Pumillio protein 10, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio-repeat, RNA-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I8Y6_LEIDO

TriTrypDb:

LdBPK_110470.1 , LdCL_110009600 , LDHU3_11.0570

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I8Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8Y6

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.432
CLV_C14_Caspase3-7	158	162	PF00656	0.730
CLV_C14_Caspase3-7	475	479	PF00656	0.459
CLV_NRD_NRD_1	113	115	PF00675	0.648
CLV_NRD_NRD_1	188	190	PF00675	0.494
CLV_NRD_NRD_1	310	312	PF00675	0.645
CLV_NRD_NRD_1	32	34	PF00675	0.607
CLV_NRD_NRD_1	359	361	PF00675	0.504
CLV_NRD_NRD_1	40	42	PF00675	0.576
CLV_NRD_NRD_1	516	518	PF00675	0.354
CLV_NRD_NRD_1	523	525	PF00675	0.413
CLV_PCSK_FUR_1	16	20	PF00082	0.604
CLV_PCSK_FUR_1	30	34	PF00082	0.637
CLV_PCSK_FUR_1	373	377	PF00082	0.460
CLV_PCSK_KEX2_1	115	117	PF00082	0.646
CLV_PCSK_KEX2_1	18	20	PF00082	0.538
CLV_PCSK_KEX2_1	188	190	PF00082	0.494
CLV_PCSK_KEX2_1	32	34	PF00082	0.524
CLV_PCSK_KEX2_1	359	361	PF00082	0.462
CLV_PCSK_KEX2_1	364	366	PF00082	0.412
CLV_PCSK_KEX2_1	375	377	PF00082	0.292
CLV_PCSK_KEX2_1	423	425	PF00082	0.508
CLV_PCSK_KEX2_1	516	518	PF00082	0.481
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.646
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.551
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.430
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.312
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.508
CLV_PCSK_PC7_1	360	366	PF00082	0.502
CLV_PCSK_SKI1_1	211	215	PF00082	0.497
CLV_PCSK_SKI1_1	314	318	PF00082	0.737
CLV_PCSK_SKI1_1	360	364	PF00082	0.489
CLV_PCSK_SKI1_1	644	648	PF00082	0.529
CLV_Separin_Metazoa	370	374	PF03568	0.392
DEG_APCC_DBOX_1	359	367	PF00400	0.504
DEG_SCF_FBW7_1	296	302	PF00400	0.551
DEG_SPOP_SBC_1	299	303	PF00917	0.532
DOC_CKS1_1	296	301	PF01111	0.538
DOC_MAPK_gen_1	364	371	PF00069	0.526
DOC_MAPK_gen_1	38	48	PF00069	0.696
DOC_MAPK_MEF2A_6	364	371	PF00069	0.397
DOC_MAPK_MEF2A_6	445	454	PF00069	0.315
DOC_PP2B_LxvP_1	71	74	PF13499	0.529
DOC_SPAK_OSR1_1	625	629	PF12202	0.346
DOC_USP7_MATH_1	104	108	PF00917	0.639
DOC_USP7_MATH_1	155	159	PF00917	0.702
DOC_USP7_MATH_1	200	204	PF00917	0.528
DOC_USP7_MATH_1	299	303	PF00917	0.532
DOC_USP7_MATH_1	586	590	PF00917	0.406
DOC_USP7_UBL2_3	313	317	PF12436	0.626
DOC_USP7_UBL2_3	38	42	PF12436	0.675
DOC_WW_Pin1_4	295	300	PF00397	0.551
DOC_WW_Pin1_4	582	587	PF00397	0.484
LIG_14-3-3_CanoR_1	189	195	PF00244	0.449
LIG_14-3-3_CanoR_1	231	239	PF00244	0.473
LIG_14-3-3_CanoR_1	253	262	PF00244	0.501
LIG_14-3-3_CanoR_1	269	275	PF00244	0.288
LIG_14-3-3_CanoR_1	331	340	PF00244	0.465
LIG_14-3-3_CanoR_1	499	507	PF00244	0.486
LIG_14-3-3_CanoR_1	713	720	PF00244	0.534
LIG_Actin_RPEL_3	353	372	PF02755	0.505
LIG_APCC_ABBA_1	402	407	PF00400	0.488
LIG_BIR_III_4	667	671	PF00653	0.499
LIG_BRCT_BRCA1_1	642	646	PF00533	0.514
LIG_EH1_1	426	434	PF00400	0.386
LIG_EH1_1	470	478	PF00400	0.357
LIG_EH1_1	499	507	PF00400	0.409
LIG_EH1_1	625	633	PF00400	0.443
LIG_FHA_1	172	178	PF00498	0.577
LIG_FHA_1	332	338	PF00498	0.507
LIG_FHA_1	376	382	PF00498	0.471
LIG_FHA_1	386	392	PF00498	0.460
LIG_FHA_1	442	448	PF00498	0.383
LIG_FHA_1	501	507	PF00498	0.515
LIG_FHA_1	553	559	PF00498	0.447
LIG_FHA_1	601	607	PF00498	0.493
LIG_FHA_1	653	659	PF00498	0.365
LIG_FHA_1	97	103	PF00498	0.732
LIG_FHA_2	135	141	PF00498	0.488
LIG_FHA_2	255	261	PF00498	0.550
LIG_FHA_2	592	598	PF00498	0.411
LIG_GBD_Chelix_1	190	198	PF00786	0.387
LIG_GBD_Chelix_1	428	436	PF00786	0.456
LIG_Integrin_isoDGR_2	623	625	PF01839	0.334
LIG_LIR_Gen_1	538	549	PF02991	0.419
LIG_LIR_Gen_1	594	601	PF02991	0.383
LIG_LIR_LC3C_4	512	515	PF02991	0.320
LIG_LIR_Nem_3	538	544	PF02991	0.426
LIG_LIR_Nem_3	594	599	PF02991	0.376
LIG_LIR_Nem_3	643	649	PF02991	0.480
LIG_MAD2	45	53	PF02301	0.630
LIG_NRBOX	349	355	PF00104	0.552
LIG_NRBOX	380	386	PF00104	0.426
LIG_NRBOX	658	664	PF00104	0.438
LIG_PCNA_PIPBox_1	78	87	PF02747	0.521
LIG_PCNA_yPIPBox_3	423	433	PF02747	0.432
LIG_PCNA_yPIPBox_3	551	563	PF02747	0.350
LIG_PCNA_yPIPBox_3	653	663	PF02747	0.384
LIG_Pex14_2	728	732	PF04695	0.381
LIG_PTB_Apo_2	540	547	PF02174	0.483
LIG_PTB_Phospho_1	540	546	PF10480	0.483
LIG_REV1ctd_RIR_1	726	735	PF16727	0.400
LIG_RPA_C_Fungi	660	672	PF08784	0.488
LIG_SH2_CRK	85	89	PF00017	0.526
LIG_SH2_NCK_1	546	550	PF00017	0.361
LIG_SH2_NCK_1	85	89	PF00017	0.526
LIG_SH2_STAP1	587	591	PF00017	0.348
LIG_SH2_STAP1	85	89	PF00017	0.596
LIG_SH2_STAT5	546	549	PF00017	0.490
LIG_SH2_STAT5	557	560	PF00017	0.350
LIG_SH3_3	338	344	PF00018	0.443
LIG_SH3_3	435	441	PF00018	0.530
LIG_SH3_3	45	51	PF00018	0.673
LIG_Sin3_3	148	155	PF02671	0.561
LIG_SUMO_SIM_anti_2	168	180	PF11976	0.526
LIG_SUMO_SIM_par_1	292	298	PF11976	0.517
LIG_SUMO_SIM_par_1	382	388	PF11976	0.452
LIG_SUMO_SIM_par_1	472	478	PF11976	0.391
LIG_TRAF2_1	121	124	PF00917	0.619
LIG_TRAF2_1	322	325	PF00917	0.730
LIG_TRAF2_1	740	743	PF00917	0.656
LIG_UBA3_1	518	525	PF00899	0.375
LIG_UBA3_1	662	671	PF00899	0.405
MOD_CK1_1	105	111	PF00069	0.668
MOD_CK1_1	241	247	PF00069	0.517
MOD_CK1_1	295	301	PF00069	0.540
MOD_CK1_1	390	396	PF00069	0.537
MOD_CK1_1	484	490	PF00069	0.529
MOD_CK1_1	564	570	PF00069	0.489
MOD_CK1_1	715	721	PF00069	0.538
MOD_CK1_1	96	102	PF00069	0.703
MOD_CK2_1	201	207	PF00069	0.498
MOD_CK2_1	23	29	PF00069	0.643
MOD_CK2_1	254	260	PF00069	0.560
MOD_CK2_1	301	307	PF00069	0.718
MOD_CK2_1	484	490	PF00069	0.460
MOD_CK2_1	591	597	PF00069	0.370
MOD_Cter_Amidation	1	4	PF01082	0.545
MOD_Cter_Amidation	186	189	PF01082	0.494
MOD_Cter_Amidation	309	312	PF01082	0.716
MOD_GlcNHglycan	104	107	PF01048	0.659
MOD_GlcNHglycan	157	160	PF01048	0.699
MOD_GlcNHglycan	184	188	PF01048	0.461
MOD_GlcNHglycan	233	236	PF01048	0.448
MOD_GlcNHglycan	303	306	PF01048	0.731
MOD_GlcNHglycan	327	330	PF01048	0.749
MOD_GlcNHglycan	345	348	PF01048	0.320
MOD_GlcNHglycan	460	463	PF01048	0.463
MOD_GlcNHglycan	486	489	PF01048	0.486
MOD_GlcNHglycan	563	566	PF01048	0.508
MOD_GlcNHglycan	707	710	PF01048	0.493
MOD_GlcNHglycan	714	717	PF01048	0.438
MOD_GSK3_1	102	109	PF00069	0.677
MOD_GSK3_1	190	197	PF00069	0.425
MOD_GSK3_1	264	271	PF00069	0.516
MOD_GSK3_1	294	301	PF00069	0.505
MOD_GSK3_1	371	378	PF00069	0.454
MOD_GSK3_1	379	386	PF00069	0.403
MOD_GSK3_1	387	394	PF00069	0.391
MOD_GSK3_1	458	465	PF00069	0.334
MOD_GSK3_1	520	527	PF00069	0.429
MOD_GSK3_1	552	559	PF00069	0.482
MOD_GSK3_1	578	585	PF00069	0.488
MOD_GSK3_1	681	688	PF00069	0.398
MOD_GSK3_1	715	722	PF00069	0.519
MOD_GSK3_1	93	100	PF00069	0.676
MOD_N-GLC_1	500	505	PF02516	0.455
MOD_N-GLC_1	681	686	PF02516	0.540
MOD_NEK2_1	134	139	PF00069	0.465
MOD_NEK2_1	142	147	PF00069	0.517
MOD_NEK2_1	194	199	PF00069	0.450
MOD_NEK2_1	23	28	PF00069	0.620
MOD_NEK2_1	278	283	PF00069	0.500
MOD_NEK2_1	294	299	PF00069	0.363
MOD_NEK2_1	371	376	PF00069	0.459
MOD_NEK2_1	385	390	PF00069	0.403
MOD_NEK2_1	552	557	PF00069	0.483
MOD_NEK2_1	561	566	PF00069	0.480
MOD_NEK2_1	7	12	PF00069	0.619
MOD_PIKK_1	142	148	PF00454	0.514
MOD_PIKK_1	379	385	PF00454	0.494
MOD_PIKK_1	652	658	PF00454	0.365
MOD_PKA_1	375	381	PF00069	0.516
MOD_PKA_1	524	530	PF00069	0.438
MOD_PKA_2	201	207	PF00069	0.329
MOD_PKA_2	254	260	PF00069	0.508
MOD_PKA_2	268	274	PF00069	0.322
MOD_PKA_2	330	336	PF00069	0.576
MOD_PKA_2	375	381	PF00069	0.503
MOD_PKA_2	638	644	PF00069	0.486
MOD_PKA_2	652	658	PF00069	0.406
MOD_PKA_2	712	718	PF00069	0.519
MOD_PKB_1	253	261	PF00069	0.538
MOD_Plk_1	171	177	PF00069	0.628
MOD_Plk_1	675	681	PF00069	0.490
MOD_Plk_1	96	102	PF00069	0.505
MOD_Plk_4	173	179	PF00069	0.434
MOD_Plk_4	190	196	PF00069	0.354
MOD_Plk_4	472	478	PF00069	0.434
MOD_Plk_4	509	515	PF00069	0.364
MOD_Plk_4	564	570	PF00069	0.520
MOD_Plk_4	602	608	PF00069	0.491
MOD_Plk_4	675	681	PF00069	0.516
MOD_Plk_4	690	696	PF00069	0.290
MOD_Plk_4	702	708	PF00069	0.356
MOD_Plk_4	715	721	PF00069	0.509
MOD_Plk_4	97	103	PF00069	0.626
MOD_ProDKin_1	295	301	PF00069	0.566
MOD_ProDKin_1	582	588	PF00069	0.478
MOD_SUMO_rev_2	90	96	PF00179	0.512
TRG_DiLeu_BaEn_1	548	553	PF01217	0.469
TRG_DiLeu_BaEn_4	218	224	PF01217	0.431
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.474
TRG_DiLeu_BaLyEn_6	517	522	PF01217	0.468
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.497
TRG_ENDOCYTIC_2	85	88	PF00928	0.546
TRG_ER_diArg_1	188	190	PF00400	0.499
TRG_ER_diArg_1	252	255	PF00400	0.508
TRG_ER_diArg_1	515	517	PF00400	0.484
TRG_ER_diArg_1	9	12	PF00400	0.664
TRG_NES_CRM1_1	37	49	PF08389	0.580
TRG_NES_CRM1_1	410	422	PF08389	0.481
TRG_NES_CRM1_1	723	738	PF08389	0.502
TRG_NLS_MonoCore_2	113	118	PF00514	0.765
TRG_NLS_MonoCore_2	310	315	PF00514	0.746
TRG_NLS_MonoExtC_3	113	118	PF00514	0.665
TRG_NLS_MonoExtN_4	311	316	PF00514	0.681
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	625	629	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F3	Leptomonas seymouri	69%	100%
A0A0S4IWW4	Bodo saltans	35%	100%
A0A1X0NV47	Trypanosomatidae	38%	100%
A0A3R7MZX0	Trypanosoma rangeli	38%	100%
A4H6G3	Leishmania braziliensis	84%	100%
A4HUV8	Leishmania infantum	99%	100%
D0A7J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ANJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QH33	Leishmania major	94%	100%
V5DSY9	Trypanosoma cruzi	38%	100%