Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8I8R8_LEIDO

TriTrypDb:

LdBPK_100440.1 , LdCL_100009700 , LDHU3_10.0620

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I8R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8R8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.594
CLV_C14_Caspase3-7	59	63	PF00656	0.535
CLV_NRD_NRD_1	119	121	PF00675	0.602
CLV_NRD_NRD_1	2	4	PF00675	0.675
CLV_NRD_NRD_1	345	347	PF00675	0.568
CLV_NRD_NRD_1	377	379	PF00675	0.582
CLV_NRD_NRD_1	427	429	PF00675	0.434
CLV_PCSK_KEX2_1	119	121	PF00082	0.588
CLV_PCSK_KEX2_1	2	4	PF00082	0.602
CLV_PCSK_KEX2_1	345	347	PF00082	0.567
CLV_PCSK_KEX2_1	377	379	PF00082	0.582
CLV_PCSK_KEX2_1	427	429	PF00082	0.548
DEG_Nend_UBRbox_1	1	4	PF02207	0.580
DEG_SCF_FBW7_1	328	333	PF00400	0.605
DEG_SPOP_SBC_1	108	112	PF00917	0.613
DEG_SPOP_SBC_1	113	117	PF00917	0.592
DEG_SPOP_SBC_1	151	155	PF00917	0.595
DOC_CKS1_1	4	9	PF01111	0.564
DOC_CYCLIN_RxL_1	87	97	PF00134	0.609
DOC_MAPK_DCC_7	26	34	PF00069	0.582
DOC_MAPK_FxFP_2	66	69	PF00069	0.584
DOC_MAPK_gen_1	22	32	PF00069	0.597
DOC_MAPK_gen_1	374	384	PF00069	0.631
DOC_MAPK_gen_1	427	433	PF00069	0.411
DOC_MAPK_gen_1	443	451	PF00069	0.427
DOC_MAPK_MEF2A_6	26	34	PF00069	0.582
DOC_MAPK_MEF2A_6	377	386	PF00069	0.629
DOC_PP4_FxxP_1	66	69	PF00568	0.584
DOC_USP7_MATH_1	151	155	PF00917	0.741
DOC_USP7_MATH_1	179	183	PF00917	0.676
DOC_USP7_MATH_1	261	265	PF00917	0.615
DOC_USP7_MATH_1	315	319	PF00917	0.676
DOC_USP7_MATH_1	330	334	PF00917	0.760
DOC_USP7_MATH_1	398	402	PF00917	0.668
DOC_USP7_MATH_1	462	466	PF00917	0.638
DOC_WW_Pin1_4	181	186	PF00397	0.670
DOC_WW_Pin1_4	215	220	PF00397	0.656
DOC_WW_Pin1_4	282	287	PF00397	0.665
DOC_WW_Pin1_4	292	297	PF00397	0.660
DOC_WW_Pin1_4	3	8	PF00397	0.708
DOC_WW_Pin1_4	320	325	PF00397	0.738
DOC_WW_Pin1_4	326	331	PF00397	0.689
DOC_WW_Pin1_4	338	343	PF00397	0.625
DOC_WW_Pin1_4	34	39	PF00397	0.728
DOC_WW_Pin1_4	358	363	PF00397	0.469
DOC_WW_Pin1_4	47	52	PF00397	0.587
DOC_WW_Pin1_4	76	81	PF00397	0.782
LIG_14-3-3_CanoR_1	120	126	PF00244	0.583
LIG_14-3-3_CanoR_1	145	150	PF00244	0.606
LIG_14-3-3_CanoR_1	224	234	PF00244	0.594
LIG_14-3-3_CanoR_1	345	350	PF00244	0.732
LIG_14-3-3_CanoR_1	427	432	PF00244	0.410
LIG_Actin_WH2_2	409	424	PF00022	0.488
LIG_Actin_WH2_2	431	447	PF00022	0.482
LIG_BIR_III_2	74	78	PF00653	0.585
LIG_BIR_III_4	303	307	PF00653	0.597
LIG_CSL_BTD_1	293	296	PF09270	0.556
LIG_eIF4E_1	453	459	PF01652	0.413
LIG_FHA_1	109	115	PF00498	0.617
LIG_FHA_1	121	127	PF00498	0.550
LIG_FHA_1	133	139	PF00498	0.496
LIG_FHA_1	268	274	PF00498	0.559
LIG_FHA_1	314	320	PF00498	0.607
LIG_FHA_1	418	424	PF00498	0.467
LIG_FHA_1	454	460	PF00498	0.505
LIG_FHA_1	462	468	PF00498	0.532
LIG_FHA_2	218	224	PF00498	0.568
LIG_FHA_2	308	314	PF00498	0.592
LIG_LIR_Apic_2	64	69	PF02991	0.579
LIG_LIR_Nem_3	312	317	PF02991	0.602
LIG_PCNA_yPIPBox_3	140	150	PF02747	0.541
LIG_SH2_NCK_1	245	249	PF00017	0.580
LIG_SH2_STAT5	441	444	PF00017	0.484
LIG_SH3_3	1	7	PF00018	0.572
LIG_SH3_3	154	160	PF00018	0.653
LIG_SH3_3	190	196	PF00018	0.664
LIG_SH3_3	200	206	PF00018	0.570
LIG_SH3_3	290	296	PF00018	0.591
LIG_SH3_3	32	38	PF00018	0.735
LIG_SH3_3	331	337	PF00018	0.663
LIG_SH3_3	74	80	PF00018	0.699
LIG_SUMO_SIM_anti_2	429	435	PF11976	0.382
LIG_SUMO_SIM_par_1	30	37	PF11976	0.586
LIG_SUMO_SIM_par_1	379	385	PF11976	0.589
LIG_TRAF2_1	385	388	PF00917	0.596
LIG_TYR_ITIM	439	444	PF00017	0.390
LIG_WW_3	184	188	PF00397	0.611
LIG_WW_3	285	289	PF00397	0.581
MOD_CDK_SPK_2	320	325	PF00069	0.670
MOD_CDK_SPK_2	340	345	PF00069	0.581
MOD_CDK_SPxK_1	181	187	PF00069	0.613
MOD_CDK_SPxK_1	282	288	PF00069	0.583
MOD_CDK_SPxK_1	340	346	PF00069	0.583
MOD_CDK_SPxxK_3	338	345	PF00069	0.643
MOD_CK1_1	225	231	PF00069	0.709
MOD_CK1_1	275	281	PF00069	0.607
MOD_CK1_1	417	423	PF00069	0.610
MOD_CK1_1	465	471	PF00069	0.648
MOD_CK1_1	49	55	PF00069	0.694
MOD_CK1_1	57	63	PF00069	0.589
MOD_CK1_1	79	85	PF00069	0.691
MOD_CK2_1	112	118	PF00069	0.631
MOD_CK2_1	217	223	PF00069	0.560
MOD_CK2_1	243	249	PF00069	0.647
MOD_CK2_1	382	388	PF00069	0.600
MOD_CK2_1	465	471	PF00069	0.541
MOD_DYRK1A_RPxSP_1	3	7	PF00069	0.659
MOD_GlcNHglycan	175	178	PF01048	0.692
MOD_GlcNHglycan	199	202	PF01048	0.613
MOD_GlcNHglycan	210	213	PF01048	0.698
MOD_GlcNHglycan	227	230	PF01048	0.568
MOD_GlcNHglycan	245	248	PF01048	0.653
MOD_GlcNHglycan	259	262	PF01048	0.674
MOD_GlcNHglycan	263	266	PF01048	0.661
MOD_GlcNHglycan	279	282	PF01048	0.526
MOD_GlcNHglycan	296	299	PF01048	0.536
MOD_GlcNHglycan	364	367	PF01048	0.664
MOD_GlcNHglycan	393	396	PF01048	0.724
MOD_GlcNHglycan	416	419	PF01048	0.535
MOD_GlcNHglycan	466	470	PF01048	0.562
MOD_GlcNHglycan	96	99	PF01048	0.542
MOD_GSK3_1	108	115	PF00069	0.621
MOD_GSK3_1	204	211	PF00069	0.715
MOD_GSK3_1	257	264	PF00069	0.750
MOD_GSK3_1	273	280	PF00069	0.564
MOD_GSK3_1	282	289	PF00069	0.688
MOD_GSK3_1	294	301	PF00069	0.613
MOD_GSK3_1	309	316	PF00069	0.698
MOD_GSK3_1	320	327	PF00069	0.609
MOD_GSK3_1	358	365	PF00069	0.751
MOD_GSK3_1	417	424	PF00069	0.505
MOD_GSK3_1	46	53	PF00069	0.679
MOD_GSK3_1	461	468	PF00069	0.631
MOD_GSK3_1	75	82	PF00069	0.688
MOD_NEK2_1	126	131	PF00069	0.608
MOD_NEK2_1	150	155	PF00069	0.639
MOD_NEK2_1	173	178	PF00069	0.630
MOD_NEK2_1	267	272	PF00069	0.567
MOD_NEK2_1	273	278	PF00069	0.522
MOD_NEK2_1	382	387	PF00069	0.585
MOD_NEK2_1	56	61	PF00069	0.553
MOD_NEK2_1	94	99	PF00069	0.568
MOD_PIKK_1	79	85	PF00454	0.657
MOD_PK_1	345	351	PF00069	0.653
MOD_PK_1	427	433	PF00069	0.441
MOD_PKA_1	345	351	PF00069	0.653
MOD_PKA_1	427	433	PF00069	0.411
MOD_PKA_2	118	124	PF00069	0.583
MOD_PKA_2	173	179	PF00069	0.661
MOD_PKA_2	223	229	PF00069	0.589
MOD_PKA_2	267	273	PF00069	0.709
MOD_PKA_2	345	351	PF00069	0.797
MOD_PKA_2	396	402	PF00069	0.712
MOD_PKA_2	421	427	PF00069	0.559
MOD_Plk_4	121	127	PF00069	0.671
MOD_Plk_4	145	151	PF00069	0.569
MOD_Plk_4	189	195	PF00069	0.619
MOD_Plk_4	330	336	PF00069	0.763
MOD_Plk_4	345	351	PF00069	0.550
MOD_Plk_4	50	56	PF00069	0.672
MOD_ProDKin_1	181	187	PF00069	0.673
MOD_ProDKin_1	215	221	PF00069	0.657
MOD_ProDKin_1	282	288	PF00069	0.667
MOD_ProDKin_1	292	298	PF00069	0.662
MOD_ProDKin_1	3	9	PF00069	0.713
MOD_ProDKin_1	320	326	PF00069	0.739
MOD_ProDKin_1	338	344	PF00069	0.686
MOD_ProDKin_1	34	40	PF00069	0.731
MOD_ProDKin_1	358	364	PF00069	0.471
MOD_ProDKin_1	47	53	PF00069	0.586
MOD_ProDKin_1	76	82	PF00069	0.784
MOD_SUMO_rev_2	249	259	PF00179	0.582
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.753
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.560
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.614
TRG_ENDOCYTIC_2	441	444	PF00928	0.484
TRG_ER_diArg_1	1	3	PF00400	0.582
TRG_ER_diArg_1	139	142	PF00400	0.508
TRG_ER_diArg_1	344	346	PF00400	0.647
TRG_ER_diArg_1	372	375	PF00400	0.551
TRG_Pf-PMV_PEXEL_1	90	95	PF00026	0.607
TRG_PTS1	477	480	PF00515	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H622	Leishmania braziliensis	55%	100%
A4HUF0	Leishmania infantum	98%	100%
E9AN49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%