MIF4G domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8I8Y2_LEIDO

TriTrypDb:

LdBPK_141470.1 , LdCL_140020500 , LDHU3_14.1830

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I8Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8Y2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	151	157	PF00089	0.430
CLV_NRD_NRD_1	105	107	PF00675	0.471
CLV_NRD_NRD_1	167	169	PF00675	0.419
CLV_NRD_NRD_1	310	312	PF00675	0.577
CLV_PCSK_KEX2_1	105	107	PF00082	0.452
CLV_PCSK_KEX2_1	167	169	PF00082	0.419
CLV_PCSK_KEX2_1	310	312	PF00082	0.577
CLV_PCSK_PC7_1	163	169	PF00082	0.390
CLV_PCSK_SKI1_1	125	129	PF00082	0.439
CLV_PCSK_SKI1_1	247	251	PF00082	0.543
CLV_PCSK_SKI1_1	84	88	PF00082	0.377
CLV_PCSK_SKI1_1	99	103	PF00082	0.359
DEG_Nend_UBRbox_2	1	3	PF02207	0.469
DOC_CYCLIN_RxL_1	78	91	PF00134	0.381
DOC_CYCLIN_RxL_1	96	104	PF00134	0.315
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.498
DOC_MAPK_gen_1	53	61	PF00069	0.442
DOC_PP1_RVXF_1	176	183	PF00149	0.432
DOC_PP4_FxxP_1	155	158	PF00568	0.466
DOC_PP4_FxxP_1	278	281	PF00568	0.593
DOC_SPAK_OSR1_1	154	158	PF12202	0.433
DOC_USP7_MATH_1	172	176	PF00917	0.419
DOC_WW_Pin1_4	277	282	PF00397	0.612
LIG_14-3-3_CanoR_1	154	158	PF00244	0.434
LIG_14-3-3_CanoR_1	167	173	PF00244	0.381
LIG_14-3-3_CanoR_1	24	32	PF00244	0.353
LIG_14-3-3_CanoR_1	274	279	PF00244	0.562
LIG_14-3-3_CanoR_1	82	87	PF00244	0.363
LIG_FHA_1	102	108	PF00498	0.408
LIG_FHA_2	217	223	PF00498	0.631
LIG_FHA_2	83	89	PF00498	0.434
LIG_LIR_Apic_2	276	281	PF02991	0.588
LIG_LIR_Gen_1	38	48	PF02991	0.365
LIG_LIR_Gen_1	58	69	PF02991	0.322
LIG_LIR_Nem_3	161	165	PF02991	0.438
LIG_LIR_Nem_3	22	26	PF02991	0.373
LIG_LIR_Nem_3	38	43	PF02991	0.380
LIG_LIR_Nem_3	58	64	PF02991	0.306
LIG_LIR_Nem_3	85	90	PF02991	0.537
LIG_NRBOX	123	129	PF00104	0.433
LIG_NRBOX	97	103	PF00104	0.501
LIG_SH2_STAP1	297	301	PF00017	0.468
LIG_SH3_3	126	132	PF00018	0.410
LIG_SH3_3	154	160	PF00018	0.473
LIG_SH3_3	200	206	PF00018	0.609
LIG_SH3_3	284	290	PF00018	0.623
LIG_SUMO_SIM_anti_2	88	94	PF11976	0.402
LIG_SUMO_SIM_par_1	130	136	PF11976	0.427
LIG_WRC_WIRS_1	159	164	PF05994	0.378
LIG_WRC_WIRS_1	275	280	PF05994	0.552
MOD_CK1_1	216	222	PF00069	0.702
MOD_CK1_1	273	279	PF00069	0.594
MOD_CK1_1	28	34	PF00069	0.430
MOD_CK1_1	280	286	PF00069	0.585
MOD_CK2_1	110	116	PF00069	0.382
MOD_CK2_1	216	222	PF00069	0.573
MOD_CK2_1	235	241	PF00069	0.410
MOD_CK2_1	82	88	PF00069	0.403
MOD_GlcNHglycan	168	171	PF01048	0.459
MOD_GlcNHglycan	174	177	PF01048	0.368
MOD_GlcNHglycan	231	235	PF01048	0.537
MOD_GlcNHglycan	237	240	PF01048	0.484
MOD_GlcNHglycan	282	285	PF01048	0.659
MOD_GlcNHglycan	299	302	PF01048	0.525
MOD_GSK3_1	172	179	PF00069	0.321
MOD_GSK3_1	22	29	PF00069	0.362
MOD_GSK3_1	270	277	PF00069	0.569
MOD_N-GLC_1	110	115	PF02516	0.419
MOD_NEK2_1	101	106	PF00069	0.398
MOD_NEK2_1	26	31	PF00069	0.398
MOD_PKA_2	153	159	PF00069	0.437
MOD_PKA_2	166	172	PF00069	0.382
MOD_PKA_2	273	279	PF00069	0.558
MOD_Plk_1	110	116	PF00069	0.390
MOD_Plk_1	38	44	PF00069	0.402
MOD_Plk_4	251	257	PF00069	0.523
MOD_ProDKin_1	277	283	PF00069	0.614
MOD_SUMO_rev_2	179	186	PF00179	0.342
TRG_AP2beta_CARGO_1	58	68	PF09066	0.392
TRG_DiLeu_BaEn_2	37	43	PF01217	0.404
TRG_DiLeu_BaEn_4	38	44	PF01217	0.376
TRG_ER_diArg_1	105	107	PF00400	0.471
TRG_ER_diArg_1	166	168	PF00400	0.408
TRG_ER_diArg_1	52	55	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	178	183	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q5	Leptomonas seymouri	43%	76%
A4H7V8	Leishmania braziliensis	69%	100%
A4HW84	Leishmania infantum	99%	100%
E9APY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QFJ6	Leishmania major	90%	100%