Pyridine nucleotide-disulfide oxidoreductase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyridine nucleotide-disulphide oxidoreductase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I8R3_LEIDO

TriTrypDb:

LdBPK_140450.1 , LdCL_140009700 , LDHU3_14.0570

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I8R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8R3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0000166	nucleotide binding	3	1
GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	4	1
GO:0005488	binding	1	1
GO:0009055	electron transfer activity	3	1
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	1
GO:0016649	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.356
CLV_C14_Caspase3-7	399	403	PF00656	0.429
CLV_MEL_PAP_1	529	535	PF00089	0.426
CLV_NRD_NRD_1	104	106	PF00675	0.297
CLV_NRD_NRD_1	151	153	PF00675	0.338
CLV_NRD_NRD_1	227	229	PF00675	0.335
CLV_NRD_NRD_1	313	315	PF00675	0.681
CLV_NRD_NRD_1	388	390	PF00675	0.588
CLV_PCSK_KEX2_1	104	106	PF00082	0.305
CLV_PCSK_KEX2_1	115	117	PF00082	0.280
CLV_PCSK_KEX2_1	172	174	PF00082	0.432
CLV_PCSK_KEX2_1	227	229	PF00082	0.432
CLV_PCSK_KEX2_1	313	315	PF00082	0.681
CLV_PCSK_KEX2_1	346	348	PF00082	0.511
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.312
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.432
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.582
CLV_PCSK_PC7_1	111	117	PF00082	0.312
CLV_PCSK_SKI1_1	243	247	PF00082	0.421
CLV_PCSK_SKI1_1	304	308	PF00082	0.659
CLV_PCSK_SKI1_1	442	446	PF00082	0.383
CLV_PCSK_SKI1_1	517	521	PF00082	0.593
DEG_APCC_DBOX_1	303	311	PF00400	0.649
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DEG_SPOP_SBC_1	263	267	PF00917	0.707
DOC_CYCLIN_yClb5_NLxxxL_5	235	244	PF00134	0.334
DOC_MAPK_gen_1	101	109	PF00069	0.411
DOC_MAPK_gen_1	472	482	PF00069	0.495
DOC_MAPK_MEF2A_6	20	29	PF00069	0.662
DOC_MAPK_MEF2A_6	204	211	PF00069	0.301
DOC_MAPK_MEF2A_6	233	242	PF00069	0.309
DOC_MAPK_MEF2A_6	472	480	PF00069	0.421
DOC_PP2B_LxvP_1	29	32	PF13499	0.613
DOC_PP2B_PxIxI_1	473	479	PF00149	0.443
DOC_PP4_FxxP_1	515	518	PF00568	0.454
DOC_USP7_MATH_1	263	267	PF00917	0.707
DOC_USP7_MATH_1	270	274	PF00917	0.507
DOC_USP7_MATH_1	289	293	PF00917	0.617
DOC_WW_Pin1_4	265	270	PF00397	0.698
DOC_WW_Pin1_4	372	377	PF00397	0.514
DOC_WW_Pin1_4	486	491	PF00397	0.376
LIG_14-3-3_CanoR_1	247	255	PF00244	0.369
LIG_14-3-3_CanoR_1	271	279	PF00244	0.621
LIG_14-3-3_CanoR_1	304	312	PF00244	0.467
LIG_14-3-3_CanoR_1	406	411	PF00244	0.362
LIG_Actin_WH2_2	102	117	PF00022	0.296
LIG_Actin_WH2_2	120	137	PF00022	0.296
LIG_BIR_III_4	484	488	PF00653	0.345
LIG_CaM_NSCaTE_8	302	309	PF13499	0.463
LIG_EH1_1	4	12	PF00400	0.614
LIG_EH1_1	404	412	PF00400	0.363
LIG_eIF4E_1	405	411	PF01652	0.367
LIG_FHA_1	119	125	PF00498	0.330
LIG_FHA_1	281	287	PF00498	0.615
LIG_FHA_1	31	37	PF00498	0.456
LIG_FHA_1	439	445	PF00498	0.549
LIG_FHA_1	455	461	PF00498	0.474
LIG_FHA_1	540	546	PF00498	0.462
LIG_FHA_1	81	87	PF00498	0.323
LIG_FHA_2	247	253	PF00498	0.308
LIG_FHA_2	70	76	PF00498	0.296
LIG_LIR_Apic_2	514	518	PF02991	0.444
LIG_LIR_Gen_1	139	148	PF02991	0.334
LIG_LIR_Gen_1	322	332	PF02991	0.435
LIG_LIR_Gen_1	362	371	PF02991	0.385
LIG_LIR_Nem_3	139	145	PF02991	0.334
LIG_LIR_Nem_3	322	328	PF02991	0.462
LIG_LIR_Nem_3	362	368	PF02991	0.363
LIG_LIR_Nem_3	443	448	PF02991	0.372
LIG_LIR_Nem_3	76	82	PF02991	0.310
LIG_NRBOX	409	415	PF00104	0.318
LIG_PCNA_PIPBox_1	106	115	PF02747	0.432
LIG_PCNA_yPIPBox_3	333	343	PF02747	0.592
LIG_PDZ_Class_1	545	550	PF00595	0.525
LIG_Pex14_2	365	369	PF04695	0.368
LIG_Rb_pABgroove_1	63	71	PF01858	0.308
LIG_SH2_CRK	142	146	PF00017	0.296
LIG_SH2_CRK	325	329	PF00017	0.464
LIG_SH2_STAP1	142	146	PF00017	0.296
LIG_SH2_STAP1	321	325	PF00017	0.438
LIG_SH2_STAT3	521	524	PF00017	0.467
LIG_SH2_STAT5	113	116	PF00017	0.315
LIG_SH2_STAT5	133	136	PF00017	0.145
LIG_SH2_STAT5	367	370	PF00017	0.376
LIG_SH2_STAT5	510	513	PF00017	0.572
LIG_SH3_3	217	223	PF00018	0.312
LIG_SH3_3	251	257	PF00018	0.552
LIG_SH3_3	276	282	PF00018	0.665
LIG_SH3_3	283	289	PF00018	0.597
LIG_SH3_3	449	455	PF00018	0.393
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.433
LIG_TYR_ITIM	140	145	PF00017	0.296
LIG_TYR_ITIM	323	328	PF00017	0.438
MOD_CDC14_SPxK_1	268	271	PF00782	0.687
MOD_CDK_SPK_2	372	377	PF00069	0.514
MOD_CDK_SPxK_1	265	271	PF00069	0.696
MOD_CK1_1	13	19	PF00069	0.581
MOD_CK1_1	265	271	PF00069	0.696
MOD_CK1_1	291	297	PF00069	0.671
MOD_CK1_1	305	311	PF00069	0.447
MOD_CK1_1	450	456	PF00069	0.499
MOD_CK2_1	434	440	PF00069	0.429
MOD_CK2_1	497	503	PF00069	0.510
MOD_Cter_Amidation	344	347	PF01082	0.500
MOD_GlcNHglycan	12	15	PF01048	0.505
MOD_GlcNHglycan	164	167	PF01048	0.356
MOD_GlcNHglycan	491	494	PF01048	0.414
MOD_GlcNHglycan	7	10	PF01048	0.551
MOD_GSK3_1	114	121	PF00069	0.362
MOD_GSK3_1	156	163	PF00069	0.309
MOD_GSK3_1	302	309	PF00069	0.635
MOD_GSK3_1	434	441	PF00069	0.412
MOD_GSK3_1	450	457	PF00069	0.395
MOD_GSK3_1	489	496	PF00069	0.470
MOD_LATS_1	241	247	PF00433	0.245
MOD_LATS_1	404	410	PF00433	0.369
MOD_N-GLC_1	23	28	PF02516	0.659
MOD_NEK2_1	114	119	PF00069	0.365
MOD_NEK2_1	177	182	PF00069	0.313
MOD_NEK2_1	200	205	PF00069	0.357
MOD_NEK2_1	306	311	PF00069	0.700
MOD_NEK2_1	5	10	PF00069	0.569
MOD_NEK2_1	69	74	PF00069	0.388
MOD_NEK2_2	497	502	PF00069	0.511
MOD_PIKK_1	531	537	PF00454	0.528
MOD_PKA_2	246	252	PF00069	0.312
MOD_PKA_2	270	276	PF00069	0.626
MOD_PKA_2	405	411	PF00069	0.367
MOD_PKA_2	423	429	PF00069	0.363
MOD_PKA_2	531	537	PF00069	0.408
MOD_PKB_1	160	168	PF00069	0.432
MOD_Plk_1	160	166	PF00069	0.381
MOD_Plk_1	23	29	PF00069	0.658
MOD_Plk_1	289	295	PF00069	0.734
MOD_Plk_1	506	512	PF00069	0.568
MOD_Plk_1	69	75	PF00069	0.280
MOD_Plk_4	120	126	PF00069	0.362
MOD_Plk_4	306	312	PF00069	0.652
MOD_Plk_4	32	38	PF00069	0.604
MOD_Plk_4	334	340	PF00069	0.479
MOD_Plk_4	406	412	PF00069	0.376
MOD_Plk_4	447	453	PF00069	0.409
MOD_Plk_4	454	460	PF00069	0.445
MOD_Plk_4	64	70	PF00069	0.313
MOD_ProDKin_1	265	271	PF00069	0.696
MOD_ProDKin_1	372	378	PF00069	0.508
MOD_ProDKin_1	486	492	PF00069	0.382
MOD_SUMO_rev_2	165	174	PF00179	0.356
MOD_SUMO_rev_2	382	388	PF00179	0.485
MOD_SUMO_rev_2	70	79	PF00179	0.359
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.245
TRG_ENDOCYTIC_2	142	145	PF00928	0.304
TRG_ENDOCYTIC_2	325	328	PF00928	0.410
TRG_ER_diArg_1	104	106	PF00400	0.312
TRG_ER_diArg_1	312	314	PF00400	0.681
TRG_Pf-PMV_PEXEL_1	442	447	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3U1	Leptomonas seymouri	76%	100%
A0A0S4KJN5	Bodo saltans	43%	100%
A0A1X0NNQ7	Trypanosomatidae	56%	100%
A0A422MYM5	Trypanosoma rangeli	56%	100%
A4H7K4	Leishmania braziliensis	89%	100%
A4HVY7	Leishmania infantum	100%	100%
C9ZT37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9APN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QFU0	Leishmania major	96%	100%
V5AXT2	Trypanosoma cruzi	55%	100%