LeishMANIAdb
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Zinc finger, C3HC4 type (RING finger) containing protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Zinc finger, C3HC4 type (RING finger) containing protein, putative
Gene product:
Zinc finger, C3HC4 type (RING finger), putative
Species:
Leishmania donovani
UniProt:
A0A3Q8I8R6_LEIDO
TriTrypDb:
LdBPK_100460.1 , LdCL_100009900 , LDHU3_10.0640
Length:
165

Annotations

LeishMANIAdb annotations

Related to divere Eukaryotic membrane-associated ubiquitin ligases (animal RNF180 or plant SPL1). If it has similar function, this protein is likely anchored to the ER. The topology must be in-out due to the RING finger being redox sensitive. The genes have duplicated in Leishmaniids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A0A3Q8I8R6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8R6

Putative motif mimicry

Leishmania From To Domain/Motif Score
DOC_PP4_FxxP_1 142 145 PF00568 0.622
DOC_USP7_MATH_1 13 17 PF00917 0.340
DOC_USP7_MATH_1 52 56 PF00917 0.722
DOC_WW_Pin1_4 76 81 PF00397 0.643
LIG_14-3-3_CanoR_1 107 112 PF00244 0.538
LIG_BIR_II_1 1 5 PF00653 0.322
LIG_BIR_III_3 1 5 PF00653 0.322
LIG_BRCT_BRCA1_1 109 113 PF00533 0.508
LIG_LIR_Gen_1 110 119 PF02991 0.522
LIG_LIR_Nem_3 110 114 PF02991 0.510
LIG_LIR_Nem_3 16 22 PF02991 0.672
LIG_LIR_Nem_3 30 36 PF02991 0.538
LIG_Pex14_2 53 57 PF04695 0.633
LIG_SH2_CRK 34 38 PF00017 0.678
LIG_SH2_STAP1 19 23 PF00017 0.509
LIG_SH2_STAT5 158 161 PF00017 0.656
LIG_SH2_STAT5 34 37 PF00017 0.518
LIG_SH3_3 143 149 PF00018 0.675
LIG_TRFH_1 34 38 PF08558 0.695
LIG_WW_3 36 40 PF00397 0.575
MOD_GlcNHglycan 15 18 PF01048 0.340
MOD_GlcNHglycan 5 8 PF01048 0.402
MOD_GlcNHglycan 60 63 PF01048 0.443
MOD_GlcNHglycan 91 94 PF01048 0.474
MOD_GSK3_1 13 20 PF00069 0.385
MOD_NEK2_1 3 8 PF00069 0.530
MOD_NEK2_1 53 58 PF00069 0.632
MOD_PKA_2 67 73 PF00069 0.685
MOD_Plk_4 107 113 PF00069 0.533
MOD_Plk_4 17 23 PF00069 0.597
MOD_Plk_4 53 59 PF00069 0.748
MOD_ProDKin_1 76 82 PF00069 0.642
MOD_SUMO_rev_2 134 138 PF00179 0.570
TRG_ENDOCYTIC_2 33 36 PF00928 0.572

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HT25 Leptomonas seymouri 40% 100%
A0A3S7WR53 Leishmania donovani 42% 100%
A4H623 Leishmania braziliensis 43% 95%
A4HUF1 Leishmania infantum 41% 90%
A4HUF2 Leishmania infantum 99% 100%
E9AN50 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 94%
E9AN51 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QHH4 Leishmania major 92% 100%
Q4QHH5 Leishmania major 41% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS