GDA1/CD39 (Nucleoside phosphatase) family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP diphosphohydrolase

Species:

Leishmania donovani

UniProt:

A0A3Q8I8Z5_LEIDO

TriTrypDb:

LdBPK_150030.1 , LdCL_150005200 , LDHU3_15.0030

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8I8Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8Z5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009132	nucleoside diphosphate metabolic process	5	1
GO:0009134	nucleoside diphosphate catabolic process	6	1
GO:0009987	cellular process	1	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016787	hydrolase activity	2	10
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0016462	pyrophosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017110	nucleoside diphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.212
CLV_NRD_NRD_1	324	326	PF00675	0.425
CLV_NRD_NRD_1	367	369	PF00675	0.400
CLV_NRD_NRD_1	8	10	PF00675	0.380
CLV_PCSK_FUR_1	84	88	PF00082	0.488
CLV_PCSK_KEX2_1	15	17	PF00082	0.189
CLV_PCSK_KEX2_1	230	232	PF00082	0.488
CLV_PCSK_KEX2_1	274	276	PF00082	0.545
CLV_PCSK_KEX2_1	324	326	PF00082	0.412
CLV_PCSK_KEX2_1	367	369	PF00082	0.400
CLV_PCSK_KEX2_1	8	10	PF00082	0.370
CLV_PCSK_KEX2_1	86	88	PF00082	0.488
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.209
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.488
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.525
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.437
CLV_PCSK_PC7_1	270	276	PF00082	0.400
CLV_PCSK_PC7_1	363	369	PF00082	0.479
CLV_PCSK_PC7_1	82	88	PF00082	0.425
CLV_PCSK_SKI1_1	231	235	PF00082	0.481
CLV_PCSK_SKI1_1	8	12	PF00082	0.425
DEG_APCC_DBOX_1	74	82	PF00400	0.168
DEG_SCF_FBW7_1	226	232	PF00400	0.225
DOC_CKS1_1	226	231	PF01111	0.225
DOC_MAPK_gen_1	15	25	PF00069	0.459
DOC_MAPK_gen_1	249	256	PF00069	0.356
DOC_MAPK_gen_1	274	281	PF00069	0.200
DOC_MAPK_gen_1	73	81	PF00069	0.272
DOC_PP2B_LxvP_1	399	402	PF13499	0.234
DOC_USP7_MATH_1	102	106	PF00917	0.258
DOC_USP7_MATH_1	158	162	PF00917	0.237
DOC_USP7_MATH_1	3	7	PF00917	0.592
DOC_USP7_MATH_1	44	48	PF00917	0.341
DOC_USP7_UBL2_3	303	307	PF12436	0.331
DOC_WW_Pin1_4	154	159	PF00397	0.272
DOC_WW_Pin1_4	208	213	PF00397	0.297
DOC_WW_Pin1_4	225	230	PF00397	0.281
DOC_WW_Pin1_4	343	348	PF00397	0.175
DOC_WW_Pin1_4	36	41	PF00397	0.389
LIG_14-3-3_CanoR_1	2	8	PF00244	0.623
LIG_14-3-3_CanoR_1	231	236	PF00244	0.220
LIG_14-3-3_CanoR_1	282	289	PF00244	0.251
LIG_14-3-3_CanoR_1	367	372	PF00244	0.211
LIG_14-3-3_CanoR_1	9	17	PF00244	0.580
LIG_Actin_WH2_2	3	20	PF00022	0.564
LIG_BIR_III_4	309	313	PF00653	0.237
LIG_BRCT_BRCA1_1	416	420	PF00533	0.275
LIG_Clathr_ClatBox_1	421	425	PF01394	0.277
LIG_deltaCOP1_diTrp_1	216	220	PF00928	0.288
LIG_eIF4E_1	36	42	PF01652	0.322
LIG_FHA_1	130	136	PF00498	0.205
LIG_FHA_1	20	26	PF00498	0.268
LIG_FHA_1	202	208	PF00498	0.221
LIG_FHA_1	386	392	PF00498	0.285
LIG_FHA_1	74	80	PF00498	0.343
LIG_FHA_2	211	217	PF00498	0.308
LIG_FHA_2	285	291	PF00498	0.206
LIG_FHA_2	368	374	PF00498	0.236
LIG_FHA_2	95	101	PF00498	0.316
LIG_LIR_Gen_1	125	133	PF02991	0.168
LIG_LIR_Gen_1	332	341	PF02991	0.221
LIG_LIR_Gen_1	46	57	PF02991	0.296
LIG_LIR_Nem_3	125	129	PF02991	0.168
LIG_LIR_Nem_3	172	178	PF02991	0.252
LIG_LIR_Nem_3	214	220	PF02991	0.315
LIG_LIR_Nem_3	239	243	PF02991	0.207
LIG_LIR_Nem_3	262	268	PF02991	0.246
LIG_LIR_Nem_3	332	338	PF02991	0.286
LIG_LIR_Nem_3	351	356	PF02991	0.344
LIG_LIR_Nem_3	385	389	PF02991	0.241
LIG_LIR_Nem_3	46	52	PF02991	0.318
LIG_LIR_Nem_3	83	88	PF02991	0.240
LIG_MYND_1	40	44	PF01753	0.262
LIG_NRBOX	105	111	PF00104	0.288
LIG_NRBOX	417	423	PF00104	0.212
LIG_SH2_CRK	335	339	PF00017	0.283
LIG_SH2_CRK	37	41	PF00017	0.465
LIG_SH2_CRK	384	388	PF00017	0.205
LIG_SH2_CRK	4	8	PF00017	0.641
LIG_SH2_CRK	49	53	PF00017	0.256
LIG_SH2_GRB2like	49	52	PF00017	0.342
LIG_SH2_NCK_1	49	53	PF00017	0.336
LIG_SH2_SRC	236	239	PF00017	0.246
LIG_SH2_SRC	49	52	PF00017	0.303
LIG_SH2_STAP1	222	226	PF00017	0.237
LIG_SH2_STAP1	272	276	PF00017	0.212
LIG_SH2_STAP1	329	333	PF00017	0.260
LIG_SH2_STAP1	335	339	PF00017	0.268
LIG_SH2_STAP1	49	53	PF00017	0.262
LIG_SH2_STAT3	222	225	PF00017	0.288
LIG_SH2_STAT5	182	185	PF00017	0.221
LIG_SH2_STAT5	240	243	PF00017	0.243
LIG_SH2_STAT5	333	336	PF00017	0.279
LIG_SH2_STAT5	349	352	PF00017	0.329
LIG_SH3_2	319	324	PF14604	0.237
LIG_SH3_3	263	269	PF00018	0.192
LIG_SH3_3	313	319	PF00018	0.256
LIG_SUMO_SIM_anti_2	76	83	PF11976	0.265
LIG_SUMO_SIM_par_1	21	26	PF11976	0.341
LIG_SUMO_SIM_par_1	76	83	PF11976	0.265
LIG_TRAF2_1	371	374	PF00917	0.212
LIG_WRC_WIRS_1	253	258	PF05994	0.212
LIG_WRC_WIRS_1	383	388	PF05994	0.288
LIG_WRC_WIRS_1	92	97	PF05994	0.237
MOD_CDK_SPK_2	225	230	PF00069	0.225
MOD_CDK_SPxK_1	225	231	PF00069	0.225
MOD_CK1_1	165	171	PF00069	0.288
MOD_CK1_1	284	290	PF00069	0.212
MOD_CK1_1	385	391	PF00069	0.229
MOD_CK1_1	394	400	PF00069	0.196
MOD_CK1_1	413	419	PF00069	0.256
MOD_CK1_1	61	67	PF00069	0.196
MOD_CK1_1	94	100	PF00069	0.324
MOD_CK2_1	210	216	PF00069	0.237
MOD_CK2_1	252	258	PF00069	0.231
MOD_CK2_1	349	355	PF00069	0.323
MOD_CK2_1	367	373	PF00069	0.236
MOD_GlcNHglycan	167	170	PF01048	0.488
MOD_GlcNHglycan	213	216	PF01048	0.524
MOD_GlcNHglycan	25	28	PF01048	0.262
MOD_GlcNHglycan	364	367	PF01048	0.454
MOD_GlcNHglycan	46	49	PF01048	0.569
MOD_GSK3_1	125	132	PF00069	0.221
MOD_GSK3_1	150	157	PF00069	0.287
MOD_GSK3_1	158	165	PF00069	0.308
MOD_GSK3_1	186	193	PF00069	0.288
MOD_GSK3_1	19	26	PF00069	0.313
MOD_GSK3_1	207	214	PF00069	0.320
MOD_GSK3_1	225	232	PF00069	0.256
MOD_GSK3_1	339	346	PF00069	0.214
MOD_GSK3_1	36	43	PF00069	0.408
MOD_GSK3_1	362	369	PF00069	0.323
MOD_GSK3_1	410	417	PF00069	0.249
MOD_GSK3_1	90	97	PF00069	0.291
MOD_N-GLC_1	154	159	PF02516	0.412
MOD_N-GLC_1	259	264	PF02516	0.446
MOD_NEK2_1	129	134	PF00069	0.228
MOD_NEK2_1	23	28	PF00069	0.274
MOD_NEK2_1	252	257	PF00069	0.212
MOD_NEK2_1	408	413	PF00069	0.260
MOD_NEK2_1	414	419	PF00069	0.244
MOD_NEK2_2	3	8	PF00069	0.719
MOD_PIKK_1	201	207	PF00454	0.221
MOD_PIKK_1	8	14	PF00454	0.569
MOD_PK_1	162	168	PF00069	0.288
MOD_PKA_1	367	373	PF00069	0.200
MOD_PKA_1	8	14	PF00069	0.648
MOD_PKA_2	281	287	PF00069	0.214
MOD_PKA_2	362	368	PF00069	0.288
MOD_PKA_2	8	14	PF00069	0.623
MOD_Plk_1	394	400	PF00069	0.328
MOD_Plk_4	122	128	PF00069	0.184
MOD_Plk_4	162	168	PF00069	0.225
MOD_Plk_4	19	25	PF00069	0.324
MOD_Plk_4	236	242	PF00069	0.246
MOD_Plk_4	382	388	PF00069	0.232
MOD_Plk_4	416	422	PF00069	0.227
MOD_ProDKin_1	154	160	PF00069	0.272
MOD_ProDKin_1	208	214	PF00069	0.297
MOD_ProDKin_1	225	231	PF00069	0.281
MOD_ProDKin_1	343	349	PF00069	0.175
MOD_ProDKin_1	36	42	PF00069	0.388
MOD_SUMO_for_1	422	425	PF00179	0.309
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.205
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.281
TRG_ENDOCYTIC_2	175	178	PF00928	0.288
TRG_ENDOCYTIC_2	240	243	PF00928	0.245
TRG_ENDOCYTIC_2	335	338	PF00928	0.277
TRG_ENDOCYTIC_2	353	356	PF00928	0.207
TRG_ENDOCYTIC_2	384	387	PF00928	0.205
TRG_ENDOCYTIC_2	4	7	PF00928	0.648
TRG_ENDOCYTIC_2	49	52	PF00928	0.268
TRG_ENDOCYTIC_2	53	56	PF00928	0.197
TRG_ER_diArg_1	16	19	PF00400	0.227
TRG_ER_diArg_1	7	9	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE5	Leptomonas seymouri	62%	100%
A0A0S4IR76	Bodo saltans	39%	74%
A0A1X0NQR7	Trypanosomatidae	33%	68%
A0A1X0NTJ7	Trypanosomatidae	39%	98%
A0A3R7NV38	Trypanosoma rangeli	32%	67%
A0JND9	Bos taurus	29%	86%
A4H7X3	Leishmania braziliensis	79%	100%
A4HWA0	Leishmania infantum	100%	100%
C9ZS87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	96%
C9ZVG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	70%
D2GZV9	Ailuropoda melanoleuca	31%	98%
E1BPW0	Bos taurus	31%	98%
E1C1L6	Gallus gallus	31%	99%
E9AQ00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O18956	Bos taurus	27%	83%
O35795	Rattus norvegicus	28%	86%
O55026	Mus musculus	29%	86%
O75354	Homo sapiens	30%	88%
O75355	Homo sapiens	27%	80%
O75356	Homo sapiens	31%	99%
O80612	Arabidopsis thaliana	31%	77%
O93295	Gallus gallus	28%	86%
P32621	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	82%
P40009	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	67%
P49961	Homo sapiens	26%	83%
P52914	Pisum sativum	29%	93%
P55772	Mus musculus	27%	83%
P79784	Gallus gallus	27%	86%
P80595	Solanum tuberosum	30%	94%
P97687	Rattus norvegicus	27%	83%
Q18411	Caenorhabditis elegans	29%	78%
Q21815	Caenorhabditis elegans	25%	77%
Q28CF8	Xenopus tropicalis	24%	70%
Q2QYE1	Oryza sativa subsp. japonica	29%	94%
Q3TCT4	Mus musculus	27%	70%
Q3U0P5	Mus musculus	30%	93%
Q4QFI1	Leishmania major	92%	100%
Q5DRK1	Rattus norvegicus	27%	86%
Q5MY95	Homo sapiens	27%	86%
Q5REF6	Pongo abelii	27%	70%
Q617Y0	Caenorhabditis briggsae	26%	77%
Q6NQA8	Arabidopsis thaliana	29%	87%
Q6P6S9	Rattus norvegicus	31%	100%
Q6Z4P2	Oryza sativa subsp. japonica	29%	91%
Q8BFW6	Mus musculus	29%	80%
Q8H1D8	Arabidopsis thaliana	31%	84%
Q8H7L6	Oryza sativa subsp. japonica	30%	87%
Q8K0L2	Mus musculus	26%	86%
Q8TGG8	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	84%
Q8TGH6	Candida albicans (strain SC5314 / ATCC MYA-2876)	32%	71%
Q9DBT4	Mus musculus	25%	69%
Q9ER31	Rattus norvegicus	32%	93%
Q9HEM6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	31%	81%
Q9MYU4	Sus scrofa	28%	83%
Q9NQZ7	Homo sapiens	26%	70%
Q9QYC8	Mesocricetus auratus	31%	91%
Q9SPM5	Arabidopsis thaliana	28%	90%
Q9SQG2	Arabidopsis thaliana	27%	90%
Q9USP2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	74%
Q9UT35	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	76%
Q9WUZ9	Mus musculus	31%	100%
Q9XI62	Arabidopsis thaliana	30%	88%
Q9XU84	Caenorhabditis elegans	30%	89%
Q9Y227	Homo sapiens	25%	69%
Q9Y5L3	Homo sapiens	29%	86%