LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8I8Q7_LEIDO
TriTrypDb:
LdBPK_100260.1 * , LdCL_100007900 , LDHU3_10.0390
Length:
736

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I8Q7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8Q7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 129 133 PF00656 0.497
CLV_C14_Caspase3-7 207 211 PF00656 0.711
CLV_C14_Caspase3-7 519 523 PF00656 0.510
CLV_C14_Caspase3-7 655 659 PF00656 0.639
CLV_NRD_NRD_1 112 114 PF00675 0.584
CLV_NRD_NRD_1 143 145 PF00675 0.655
CLV_NRD_NRD_1 226 228 PF00675 0.516
CLV_NRD_NRD_1 295 297 PF00675 0.574
CLV_NRD_NRD_1 44 46 PF00675 0.608
CLV_NRD_NRD_1 462 464 PF00675 0.594
CLV_NRD_NRD_1 494 496 PF00675 0.611
CLV_NRD_NRD_1 516 518 PF00675 0.480
CLV_NRD_NRD_1 573 575 PF00675 0.656
CLV_PCSK_KEX2_1 112 114 PF00082 0.584
CLV_PCSK_KEX2_1 143 145 PF00082 0.614
CLV_PCSK_KEX2_1 226 228 PF00082 0.507
CLV_PCSK_KEX2_1 44 46 PF00082 0.608
CLV_PCSK_KEX2_1 462 464 PF00082 0.594
CLV_PCSK_KEX2_1 494 496 PF00082 0.611
CLV_PCSK_KEX2_1 516 518 PF00082 0.480
CLV_PCSK_KEX2_1 62 64 PF00082 0.474
CLV_PCSK_PC1ET2_1 62 64 PF00082 0.549
CLV_PCSK_SKI1_1 112 116 PF00082 0.582
CLV_PCSK_SKI1_1 233 237 PF00082 0.527
CLV_PCSK_SKI1_1 463 467 PF00082 0.590
CLV_PCSK_SKI1_1 721 725 PF00082 0.582
CLV_PCSK_SKI1_1 78 82 PF00082 0.618
CLV_Separin_Metazoa 668 672 PF03568 0.640
DEG_APCC_DBOX_1 447 455 PF00400 0.564
DEG_SIAH_1 9 17 PF03145 0.580
DEG_SPOP_SBC_1 349 353 PF00917 0.670
DEG_SPOP_SBC_1 377 381 PF00917 0.683
DEG_SPOP_SBC_1 731 735 PF00917 0.551
DOC_CKS1_1 603 608 PF01111 0.663
DOC_CKS1_1 629 634 PF01111 0.654
DOC_CYCLIN_RxL_1 231 242 PF00134 0.532
DOC_CYCLIN_RxL_1 457 468 PF00134 0.585
DOC_MAPK_FxFP_2 69 72 PF00069 0.665
DOC_MAPK_gen_1 232 238 PF00069 0.529
DOC_MAPK_gen_1 296 304 PF00069 0.577
DOC_PP2B_LxvP_1 361 364 PF13499 0.677
DOC_PP2B_LxvP_1 375 378 PF13499 0.657
DOC_PP4_FxxP_1 69 72 PF00568 0.665
DOC_USP7_MATH_1 150 154 PF00917 0.653
DOC_USP7_MATH_1 172 176 PF00917 0.677
DOC_USP7_MATH_1 335 339 PF00917 0.707
DOC_USP7_MATH_1 376 380 PF00917 0.715
DOC_USP7_MATH_1 598 602 PF00917 0.770
DOC_USP7_MATH_1 613 617 PF00917 0.698
DOC_USP7_MATH_1 625 629 PF00917 0.620
DOC_USP7_MATH_1 645 649 PF00917 0.614
DOC_USP7_MATH_1 72 76 PF00917 0.633
DOC_USP7_MATH_1 732 736 PF00917 0.612
DOC_WW_Pin1_4 161 166 PF00397 0.769
DOC_WW_Pin1_4 183 188 PF00397 0.784
DOC_WW_Pin1_4 191 196 PF00397 0.692
DOC_WW_Pin1_4 350 355 PF00397 0.771
DOC_WW_Pin1_4 359 364 PF00397 0.657
DOC_WW_Pin1_4 577 582 PF00397 0.710
DOC_WW_Pin1_4 588 593 PF00397 0.541
DOC_WW_Pin1_4 602 607 PF00397 0.589
DOC_WW_Pin1_4 611 616 PF00397 0.641
DOC_WW_Pin1_4 628 633 PF00397 0.647
DOC_WW_Pin1_4 643 648 PF00397 0.615
LIG_14-3-3_CanoR_1 383 393 PF00244 0.612
LIG_14-3-3_CanoR_1 475 483 PF00244 0.648
LIG_14-3-3_CanoR_1 494 500 PF00244 0.641
LIG_14-3-3_CanoR_1 608 615 PF00244 0.608
LIG_14-3-3_CanoR_1 654 658 PF00244 0.583
LIG_APCC_ABBA_1 14 19 PF00400 0.566
LIG_CaM_IQ_9 91 107 PF13499 0.552
LIG_FHA_1 280 286 PF00498 0.568
LIG_FHA_1 299 305 PF00498 0.372
LIG_FHA_1 75 81 PF00498 0.620
LIG_FHA_1 92 98 PF00498 0.433
LIG_FHA_1 99 105 PF00498 0.516
LIG_FHA_2 279 285 PF00498 0.495
LIG_LIR_Apic_2 626 632 PF02991 0.656
LIG_LIR_Apic_2 68 72 PF02991 0.659
LIG_LIR_Gen_1 273 283 PF02991 0.564
LIG_LIR_Gen_1 543 553 PF02991 0.643
LIG_LIR_Gen_1 665 673 PF02991 0.658
LIG_LIR_LC3C_4 282 287 PF02991 0.571
LIG_LIR_Nem_3 273 279 PF02991 0.565
LIG_LIR_Nem_3 543 549 PF02991 0.625
LIG_LIR_Nem_3 665 670 PF02991 0.714
LIG_MYND_1 359 363 PF01753 0.727
LIG_NRBOX 536 542 PF00104 0.689
LIG_NRBOX 719 725 PF00104 0.632
LIG_Pex14_2 318 322 PF04695 0.516
LIG_SH2_PTP2 170 173 PF00017 0.591
LIG_SH2_STAT3 461 464 PF00017 0.521
LIG_SH2_STAT3 530 533 PF00017 0.608
LIG_SH2_STAT5 170 173 PF00017 0.652
LIG_SH2_STAT5 240 243 PF00017 0.534
LIG_SH2_STAT5 366 369 PF00017 0.656
LIG_SH2_STAT5 51 54 PF00017 0.618
LIG_SH2_STAT5 552 555 PF00017 0.632
LIG_SH3_3 353 359 PF00018 0.796
LIG_SH3_3 4 10 PF00018 0.541
LIG_SH3_3 630 636 PF00018 0.618
LIG_SH3_3 691 697 PF00018 0.662
LIG_SUMO_SIM_anti_2 683 689 PF11976 0.629
LIG_SUMO_SIM_anti_2 79 84 PF11976 0.610
LIG_SUMO_SIM_par_1 299 307 PF11976 0.562
LIG_TRAF2_1 281 284 PF00917 0.495
LIG_TRAF2_1 312 315 PF00917 0.537
LIG_TRAF2_1 409 412 PF00917 0.660
LIG_TRAF2_1 569 572 PF00917 0.650
LIG_TRAF2_1 716 719 PF00917 0.605
LIG_TRAF2_2 197 202 PF00917 0.715
LIG_WW_1 363 366 PF00397 0.650
LIG_WW_3 186 190 PF00397 0.549
MOD_CDK_SPK_2 191 196 PF00069 0.745
MOD_CDK_SPK_2 350 355 PF00069 0.674
MOD_CDK_SPxK_1 183 189 PF00069 0.738
MOD_CDK_SPxK_1 588 594 PF00069 0.656
MOD_CDK_SPxK_1 602 608 PF00069 0.576
MOD_CDK_SPxK_1 628 634 PF00069 0.726
MOD_CK1_1 160 166 PF00069 0.790
MOD_CK1_1 362 368 PF00069 0.723
MOD_CK1_1 369 375 PF00069 0.545
MOD_CK1_1 379 385 PF00069 0.646
MOD_CK1_1 428 434 PF00069 0.702
MOD_CK1_1 521 527 PF00069 0.656
MOD_CK1_1 545 551 PF00069 0.600
MOD_CK1_1 580 586 PF00069 0.727
MOD_CK1_1 599 605 PF00069 0.774
MOD_CK1_1 616 622 PF00069 0.827
MOD_CK1_1 628 634 PF00069 0.647
MOD_CK1_1 638 644 PF00069 0.566
MOD_CK1_1 648 654 PF00069 0.628
MOD_CK1_1 656 662 PF00069 0.546
MOD_CK2_1 278 284 PF00069 0.505
MOD_CK2_1 335 341 PF00069 0.772
MOD_CK2_1 565 571 PF00069 0.652
MOD_CK2_1 662 668 PF00069 0.658
MOD_GlcNHglycan 122 125 PF01048 0.643
MOD_GlcNHglycan 134 137 PF01048 0.504
MOD_GlcNHglycan 153 156 PF01048 0.645
MOD_GlcNHglycan 174 177 PF01048 0.664
MOD_GlcNHglycan 189 192 PF01048 0.654
MOD_GlcNHglycan 210 214 PF01048 0.668
MOD_GlcNHglycan 218 221 PF01048 0.517
MOD_GlcNHglycan 241 244 PF01048 0.531
MOD_GlcNHglycan 368 371 PF01048 0.685
MOD_GlcNHglycan 412 416 PF01048 0.705
MOD_GlcNHglycan 422 425 PF01048 0.663
MOD_GlcNHglycan 427 430 PF01048 0.589
MOD_GlcNHglycan 566 570 PF01048 0.653
MOD_GlcNHglycan 596 599 PF01048 0.745
MOD_GlcNHglycan 609 612 PF01048 0.695
MOD_GlcNHglycan 625 628 PF01048 0.549
MOD_GlcNHglycan 648 651 PF01048 0.821
MOD_GlcNHglycan 658 661 PF01048 0.644
MOD_GlcNHglycan 698 701 PF01048 0.726
MOD_GlcNHglycan 711 714 PF01048 0.523
MOD_GlcNHglycan 74 77 PF01048 0.632
MOD_GSK3_1 116 123 PF00069 0.614
MOD_GSK3_1 157 164 PF00069 0.746
MOD_GSK3_1 183 190 PF00069 0.789
MOD_GSK3_1 239 246 PF00069 0.576
MOD_GSK3_1 298 305 PF00069 0.655
MOD_GSK3_1 362 369 PF00069 0.725
MOD_GSK3_1 377 384 PF00069 0.726
MOD_GSK3_1 398 405 PF00069 0.725
MOD_GSK3_1 425 432 PF00069 0.691
MOD_GSK3_1 577 584 PF00069 0.662
MOD_GSK3_1 594 601 PF00069 0.727
MOD_GSK3_1 607 614 PF00069 0.840
MOD_GSK3_1 648 655 PF00069 0.720
MOD_GSK3_1 698 705 PF00069 0.729
MOD_GSK3_1 70 77 PF00069 0.596
MOD_N-GLC_1 638 643 PF02516 0.778
MOD_NEK2_1 120 125 PF00069 0.638
MOD_NEK2_1 476 481 PF00069 0.721
MOD_NEK2_1 493 498 PF00069 0.701
MOD_NEK2_1 511 516 PF00069 0.418
MOD_PIKK_1 211 217 PF00454 0.698
MOD_PIKK_1 245 251 PF00454 0.531
MOD_PIKK_1 476 482 PF00454 0.603
MOD_PIKK_1 91 97 PF00454 0.560
MOD_PKA_2 336 342 PF00069 0.526
MOD_PKA_2 449 455 PF00069 0.556
MOD_PKA_2 456 462 PF00069 0.483
MOD_PKA_2 493 499 PF00069 0.625
MOD_PKA_2 607 613 PF00069 0.658
MOD_PKA_2 653 659 PF00069 0.580
MOD_PKA_2 98 104 PF00069 0.600
MOD_PKB_1 728 736 PF00069 0.537
MOD_Plk_1 116 122 PF00069 0.610
MOD_Plk_1 298 304 PF00069 0.609
MOD_Plk_1 542 548 PF00069 0.581
MOD_Plk_2-3 203 209 PF00069 0.674
MOD_Plk_4 298 304 PF00069 0.576
MOD_Plk_4 362 368 PF00069 0.651
MOD_Plk_4 506 512 PF00069 0.573
MOD_ProDKin_1 161 167 PF00069 0.769
MOD_ProDKin_1 183 189 PF00069 0.787
MOD_ProDKin_1 191 197 PF00069 0.691
MOD_ProDKin_1 350 356 PF00069 0.770
MOD_ProDKin_1 359 365 PF00069 0.656
MOD_ProDKin_1 577 583 PF00069 0.711
MOD_ProDKin_1 588 594 PF00069 0.543
MOD_ProDKin_1 602 608 PF00069 0.590
MOD_ProDKin_1 611 617 PF00069 0.642
MOD_ProDKin_1 628 634 PF00069 0.650
MOD_ProDKin_1 643 649 PF00069 0.611
MOD_SUMO_rev_2 229 235 PF00179 0.518
TRG_DiLeu_BaEn_1 299 304 PF01217 0.617
TRG_DiLeu_BaEn_1 560 565 PF01217 0.577
TRG_DiLeu_BaEn_1 719 724 PF01217 0.632
TRG_DiLeu_BaEn_4 299 305 PF01217 0.567
TRG_DiLeu_BaEn_4 571 577 PF01217 0.672
TRG_DiLeu_BaLyEn_6 261 266 PF01217 0.581
TRG_ENDOCYTIC_2 170 173 PF00928 0.700
TRG_ENDOCYTIC_2 276 279 PF00928 0.571
TRG_ENDOCYTIC_2 546 549 PF00928 0.632
TRG_ENDOCYTIC_2 667 670 PF00928 0.667
TRG_ENDOCYTIC_2 717 720 PF00928 0.630
TRG_ER_diArg_1 111 113 PF00400 0.593
TRG_ER_diArg_1 253 256 PF00400 0.455
TRG_ER_diArg_1 447 450 PF00400 0.595
TRG_ER_diArg_1 461 463 PF00400 0.452
TRG_ER_diArg_1 493 495 PF00400 0.629
TRG_ER_diArg_1 516 518 PF00400 0.480
TRG_ER_diArg_1 664 667 PF00400 0.659
TRG_NLS_MonoExtN_4 143 148 PF00514 0.621
TRG_Pf-PMV_PEXEL_1 113 117 PF00026 0.582
TRG_Pf-PMV_PEXEL_1 264 268 PF00026 0.573
TRG_Pf-PMV_PEXEL_1 383 388 PF00026 0.663
TRG_Pf-PMV_PEXEL_1 463 468 PF00026 0.590
TRG_Pf-PMV_PEXEL_1 475 480 PF00026 0.482
TRG_Pf-PMV_PEXEL_1 721 726 PF00026 0.584

Homologs

Protein Taxonomy Sequence identity Coverage
A4H607 Leishmania braziliensis 68% 99%
A4HUD4 Leishmania infantum 99% 100%
E9AN34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4QHJ2 Leishmania major 91% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS