CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 47, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I8Z7_LEIDO

TriTrypDb:

LdBPK_110610.1 , LdCL_110011500 , LDHU3_11.0800

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I8Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8Z7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.660
CLV_C14_Caspase3-7	178	182	PF00656	0.668
CLV_C14_Caspase3-7	187	191	PF00656	0.584
CLV_NRD_NRD_1	28	30	PF00675	0.444
CLV_NRD_NRD_1	382	384	PF00675	0.518
CLV_NRD_NRD_1	392	394	PF00675	0.556
CLV_NRD_NRD_1	454	456	PF00675	0.619
CLV_NRD_NRD_1	496	498	PF00675	0.577
CLV_NRD_NRD_1	580	582	PF00675	0.656
CLV_NRD_NRD_1	77	79	PF00675	0.690
CLV_PCSK_KEX2_1	265	267	PF00082	0.472
CLV_PCSK_KEX2_1	28	30	PF00082	0.595
CLV_PCSK_KEX2_1	382	384	PF00082	0.518
CLV_PCSK_KEX2_1	392	394	PF00082	0.556
CLV_PCSK_KEX2_1	454	456	PF00082	0.619
CLV_PCSK_KEX2_1	495	497	PF00082	0.574
CLV_PCSK_KEX2_1	580	582	PF00082	0.663
CLV_PCSK_KEX2_1	77	79	PF00082	0.611
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.462
CLV_PCSK_PC7_1	491	497	PF00082	0.645
CLV_PCSK_SKI1_1	294	298	PF00082	0.599
CLV_PCSK_SKI1_1	37	41	PF00082	0.555
DEG_SCF_TRCP1_1	587	592	PF00400	0.657
DEG_SPOP_SBC_1	142	146	PF00917	0.527
DEG_SPOP_SBC_1	338	342	PF00917	0.594
DEG_SPOP_SBC_1	433	437	PF00917	0.606
DEG_SPOP_SBC_1	511	515	PF00917	0.651
DEG_SPOP_SBC_1	95	99	PF00917	0.598
DOC_ANK_TNKS_1	77	84	PF00023	0.643
DOC_CKS1_1	278	283	PF01111	0.572
DOC_CKS1_1	287	292	PF01111	0.483
DOC_PP1_RVXF_1	237	243	PF00149	0.510
DOC_USP7_MATH_1	123	127	PF00917	0.690
DOC_USP7_MATH_1	136	140	PF00917	0.600
DOC_USP7_MATH_1	141	145	PF00917	0.545
DOC_USP7_MATH_1	154	158	PF00917	0.543
DOC_USP7_MATH_1	208	212	PF00917	0.593
DOC_USP7_MATH_1	288	292	PF00917	0.558
DOC_USP7_MATH_1	339	343	PF00917	0.580
DOC_USP7_MATH_1	434	438	PF00917	0.672
DOC_USP7_MATH_1	510	514	PF00917	0.692
DOC_USP7_MATH_1	71	75	PF00917	0.686
DOC_USP7_UBL2_3	155	159	PF12436	0.653
DOC_WW_Pin1_4	137	142	PF00397	0.613
DOC_WW_Pin1_4	150	155	PF00397	0.613
DOC_WW_Pin1_4	200	205	PF00397	0.593
DOC_WW_Pin1_4	268	273	PF00397	0.566
DOC_WW_Pin1_4	277	282	PF00397	0.494
DOC_WW_Pin1_4	286	291	PF00397	0.451
DOC_WW_Pin1_4	425	430	PF00397	0.641
DOC_WW_Pin1_4	497	502	PF00397	0.702
DOC_WW_Pin1_4	512	517	PF00397	0.710
LIG_14-3-3_CanoR_1	362	367	PF00244	0.462
LIG_APCC_ABBAyCdc20_2	383	389	PF00400	0.650
LIG_BRCT_BRCA1_1	125	129	PF00533	0.601
LIG_BRCT_BRCA1_1	194	198	PF00533	0.607
LIG_BRCT_BRCA1_1	435	439	PF00533	0.637
LIG_BRCT_BRCA1_1	499	503	PF00533	0.658
LIG_eIF4E_1	591	597	PF01652	0.640
LIG_FHA_1	184	190	PF00498	0.579
LIG_FHA_1	22	28	PF00498	0.459
LIG_FHA_1	274	280	PF00498	0.628
LIG_FHA_1	326	332	PF00498	0.559
LIG_FHA_2	176	182	PF00498	0.622
LIG_FHA_2	287	293	PF00498	0.590
LIG_FHA_2	363	369	PF00498	0.433
LIG_Integrin_RGD_1	164	166	PF01839	0.596
LIG_LIR_Apic_2	410	416	PF02991	0.723
LIG_LIR_Gen_1	333	339	PF02991	0.614
LIG_LIR_Gen_1	48	57	PF02991	0.393
LIG_LIR_Nem_3	282	287	PF02991	0.545
LIG_LIR_Nem_3	320	324	PF02991	0.553
LIG_LIR_Nem_3	333	338	PF02991	0.490
LIG_LIR_Nem_3	355	361	PF02991	0.455
LIG_LIR_Nem_3	436	442	PF02991	0.682
LIG_LIR_Nem_3	48	52	PF02991	0.385
LIG_Pex14_2	129	133	PF04695	0.587
LIG_PTB_Apo_2	373	380	PF02174	0.576
LIG_PTB_Apo_2	481	488	PF02174	0.644
LIG_PTB_Phospho_1	373	379	PF10480	0.583
LIG_PTB_Phospho_1	481	487	PF10480	0.643
LIG_SH2_CRK	223	227	PF00017	0.649
LIG_SH2_CRK	269	273	PF00017	0.503
LIG_SH2_CRK	335	339	PF00017	0.621
LIG_SH2_CRK	426	430	PF00017	0.618
LIG_SH2_GRB2like	482	485	PF00017	0.605
LIG_SH2_NCK_1	223	227	PF00017	0.559
LIG_SH2_NCK_1	335	339	PF00017	0.621
LIG_SH2_NCK_1	498	502	PF00017	0.639
LIG_SH2_PTP2	49	52	PF00017	0.357
LIG_SH2_STAP1	335	339	PF00017	0.621
LIG_SH2_STAT3	566	569	PF00017	0.694
LIG_SH2_STAT5	379	382	PF00017	0.636
LIG_SH2_STAT5	49	52	PF00017	0.357
LIG_SH3_3	210	216	PF00018	0.665
LIG_SH3_3	249	255	PF00018	0.469
LIG_SH3_3	275	281	PF00018	0.539
LIG_SH3_3	326	332	PF00018	0.545
LIG_SH3_4	155	162	PF00018	0.634
LIG_SUMO_SIM_par_1	327	334	PF11976	0.578
LIG_SUMO_SIM_par_1	89	94	PF11976	0.610
LIG_TYR_ITIM	47	52	PF00017	0.390
MOD_CDC14_SPxK_1	271	274	PF00782	0.523
MOD_CDK_SPK_2	150	155	PF00069	0.692
MOD_CDK_SPxK_1	268	274	PF00069	0.527
MOD_CK1_1	137	143	PF00069	0.599
MOD_CK1_1	14	20	PF00069	0.561
MOD_CK1_1	340	346	PF00069	0.589
MOD_CK1_1	395	401	PF00069	0.662
MOD_CK1_1	407	413	PF00069	0.578
MOD_CK1_1	435	441	PF00069	0.621
MOD_CK1_1	536	542	PF00069	0.643
MOD_CK1_1	567	573	PF00069	0.633
MOD_CK1_1	96	102	PF00069	0.671
MOD_CK2_1	244	250	PF00069	0.659
MOD_CK2_1	286	292	PF00069	0.594
MOD_CK2_1	472	478	PF00069	0.687
MOD_CK2_1	545	551	PF00069	0.692
MOD_CK2_1	58	64	PF00069	0.507
MOD_GlcNHglycan	113	116	PF01048	0.628
MOD_GlcNHglycan	13	16	PF01048	0.511
MOD_GlcNHglycan	145	148	PF01048	0.653
MOD_GlcNHglycan	156	159	PF01048	0.778
MOD_GlcNHglycan	193	197	PF01048	0.607
MOD_GlcNHglycan	246	249	PF01048	0.479
MOD_GlcNHglycan	406	409	PF01048	0.658
MOD_GlcNHglycan	410	413	PF01048	0.689
MOD_GlcNHglycan	450	453	PF01048	0.669
MOD_GlcNHglycan	478	482	PF01048	0.669
MOD_GlcNHglycan	587	590	PF01048	0.607
MOD_GlcNHglycan	60	63	PF01048	0.525
MOD_GlcNHglycan	84	88	PF01048	0.634
MOD_GSK3_1	137	144	PF00069	0.590
MOD_GSK3_1	150	157	PF00069	0.614
MOD_GSK3_1	175	182	PF00069	0.685
MOD_GSK3_1	188	195	PF00069	0.727
MOD_GSK3_1	196	203	PF00069	0.539
MOD_GSK3_1	273	280	PF00069	0.634
MOD_GSK3_1	348	355	PF00069	0.701
MOD_GSK3_1	392	399	PF00069	0.595
MOD_GSK3_1	404	411	PF00069	0.627
MOD_GSK3_1	433	440	PF00069	0.641
MOD_GSK3_1	497	504	PF00069	0.699
MOD_GSK3_1	536	543	PF00069	0.624
MOD_GSK3_1	585	592	PF00069	0.637
MOD_GSK3_1	60	67	PF00069	0.565
MOD_GSK3_1	7	14	PF00069	0.600
MOD_GSK3_1	94	101	PF00069	0.746
MOD_N-GLC_1	227	232	PF02516	0.579
MOD_N-GLC_1	404	409	PF02516	0.627
MOD_N-GLC_1	483	488	PF02516	0.643
MOD_NEK2_1	129	134	PF00069	0.572
MOD_NEK2_1	192	197	PF00069	0.553
MOD_NEK2_1	258	263	PF00069	0.479
MOD_NEK2_1	324	329	PF00069	0.487
MOD_NEK2_1	337	342	PF00069	0.595
MOD_NEK2_1	352	357	PF00069	0.386
MOD_NEK2_1	387	392	PF00069	0.644
MOD_NEK2_1	404	409	PF00069	0.585
MOD_NEK2_1	564	569	PF00069	0.574
MOD_NEK2_1	585	590	PF00069	0.597
MOD_NEK2_2	124	129	PF00069	0.645
MOD_OFUCOSY	53	59	PF10250	0.512
MOD_PIKK_1	294	300	PF00454	0.674
MOD_PIKK_1	414	420	PF00454	0.659
MOD_PIKK_1	564	570	PF00454	0.685
MOD_PK_1	393	399	PF00069	0.511
MOD_PKA_1	392	398	PF00069	0.586
MOD_PKA_2	392	398	PF00069	0.586
MOD_PKA_2	472	478	PF00069	0.523
MOD_PKA_2	536	542	PF00069	0.651
MOD_PKA_2	545	551	PF00069	0.614
MOD_PKA_2	64	70	PF00069	0.638
MOD_Plk_1	324	330	PF00069	0.490
MOD_Plk_1	483	489	PF00069	0.645
MOD_Plk_2-3	181	187	PF00069	0.667
MOD_Plk_2-3	188	194	PF00069	0.600
MOD_Plk_4	124	130	PF00069	0.580
MOD_Plk_4	325	331	PF00069	0.552
MOD_Plk_4	348	354	PF00069	0.611
MOD_Plk_4	362	368	PF00069	0.410
MOD_ProDKin_1	137	143	PF00069	0.613
MOD_ProDKin_1	150	156	PF00069	0.612
MOD_ProDKin_1	200	206	PF00069	0.595
MOD_ProDKin_1	268	274	PF00069	0.569
MOD_ProDKin_1	277	283	PF00069	0.495
MOD_ProDKin_1	286	292	PF00069	0.448
MOD_ProDKin_1	425	431	PF00069	0.641
MOD_ProDKin_1	497	503	PF00069	0.704
MOD_ProDKin_1	512	518	PF00069	0.709
MOD_SUMO_rev_2	32	39	PF00179	0.416
TRG_DiLeu_BaLyEn_6	513	518	PF01217	0.579
TRG_ENDOCYTIC_2	223	226	PF00928	0.785
TRG_ENDOCYTIC_2	321	324	PF00928	0.537
TRG_ENDOCYTIC_2	335	338	PF00928	0.507
TRG_ENDOCYTIC_2	49	52	PF00928	0.377
TRG_ER_diArg_1	219	222	PF00400	0.591
TRG_ER_diArg_1	27	29	PF00400	0.444
TRG_ER_diArg_1	391	393	PF00400	0.550
TRG_ER_diArg_1	495	497	PF00400	0.624
TRG_NES_CRM1_1	35	48	PF08389	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T4	Leptomonas seymouri	46%	100%
A4H6I6	Leishmania braziliensis	69%	100%
A4HUX1	Leishmania infantum	100%	100%
E9ANK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QH20	Leishmania major	91%	100%