Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I8W5_LEIDO

TriTrypDb:

LdBPK_110150.1 , LdCL_110006400 , LDHU3_11.0170

Length:

880

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I8W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.651
CLV_C14_Caspase3-7	119	123	PF00656	0.719
CLV_NRD_NRD_1	177	179	PF00675	0.804
CLV_NRD_NRD_1	247	249	PF00675	0.723
CLV_NRD_NRD_1	28	30	PF00675	0.730
CLV_NRD_NRD_1	283	285	PF00675	0.708
CLV_NRD_NRD_1	45	47	PF00675	0.588
CLV_NRD_NRD_1	502	504	PF00675	0.754
CLV_NRD_NRD_1	511	513	PF00675	0.669
CLV_NRD_NRD_1	60	62	PF00675	0.605
CLV_NRD_NRD_1	615	617	PF00675	0.662
CLV_NRD_NRD_1	82	84	PF00675	0.788
CLV_NRD_NRD_1	836	838	PF00675	0.574
CLV_NRD_NRD_1	849	851	PF00675	0.666
CLV_NRD_NRD_1	92	94	PF00675	0.655
CLV_NRD_NRD_1	95	97	PF00675	0.618
CLV_PCSK_FUR_1	509	513	PF00082	0.727
CLV_PCSK_FUR_1	92	96	PF00082	0.674
CLV_PCSK_KEX2_1	177	179	PF00082	0.740
CLV_PCSK_KEX2_1	238	240	PF00082	0.671
CLV_PCSK_KEX2_1	247	249	PF00082	0.595
CLV_PCSK_KEX2_1	283	285	PF00082	0.708
CLV_PCSK_KEX2_1	45	47	PF00082	0.791
CLV_PCSK_KEX2_1	501	503	PF00082	0.754
CLV_PCSK_KEX2_1	509	511	PF00082	0.685
CLV_PCSK_KEX2_1	539	541	PF00082	0.804
CLV_PCSK_KEX2_1	60	62	PF00082	0.605
CLV_PCSK_KEX2_1	615	617	PF00082	0.632
CLV_PCSK_KEX2_1	82	84	PF00082	0.788
CLV_PCSK_KEX2_1	849	851	PF00082	0.748
CLV_PCSK_KEX2_1	92	94	PF00082	0.655
CLV_PCSK_KEX2_1	95	97	PF00082	0.618
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.623
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.740
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.788
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.633
CLV_PCSK_SKI1_1	218	222	PF00082	0.600
CLV_PCSK_SKI1_1	486	490	PF00082	0.837
CLV_PCSK_SKI1_1	502	506	PF00082	0.755
CLV_PCSK_SKI1_1	641	645	PF00082	0.678
CLV_PCSK_SKI1_1	837	841	PF00082	0.604
CLV_PCSK_SKI1_1	850	854	PF00082	0.673
DEG_Nend_UBRbox_2	1	3	PF02207	0.750
DEG_SCF_FBW7_1	326	333	PF00400	0.649
DEG_SCF_FBW7_1	869	876	PF00400	0.589
DEG_SPOP_SBC_1	121	125	PF00917	0.743
DEG_SPOP_SBC_1	151	155	PF00917	0.787
DOC_CKS1_1	327	332	PF01111	0.722
DOC_CKS1_1	413	418	PF01111	0.801
DOC_CKS1_1	702	707	PF01111	0.687
DOC_CKS1_1	870	875	PF01111	0.686
DOC_CYCLIN_RxL_1	577	588	PF00134	0.627
DOC_CYCLIN_RxL_1	846	857	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	567	570	PF00134	0.780
DOC_MAPK_DCC_7	756	765	PF00069	0.579
DOC_MAPK_gen_1	501	508	PF00069	0.696
DOC_MAPK_gen_1	718	727	PF00069	0.788
DOC_MAPK_MEF2A_6	501	508	PF00069	0.696
DOC_MAPK_MEF2A_6	756	765	PF00069	0.579
DOC_PP1_RVXF_1	580	587	PF00149	0.699
DOC_PP1_RVXF_1	847	854	PF00149	0.725
DOC_PP2B_LxvP_1	567	570	PF13499	0.780
DOC_PP4_FxxP_1	586	589	PF00568	0.763
DOC_PP4_FxxP_1	776	779	PF00568	0.759
DOC_PP4_FxxP_1	853	856	PF00568	0.723
DOC_PP4_MxPP_1	787	790	PF00568	0.779
DOC_USP7_MATH_1	11	15	PF00917	0.656
DOC_USP7_MATH_1	143	147	PF00917	0.763
DOC_USP7_MATH_1	151	155	PF00917	0.679
DOC_USP7_MATH_1	34	38	PF00917	0.693
DOC_USP7_MATH_1	378	382	PF00917	0.751
DOC_USP7_MATH_1	423	427	PF00917	0.675
DOC_USP7_MATH_1	430	434	PF00917	0.604
DOC_USP7_MATH_1	482	486	PF00917	0.804
DOC_USP7_MATH_1	519	523	PF00917	0.632
DOC_USP7_MATH_1	549	553	PF00917	0.740
DOC_USP7_MATH_1	59	63	PF00917	0.630
DOC_USP7_MATH_1	614	618	PF00917	0.655
DOC_USP7_MATH_1	703	707	PF00917	0.715
DOC_USP7_MATH_1	73	77	PF00917	0.713
DOC_USP7_UBL2_3	82	86	PF12436	0.791
DOC_USP7_UBL2_3	90	94	PF12436	0.677
DOC_WW_Pin1_4	272	277	PF00397	0.692
DOC_WW_Pin1_4	326	331	PF00397	0.748
DOC_WW_Pin1_4	358	363	PF00397	0.787
DOC_WW_Pin1_4	367	372	PF00397	0.686
DOC_WW_Pin1_4	408	413	PF00397	0.787
DOC_WW_Pin1_4	51	56	PF00397	0.726
DOC_WW_Pin1_4	532	537	PF00397	0.753
DOC_WW_Pin1_4	543	548	PF00397	0.718
DOC_WW_Pin1_4	570	575	PF00397	0.790
DOC_WW_Pin1_4	631	636	PF00397	0.738
DOC_WW_Pin1_4	650	655	PF00397	0.726
DOC_WW_Pin1_4	701	706	PF00397	0.741
DOC_WW_Pin1_4	746	751	PF00397	0.714
DOC_WW_Pin1_4	869	874	PF00397	0.682
LIG_14-3-3_CanoR_1	247	252	PF00244	0.677
LIG_14-3-3_CanoR_1	283	290	PF00244	0.731
LIG_14-3-3_CanoR_1	387	396	PF00244	0.720
LIG_14-3-3_CanoR_1	492	499	PF00244	0.701
LIG_14-3-3_CanoR_1	60	64	PF00244	0.728
LIG_14-3-3_CanoR_1	721	726	PF00244	0.838
LIG_14-3-3_CanoR_1	98	103	PF00244	0.801
LIG_APCC_ABBAyCdc20_2	582	588	PF00400	0.586
LIG_BRCT_BRCA1_1	823	827	PF00533	0.648
LIG_BRCT_BRCA1_1	98	102	PF00533	0.802
LIG_EVH1_1	568	572	PF00568	0.744
LIG_EVH1_1	776	780	PF00568	0.760
LIG_FHA_1	106	112	PF00498	0.658
LIG_FHA_1	273	279	PF00498	0.694
LIG_FHA_1	368	374	PF00498	0.761
LIG_FHA_1	655	661	PF00498	0.706
LIG_FHA_1	873	879	PF00498	0.594
LIG_FHA_2	101	107	PF00498	0.619
LIG_FHA_2	377	383	PF00498	0.764
LIG_FHA_2	387	393	PF00498	0.763
LIG_FHA_2	413	419	PF00498	0.740
LIG_FHA_2	492	498	PF00498	0.705
LIG_FHA_2	522	528	PF00498	0.742
LIG_GSK3_LRP6_1	326	332	PF00069	0.672
LIG_GSK3_LRP6_1	412	417	PF00069	0.701
LIG_GSK3_LRP6_1	570	576	PF00069	0.743
LIG_Integrin_RGD_1	766	768	PF01839	0.578
LIG_LIR_Apic_2	37	42	PF02991	0.695
LIG_LIR_Apic_2	649	654	PF02991	0.711
LIG_LIR_Apic_2	775	779	PF02991	0.763
LIG_LIR_Gen_1	821	831	PF02991	0.600
LIG_LIR_LC3C_4	769	774	PF02991	0.699
LIG_LIR_Nem_3	642	646	PF02991	0.684
LIG_LIR_Nem_3	690	695	PF02991	0.699
LIG_LIR_Nem_3	824	830	PF02991	0.599
LIG_MAD2	322	330	PF02301	0.706
LIG_MYND_1	55	59	PF01753	0.622
LIG_Pex14_1	31	35	PF04695	0.697
LIG_Pex14_1	823	827	PF04695	0.660
LIG_Pex14_2	819	823	PF04695	0.641
LIG_Pex14_2	827	831	PF04695	0.588
LIG_PROFILIN_1	64	70	PF00235	0.752
LIG_Rb_LxCxE_1	642	658	PF01857	0.708
LIG_RPA_C_Fungi	498	510	PF08784	0.707
LIG_SH2_CRK	39	43	PF00017	0.693
LIG_SH2_GRB2like	47	50	PF00017	0.794
LIG_SH2_NCK_1	39	43	PF00017	0.693
LIG_SH2_PTP2	651	654	PF00017	0.713
LIG_SH2_SRC	141	144	PF00017	0.694
LIG_SH2_SRC	39	42	PF00017	0.709
LIG_SH2_STAT3	23	26	PF00017	0.688
LIG_SH2_STAT5	27	30	PF00017	0.584
LIG_SH2_STAT5	303	306	PF00017	0.771
LIG_SH2_STAT5	47	50	PF00017	0.699
LIG_SH2_STAT5	651	654	PF00017	0.713
LIG_SH2_STAT5	692	695	PF00017	0.699
LIG_SH3_1	410	416	PF00018	0.799
LIG_SH3_1	61	67	PF00018	0.770
LIG_SH3_2	41	46	PF14604	0.766
LIG_SH3_2	55	60	PF14604	0.605
LIG_SH3_2	70	75	PF14604	0.541
LIG_SH3_3	321	327	PF00018	0.684
LIG_SH3_3	348	354	PF00018	0.784
LIG_SH3_3	38	44	PF00018	0.758
LIG_SH3_3	410	416	PF00018	0.799
LIG_SH3_3	49	55	PF00018	0.636
LIG_SH3_3	541	547	PF00018	0.656
LIG_SH3_3	566	572	PF00018	0.777
LIG_SH3_3	61	67	PF00018	0.665
LIG_SH3_3	656	662	PF00018	0.688
LIG_SH3_3	699	705	PF00018	0.708
LIG_SH3_3	771	777	PF00018	0.767
LIG_SH3_3	860	866	PF00018	0.728
LIG_SH3_4	90	97	PF00018	0.693
LIG_SUMO_SIM_anti_2	341	350	PF11976	0.742
LIG_SUMO_SIM_par_1	267	275	PF11976	0.687
LIG_SUMO_SIM_par_1	341	350	PF11976	0.704
LIG_TRAF2_1	277	280	PF00917	0.693
LIG_WW_3	42	46	PF00397	0.705
LIG_WW_3	57	61	PF00397	0.581
LIG_WW_3	612	616	PF00397	0.649
MOD_CDC14_SPxK_1	749	752	PF00782	0.671
MOD_CDK_SPK_2	51	56	PF00069	0.688
MOD_CDK_SPxK_1	701	707	PF00069	0.686
MOD_CDK_SPxK_1	746	752	PF00069	0.672
MOD_CDK_SPxxK_3	412	419	PF00069	0.723
MOD_CDK_SPxxK_3	532	539	PF00069	0.716
MOD_CK1_1	101	107	PF00069	0.791
MOD_CK1_1	109	115	PF00069	0.692
MOD_CK1_1	116	122	PF00069	0.611
MOD_CK1_1	123	129	PF00069	0.623
MOD_CK1_1	131	137	PF00069	0.592
MOD_CK1_1	150	156	PF00069	0.720
MOD_CK1_1	157	163	PF00069	0.663
MOD_CK1_1	170	176	PF00069	0.729
MOD_CK1_1	292	298	PF00069	0.729
MOD_CK1_1	356	362	PF00069	0.804
MOD_CK1_1	367	373	PF00069	0.645
MOD_CK1_1	376	382	PF00069	0.510
MOD_CK1_1	573	579	PF00069	0.833
MOD_CK1_1	706	712	PF00069	0.777
MOD_CK1_1	807	813	PF00069	0.610
MOD_CK1_1	821	827	PF00069	0.470
MOD_CK2_1	141	147	PF00069	0.792
MOD_CK2_1	170	176	PF00069	0.791
MOD_CK2_1	376	382	PF00069	0.764
MOD_CK2_1	386	392	PF00069	0.766
MOD_CK2_1	491	497	PF00069	0.709
MOD_CK2_1	532	538	PF00069	0.734
MOD_CK2_1	636	642	PF00069	0.633
MOD_CK2_1	792	798	PF00069	0.743
MOD_Cter_Amidation	835	838	PF01082	0.637
MOD_DYRK1A_RPxSP_1	543	547	PF00069	0.704
MOD_GlcNHglycan	119	122	PF01048	0.649
MOD_GlcNHglycan	137	140	PF01048	0.731
MOD_GlcNHglycan	149	152	PF01048	0.612
MOD_GlcNHglycan	159	162	PF01048	0.647
MOD_GlcNHglycan	291	294	PF01048	0.737
MOD_GlcNHglycan	358	361	PF01048	0.842
MOD_GlcNHglycan	366	369	PF01048	0.743
MOD_GlcNHglycan	375	378	PF01048	0.588
MOD_GlcNHglycan	389	392	PF01048	0.692
MOD_GlcNHglycan	61	64	PF01048	0.786
MOD_GlcNHglycan	678	681	PF01048	0.761
MOD_GlcNHglycan	732	736	PF01048	0.653
MOD_GlcNHglycan	741	744	PF01048	0.621
MOD_GlcNHglycan	757	760	PF01048	0.654
MOD_GlcNHglycan	806	809	PF01048	0.681
MOD_GlcNHglycan	812	815	PF01048	0.673
MOD_GlcNHglycan	823	826	PF01048	0.473
MOD_GlcNHglycan	859	862	PF01048	0.738
MOD_GlcNHglycan	98	101	PF01048	0.818
MOD_GSK3_1	105	112	PF00069	0.681
MOD_GSK3_1	113	120	PF00069	0.581
MOD_GSK3_1	121	128	PF00069	0.606
MOD_GSK3_1	129	136	PF00069	0.564
MOD_GSK3_1	137	144	PF00069	0.555
MOD_GSK3_1	147	154	PF00069	0.653
MOD_GSK3_1	155	162	PF00069	0.595
MOD_GSK3_1	163	170	PF00069	0.635
MOD_GSK3_1	289	296	PF00069	0.722
MOD_GSK3_1	299	306	PF00069	0.546
MOD_GSK3_1	326	333	PF00069	0.658
MOD_GSK3_1	352	359	PF00069	0.738
MOD_GSK3_1	408	415	PF00069	0.800
MOD_GSK3_1	591	598	PF00069	0.587
MOD_GSK3_1	642	649	PF00069	0.731
MOD_GSK3_1	650	657	PF00069	0.560
MOD_GSK3_1	676	683	PF00069	0.753
MOD_GSK3_1	717	724	PF00069	0.707
MOD_GSK3_1	821	828	PF00069	0.625
MOD_GSK3_1	868	875	PF00069	0.700
MOD_GSK3_1	96	103	PF00069	0.802
MOD_N-GLC_1	168	173	PF02516	0.611
MOD_NEK2_1	271	276	PF00069	0.694
MOD_NEK2_1	282	287	PF00069	0.567
MOD_NEK2_1	386	391	PF00069	0.793
MOD_NEK2_1	397	402	PF00069	0.768
MOD_OFUCOSY	804	811	PF10250	0.616
MOD_OFUCOSY	816	822	PF10250	0.529
MOD_OGLYCOS	811	816	PF02709	0.579
MOD_PIKK_1	247	253	PF00454	0.620
MOD_PIKK_1	353	359	PF00454	0.741
MOD_PIKK_1	549	555	PF00454	0.798
MOD_PIKK_1	591	597	PF00454	0.775
MOD_PIKK_1	615	621	PF00454	0.655
MOD_PIKK_1	75	81	PF00454	0.739
MOD_PK_1	557	563	PF00069	0.697
MOD_PK_1	721	727	PF00069	0.729
MOD_PKA_1	247	253	PF00069	0.620
MOD_PKA_1	283	289	PF00069	0.616
MOD_PKA_1	510	516	PF00069	0.700
MOD_PKA_1	615	621	PF00069	0.655
MOD_PKA_2	113	119	PF00069	0.796
MOD_PKA_2	147	153	PF00069	0.769
MOD_PKA_2	246	252	PF00069	0.673
MOD_PKA_2	282	288	PF00069	0.718
MOD_PKA_2	386	392	PF00069	0.727
MOD_PKA_2	491	497	PF00069	0.709
MOD_PKA_2	510	516	PF00069	0.552
MOD_PKA_2	59	65	PF00069	0.721
MOD_PKA_2	614	620	PF00069	0.776
MOD_PKA_2	706	712	PF00069	0.784
MOD_PKA_2	717	723	PF00069	0.699
MOD_PKB_1	510	518	PF00069	0.761
MOD_PKB_1	96	104	PF00069	0.797
MOD_Plk_1	397	403	PF00069	0.770
MOD_Plk_1	654	660	PF00069	0.675
MOD_Plk_1	665	671	PF00069	0.586
MOD_Plk_2-3	392	398	PF00069	0.775
MOD_Plk_2-3	792	798	PF00069	0.743
MOD_Plk_4	299	305	PF00069	0.670
MOD_Plk_4	392	398	PF00069	0.775
MOD_Plk_4	642	648	PF00069	0.689
MOD_Plk_4	655	661	PF00069	0.488
MOD_ProDKin_1	272	278	PF00069	0.693
MOD_ProDKin_1	326	332	PF00069	0.751
MOD_ProDKin_1	358	364	PF00069	0.788
MOD_ProDKin_1	367	373	PF00069	0.686
MOD_ProDKin_1	408	414	PF00069	0.787
MOD_ProDKin_1	51	57	PF00069	0.729
MOD_ProDKin_1	532	538	PF00069	0.751
MOD_ProDKin_1	543	549	PF00069	0.718
MOD_ProDKin_1	570	576	PF00069	0.791
MOD_ProDKin_1	631	637	PF00069	0.734
MOD_ProDKin_1	650	656	PF00069	0.729
MOD_ProDKin_1	701	707	PF00069	0.745
MOD_ProDKin_1	746	752	PF00069	0.717
MOD_ProDKin_1	869	875	PF00069	0.684
MOD_SUMO_rev_2	639	646	PF00179	0.688
TRG_DiLeu_BaEn_1	392	397	PF01217	0.777
TRG_DiLeu_BaEn_1	642	647	PF01217	0.621
TRG_DiLeu_BaEn_3	341	347	PF01217	0.671
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.544
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.756
TRG_ER_diArg_1	19	22	PF00400	0.700
TRG_ER_diArg_1	282	284	PF00400	0.701
TRG_ER_diArg_1	44	46	PF00400	0.785
TRG_ER_diArg_1	501	503	PF00400	0.754
TRG_ER_diArg_1	508	511	PF00400	0.695
TRG_ER_diArg_1	59	61	PF00400	0.600
TRG_ER_diArg_1	614	616	PF00400	0.626
TRG_ER_diArg_1	849	851	PF00400	0.751
TRG_ER_diArg_1	91	93	PF00400	0.774
TRG_ER_diArg_1	95	98	PF00400	0.756
TRG_NES_CRM1_1	260	273	PF08389	0.603
TRG_NLS_Bipartite_1	82	98	PF00514	0.759
TRG_NLS_MonoCore_2	92	97	PF00514	0.617
TRG_NLS_MonoExtC_3	81	86	PF00514	0.794
TRG_NLS_MonoExtC_3	93	98	PF00514	0.633
TRG_NLS_MonoExtN_4	82	87	PF00514	0.791
TRG_NLS_MonoExtN_4	90	97	PF00514	0.680
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	849	854	PF00026	0.764

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H9U3	Leishmania braziliensis	65%	99%
A4HUS7	Leishmania infantum	99%	100%
E9ANG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%
Q4QH65	Leishmania major	89%	100%