Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I8X0_LEIDO

TriTrypDb:

LdBPK_141300.1 , LdCL_140018900 , LDHU3_14.1640

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I8X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8X0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.639
CLV_C14_Caspase3-7	263	267	PF00656	0.681
CLV_C14_Caspase3-7	436	440	PF00656	0.670
CLV_C14_Caspase3-7	451	455	PF00656	0.542
CLV_C14_Caspase3-7	486	490	PF00656	0.588
CLV_C14_Caspase3-7	532	536	PF00656	0.586
CLV_C14_Caspase3-7	737	741	PF00656	0.397
CLV_C14_Caspase3-7	799	803	PF00656	0.525
CLV_C14_Caspase3-7	80	84	PF00656	0.639
CLV_NRD_NRD_1	122	124	PF00675	0.507
CLV_NRD_NRD_1	259	261	PF00675	0.689
CLV_NRD_NRD_1	339	341	PF00675	0.616
CLV_NRD_NRD_1	355	357	PF00675	0.637
CLV_NRD_NRD_1	385	387	PF00675	0.506
CLV_NRD_NRD_1	443	445	PF00675	0.488
CLV_NRD_NRD_1	576	578	PF00675	0.515
CLV_NRD_NRD_1	74	76	PF00675	0.579
CLV_PCSK_FUR_1	257	261	PF00082	0.627
CLV_PCSK_KEX2_1	259	261	PF00082	0.682
CLV_PCSK_KEX2_1	339	341	PF00082	0.675
CLV_PCSK_KEX2_1	347	349	PF00082	0.627
CLV_PCSK_KEX2_1	355	357	PF00082	0.520
CLV_PCSK_KEX2_1	385	387	PF00082	0.503
CLV_PCSK_KEX2_1	443	445	PF00082	0.492
CLV_PCSK_KEX2_1	474	476	PF00082	0.547
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.637
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.441
CLV_PCSK_PC7_1	255	261	PF00082	0.553
CLV_PCSK_SKI1_1	32	36	PF00082	0.492
CLV_PCSK_SKI1_1	321	325	PF00082	0.660
CLV_PCSK_SKI1_1	347	351	PF00082	0.721
CLV_PCSK_SKI1_1	481	485	PF00082	0.492
CLV_PCSK_SKI1_1	664	668	PF00082	0.538
DEG_APCC_DBOX_1	663	671	PF00400	0.539
DEG_APCC_KENBOX_2	42	46	PF00400	0.485
DOC_CKS1_1	374	379	PF01111	0.601
DOC_CYCLIN_RxL_1	497	505	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.549
DOC_MAPK_gen_1	255	264	PF00069	0.625
DOC_MAPK_HePTP_8	201	213	PF00069	0.516
DOC_MAPK_MEF2A_6	16	24	PF00069	0.529
DOC_MAPK_MEF2A_6	204	213	PF00069	0.520
DOC_PIKK_1	93	101	PF02985	0.518
DOC_PP2B_LxvP_1	213	216	PF13499	0.535
DOC_USP7_MATH_1	161	165	PF00917	0.703
DOC_USP7_MATH_1	178	182	PF00917	0.557
DOC_USP7_MATH_1	190	194	PF00917	0.594
DOC_USP7_MATH_1	243	247	PF00917	0.575
DOC_USP7_MATH_1	273	277	PF00917	0.586
DOC_USP7_MATH_1	330	334	PF00917	0.675
DOC_USP7_MATH_1	490	494	PF00917	0.498
DOC_USP7_MATH_1	510	514	PF00917	0.322
DOC_USP7_MATH_1	618	622	PF00917	0.598
DOC_USP7_MATH_1	638	642	PF00917	0.626
DOC_USP7_MATH_1	662	666	PF00917	0.520
DOC_USP7_MATH_1	702	706	PF00917	0.538
DOC_USP7_MATH_1	871	875	PF00917	0.831
DOC_USP7_MATH_1	912	916	PF00917	0.690
DOC_USP7_UBL2_3	553	557	PF12436	0.480
DOC_WW_Pin1_4	148	153	PF00397	0.729
DOC_WW_Pin1_4	245	250	PF00397	0.648
DOC_WW_Pin1_4	282	287	PF00397	0.626
DOC_WW_Pin1_4	290	295	PF00397	0.633
DOC_WW_Pin1_4	322	327	PF00397	0.558
DOC_WW_Pin1_4	370	375	PF00397	0.767
DOC_WW_Pin1_4	67	72	PF00397	0.500
DOC_WW_Pin1_4	857	862	PF00397	0.641
DOC_WW_Pin1_4	908	913	PF00397	0.828
LIG_14-3-3_CanoR_1	123	133	PF00244	0.569
LIG_14-3-3_CanoR_1	242	249	PF00244	0.606
LIG_14-3-3_CanoR_1	259	265	PF00244	0.527
LIG_14-3-3_CanoR_1	274	280	PF00244	0.602
LIG_14-3-3_CanoR_1	339	345	PF00244	0.644
LIG_14-3-3_CanoR_1	851	856	PF00244	0.584
LIG_14-3-3_CanoR_1	918	924	PF00244	0.710
LIG_Actin_WH2_2	463	480	PF00022	0.495
LIG_Actin_WH2_2	703	720	PF00022	0.529
LIG_Actin_WH2_2	894	909	PF00022	0.607
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_BRCT_BRCA1_1	275	279	PF00533	0.680
LIG_Clathr_ClatBox_1	38	42	PF01394	0.357
LIG_EVH1_2	377	381	PF00568	0.572
LIG_FAT_LD_1	438	446	PF03623	0.452
LIG_FHA_1	161	167	PF00498	0.625
LIG_FHA_1	3	9	PF00498	0.600
LIG_FHA_1	322	328	PF00498	0.779
LIG_FHA_1	496	502	PF00498	0.452
LIG_FHA_1	54	60	PF00498	0.446
LIG_FHA_1	571	577	PF00498	0.656
LIG_FHA_1	858	864	PF00498	0.769
LIG_FHA_1	874	880	PF00498	0.675
LIG_FHA_2	113	119	PF00498	0.504
LIG_FHA_2	28	34	PF00498	0.475
LIG_FHA_2	310	316	PF00498	0.662
LIG_FHA_2	341	347	PF00498	0.573
LIG_FHA_2	530	536	PF00498	0.583
LIG_FHA_2	804	810	PF00498	0.489
LIG_FHA_2	918	924	PF00498	0.678
LIG_GBD_Chelix_1	397	405	PF00786	0.481
LIG_LIR_Gen_1	214	222	PF02991	0.579
LIG_LIR_Gen_1	379	387	PF02991	0.534
LIG_LIR_Gen_1	520	528	PF02991	0.481
LIG_LIR_Nem_3	214	220	PF02991	0.574
LIG_LIR_Nem_3	23	27	PF02991	0.523
LIG_LIR_Nem_3	276	282	PF02991	0.629
LIG_LIR_Nem_3	379	384	PF02991	0.552
LIG_LIR_Nem_3	520	525	PF02991	0.469
LIG_LIR_Nem_3	833	838	PF02991	0.572
LIG_NRBOX	437	443	PF00104	0.457
LIG_NRBOX	558	564	PF00104	0.510
LIG_NRBOX	679	685	PF00104	0.503
LIG_NRBOX	97	103	PF00104	0.520
LIG_RPA_C_Fungi	350	362	PF08784	0.586
LIG_SH2_GRB2like	393	396	PF00017	0.489
LIG_SH2_STAT5	393	396	PF00017	0.524
LIG_SH2_STAT5	763	766	PF00017	0.424
LIG_SH3_3	262	268	PF00018	0.715
LIG_SH3_3	274	280	PF00018	0.584
LIG_SH3_3	291	297	PF00018	0.522
LIG_SH3_3	371	377	PF00018	0.703
LIG_SH3_3	921	927	PF00018	0.688
LIG_SUMO_SIM_anti_2	207	214	PF11976	0.599
LIG_SUMO_SIM_anti_2	410	417	PF11976	0.444
LIG_SUMO_SIM_par_1	524	530	PF11976	0.545
LIG_TRAF2_1	564	567	PF00917	0.495
LIG_UBA3_1	34	43	PF00899	0.496
LIG_UBA3_1	401	406	PF00899	0.433
LIG_UBA3_1	786	792	PF00899	0.419
LIG_UBA3_1	796	804	PF00899	0.461
LIG_WW_3	884	888	PF00397	0.692
MOD_CDK_SPxxK_3	293	300	PF00069	0.610
MOD_CK1_1	138	144	PF00069	0.670
MOD_CK1_1	148	154	PF00069	0.664
MOD_CK1_1	156	162	PF00069	0.521
MOD_CK1_1	174	180	PF00069	0.731
MOD_CK1_1	191	197	PF00069	0.587
MOD_CK1_1	2	8	PF00069	0.566
MOD_CK1_1	247	253	PF00069	0.716
MOD_CK1_1	275	281	PF00069	0.814
MOD_CK1_1	373	379	PF00069	0.686
MOD_CK1_1	645	651	PF00069	0.577
MOD_CK1_1	70	76	PF00069	0.524
MOD_CK1_1	905	911	PF00069	0.703
MOD_CK1_1	919	925	PF00069	0.705
MOD_CK2_1	112	118	PF00069	0.508
MOD_CK2_1	301	307	PF00069	0.659
MOD_CK2_1	309	315	PF00069	0.744
MOD_CK2_1	340	346	PF00069	0.580
MOD_CK2_1	618	624	PF00069	0.553
MOD_CK2_1	645	651	PF00069	0.521
MOD_CK2_1	917	923	PF00069	0.726
MOD_GlcNHglycan	127	130	PF01048	0.607
MOD_GlcNHglycan	147	150	PF01048	0.804
MOD_GlcNHglycan	158	161	PF01048	0.550
MOD_GlcNHglycan	163	166	PF01048	0.607
MOD_GlcNHglycan	173	176	PF01048	0.708
MOD_GlcNHglycan	189	193	PF01048	0.586
MOD_GlcNHglycan	222	225	PF01048	0.636
MOD_GlcNHglycan	250	253	PF01048	0.723
MOD_GlcNHglycan	357	360	PF01048	0.768
MOD_GlcNHglycan	428	431	PF01048	0.515
MOD_GlcNHglycan	512	515	PF01048	0.468
MOD_GlcNHglycan	591	594	PF01048	0.447
MOD_GlcNHglycan	663	667	PF01048	0.570
MOD_GlcNHglycan	699	702	PF01048	0.576
MOD_GlcNHglycan	713	717	PF01048	0.630
MOD_GlcNHglycan	730	733	PF01048	0.481
MOD_GlcNHglycan	887	890	PF01048	0.727
MOD_GlcNHglycan	907	910	PF01048	0.693
MOD_GSK3_1	131	138	PF00069	0.652
MOD_GSK3_1	141	148	PF00069	0.734
MOD_GSK3_1	156	163	PF00069	0.548
MOD_GSK3_1	174	181	PF00069	0.634
MOD_GSK3_1	234	241	PF00069	0.575
MOD_GSK3_1	243	250	PF00069	0.735
MOD_GSK3_1	298	305	PF00069	0.706
MOD_GSK3_1	366	373	PF00069	0.676
MOD_GSK3_1	419	426	PF00069	0.576
MOD_GSK3_1	638	645	PF00069	0.561
MOD_GSK3_1	786	793	PF00069	0.418
MOD_GSK3_1	851	858	PF00069	0.585
MOD_GSK3_1	871	878	PF00069	0.504
MOD_GSK3_1	901	908	PF00069	0.720
MOD_GSK3_1	912	919	PF00069	0.631
MOD_N-GLC_1	612	617	PF02516	0.570
MOD_N-GLC_1	779	784	PF02516	0.448
MOD_NEK2_1	27	32	PF00069	0.438
MOD_NEK2_1	414	419	PF00069	0.609
MOD_NEK2_1	779	784	PF00069	0.422
MOD_NEK2_1	790	795	PF00069	0.412
MOD_NEK2_1	916	921	PF00069	0.698
MOD_NEK2_2	912	917	PF00069	0.685
MOD_PIKK_1	178	184	PF00454	0.675
MOD_PIKK_1	2	8	PF00454	0.574
MOD_PIKK_1	241	247	PF00454	0.761
MOD_PK_1	260	266	PF00069	0.638
MOD_PKA_1	339	345	PF00069	0.655
MOD_PKA_1	347	353	PF00069	0.662
MOD_PKA_1	355	361	PF00069	0.585
MOD_PKA_2	112	118	PF00069	0.535
MOD_PKA_2	234	240	PF00069	0.665
MOD_PKA_2	241	247	PF00069	0.600
MOD_PKA_2	273	279	PF00069	0.680
MOD_PKA_2	339	345	PF00069	0.652
MOD_PKA_2	347	353	PF00069	0.616
MOD_PKA_2	354	360	PF00069	0.459
MOD_PKA_2	645	651	PF00069	0.622
MOD_PKA_2	697	703	PF00069	0.634
MOD_PKA_2	917	923	PF00069	0.800
MOD_Plk_1	618	624	PF00069	0.598
MOD_Plk_1	662	668	PF00069	0.536
MOD_Plk_1	712	718	PF00069	0.566
MOD_Plk_1	750	756	PF00069	0.481
MOD_Plk_1	790	796	PF00069	0.417
MOD_Plk_1	93	99	PF00069	0.553
MOD_Plk_4	20	26	PF00069	0.591
MOD_Plk_4	260	266	PF00069	0.649
MOD_Plk_4	376	382	PF00069	0.532
MOD_Plk_4	618	624	PF00069	0.598
MOD_Plk_4	702	708	PF00069	0.428
MOD_Plk_4	750	756	PF00069	0.481
MOD_ProDKin_1	148	154	PF00069	0.727
MOD_ProDKin_1	245	251	PF00069	0.648
MOD_ProDKin_1	282	288	PF00069	0.627
MOD_ProDKin_1	290	296	PF00069	0.632
MOD_ProDKin_1	322	328	PF00069	0.560
MOD_ProDKin_1	370	376	PF00069	0.763
MOD_ProDKin_1	67	73	PF00069	0.507
MOD_ProDKin_1	857	863	PF00069	0.643
MOD_ProDKin_1	908	914	PF00069	0.829
MOD_SUMO_rev_2	400	408	PF00179	0.432
MOD_SUMO_rev_2	603	612	PF00179	0.508
MOD_SUMO_rev_2	655	662	PF00179	0.573
MOD_SUMO_rev_2	731	738	PF00179	0.645
MOD_SUMO_rev_2	74	84	PF00179	0.615
MOD_SUMO_rev_2	799	806	PF00179	0.472
TRG_DiLeu_BaEn_1	207	212	PF01217	0.568
TRG_DiLeu_BaEn_4	468	474	PF01217	0.455
TRG_DiLeu_BaEn_4	93	99	PF01217	0.517
TRG_ENDOCYTIC_2	217	220	PF00928	0.582
TRG_ER_diArg_1	255	258	PF00400	0.682
TRG_ER_diArg_1	338	340	PF00400	0.680
TRG_ER_diArg_1	384	386	PF00400	0.525
TRG_ER_diArg_1	442	444	PF00400	0.491
TRG_ER_diArg_1	850	853	PF00400	0.550
TRG_NES_CRM1_1	672	687	PF08389	0.455
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.677
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	577	581	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	678	682	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	689	693	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	708	713	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	877	881	PF00026	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B0	Leptomonas seymouri	49%	100%
A4H7U2	Leishmania braziliensis	75%	99%
A4HW68	Leishmania infantum	99%	100%
E9APW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFL2	Leishmania major	93%	100%
V5BBE5	Trypanosoma cruzi	32%	100%