Amastin surface glycoprotein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I8Q6_LEIDO

TriTrypDb:

LdBPK_100240.1 , LdCL_100007700 , LDHU3_10.0370

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A0A3Q8I8Q6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8Q6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.502
CLV_NRD_NRD_1	344	346	PF00675	0.543
CLV_NRD_NRD_1	35	37	PF00675	0.501
CLV_NRD_NRD_1	52	54	PF00675	0.405
CLV_NRD_NRD_1	58	60	PF00675	0.292
CLV_NRD_NRD_1	76	78	PF00675	0.419
CLV_PCSK_FUR_1	74	78	PF00082	0.355
CLV_PCSK_KEX2_1	35	37	PF00082	0.507
CLV_PCSK_KEX2_1	65	67	PF00082	0.339
CLV_PCSK_KEX2_1	76	78	PF00082	0.417
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.316
CLV_PCSK_SKI1_1	61	65	PF00082	0.412
DEG_MDM2_SWIB_1	284	292	PF02201	0.494
DOC_AGCK_PIF_1	225	230	PF00069	0.212
DOC_ANK_TNKS_1	113	120	PF00023	0.533
DOC_MAPK_gen_1	296	305	PF00069	0.447
DOC_MAPK_gen_1	366	375	PF00069	0.328
DOC_MAPK_MEF2A_6	298	307	PF00069	0.447
DOC_MAPK_MEF2A_6	394	402	PF00069	0.547
DOC_MAPK_RevD_3	333	346	PF00069	0.231
DOC_PP1_RVXF_1	296	303	PF00149	0.447
DOC_USP7_MATH_1	190	194	PF00917	0.275
DOC_USP7_MATH_1	333	337	PF00917	0.235
DOC_USP7_MATH_1	5	9	PF00917	0.644
DOC_USP7_UBL2_3	61	65	PF12436	0.535
DOC_WW_Pin1_4	429	434	PF00397	0.268
LIG_14-3-3_CanoR_1	24	28	PF00244	0.667
LIG_14-3-3_CanoR_1	348	353	PF00244	0.413
LIG_14-3-3_CanoR_1	4	14	PF00244	0.631
LIG_BIR_II_1	1	5	PF00653	0.709
LIG_BRCT_BRCA1_1	226	230	PF00533	0.279
LIG_BRCT_BRCA1_1	400	404	PF00533	0.368
LIG_BRCT_BRCA1_1	407	411	PF00533	0.376
LIG_FHA_1	20	26	PF00498	0.605
LIG_FHA_1	287	293	PF00498	0.583
LIG_FHA_1	295	301	PF00498	0.567
LIG_FHA_1	309	315	PF00498	0.299
LIG_FHA_1	412	418	PF00498	0.379
LIG_FHA_1	476	482	PF00498	0.314
LIG_FHA_2	113	119	PF00498	0.567
LIG_FHA_2	28	34	PF00498	0.706
LIG_Integrin_isoDGR_2	424	426	PF01839	0.411
LIG_LIR_Gen_1	197	205	PF02991	0.442
LIG_LIR_Gen_1	227	238	PF02991	0.343
LIG_LIR_Gen_1	377	387	PF02991	0.331
LIG_LIR_Gen_1	395	404	PF02991	0.591
LIG_LIR_Gen_1	414	421	PF02991	0.409
LIG_LIR_Gen_1	437	447	PF02991	0.309
LIG_LIR_LC3C_4	234	239	PF02991	0.361
LIG_LIR_Nem_3	197	201	PF02991	0.402
LIG_LIR_Nem_3	224	228	PF02991	0.345
LIG_LIR_Nem_3	229	233	PF02991	0.364
LIG_LIR_Nem_3	234	238	PF02991	0.394
LIG_LIR_Nem_3	377	383	PF02991	0.331
LIG_LIR_Nem_3	395	400	PF02991	0.523
LIG_LIR_Nem_3	414	419	PF02991	0.333
LIG_LIR_Nem_3	441	447	PF02991	0.305
LIG_LIR_Nem_3	465	470	PF02991	0.290
LIG_PAM2_1	130	142	PF00658	0.263
LIG_Pex14_1	324	328	PF04695	0.290
LIG_Pex14_2	137	141	PF04695	0.422
LIG_Pex14_2	221	225	PF04695	0.302
LIG_Pex14_2	284	288	PF04695	0.484
LIG_RPA_C_Fungi	361	373	PF08784	0.190
LIG_SH2_CRK	129	133	PF00017	0.361
LIG_SH2_CRK	444	448	PF00017	0.432
LIG_SH2_PTP2	304	307	PF00017	0.274
LIG_SH2_PTP2	397	400	PF00017	0.375
LIG_SH2_STAP1	181	185	PF00017	0.250
LIG_SH2_STAP1	226	230	PF00017	0.252
LIG_SH2_STAP1	406	410	PF00017	0.444
LIG_SH2_STAT3	181	184	PF00017	0.274
LIG_SH2_STAT3	393	396	PF00017	0.263
LIG_SH2_STAT5	129	132	PF00017	0.361
LIG_SH2_STAT5	304	307	PF00017	0.302
LIG_SH2_STAT5	321	324	PF00017	0.238
LIG_SH2_STAT5	397	400	PF00017	0.412
LIG_Sin3_2	367	376	PF02671	0.212
LIG_SUMO_SIM_anti_2	477	483	PF11976	0.358
LIG_SUMO_SIM_par_1	39	46	PF11976	0.516
LIG_SUMO_SIM_par_1	417	422	PF11976	0.383
LIG_TRAF2_1	15	18	PF00917	0.696
LIG_TYR_ITIM	127	132	PF00017	0.361
LIG_WRC_WIRS_1	195	200	PF05994	0.321
LIG_WRC_WIRS_1	222	227	PF05994	0.361
LIG_WRC_WIRS_1	242	247	PF05994	0.178
LIG_WRC_WIRS_1	349	354	PF05994	0.361
MOD_CK1_1	224	230	PF00069	0.407
MOD_CK1_1	231	237	PF00069	0.326
MOD_CK1_1	291	297	PF00069	0.503
MOD_CK1_1	434	440	PF00069	0.255
MOD_CK1_1	459	465	PF00069	0.262
MOD_CK2_1	112	118	PF00069	0.631
MOD_CK2_1	459	465	PF00069	0.358
MOD_CK2_1	49	55	PF00069	0.508
MOD_CK2_1	91	97	PF00069	0.724
MOD_Cter_Amidation	154	157	PF01082	0.350
MOD_GlcNHglycan	132	135	PF01048	0.448
MOD_GlcNHglycan	153	156	PF01048	0.294
MOD_GlcNHglycan	205	208	PF01048	0.367
MOD_GlcNHglycan	25	28	PF01048	0.624
MOD_GlcNHglycan	293	296	PF01048	0.539
MOD_GlcNHglycan	433	436	PF01048	0.402
MOD_GlcNHglycan	448	451	PF01048	0.457
MOD_GlcNHglycan	458	461	PF01048	0.401
MOD_GSK3_1	108	115	PF00069	0.632
MOD_GSK3_1	19	26	PF00069	0.675
MOD_GSK3_1	190	197	PF00069	0.324
MOD_GSK3_1	217	224	PF00069	0.307
MOD_GSK3_1	344	351	PF00069	0.349
MOD_GSK3_1	411	418	PF00069	0.386
MOD_GSK3_1	431	438	PF00069	0.459
MOD_LATS_1	47	53	PF00433	0.408
MOD_N-GLC_1	456	461	PF02516	0.240
MOD_NEK2_1	139	144	PF00069	0.353
MOD_NEK2_1	217	222	PF00069	0.305
MOD_NEK2_1	228	233	PF00069	0.309
MOD_NEK2_1	241	246	PF00069	0.338
MOD_NEK2_1	313	318	PF00069	0.419
MOD_NEK2_1	374	379	PF00069	0.396
MOD_NEK2_1	411	416	PF00069	0.470
MOD_NEK2_1	419	424	PF00069	0.502
MOD_NEK2_2	308	313	PF00069	0.240
MOD_PIKK_1	112	118	PF00454	0.423
MOD_PIKK_1	392	398	PF00454	0.252
MOD_PKA_2	161	167	PF00069	0.449
MOD_PKA_2	23	29	PF00069	0.577
MOD_PKA_2	344	350	PF00069	0.389
MOD_PKA_2	5	11	PF00069	0.526
MOD_Plk_1	177	183	PF00069	0.315
MOD_Plk_1	331	337	PF00069	0.374
MOD_Plk_1	47	53	PF00069	0.544
MOD_Plk_4	190	196	PF00069	0.379
MOD_Plk_4	217	223	PF00069	0.284
MOD_Plk_4	263	269	PF00069	0.330
MOD_Plk_4	275	281	PF00069	0.283
MOD_Plk_4	308	314	PF00069	0.389
MOD_Plk_4	319	325	PF00069	0.315
MOD_Plk_4	333	339	PF00069	0.293
MOD_Plk_4	348	354	PF00069	0.459
MOD_Plk_4	374	380	PF00069	0.358
MOD_Plk_4	482	488	PF00069	0.335
MOD_ProDKin_1	429	435	PF00069	0.304
TRG_DiLeu_BaEn_1	465	470	PF01217	0.361
TRG_ENDOCYTIC_2	129	132	PF00928	0.361
TRG_ENDOCYTIC_2	242	245	PF00928	0.468
TRG_ENDOCYTIC_2	304	307	PF00928	0.422
TRG_ENDOCYTIC_2	397	400	PF00928	0.288
TRG_ENDOCYTIC_2	444	447	PF00928	0.361
TRG_ER_diArg_1	3	6	PF00400	0.544
TRG_ER_diArg_1	34	36	PF00400	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X2	Leptomonas seymouri	63%	97%
A0A0N1PC74	Leptomonas seymouri	26%	97%
A0A0N1PCA2	Leptomonas seymouri	28%	100%
A0A0S4IH58	Bodo saltans	22%	83%
A0A3S7WR28	Leishmania donovani	27%	100%
A0A3S7X1E1	Leishmania donovani	28%	94%
A4H605	Leishmania braziliensis	71%	100%
A4H606	Leishmania braziliensis	25%	99%
A4HGF8	Leishmania braziliensis	29%	100%
A4HUD2	Leishmania infantum	100%	100%
A4HUD3	Leishmania infantum	27%	97%
A4I3I9	Leishmania infantum	27%	100%
E9AN32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AN33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AZT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4Q8F3	Leishmania major	27%	100%
Q4QHJ3	Leishmania major	27%	97%
Q4QHJ4	Leishmania major	92%	100%