Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I8V9_LEIDO

TriTrypDb:

LdBPK_141110.1 , LdCL_140016800 , LDHU3_14.1380

Length:

207

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3Q8I8V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8V9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.464
CLV_NRD_NRD_1	203	205	PF00675	0.525
DEG_Nend_UBRbox_2	1	3	PF02207	0.692
DEG_SPOP_SBC_1	44	48	PF00917	0.332
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.654
DOC_MAPK_DCC_7	98	106	PF00069	0.656
DOC_PP1_RVXF_1	155	162	PF00149	0.360
DOC_PP4_FxxP_1	16	19	PF00568	0.626
DOC_PP4_FxxP_1	21	24	PF00568	0.363
DOC_USP7_MATH_1	184	188	PF00917	0.628
DOC_WW_Pin1_4	86	91	PF00397	0.592
LIG_BRCT_BRCA1_1	12	16	PF00533	0.607
LIG_BRCT_BRCA1_1	122	126	PF00533	0.391
LIG_BRCT_BRCA1_1	70	74	PF00533	0.388
LIG_FHA_1	127	133	PF00498	0.491
LIG_FHA_1	174	180	PF00498	0.454
LIG_FHA_1	18	24	PF00498	0.525
LIG_FHA_1	183	189	PF00498	0.645
LIG_FHA_1	55	61	PF00498	0.364
LIG_FHA_1	64	70	PF00498	0.331
LIG_FHA_1	79	85	PF00498	0.564
LIG_LIR_Apic_2	13	19	PF02991	0.570
LIG_LIR_Apic_2	148	154	PF02991	0.368
LIG_LIR_Apic_2	193	199	PF02991	0.729
LIG_LIR_Apic_2	2	7	PF02991	0.594
LIG_LIR_Apic_2	20	24	PF02991	0.268
LIG_LIR_Gen_1	64	72	PF02991	0.460
LIG_LIR_Gen_1	9	19	PF02991	0.619
LIG_LIR_LC3C_4	129	132	PF02991	0.491
LIG_LIR_Nem_3	148	153	PF02991	0.369
LIG_LIR_Nem_3	162	168	PF02991	0.391
LIG_LIR_Nem_3	64	68	PF02991	0.460
LIG_LIR_Nem_3	9	15	PF02991	0.577
LIG_PCNA_PIPBox_1	152	161	PF02747	0.449
LIG_PCNA_yPIPBox_3	152	166	PF02747	0.397
LIG_Pex14_2	12	16	PF04695	0.595
LIG_Pex14_2	21	25	PF04695	0.364
LIG_PTB_Apo_2	144	151	PF02174	0.391
LIG_SH2_CRK	122	126	PF00017	0.438
LIG_SH2_CRK	196	200	PF00017	0.708
LIG_SH2_NCK_1	122	126	PF00017	0.426
LIG_SH2_STAP1	122	126	PF00017	0.422
LIG_SH2_STAT5	158	161	PF00017	0.417
LIG_SH2_STAT5	178	181	PF00017	0.193
LIG_SH2_STAT5	37	40	PF00017	0.388
LIG_SH2_STAT5	4	7	PF00017	0.598
LIG_SH3_3	185	191	PF00018	0.649
LIG_Sin3_3	49	56	PF02671	0.279
LIG_SUMO_SIM_par_1	128	134	PF11976	0.429
LIG_TYR_ITIM	120	125	PF00017	0.438
LIG_WRC_WIRS_1	62	67	PF05994	0.410
MOD_CDK_SPxxK_3	86	93	PF00069	0.603
MOD_CK1_1	192	198	PF00069	0.756
MOD_CK1_1	26	32	PF00069	0.491
MOD_CK1_1	75	81	PF00069	0.629
MOD_CK2_1	39	45	PF00069	0.424
MOD_Cter_Amidation	202	205	PF01082	0.525
MOD_GlcNHglycan	47	50	PF01048	0.661
MOD_GSK3_1	168	175	PF00069	0.359
MOD_GSK3_1	23	30	PF00069	0.279
MOD_GSK3_1	39	46	PF00069	0.409
MOD_GSK3_1	6	13	PF00069	0.654
MOD_GSK3_1	68	75	PF00069	0.403
MOD_GSK3_1	92	99	PF00069	0.560
MOD_N-GLC_1	75	80	PF02516	0.339
MOD_NEK2_1	145	150	PF00069	0.326
MOD_NEK2_1	159	164	PF00069	0.438
MOD_NEK2_1	39	44	PF00069	0.400
MOD_NEK2_1	63	68	PF00069	0.399
MOD_NEK2_1	74	79	PF00069	0.571
MOD_NEK2_1	92	97	PF00069	0.436
MOD_PIKK_1	10	16	PF00454	0.606
MOD_PIKK_1	182	188	PF00454	0.582
MOD_PIKK_1	75	81	PF00454	0.608
MOD_PKA_2	17	23	PF00069	0.560
MOD_Plk_1	145	151	PF00069	0.380
MOD_Plk_1	39	45	PF00069	0.403
MOD_Plk_1	75	81	PF00069	0.536
MOD_Plk_2-3	40	46	PF00069	0.433
MOD_Plk_4	102	108	PF00069	0.637
MOD_Plk_4	120	126	PF00069	0.224
MOD_Plk_4	145	151	PF00069	0.319
MOD_Plk_4	184	190	PF00069	0.626
MOD_Plk_4	92	98	PF00069	0.573
MOD_ProDKin_1	86	92	PF00069	0.587
TRG_ENDOCYTIC_2	122	125	PF00928	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I195	Leptomonas seymouri	64%	100%
A0A0S4IKP2	Bodo saltans	30%	96%
A0A0S4JKJ4	Bodo saltans	25%	90%
A4H7Q8	Leishmania braziliensis	79%	100%
E9ACR4	Leishmania major	93%	100%
E9AGL4	Leishmania infantum	100%	100%
E9APV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%