_1	188	193	PF02516	0.742
MOD_N-GLC_1	70	75	PF02516	0.714
MOD_NEK2_1	123	128	PF00069	0.788
MOD_NEK2_1	150	155	PF00069	0.738
MOD_NEK2_1	305	310	PF00069	0.593
MOD_NEK2_1	52	57	PF00069	0.689
MOD_NEK2_2	199	204	PF00069	0.693
MOD_OFUCOSY	157	164	PF10250	0.709
MOD_PIKK_1	385	391	PF00454	0.768
MOD_PIKK_1	407	413	PF00454	0.628
MOD_PIKK_1	94	100	PF00454	0.664
MOD_PKA_1	425	431	PF00069	0.713
MOD_PKA_2	135	141	PF00069	0.804
MOD_PKA_2	425	431	PF00069	0.701
MOD_Plk_1	188	194	PF00069	0.725
MOD_Plk_4	145	151	PF00069	0.779
MOD_Plk_4	193	199	PF00069	0.642
MOD_Plk_4	259	265	PF00069	0.655
MOD_Plk_4	300	306	PF00069	0.587
MOD_ProDKin_1	127	133	PF00069	0.758
MOD_ProDKin_1	162	168	PF00069	0.771
MOD_ProDKin_1	214	220	PF00069	0.674
MOD_ProDKin_1	233	239	PF00069	0.759
MOD_ProDKin_1	273	279	PF00069	0.805
MOD_ProDKin_1	351	357	PF00069	0.789
MOD_ProDKin_1	362	368	PF00069	0.782
MOD_ProDKin_1	369	375	PF00069	0.677
MOD_ProDKin_1	79	85	PF00069	0.696
TRG_ENDOCYTIC_2	298	301	PF00928	0.613
TRG_ER_diArg_1	396	399	PF00400	0.728
TRG_NLS_MonoCore_2	3	8	PF00514	0.730
TRG_NLS_MonoExtC_3	9	14	PF00514	0.729
TRG_NLS_MonoExtN_4	4	9	PF00514	0.796

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY1	Leptomonas seymouri	32%	100%
A4H6F1	Leishmania braziliensis	65%	97%
A4HUU5	Leishmania infantum	99%	100%
E9ANI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
Q4QH46	Leishmania major	80%	100%