Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I8Z4_LEIDO

TriTrypDb:

LdBPK_110120.1 , LdCL_110006100 , LDHU3_11.0130

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I8Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8Z4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.685
CLV_NRD_NRD_1	9	11	PF00675	0.598
CLV_NRD_NRD_1	93	95	PF00675	0.598
CLV_PCSK_KEX2_1	131	133	PF00082	0.686
CLV_PCSK_KEX2_1	9	11	PF00082	0.598
CLV_PCSK_KEX2_1	93	95	PF00082	0.622
CLV_PCSK_SKI1_1	32	36	PF00082	0.740
DEG_Nend_Nbox_1	1	3	PF02207	0.680
DOC_MAPK_gen_1	28	37	PF00069	0.639
DOC_MAPK_gen_1	75	82	PF00069	0.695
DOC_MAPK_gen_1	9	16	PF00069	0.648
DOC_MAPK_gen_1	93	100	PF00069	0.447
DOC_PP4_FxxP_1	60	63	PF00568	0.648
DOC_USP7_MATH_1	123	127	PF00917	0.654
DOC_USP7_MATH_1	161	165	PF00917	0.710
LIG_14-3-3_CanoR_1	32	38	PF00244	0.699
LIG_APCC_ABBA_1	14	19	PF00400	0.643
LIG_BRCT_BRCA1_1	102	106	PF00533	0.643
LIG_BRCT_BRCA1_1	142	146	PF00533	0.697
LIG_BRCT_BRCA1_1	163	167	PF00533	0.595
LIG_BRCT_BRCA1_1	75	79	PF00533	0.612
LIG_FHA_1	62	68	PF00498	0.626
LIG_FHA_2	34	40	PF00498	0.617
LIG_LIR_Apic_2	58	63	PF02991	0.646
LIG_LIR_Gen_1	11	18	PF02991	0.635
LIG_LIR_Gen_1	143	154	PF02991	0.712
LIG_LIR_Gen_1	76	87	PF02991	0.584
LIG_LIR_Nem_3	103	109	PF02991	0.506
LIG_LIR_Nem_3	11	16	PF02991	0.639
LIG_LIR_Nem_3	164	170	PF02991	0.615
LIG_LIR_Nem_3	76	82	PF02991	0.584
LIG_LIR_Nem_3	86	91	PF02991	0.530
LIG_NRP_CendR_1	187	189	PF00754	0.563
LIG_SH2_STAT5	13	16	PF00017	0.591
LIG_SH2_STAT5	170	173	PF00017	0.637
LIG_SH3_3	151	157	PF00018	0.717
LIG_SH3_3	60	66	PF00018	0.746
LIG_SUMO_SIM_anti_2	95	101	PF11976	0.622
LIG_TRAF2_1	18	21	PF00917	0.754
LIG_TRAF2_1	36	39	PF00917	0.441
LIG_TRAF2_1	56	59	PF00917	0.640
MOD_CK1_1	108	114	PF00069	0.640
MOD_CK1_1	126	132	PF00069	0.643
MOD_CK2_1	160	166	PF00069	0.613
MOD_CK2_1	33	39	PF00069	0.626
MOD_CK2_1	46	52	PF00069	0.641
MOD_CK2_1	53	59	PF00069	0.606
MOD_GlcNHglycan	125	128	PF01048	0.727
MOD_GlcNHglycan	146	149	PF01048	0.685
MOD_GlcNHglycan	176	179	PF01048	0.612
MOD_GSK3_1	100	107	PF00069	0.635
MOD_GSK3_1	140	147	PF00069	0.693
MOD_GSK3_1	161	168	PF00069	0.587
MOD_GSK3_1	61	68	PF00069	0.628
MOD_GSK3_1	83	90	PF00069	0.583
MOD_LATS_1	51	57	PF00433	0.621
MOD_N-GLC_1	104	109	PF02516	0.641
MOD_NEK2_1	174	179	PF00069	0.651
MOD_NEK2_1	73	78	PF00069	0.616
MOD_PIKK_1	100	106	PF00454	0.739
MOD_PK_1	53	59	PF00069	0.666
MOD_Plk_1	104	110	PF00069	0.640
MOD_Plk_2-3	46	52	PF00069	0.743
MOD_Plk_4	65	71	PF00069	0.564
MOD_Plk_4	83	89	PF00069	0.587
TRG_ENDOCYTIC_2	13	16	PF00928	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM1	Leptomonas seymouri	67%	100%
A4H9U6	Leishmania braziliensis	84%	100%
A4HUS4	Leishmania infantum	100%	100%
E9ANF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QH68	Leishmania major	96%	100%