Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I8W1_LEIDO

TriTrypDb:

LdBPK_101040.1 , LdCL_100017300 , LDHU3_10.1380

Length:

806

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0035253	ciliary rootlet	2	1
GO:0036064	ciliary basal body	3	1
GO:0097542	ciliary tip	2	1

Expansion

Sequence features

A0A3Q8I8W1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8W1

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0036158	outer dynein arm assembly	7	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	567	571	PF00656	0.730
CLV_C14_Caspase3-7	719	723	PF00656	0.720
CLV_NRD_NRD_1	131	133	PF00675	0.477
CLV_NRD_NRD_1	21	23	PF00675	0.665
CLV_NRD_NRD_1	280	282	PF00675	0.487
CLV_NRD_NRD_1	295	297	PF00675	0.495
CLV_NRD_NRD_1	58	60	PF00675	0.520
CLV_NRD_NRD_1	590	592	PF00675	0.758
CLV_NRD_NRD_1	611	613	PF00675	0.816
CLV_NRD_NRD_1	655	657	PF00675	0.745
CLV_NRD_NRD_1	741	743	PF00675	0.743
CLV_NRD_NRD_1	780	782	PF00675	0.671
CLV_NRD_NRD_1	80	82	PF00675	0.602
CLV_NRD_NRD_1	804	806	PF00675	0.633
CLV_PCSK_FUR_1	129	133	PF00082	0.581
CLV_PCSK_FUR_1	653	657	PF00082	0.747
CLV_PCSK_FUR_1	739	743	PF00082	0.752
CLV_PCSK_FUR_1	80	84	PF00082	0.642
CLV_PCSK_KEX2_1	129	131	PF00082	0.475
CLV_PCSK_KEX2_1	279	281	PF00082	0.488
CLV_PCSK_KEX2_1	295	297	PF00082	0.481
CLV_PCSK_KEX2_1	516	518	PF00082	0.623
CLV_PCSK_KEX2_1	58	60	PF00082	0.513
CLV_PCSK_KEX2_1	590	592	PF00082	0.758
CLV_PCSK_KEX2_1	611	613	PF00082	0.816
CLV_PCSK_KEX2_1	653	655	PF00082	0.757
CLV_PCSK_KEX2_1	741	743	PF00082	0.744
CLV_PCSK_KEX2_1	780	782	PF00082	0.622
CLV_PCSK_KEX2_1	785	787	PF00082	0.545
CLV_PCSK_KEX2_1	80	82	PF00082	0.607
CLV_PCSK_KEX2_1	804	806	PF00082	0.639
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.579
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.623
CLV_PCSK_PC1ET2_1	785	787	PF00082	0.539
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.436
CLV_PCSK_PC7_1	781	787	PF00082	0.549
CLV_PCSK_SKI1_1	269	273	PF00082	0.496
CLV_PCSK_SKI1_1	369	373	PF00082	0.621
CLV_PCSK_SKI1_1	430	434	PF00082	0.694
CLV_PCSK_SKI1_1	628	632	PF00082	0.760
DEG_APCC_DBOX_1	205	213	PF00400	0.547
DEG_APCC_DBOX_1	234	242	PF00400	0.557
DEG_APCC_DBOX_1	57	65	PF00400	0.628
DOC_ANK_TNKS_1	717	724	PF00023	0.694
DOC_CYCLIN_RxL_1	233	246	PF00134	0.589
DOC_CYCLIN_RxL_1	528	538	PF00134	0.582
DOC_MAPK_gen_1	129	141	PF00069	0.561
DOC_MAPK_gen_1	194	202	PF00069	0.548
DOC_MAPK_gen_1	233	240	PF00069	0.466
DOC_MAPK_gen_1	462	472	PF00069	0.518
DOC_MAPK_gen_1	516	523	PF00069	0.582
DOC_MAPK_JIP1_4	175	181	PF00069	0.535
DOC_MAPK_MEF2A_6	465	472	PF00069	0.593
DOC_MAPK_MEF2A_6	516	525	PF00069	0.641
DOC_PP1_RVXF_1	294	301	PF00149	0.407
DOC_PP1_RVXF_1	687	694	PF00149	0.757
DOC_PP2B_LxvP_1	683	686	PF13499	0.711
DOC_PP2B_LxvP_1	93	96	PF13499	0.573
DOC_USP7_MATH_1	432	436	PF00917	0.612
DOC_USP7_MATH_1	515	519	PF00917	0.663
DOC_USP7_MATH_1	576	580	PF00917	0.747
DOC_USP7_MATH_1	606	610	PF00917	0.757
DOC_USP7_UBL2_3	190	194	PF12436	0.515
DOC_WW_Pin1_4	447	452	PF00397	0.647
DOC_WW_Pin1_4	550	555	PF00397	0.711
LIG_14-3-3_CanoR_1	14	19	PF00244	0.669
LIG_14-3-3_CanoR_1	22	29	PF00244	0.551
LIG_14-3-3_CanoR_1	267	276	PF00244	0.418
LIG_14-3-3_CanoR_1	325	334	PF00244	0.570
LIG_14-3-3_CanoR_1	430	438	PF00244	0.724
LIG_14-3-3_CanoR_1	517	522	PF00244	0.580
LIG_14-3-3_CanoR_1	59	65	PF00244	0.589
LIG_14-3-3_CanoR_1	611	619	PF00244	0.774
LIG_Actin_WH2_2	57	74	PF00022	0.498
LIG_BIR_III_4	538	542	PF00653	0.609
LIG_BIR_III_4	712	716	PF00653	0.798
LIG_BRCT_BRCA1_1	434	438	PF00533	0.614
LIG_CaM_IQ_9	255	271	PF13499	0.559
LIG_CaM_IQ_9	287	303	PF13499	0.582
LIG_FHA_1	306	312	PF00498	0.624
LIG_FHA_1	509	515	PF00498	0.638
LIG_FHA_1	518	524	PF00498	0.573
LIG_FHA_1	698	704	PF00498	0.749
LIG_FHA_2	110	116	PF00498	0.563
LIG_FHA_2	222	228	PF00498	0.573
LIG_FHA_2	23	29	PF00498	0.647
LIG_FHA_2	251	257	PF00498	0.552
LIG_FHA_2	268	274	PF00498	0.554
LIG_FHA_2	349	355	PF00498	0.655
LIG_FHA_2	434	440	PF00498	0.558
LIG_FHA_2	61	67	PF00498	0.634
LIG_FHA_2	613	619	PF00498	0.801
LIG_FHA_2	667	673	PF00498	0.552
LIG_LYPXL_SIV_4	250	258	PF13949	0.578
LIG_Rb_pABgroove_1	238	246	PF01858	0.543
LIG_RPA_C_Fungi	649	661	PF08784	0.752
LIG_SH2_NCK_1	360	364	PF00017	0.584
LIG_SH2_STAP1	251	255	PF00017	0.504
LIG_SH2_STAP1	360	364	PF00017	0.528
LIG_SH2_STAT3	219	222	PF00017	0.554
LIG_SH2_STAT3	391	394	PF00017	0.615
LIG_SH2_STAT3	57	60	PF00017	0.535
LIG_SH2_STAT5	178	181	PF00017	0.547
LIG_SH2_STAT5	399	402	PF00017	0.578
LIG_SH2_STAT5	423	426	PF00017	0.687
LIG_SH3_3	104	110	PF00018	0.685
LIG_SH3_3	500	506	PF00018	0.473
LIG_SUMO_SIM_anti_2	253	259	PF11976	0.561
LIG_Vh1_VBS_1	521	539	PF01044	0.580
LIG_WRC_WIRS_1	18	23	PF05994	0.510
LIG_WRC_WIRS_1	457	462	PF05994	0.519
MOD_CDC14_SPxK_1	553	556	PF00782	0.711
MOD_CDK_SPxK_1	550	556	PF00069	0.714
MOD_CK1_1	17	23	PF00069	0.646
MOD_CK1_1	350	356	PF00069	0.713
MOD_CK1_1	549	555	PF00069	0.784
MOD_CK1_1	697	703	PF00069	0.655
MOD_CK1_1	728	734	PF00069	0.711
MOD_CK2_1	109	115	PF00069	0.573
MOD_CK2_1	152	158	PF00069	0.598
MOD_CK2_1	22	28	PF00069	0.584
MOD_CK2_1	221	227	PF00069	0.585
MOD_CK2_1	250	256	PF00069	0.515
MOD_CK2_1	267	273	PF00069	0.552
MOD_CK2_1	41	47	PF00069	0.463
MOD_CK2_1	666	672	PF00069	0.556
MOD_Cter_Amidation	609	612	PF01082	0.818
MOD_Cter_Amidation	739	742	PF01082	0.741
MOD_GlcNHglycan	25	28	PF01048	0.585
MOD_GlcNHglycan	312	315	PF01048	0.644
MOD_GlcNHglycan	338	341	PF01048	0.700
MOD_GlcNHglycan	441	444	PF01048	0.713
MOD_GlcNHglycan	572	575	PF01048	0.764
MOD_GlcNHglycan	608	611	PF01048	0.745
MOD_GlcNHglycan	624	627	PF01048	0.729
MOD_GlcNHglycan	657	660	PF01048	0.722
MOD_GlcNHglycan	704	707	PF01048	0.720
MOD_GlcNHglycan	718	721	PF01048	0.699
MOD_GlcNHglycan	727	730	PF01048	0.764
MOD_GSK3_1	263	270	PF00069	0.518
MOD_GSK3_1	310	317	PF00069	0.438
MOD_GSK3_1	343	350	PF00069	0.709
MOD_GSK3_1	426	433	PF00069	0.651
MOD_GSK3_1	545	552	PF00069	0.739
MOD_GSK3_1	694	701	PF00069	0.664
MOD_N-GLC_1	23	28	PF02516	0.601
MOD_N-GLC_1	263	268	PF02516	0.596
MOD_N-GLC_1	395	400	PF02516	0.403
MOD_N-GLC_1	67	72	PF02516	0.583
MOD_N-GLC_1	708	713	PF02516	0.754
MOD_NEK2_1	152	157	PF00069	0.420
MOD_NEK2_1	243	248	PF00069	0.540
MOD_NEK2_1	287	292	PF00069	0.469
MOD_NEK2_1	335	340	PF00069	0.722
MOD_NEK2_1	6	11	PF00069	0.764
MOD_NEK2_1	646	651	PF00069	0.733
MOD_NEK2_1	790	795	PF00069	0.546
MOD_PIKK_1	119	125	PF00454	0.543
MOD_PIKK_1	287	293	PF00454	0.483
MOD_PIKK_1	305	311	PF00454	0.509
MOD_PK_1	14	20	PF00069	0.487
MOD_PKA_1	22	28	PF00069	0.487
MOD_PKA_1	516	522	PF00069	0.582
MOD_PKA_1	654	660	PF00069	0.750
MOD_PKA_1	785	791	PF00069	0.578
MOD_PKA_2	516	522	PF00069	0.582
MOD_PKA_2	654	660	PF00069	0.728
MOD_PKA_2	785	791	PF00069	0.620
MOD_PKB_1	653	661	PF00069	0.748
MOD_Plk_1	263	269	PF00069	0.543
MOD_Plk_1	305	311	PF00069	0.517
MOD_Plk_1	395	401	PF00069	0.502
MOD_Plk_1	433	439	PF00069	0.655
MOD_Plk_1	67	73	PF00069	0.498
MOD_Plk_2-3	109	115	PF00069	0.633
MOD_Plk_4	221	227	PF00069	0.564
MOD_Plk_4	330	336	PF00069	0.645
MOD_Plk_4	395	401	PF00069	0.589
MOD_Plk_4	433	439	PF00069	0.692
MOD_Plk_4	456	462	PF00069	0.572
MOD_ProDKin_1	447	453	PF00069	0.645
MOD_ProDKin_1	550	556	PF00069	0.714
MOD_SUMO_rev_2	143	152	PF00179	0.550
MOD_SUMO_rev_2	562	571	PF00179	0.717
MOD_SUMO_rev_2	777	787	PF00179	0.678
TRG_DiLeu_BaEn_2	455	461	PF01217	0.613
TRG_DiLeu_BaEn_3	305	311	PF01217	0.634
TRG_DiLeu_BaEn_4	306	312	PF01217	0.578
TRG_DiLeu_BaEn_4	463	469	PF01217	0.585
TRG_ENDOCYTIC_2	178	181	PF00928	0.547
TRG_ER_diArg_1	129	132	PF00400	0.472
TRG_ER_diArg_1	57	59	PF00400	0.611
TRG_ER_diArg_1	590	592	PF00400	0.725
TRG_ER_diArg_1	611	614	PF00400	0.823
TRG_ER_diArg_1	653	656	PF00400	0.755
TRG_ER_diArg_1	739	742	PF00400	0.756
TRG_ER_diArg_1	779	781	PF00400	0.674
TRG_ER_diArg_1	791	794	PF00400	0.447
TRG_ER_diArg_1	80	83	PF00400	0.606
TRG_ER_diArg_1	803	805	PF00400	0.556
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	689	694	PF00026	0.746
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P488	Leptomonas seymouri	51%	89%
A0A1X0NQB6	Trypanosomatidae	26%	100%
A0A422NCY5	Trypanosoma rangeli	28%	100%
A4H684	Leishmania braziliensis	71%	99%
A4HUK9	Leishmania infantum	100%	100%
C9ZVN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ANA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QHB8	Leishmania major	92%	100%
V5BJM8	Trypanosoma cruzi	27%	100%