Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FLA1-binding protein

Species:

Leishmania donovani

UniProt:

A0A3Q8I8Q8_LEIDO

TriTrypDb:

LdBPK_100670.1 , LdCL_100013500 , LDHU3_10.1000

Length:

756

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 3
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3Q8I8Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8Q8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.287
CLV_C14_Caspase3-7	614	618	PF00656	0.463
CLV_NRD_NRD_1	6	8	PF00675	0.722
CLV_NRD_NRD_1	688	690	PF00675	0.726
CLV_NRD_NRD_1	722	724	PF00675	0.430
CLV_PCSK_KEX2_1	6	8	PF00082	0.742
CLV_PCSK_KEX2_1	720	722	PF00082	0.414
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.414
CLV_PCSK_SKI1_1	306	310	PF00082	0.511
CLV_PCSK_SKI1_1	487	491	PF00082	0.530
CLV_PCSK_SKI1_1	723	727	PF00082	0.523
DEG_APCC_DBOX_1	720	728	PF00400	0.628
DEG_SCF_FBW7_1	437	444	PF00400	0.265
DEG_SPOP_SBC_1	229	233	PF00917	0.404
DEG_SPOP_SBC_1	26	30	PF00917	0.516
DEG_SPOP_SBC_1	282	286	PF00917	0.420
DOC_ANK_TNKS_1	433	440	PF00023	0.263
DOC_CKS1_1	236	241	PF01111	0.411
DOC_CKS1_1	438	443	PF01111	0.407
DOC_CYCLIN_yCln2_LP_2	490	496	PF00134	0.353
DOC_CYCLIN_yCln2_LP_2	516	522	PF00134	0.335
DOC_PP2B_LxvP_1	516	519	PF13499	0.287
DOC_PP2B_LxvP_1	638	641	PF13499	0.366
DOC_PP4_FxxP_1	236	239	PF00568	0.363
DOC_PP4_FxxP_1	461	464	PF00568	0.400
DOC_USP7_MATH_1	130	134	PF00917	0.452
DOC_USP7_MATH_1	220	224	PF00917	0.455
DOC_USP7_MATH_1	229	233	PF00917	0.373
DOC_USP7_MATH_1	283	287	PF00917	0.384
DOC_USP7_MATH_1	301	305	PF00917	0.211
DOC_USP7_MATH_1	441	445	PF00917	0.424
DOC_USP7_MATH_1	55	59	PF00917	0.357
DOC_USP7_MATH_1	700	704	PF00917	0.436
DOC_WW_Pin1_4	235	240	PF00397	0.406
DOC_WW_Pin1_4	320	325	PF00397	0.491
DOC_WW_Pin1_4	364	369	PF00397	0.405
DOC_WW_Pin1_4	405	410	PF00397	0.434
DOC_WW_Pin1_4	437	442	PF00397	0.389
DOC_WW_Pin1_4	534	539	PF00397	0.451
DOC_WW_Pin1_4	556	561	PF00397	0.435
DOC_WW_Pin1_4	602	607	PF00397	0.479
LIG_14-3-3_CanoR_1	129	137	PF00244	0.475
LIG_14-3-3_CanoR_1	275	280	PF00244	0.450
LIG_14-3-3_CanoR_1	427	433	PF00244	0.463
LIG_14-3-3_CanoR_1	6	16	PF00244	0.559
LIG_14-3-3_CanoR_1	722	728	PF00244	0.735
LIG_14-3-3_CanoR_1	93	98	PF00244	0.369
LIG_BRCT_BRCA1_1	211	215	PF00533	0.351
LIG_BRCT_BRCA1_1	221	225	PF00533	0.302
LIG_BRCT_BRCA1_1	232	236	PF00533	0.244
LIG_BRCT_BRCA1_1	248	252	PF00533	0.403
LIG_BRCT_BRCA1_1	322	326	PF00533	0.379
LIG_BRCT_BRCA1_1	424	428	PF00533	0.407
LIG_BRCT_BRCA1_1	528	532	PF00533	0.527
LIG_BRCT_BRCA1_1	85	89	PF00533	0.361
LIG_deltaCOP1_diTrp_1	242	252	PF00928	0.318
LIG_deltaCOP1_diTrp_1	412	420	PF00928	0.359
LIG_EH_1	61	65	PF12763	0.374
LIG_FHA_1	136	142	PF00498	0.442
LIG_FHA_1	238	244	PF00498	0.385
LIG_FHA_1	275	281	PF00498	0.432
LIG_FHA_1	283	289	PF00498	0.359
LIG_FHA_1	335	341	PF00498	0.418
LIG_FHA_1	406	412	PF00498	0.371
LIG_FHA_1	454	460	PF00498	0.408
LIG_FHA_1	546	552	PF00498	0.374
LIG_FHA_1	634	640	PF00498	0.357
LIG_FHA_1	649	655	PF00498	0.277
LIG_FHA_1	675	681	PF00498	0.410
LIG_FHA_1	691	697	PF00498	0.331
LIG_FHA_1	70	76	PF00498	0.494
LIG_FHA_1	77	83	PF00498	0.414
LIG_FHA_2	171	177	PF00498	0.310
LIG_FHA_2	258	264	PF00498	0.328
LIG_FHA_2	290	296	PF00498	0.317
LIG_FHA_2	357	363	PF00498	0.451
LIG_LIR_Apic_2	233	239	PF02991	0.357
LIG_LIR_Gen_1	168	174	PF02991	0.327
LIG_LIR_Gen_1	212	221	PF02991	0.435
LIG_LIR_Gen_1	297	308	PF02991	0.450
LIG_LIR_Gen_1	413	424	PF02991	0.283
LIG_LIR_Gen_1	561	572	PF02991	0.381
LIG_LIR_Gen_1	671	680	PF02991	0.371
LIG_LIR_Nem_3	120	126	PF02991	0.406
LIG_LIR_Nem_3	168	172	PF02991	0.300
LIG_LIR_Nem_3	212	218	PF02991	0.367
LIG_LIR_Nem_3	222	228	PF02991	0.301
LIG_LIR_Nem_3	242	248	PF02991	0.340
LIG_LIR_Nem_3	297	303	PF02991	0.437
LIG_LIR_Nem_3	323	329	PF02991	0.397
LIG_LIR_Nem_3	367	372	PF02991	0.426
LIG_LIR_Nem_3	413	419	PF02991	0.313
LIG_LIR_Nem_3	561	567	PF02991	0.347
LIG_LIR_Nem_3	671	676	PF02991	0.313
LIG_LIR_Nem_3	86	91	PF02991	0.335
LIG_LIR_Nem_3	95	100	PF02991	0.360
LIG_LYPXL_yS_3	492	495	PF13949	0.402
LIG_MLH1_MIPbox_1	528	532	PF16413	0.451
LIG_MLH1_MIPbox_1	85	89	PF16413	0.369
LIG_NRBOX	512	518	PF00104	0.391
LIG_Pex14_1	416	420	PF04695	0.284
LIG_Pex14_2	369	373	PF04695	0.372
LIG_PTB_Apo_2	423	430	PF02174	0.403
LIG_PTB_Apo_2	540	547	PF02174	0.371
LIG_SH2_CRK	300	304	PF00017	0.404
LIG_SH2_CRK	564	568	PF00017	0.373
LIG_SH2_CRK	591	595	PF00017	0.377
LIG_SH2_GRB2like	452	455	PF00017	0.361
LIG_SH2_GRB2like	645	648	PF00017	0.435
LIG_SH2_NCK_1	300	304	PF00017	0.389
LIG_SH2_NCK_1	34	38	PF00017	0.421
LIG_SH2_NCK_1	389	393	PF00017	0.399
LIG_SH2_NCK_1	564	568	PF00017	0.373
LIG_SH2_NCK_1	591	595	PF00017	0.355
LIG_SH2_PTP2	401	404	PF00017	0.419
LIG_SH2_SRC	34	37	PF00017	0.431
LIG_SH2_STAP1	496	500	PF00017	0.377
LIG_SH2_STAP1	564	568	PF00017	0.373
LIG_SH2_STAP1	94	98	PF00017	0.359
LIG_SH2_STAT3	142	145	PF00017	0.367
LIG_SH2_STAT3	159	162	PF00017	0.397
LIG_SH2_STAT5	143	146	PF00017	0.288
LIG_SH2_STAT5	159	162	PF00017	0.322
LIG_SH2_STAT5	180	183	PF00017	0.276
LIG_SH2_STAT5	289	292	PF00017	0.356
LIG_SH2_STAT5	372	375	PF00017	0.417
LIG_SH2_STAT5	401	404	PF00017	0.393
LIG_SH2_STAT5	494	497	PF00017	0.389
LIG_SH2_STAT5	558	561	PF00017	0.360
LIG_SH2_STAT5	591	594	PF00017	0.322
LIG_SH2_STAT5	608	611	PF00017	0.575
LIG_SH2_STAT5	679	682	PF00017	0.401
LIG_SH2_STAT5	87	90	PF00017	0.380
LIG_SH2_STAT5	97	100	PF00017	0.394
LIG_SH3_3	638	644	PF00018	0.407
LIG_SH3_3	649	655	PF00018	0.241
LIG_SH3_3	724	730	PF00018	0.639
LIG_Sin3_3	14	21	PF02671	0.558
LIG_SUMO_SIM_anti_2	698	703	PF11976	0.316
LIG_SUMO_SIM_par_1	380	385	PF11976	0.386
LIG_TRAF2_1	593	596	PF00917	0.400
LIG_TYR_ITIM	298	303	PF00017	0.401
LIG_TYR_ITIM	490	495	PF00017	0.409
LIG_TYR_ITIM	589	594	PF00017	0.370
LIG_WRC_WIRS_1	88	93	PF05994	0.286
MOD_CDK_SPK_2	405	410	PF00069	0.286
MOD_CK1_1	202	208	PF00069	0.439
MOD_CK1_1	269	275	PF00069	0.399
MOD_CK1_1	294	300	PF00069	0.386
MOD_CK1_1	320	326	PF00069	0.439
MOD_CK1_1	356	362	PF00069	0.416
MOD_CK1_1	430	436	PF00069	0.444
MOD_CK1_1	611	617	PF00069	0.531
MOD_CK2_1	301	307	PF00069	0.441
MOD_GlcNHglycan	110	113	PF01048	0.594
MOD_GlcNHglycan	201	204	PF01048	0.581
MOD_GlcNHglycan	232	235	PF01048	0.580
MOD_GlcNHglycan	248	251	PF01048	0.530
MOD_GlcNHglycan	285	288	PF01048	0.583
MOD_GlcNHglycan	303	306	PF01048	0.469
MOD_GlcNHglycan	528	531	PF01048	0.714
MOD_GlcNHglycan	610	613	PF01048	0.688
MOD_GlcNHglycan	702	705	PF01048	0.426
MOD_GlcNHglycan	9	12	PF01048	0.684
MOD_GSK3_1	205	212	PF00069	0.329
MOD_GSK3_1	253	260	PF00069	0.374
MOD_GSK3_1	261	268	PF00069	0.325
MOD_GSK3_1	283	290	PF00069	0.341
MOD_GSK3_1	341	348	PF00069	0.332
MOD_GSK3_1	356	363	PF00069	0.375
MOD_GSK3_1	411	418	PF00069	0.333
MOD_GSK3_1	437	444	PF00069	0.363
MOD_GSK3_1	533	540	PF00069	0.402
MOD_GSK3_1	602	609	PF00069	0.444
MOD_GSK3_1	611	618	PF00069	0.458
MOD_GSK3_1	681	688	PF00069	0.427
MOD_GSK3_1	743	750	PF00069	0.739
MOD_GSK3_1	83	90	PF00069	0.346
MOD_N-GLC_1	130	135	PF02516	0.639
MOD_N-GLC_1	246	251	PF02516	0.559
MOD_N-GLC_1	356	361	PF02516	0.603
MOD_N-GLC_1	375	380	PF02516	0.454
MOD_N-GLC_1	404	409	PF02516	0.587
MOD_N-GLC_1	453	458	PF02516	0.568
MOD_N-GLC_1	470	475	PF02516	0.457
MOD_N-GLC_1	501	506	PF02516	0.600
MOD_N-GLC_1	509	514	PF02516	0.537
MOD_N-GLC_1	526	531	PF02516	0.666
MOD_N-GLC_1	533	538	PF02516	0.568
MOD_N-GLC_1	546	551	PF02516	0.430
MOD_N-GLC_1	633	638	PF02516	0.534
MOD_N-GLC_1	648	653	PF02516	0.476
MOD_N-GLC_1	660	665	PF02516	0.504
MOD_N-GLC_1	674	679	PF02516	0.543
MOD_N-GLC_1	681	686	PF02516	0.546
MOD_NEK2_1	136	141	PF00069	0.365
MOD_NEK2_1	181	186	PF00069	0.245
MOD_NEK2_1	228	233	PF00069	0.325
MOD_NEK2_1	246	251	PF00069	0.378
MOD_NEK2_1	261	266	PF00069	0.277
MOD_NEK2_1	281	286	PF00069	0.277
MOD_NEK2_1	374	379	PF00069	0.444
MOD_NEK2_1	428	433	PF00069	0.367
MOD_NEK2_1	442	447	PF00069	0.347
MOD_NEK2_1	526	531	PF00069	0.468
MOD_NEK2_1	532	537	PF00069	0.444
MOD_NEK2_1	546	551	PF00069	0.233
MOD_NEK2_1	662	667	PF00069	0.332
MOD_NEK2_2	124	129	PF00069	0.386
MOD_NEK2_2	648	653	PF00069	0.236
MOD_PIKK_1	158	164	PF00454	0.420
MOD_PIKK_1	181	187	PF00454	0.242
MOD_PIKK_1	202	208	PF00454	0.353
MOD_PK_1	275	281	PF00069	0.303
MOD_PKA_1	6	12	PF00069	0.565
MOD_PKA_2	117	123	PF00069	0.388
MOD_PKA_2	269	275	PF00069	0.484
MOD_PKA_2	6	12	PF00069	0.629
MOD_PKA_2	92	98	PF00069	0.326
MOD_PKB_1	721	729	PF00069	0.732
MOD_Plk_1	170	176	PF00069	0.346
MOD_Plk_1	294	300	PF00069	0.312
MOD_Plk_1	356	362	PF00069	0.397
MOD_Plk_1	374	380	PF00069	0.373
MOD_Plk_1	411	417	PF00069	0.356
MOD_Plk_1	501	507	PF00069	0.407
MOD_Plk_1	509	515	PF00069	0.328
MOD_Plk_1	546	552	PF00069	0.378
MOD_Plk_1	648	654	PF00069	0.362
MOD_Plk_1	660	666	PF00069	0.353
MOD_Plk_1	75	81	PF00069	0.433
MOD_Plk_2-3	412	418	PF00069	0.397
MOD_Plk_2-3	743	749	PF00069	0.739
MOD_Plk_4	137	143	PF00069	0.355
MOD_Plk_4	153	159	PF00069	0.286
MOD_Plk_4	257	263	PF00069	0.348
MOD_Plk_4	275	281	PF00069	0.461
MOD_Plk_4	345	351	PF00069	0.370
MOD_Plk_4	375	381	PF00069	0.379
MOD_Plk_4	415	421	PF00069	0.353
MOD_Plk_4	509	515	PF00069	0.444
MOD_Plk_4	546	552	PF00069	0.358
MOD_Plk_4	723	729	PF00069	0.728
MOD_Plk_4	76	82	PF00069	0.405
MOD_Plk_4	83	89	PF00069	0.348
MOD_Plk_4	93	99	PF00069	0.265
MOD_ProDKin_1	235	241	PF00069	0.409
MOD_ProDKin_1	320	326	PF00069	0.481
MOD_ProDKin_1	364	370	PF00069	0.402
MOD_ProDKin_1	405	411	PF00069	0.428
MOD_ProDKin_1	437	443	PF00069	0.393
MOD_ProDKin_1	534	540	PF00069	0.448
MOD_ProDKin_1	556	562	PF00069	0.432
MOD_ProDKin_1	602	608	PF00069	0.487
MOD_SUMO_rev_2	304	310	PF00179	0.452
TRG_DiLeu_BaEn_1	214	219	PF01217	0.341
TRG_DiLeu_BaEn_1	76	81	PF01217	0.399
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.329
TRG_ENDOCYTIC_2	300	303	PF00928	0.459
TRG_ENDOCYTIC_2	389	392	PF00928	0.411
TRG_ENDOCYTIC_2	401	404	PF00928	0.416
TRG_ENDOCYTIC_2	492	495	PF00928	0.360
TRG_ENDOCYTIC_2	564	567	PF00928	0.415
TRG_ENDOCYTIC_2	591	594	PF00928	0.426
TRG_ENDOCYTIC_2	97	100	PF00928	0.415
TRG_ER_diArg_1	5	7	PF00400	0.651
TRG_ER_diArg_1	721	723	PF00400	0.622
TRG_NLS_MonoCore_2	719	724	PF00514	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWL9	Leptomonas seymouri	39%	100%
A0A1X0NRS2	Trypanosomatidae	30%	100%
A0A422NWY1	Trypanosoma rangeli	28%	100%
A4H654	Leishmania braziliensis	72%	100%
A4HUH4	Leishmania infantum	100%	100%
C9ZQ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	92%
C9ZVJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZVJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AN72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QHF3	Leishmania major	91%	100%
V5B409	Trypanosoma cruzi	26%	100%