ULP_PROTEASE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I8U5_LEIDO

TriTrypDb:

LdBPK_100850.1 , LdCL_100015300 , LDHU3_10.1210

Length:

1080

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I8U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8U5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.543
CLV_C14_Caspase3-7	419	423	PF00656	0.532
CLV_NRD_NRD_1	1006	1008	PF00675	0.724
CLV_NRD_NRD_1	1024	1026	PF00675	0.558
CLV_NRD_NRD_1	1028	1030	PF00675	0.782
CLV_NRD_NRD_1	1076	1078	PF00675	0.658
CLV_NRD_NRD_1	172	174	PF00675	0.715
CLV_NRD_NRD_1	2	4	PF00675	0.559
CLV_NRD_NRD_1	234	236	PF00675	0.669
CLV_NRD_NRD_1	357	359	PF00675	0.571
CLV_NRD_NRD_1	743	745	PF00675	0.637
CLV_NRD_NRD_1	765	767	PF00675	0.733
CLV_NRD_NRD_1	982	984	PF00675	0.711
CLV_PCSK_FUR_1	1022	1026	PF00082	0.702
CLV_PCSK_FUR_1	1073	1077	PF00082	0.685
CLV_PCSK_KEX2_1	1006	1008	PF00082	0.724
CLV_PCSK_KEX2_1	102	104	PF00082	0.681
CLV_PCSK_KEX2_1	1024	1026	PF00082	0.558
CLV_PCSK_KEX2_1	1028	1030	PF00082	0.782
CLV_PCSK_KEX2_1	1072	1074	PF00082	0.692
CLV_PCSK_KEX2_1	1075	1077	PF00082	0.649
CLV_PCSK_KEX2_1	171	173	PF00082	0.658
CLV_PCSK_KEX2_1	234	236	PF00082	0.717
CLV_PCSK_KEX2_1	259	261	PF00082	0.685
CLV_PCSK_KEX2_1	357	359	PF00082	0.554
CLV_PCSK_KEX2_1	4	6	PF00082	0.536
CLV_PCSK_KEX2_1	458	460	PF00082	0.469
CLV_PCSK_KEX2_1	545	547	PF00082	0.474
CLV_PCSK_KEX2_1	764	766	PF00082	0.738
CLV_PCSK_KEX2_1	982	984	PF00082	0.711
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.681
CLV_PCSK_PC1ET2_1	1072	1074	PF00082	0.688
CLV_PCSK_PC1ET2_1	1075	1077	PF00082	0.658
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.685
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.612
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.469
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.474
CLV_PCSK_PC7_1	1024	1030	PF00082	0.699
CLV_PCSK_PC7_1	255	261	PF00082	0.677
CLV_PCSK_SKI1_1	102	106	PF00082	0.627
CLV_PCSK_SKI1_1	429	433	PF00082	0.461
CLV_PCSK_SKI1_1	528	532	PF00082	0.447
CLV_PCSK_SKI1_1	537	541	PF00082	0.272
CLV_PCSK_SKI1_1	60	64	PF00082	0.457
DEG_APCC_DBOX_1	357	365	PF00400	0.425
DEG_SCF_SKP2-CKS1_1	521	528	PF00560	0.465
DEG_SPOP_SBC_1	320	324	PF00917	0.697
DEG_SPOP_SBC_1	512	516	PF00917	0.663
DOC_ANK_TNKS_1	915	922	PF00023	0.593
DOC_CKS1_1	655	660	PF01111	0.494
DOC_CKS1_1	997	1002	PF01111	0.583
DOC_CYCLIN_yCln2_LP_2	655	661	PF00134	0.412
DOC_MAPK_DCC_7	602	611	PF00069	0.460
DOC_MAPK_gen_1	357	364	PF00069	0.506
DOC_MAPK_gen_1	602	611	PF00069	0.460
DOC_MAPK_MEF2A_6	602	611	PF00069	0.460
DOC_PIKK_1	666	674	PF02985	0.440
DOC_PIKK_1	875	883	PF02985	0.721
DOC_PP2B_LxvP_1	98	101	PF13499	0.656
DOC_USP7_MATH_1	1027	1031	PF00917	0.645
DOC_USP7_MATH_1	1057	1061	PF00917	0.566
DOC_USP7_MATH_1	111	115	PF00917	0.642
DOC_USP7_MATH_1	133	137	PF00917	0.585
DOC_USP7_MATH_1	152	156	PF00917	0.661
DOC_USP7_MATH_1	179	183	PF00917	0.655
DOC_USP7_MATH_1	186	190	PF00917	0.695
DOC_USP7_MATH_1	233	237	PF00917	0.698
DOC_USP7_MATH_1	249	253	PF00917	0.696
DOC_USP7_MATH_1	319	323	PF00917	0.626
DOC_USP7_MATH_1	327	331	PF00917	0.629
DOC_USP7_MATH_1	495	499	PF00917	0.458
DOC_USP7_MATH_1	510	514	PF00917	0.494
DOC_USP7_MATH_1	558	562	PF00917	0.472
DOC_USP7_MATH_1	622	626	PF00917	0.624
DOC_USP7_MATH_1	790	794	PF00917	0.742
DOC_USP7_MATH_1	812	816	PF00917	0.556
DOC_USP7_MATH_1	856	860	PF00917	0.682
DOC_USP7_MATH_1	896	900	PF00917	0.674
DOC_USP7_MATH_1	905	909	PF00917	0.592
DOC_USP7_MATH_1	932	936	PF00917	0.641
DOC_USP7_UBL2_3	1071	1075	PF12436	0.647
DOC_WW_Pin1_4	1053	1058	PF00397	0.582
DOC_WW_Pin1_4	238	243	PF00397	0.680
DOC_WW_Pin1_4	328	333	PF00397	0.711
DOC_WW_Pin1_4	484	489	PF00397	0.468
DOC_WW_Pin1_4	522	527	PF00397	0.472
DOC_WW_Pin1_4	545	550	PF00397	0.385
DOC_WW_Pin1_4	654	659	PF00397	0.494
DOC_WW_Pin1_4	753	758	PF00397	0.722
DOC_WW_Pin1_4	800	805	PF00397	0.652
DOC_WW_Pin1_4	846	851	PF00397	0.666
DOC_WW_Pin1_4	921	926	PF00397	0.682
DOC_WW_Pin1_4	992	997	PF00397	0.800
DOC_WW_Pin1_4	999	1004	PF00397	0.768
LIG_14-3-3_CanoR_1	1028	1037	PF00244	0.638
LIG_14-3-3_CanoR_1	103	110	PF00244	0.701
LIG_14-3-3_CanoR_1	234	242	PF00244	0.603
LIG_14-3-3_CanoR_1	38	44	PF00244	0.573
LIG_14-3-3_CanoR_1	52	62	PF00244	0.411
LIG_14-3-3_CanoR_1	633	640	PF00244	0.549
LIG_14-3-3_CanoR_1	74	83	PF00244	0.578
LIG_14-3-3_CanoR_1	798	806	PF00244	0.671
LIG_14-3-3_CanoR_1	897	905	PF00244	0.704
LIG_BIR_III_2	422	426	PF00653	0.510
LIG_BRCT_BRCA1_1	626	630	PF00533	0.613
LIG_EH_1	641	645	PF12763	0.505
LIG_EVH1_2	490	494	PF00568	0.413
LIG_FHA_1	345	351	PF00498	0.643
LIG_FHA_1	401	407	PF00498	0.493
LIG_FHA_1	567	573	PF00498	0.396
LIG_FHA_1	57	63	PF00498	0.443
LIG_FHA_1	633	639	PF00498	0.493
LIG_FHA_1	700	706	PF00498	0.437
LIG_FHA_1	77	83	PF00498	0.438
LIG_FHA_1	774	780	PF00498	0.665
LIG_FHA_1	85	91	PF00498	0.494
LIG_FHA_2	1049	1055	PF00498	0.619
LIG_FHA_2	135	141	PF00498	0.671
LIG_FHA_2	351	357	PF00498	0.532
LIG_FHA_2	417	423	PF00498	0.528
LIG_FHA_2	643	649	PF00498	0.503
LIG_LIR_Apic_2	376	381	PF02991	0.535
LIG_LIR_Gen_1	501	512	PF02991	0.641
LIG_LIR_Gen_1	64	71	PF02991	0.483
LIG_LIR_Gen_1	874	883	PF02991	0.641
LIG_LIR_Nem_3	433	438	PF02991	0.479
LIG_LIR_Nem_3	501	507	PF02991	0.624
LIG_LIR_Nem_3	544	550	PF02991	0.470
LIG_LIR_Nem_3	64	70	PF02991	0.581
LIG_LIR_Nem_3	666	671	PF02991	0.492
LIG_LIR_Nem_3	874	880	PF02991	0.639
LIG_NRBOX	16	22	PF00104	0.565
LIG_PTAP_UEV_1	112	117	PF05743	0.556
LIG_PTAP_UEV_1	265	270	PF05743	0.719
LIG_REV1ctd_RIR_1	537	547	PF16727	0.382
LIG_SH2_CRK	467	471	PF00017	0.431
LIG_SH2_CRK	492	496	PF00017	0.478
LIG_SH2_CRK	614	618	PF00017	0.383
LIG_SH2_CRK	67	71	PF00017	0.601
LIG_SH2_NCK_1	877	881	PF00017	0.623
LIG_SH2_SRC	378	381	PF00017	0.534
LIG_SH2_SRC	877	880	PF00017	0.623
LIG_SH2_STAP1	67	71	PF00017	0.472
LIG_SH2_STAP1	948	952	PF00017	0.562
LIG_SH2_STAT5	118	121	PF00017	0.641
LIG_SH2_STAT5	378	381	PF00017	0.469
LIG_SH2_STAT5	574	577	PF00017	0.591
LIG_SH2_STAT5	58	61	PF00017	0.441
LIG_SH3_1	546	552	PF00018	0.394
LIG_SH3_2	739	744	PF14604	0.711
LIG_SH3_3	110	116	PF00018	0.560
LIG_SH3_3	148	154	PF00018	0.650
LIG_SH3_3	263	269	PF00018	0.660
LIG_SH3_3	323	329	PF00018	0.754
LIG_SH3_3	336	342	PF00018	0.710
LIG_SH3_3	485	491	PF00018	0.579
LIG_SH3_3	546	552	PF00018	0.394
LIG_SH3_3	583	589	PF00018	0.481
LIG_SH3_3	733	739	PF00018	0.704
LIG_SH3_3	922	928	PF00018	0.629
LIG_SH3_3	967	973	PF00018	0.640
LIG_SH3_3	988	994	PF00018	0.679
LIG_SH3_3	995	1001	PF00018	0.716
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.490
LIG_SUMO_SIM_anti_2	395	403	PF11976	0.535
LIG_SUMO_SIM_anti_2	478	485	PF11976	0.512
LIG_SUMO_SIM_par_1	395	403	PF11976	0.535
LIG_SUMO_SIM_par_1	478	485	PF11976	0.452
LIG_SUMO_SIM_par_1	634	641	PF11976	0.464
LIG_TRAF2_1	193	196	PF00917	0.707
LIG_TRAF2_1	309	312	PF00917	0.656
LIG_TRAF2_1	444	447	PF00917	0.524
LIG_TRAF2_1	476	479	PF00917	0.500
LIG_TRAF2_1	645	648	PF00917	0.517
LIG_TRAF2_1	865	868	PF00917	0.716
LIG_TRAF2_1	947	950	PF00917	0.624
LIG_TYR_ITIM	465	470	PF00017	0.430
LIG_TYR_ITIM	612	617	PF00017	0.372
MOD_CDC14_SPxK_1	548	551	PF00782	0.460
MOD_CDK_SPK_2	846	851	PF00069	0.647
MOD_CDK_SPxK_1	522	528	PF00069	0.462
MOD_CDK_SPxK_1	545	551	PF00069	0.390
MOD_CDK_SPxxK_3	999	1006	PF00069	0.671
MOD_CK1_1	155	161	PF00069	0.615
MOD_CK1_1	236	242	PF00069	0.635
MOD_CK1_1	498	504	PF00069	0.561
MOD_CK1_1	513	519	PF00069	0.487
MOD_CK1_1	56	62	PF00069	0.444
MOD_CK1_1	566	572	PF00069	0.423
MOD_CK1_1	625	631	PF00069	0.539
MOD_CK1_1	634	640	PF00069	0.558
MOD_CK1_1	682	688	PF00069	0.513
MOD_CK1_1	755	761	PF00069	0.642
MOD_CK1_1	800	806	PF00069	0.611
MOD_CK1_1	899	905	PF00069	0.663
MOD_CK2_1	1048	1054	PF00069	0.615
MOD_CK2_1	134	140	PF00069	0.800
MOD_CK2_1	156	162	PF00069	0.588
MOD_CK2_1	350	356	PF00069	0.527
MOD_CK2_1	642	648	PF00069	0.432
MOD_CK2_1	862	868	PF00069	0.712
MOD_Cter_Amidation	980	983	PF01082	0.708
MOD_GlcNHglycan	1058	1062	PF01048	0.572
MOD_GlcNHglycan	112	116	PF01048	0.588
MOD_GlcNHglycan	124	127	PF01048	0.591
MOD_GlcNHglycan	154	157	PF01048	0.668
MOD_GlcNHglycan	181	184	PF01048	0.642
MOD_GlcNHglycan	235	238	PF01048	0.628
MOD_GlcNHglycan	251	254	PF01048	0.543
MOD_GlcNHglycan	516	519	PF01048	0.618
MOD_GlcNHglycan	55	58	PF01048	0.521
MOD_GlcNHglycan	555	559	PF01048	0.459
MOD_GlcNHglycan	565	568	PF01048	0.376
MOD_GlcNHglycan	679	684	PF01048	0.507
MOD_GlcNHglycan	799	802	PF01048	0.680
MOD_GlcNHglycan	864	867	PF01048	0.670
MOD_GlcNHglycan	898	901	PF01048	0.649
MOD_GlcNHglycan	905	908	PF01048	0.638
MOD_GSK3_1	1053	1060	PF00069	0.579
MOD_GSK3_1	152	159	PF00069	0.627
MOD_GSK3_1	238	245	PF00069	0.680
MOD_GSK3_1	315	322	PF00069	0.658
MOD_GSK3_1	430	437	PF00069	0.514
MOD_GSK3_1	510	517	PF00069	0.675
MOD_GSK3_1	554	561	PF00069	0.620
MOD_GSK3_1	634	641	PF00069	0.576
MOD_GSK3_1	678	685	PF00069	0.500
MOD_GSK3_1	697	704	PF00069	0.327
MOD_GSK3_1	755	762	PF00069	0.688
MOD_GSK3_1	800	807	PF00069	0.686
MOD_GSK3_1	845	852	PF00069	0.674
MOD_GSK3_1	896	903	PF00069	0.672
MOD_GSK3_1	992	999	PF00069	0.713
MOD_NEK2_1	134	139	PF00069	0.671
MOD_NEK2_1	411	416	PF00069	0.424
MOD_NEK2_1	466	471	PF00069	0.414
MOD_NEK2_1	565	570	PF00069	0.380
MOD_NEK2_1	572	577	PF00069	0.385
MOD_NEK2_1	616	621	PF00069	0.427
MOD_NEK2_1	631	636	PF00069	0.516
MOD_NEK2_1	697	702	PF00069	0.564
MOD_PIKK_1	276	282	PF00454	0.572
MOD_PIKK_1	74	80	PF00454	0.542
MOD_PIKK_1	927	933	PF00454	0.608
MOD_PK_1	458	464	PF00069	0.448
MOD_PKA_1	102	108	PF00069	0.695
MOD_PKA_1	1028	1034	PF00069	0.790
MOD_PKA_1	458	464	PF00069	0.448
MOD_PKA_2	102	108	PF00069	0.695
MOD_PKA_2	1027	1033	PF00069	0.620
MOD_PKA_2	233	239	PF00069	0.675
MOD_PKA_2	458	464	PF00069	0.448
MOD_PKA_2	563	569	PF00069	0.406
MOD_PKA_2	632	638	PF00069	0.554
MOD_PKA_2	790	796	PF00069	0.777
MOD_PKA_2	797	803	PF00069	0.651
MOD_PKA_2	836	842	PF00069	0.642
MOD_PKA_2	862	868	PF00069	0.581
MOD_PKA_2	896	902	PF00069	0.711
MOD_PKB_1	72	80	PF00069	0.639
MOD_Plk_1	164	170	PF00069	0.582
MOD_Plk_1	697	703	PF00069	0.564
MOD_Plk_1	773	779	PF00069	0.726
MOD_Plk_2-3	446	452	PF00069	0.517
MOD_Plk_4	430	436	PF00069	0.463
MOD_Plk_4	466	472	PF00069	0.429
MOD_Plk_4	558	564	PF00069	0.384
MOD_Plk_4	682	688	PF00069	0.513
MOD_ProDKin_1	1053	1059	PF00069	0.581
MOD_ProDKin_1	238	244	PF00069	0.676
MOD_ProDKin_1	328	334	PF00069	0.711
MOD_ProDKin_1	484	490	PF00069	0.459
MOD_ProDKin_1	522	528	PF00069	0.462
MOD_ProDKin_1	545	551	PF00069	0.390
MOD_ProDKin_1	654	660	PF00069	0.500
MOD_ProDKin_1	753	759	PF00069	0.724
MOD_ProDKin_1	800	806	PF00069	0.648
MOD_ProDKin_1	846	852	PF00069	0.668
MOD_ProDKin_1	921	927	PF00069	0.675
MOD_ProDKin_1	992	998	PF00069	0.800
MOD_ProDKin_1	999	1005	PF00069	0.768
MOD_SUMO_rev_2	1013	1019	PF00179	0.569
TRG_DiLeu_BaEn_3	203	209	PF01217	0.579
TRG_DiLeu_BaEn_3	218	224	PF01217	0.537
TRG_DiLeu_BaEn_4	583	589	PF01217	0.420
TRG_DiLeu_BaEn_4	647	653	PF01217	0.496
TRG_DiLeu_BaEn_4	878	884	PF01217	0.723
TRG_ENDOCYTIC_2	467	470	PF00928	0.433
TRG_ENDOCYTIC_2	536	539	PF00928	0.457
TRG_ENDOCYTIC_2	547	550	PF00928	0.343
TRG_ENDOCYTIC_2	614	617	PF00928	0.378
TRG_ENDOCYTIC_2	668	671	PF00928	0.426
TRG_ENDOCYTIC_2	67	70	PF00928	0.521
TRG_ENDOCYTIC_2	877	880	PF00928	0.623
TRG_ER_diArg_1	1005	1007	PF00400	0.851
TRG_ER_diArg_1	1021	1024	PF00400	0.575
TRG_ER_diArg_1	1076	1078	PF00400	0.604
TRG_ER_diArg_1	171	173	PF00400	0.715
TRG_ER_diArg_1	175	178	PF00400	0.662
TRG_ER_diArg_1	35	38	PF00400	0.517
TRG_ER_diArg_1	764	766	PF00400	0.738
TRG_NES_CRM1_1	359	371	PF08389	0.409
TRG_NLS_MonoCore_2	1071	1076	PF00514	0.644
TRG_NLS_MonoCore_2	2	7	PF00514	0.503
TRG_NLS_MonoExtC_3	1070	1075	PF00514	0.687
TRG_NLS_MonoExtC_3	3	8	PF00514	0.612
TRG_NLS_MonoExtN_4	1071	1076	PF00514	0.690
TRG_NLS_MonoExtN_4	3	9	PF00514	0.610
TRG_NLS_MonoExtN_4	741	748	PF00514	0.717
TRG_Pf-PMV_PEXEL_1	473	478	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	669	673	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H668	Leishmania braziliensis	68%	86%
A4HUJ2	Leishmania infantum	100%	100%
C9ZVL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AN90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QHD4	Leishmania major	89%	99%