LeishMANIAdb
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Zinc finger, C3HC4 type (RING finger) containing protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Zinc finger, C3HC4 type (RING finger) containing protein, putative
Gene product:
Zinc finger, C3HC4 type (RING finger), putative
Species:
Leishmania donovani
UniProt:
A0A3Q8I8R6_LEIDO
TriTrypDb:
LdBPK_100460.1 , LdCL_100009900 , LDHU3_10.0640
Length:
165

Annotations

LeishMANIAdb annotations

Related to divere Eukaryotic membrane-associated ubiquitin ligases (animal RNF180 or plant SPL1). If it has similar function, this protein is likely anchored to the ER. The topology must be in-out due to the RING finger being redox sensitive. The genes have duplicated in Leishmaniids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5
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Expansion

Sequence features

A0A3Q8I8R6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8R6

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
DOC_PP4_FxxP_1 142 145 PF00568 0.622
DOC_USP7_MATH_1 13 17 PF00917 0.340
DOC_USP7_MATH_1 52 56 PF00917 0.722
DOC_WW_Pin1_4 76 81 PF00397 0.643
LIG_14-3-3_CanoR_1 107 112 PF00244 0.538
LIG_BIR_II_1 1 5 PF00653 0.322
LIG_BIR_III_3 1 5 PF00653 0.322
LIG_BRCT_BRCA1_1 109 113 PF00533 0.508
LIG_LIR_Gen_1 110 119 PF02991 0.522
LIG_LIR_Nem_3 110 114 PF02991 0.510
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HT25 Leptomonas seymouri 40% 100%
A0A3S7WR53 Leishmania donovani 42% 100%
A4H623 Leishmania braziliensis 43% 95%
A4HUF1 Leishmania infantum 41% 90%
A4HUF2 Leishmania infantum 99% 100%
E9AN50 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 94%
E9AN51 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QHH4 Leishmania major 92% 100%
Q4QHH5 Leishmania major 41% 92%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS