Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I8T9_LEIDO

TriTrypDb:

LdBPK_100640.1 , LdCL_100013200 , LDHU3_10.0960

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I8T9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8T9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.559
CLV_NRD_NRD_1	47	49	PF00675	0.504
CLV_PCSK_KEX2_1	47	49	PF00082	0.575
CLV_PCSK_SKI1_1	143	147	PF00082	0.441
CLV_PCSK_SKI1_1	20	24	PF00082	0.656
CLV_PCSK_SKI1_1	232	236	PF00082	0.599
CLV_PCSK_SKI1_1	48	52	PF00082	0.485
DEG_APCC_DBOX_1	138	146	PF00400	0.379
DEG_SPOP_SBC_1	177	181	PF00917	0.403
DOC_CYCLIN_RxL_1	139	148	PF00134	0.380
DOC_CYCLIN_RxL_1	86	100	PF00134	0.322
DOC_MAPK_gen_1	139	147	PF00069	0.403
DOC_MAPK_gen_1	78	87	PF00069	0.434
DOC_MAPK_MEF2A_6	141	149	PF00069	0.392
DOC_PP1_RVXF_1	78	85	PF00149	0.574
DOC_PP2B_LxvP_1	40	43	PF13499	0.459
DOC_USP7_MATH_1	111	115	PF00917	0.589
DOC_USP7_MATH_1	5	9	PF00917	0.644
DOC_USP7_MATH_1	57	61	PF00917	0.552
DOC_USP7_MATH_1	69	73	PF00917	0.655
DOC_USP7_UBL2_3	15	19	PF12436	0.510
DOC_USP7_UBL2_3	6	10	PF12436	0.641
LIG_14-3-3_CanoR_1	172	177	PF00244	0.459
LIG_14-3-3_CanoR_1	80	85	PF00244	0.425
LIG_BIR_III_2	68	72	PF00653	0.483
LIG_FHA_1	142	148	PF00498	0.416
LIG_FHA_1	150	156	PF00498	0.421
LIG_FHA_1	224	230	PF00498	0.500
LIG_FHA_1	37	43	PF00498	0.576
LIG_FHA_2	133	139	PF00498	0.393
LIG_FHA_2	179	185	PF00498	0.545
LIG_FHA_2	233	239	PF00498	0.440
LIG_LIR_Gen_1	187	195	PF02991	0.383
LIG_LIR_Gen_1	83	91	PF02991	0.380
LIG_LIR_Nem_3	187	192	PF02991	0.404
LIG_LIR_Nem_3	241	246	PF02991	0.410
LIG_LIR_Nem_3	83	87	PF02991	0.397
LIG_LIR_Nem_3	89	94	PF02991	0.337
LIG_NRBOX	141	147	PF00104	0.428
LIG_NRBOX	216	222	PF00104	0.458
LIG_Pex14_2	189	193	PF04695	0.365
LIG_Pex14_2	259	263	PF04695	0.466
LIG_SH2_STAT3	157	160	PF00017	0.484
LIG_SH2_STAT3	32	35	PF00017	0.510
LIG_SH2_STAT5	243	246	PF00017	0.448
LIG_SH2_STAT5	41	44	PF00017	0.461
LIG_SH3_2	167	172	PF14604	0.522
LIG_SH3_3	127	133	PF00018	0.630
LIG_SH3_3	164	170	PF00018	0.456
LIG_SH3_3	22	28	PF00018	0.575
LIG_SH3_4	6	13	PF00018	0.628
LIG_SUMO_SIM_par_1	143	148	PF11976	0.372
MOD_CK2_1	176	182	PF00069	0.530
MOD_CK2_1	232	238	PF00069	0.471
MOD_Cter_Amidation	12	15	PF01082	0.662
MOD_Cter_Amidation	17	20	PF01082	0.622
MOD_GlcNHglycan	120	124	PF01048	0.647
MOD_GlcNHglycan	59	62	PF01048	0.372
MOD_GSK3_1	111	118	PF00069	0.575
MOD_GSK3_1	172	179	PF00069	0.588
MOD_GSK3_1	200	207	PF00069	0.493
MOD_GSK3_1	228	235	PF00069	0.681
MOD_GSK3_1	86	93	PF00069	0.412
MOD_NEK2_1	149	154	PF00069	0.476
MOD_NEK2_1	36	41	PF00069	0.511
MOD_PIKK_1	111	117	PF00454	0.593
MOD_PIKK_1	5	11	PF00454	0.648
MOD_PIKK_1	69	75	PF00454	0.558
MOD_PK_1	172	178	PF00069	0.503
MOD_PK_1	86	92	PF00069	0.322
MOD_PKA_2	171	177	PF00069	0.506
MOD_PKB_1	78	86	PF00069	0.443
MOD_Plk_1	36	42	PF00069	0.626
MOD_Plk_4	172	178	PF00069	0.423
MOD_Plk_4	36	42	PF00069	0.636
MOD_Plk_4	86	92	PF00069	0.385
TRG_ENDOCYTIC_2	243	246	PF00928	0.448
TRG_ER_diArg_1	46	48	PF00400	0.578
TRG_NLS_MonoExtN_4	12	18	PF00514	0.634
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKR2	Leptomonas seymouri	46%	100%
A0A3R7KUI1	Trypanosoma rangeli	27%	87%
A4H651	Leishmania braziliensis	69%	100%
A4HUH1	Leishmania infantum	99%	100%
E9AI41	Leishmania braziliensis	75%	100%
E9AN69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHF6	Leishmania major	94%	100%
V5B6H6	Trypanosoma cruzi	26%	86%