Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I8P4_LEIDO

TriTrypDb:

LdBPK_140170.1 , LdCL_140006600 , LDHU3_14.0230

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I8P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8P4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	530	534	PF00656	0.644
CLV_NRD_NRD_1	215	217	PF00675	0.648
CLV_NRD_NRD_1	290	292	PF00675	0.726
CLV_NRD_NRD_1	634	636	PF00675	0.662
CLV_NRD_NRD_1	663	665	PF00675	0.751
CLV_NRD_NRD_1	75	77	PF00675	0.632
CLV_PCSK_KEX2_1	215	217	PF00082	0.852
CLV_PCSK_KEX2_1	290	292	PF00082	0.726
CLV_PCSK_KEX2_1	634	636	PF00082	0.662
CLV_PCSK_KEX2_1	663	665	PF00082	0.751
CLV_PCSK_KEX2_1	75	77	PF00082	0.632
CLV_PCSK_SKI1_1	157	161	PF00082	0.644
CLV_PCSK_SKI1_1	305	309	PF00082	0.717
CLV_PCSK_SKI1_1	319	323	PF00082	0.648
CLV_PCSK_SKI1_1	368	372	PF00082	0.669
CLV_PCSK_SKI1_1	42	46	PF00082	0.744
DEG_APCC_DBOX_1	304	312	PF00400	0.643
DEG_APCC_DBOX_1	413	421	PF00400	0.623
DEG_SCF_FBW7_1	144	151	PF00400	0.584
DEG_SCF_FBW7_1	262	268	PF00400	0.831
DEG_SIAH_1	594	602	PF03145	0.757
DEG_SPOP_SBC_1	221	225	PF00917	0.756
DEG_SPOP_SBC_1	558	562	PF00917	0.740
DOC_CKS1_1	145	150	PF01111	0.582
DOC_CKS1_1	192	197	PF01111	0.664
DOC_CKS1_1	262	267	PF01111	0.740
DOC_CKS1_1	36	41	PF01111	0.670
DOC_MAPK_gen_1	425	434	PF00069	0.600
DOC_MAPK_gen_1	63	71	PF00069	0.591
DOC_MAPK_MEF2A_6	414	421	PF00069	0.621
DOC_MAPK_MEF2A_6	63	71	PF00069	0.694
DOC_MAPK_NFAT4_5	414	422	PF00069	0.618
DOC_PP1_RVXF_1	40	47	PF00149	0.698
DOC_PP1_RVXF_1	522	528	PF00149	0.633
DOC_PP2B_LxvP_1	115	118	PF13499	0.705
DOC_PP2B_LxvP_1	267	270	PF13499	0.779
DOC_PP4_FxxP_1	33	36	PF00568	0.709
DOC_USP7_MATH_1	12	16	PF00917	0.746
DOC_USP7_MATH_1	222	226	PF00917	0.752
DOC_USP7_MATH_1	26	30	PF00917	0.553
DOC_USP7_MATH_1	558	562	PF00917	0.640
DOC_USP7_MATH_1	67	71	PF00917	0.697
DOC_USP7_MATH_1	679	683	PF00917	0.846
DOC_USP7_MATH_1	91	95	PF00917	0.673
DOC_WW_Pin1_4	144	149	PF00397	0.594
DOC_WW_Pin1_4	191	196	PF00397	0.634
DOC_WW_Pin1_4	261	266	PF00397	0.777
DOC_WW_Pin1_4	300	305	PF00397	0.738
DOC_WW_Pin1_4	35	40	PF00397	0.718
DOC_WW_Pin1_4	445	450	PF00397	0.683
DOC_WW_Pin1_4	657	662	PF00397	0.788
DOC_WW_Pin1_4	675	680	PF00397	0.675
LIG_14-3-3_CanoR_1	216	222	PF00244	0.821
LIG_14-3-3_CanoR_1	247	252	PF00244	0.765
LIG_14-3-3_CanoR_1	425	430	PF00244	0.541
LIG_14-3-3_CanoR_1	556	564	PF00244	0.728
LIG_14-3-3_CanoR_1	625	630	PF00244	0.631
LIG_14-3-3_CanoR_1	634	640	PF00244	0.527
LIG_14-3-3_CanoR_1	646	651	PF00244	0.809
LIG_14-3-3_CanoR_1	83	88	PF00244	0.637
LIG_BRCT_BRCA1_1	560	564	PF00533	0.557
LIG_CSL_BTD_1	142	145	PF09270	0.658
LIG_DLG_GKlike_1	425	432	PF00625	0.533
LIG_FHA_1	112	118	PF00498	0.628
LIG_FHA_1	145	151	PF00498	0.581
LIG_FHA_1	171	177	PF00498	0.631
LIG_FHA_1	262	268	PF00498	0.790
LIG_FHA_1	337	343	PF00498	0.591
LIG_FHA_1	491	497	PF00498	0.566
LIG_FHA_1	56	62	PF00498	0.734
LIG_FHA_1	614	620	PF00498	0.594
LIG_FHA_1	66	72	PF00498	0.677
LIG_FHA_2	105	111	PF00498	0.587
LIG_FHA_2	160	166	PF00498	0.583
LIG_FHA_2	231	237	PF00498	0.595
LIG_FHA_2	301	307	PF00498	0.752
LIG_FHA_2	329	335	PF00498	0.677
LIG_FHA_2	349	355	PF00498	0.420
LIG_FHA_2	528	534	PF00498	0.586
LIG_FHA_2	663	669	PF00498	0.649
LIG_FXI_DFP_1	409	413	PF00024	0.681
LIG_LIR_Apic_2	191	195	PF02991	0.675
LIG_LIR_Apic_2	30	36	PF02991	0.714
LIG_LIR_Apic_2	652	657	PF02991	0.767
LIG_LIR_Gen_1	107	116	PF02991	0.654
LIG_LIR_Gen_1	415	424	PF02991	0.474
LIG_LIR_Gen_1	552	559	PF02991	0.569
LIG_LIR_Gen_1	565	574	PF02991	0.681
LIG_LIR_Nem_3	107	111	PF02991	0.638
LIG_LIR_Nem_3	140	146	PF02991	0.600
LIG_LIR_Nem_3	165	171	PF02991	0.584
LIG_LIR_Nem_3	415	419	PF02991	0.482
LIG_LIR_Nem_3	552	557	PF02991	0.615
LIG_LIR_Nem_3	561	567	PF02991	0.492
LIG_MYND_1	265	269	PF01753	0.820
LIG_NRBOX	416	422	PF00104	0.514
LIG_Pex14_2	412	416	PF04695	0.531
LIG_SH2_CRK	567	571	PF00017	0.685
LIG_SH2_STAP1	567	571	PF00017	0.651
LIG_SH2_STAT5	158	161	PF00017	0.579
LIG_SH2_STAT5	504	507	PF00017	0.565
LIG_SH2_STAT5	608	611	PF00017	0.682
LIG_SH3_1	655	661	PF00018	0.736
LIG_SH3_2	207	212	PF14604	0.726
LIG_SH3_2	658	663	PF14604	0.679
LIG_SH3_3	117	123	PF00018	0.706
LIG_SH3_3	142	148	PF00018	0.592
LIG_SH3_3	20	26	PF00018	0.659
LIG_SH3_3	204	210	PF00018	0.732
LIG_SH3_3	259	265	PF00018	0.726
LIG_SH3_3	324	330	PF00018	0.645
LIG_SH3_3	33	39	PF00018	0.640
LIG_SH3_3	443	449	PF00018	0.531
LIG_SH3_3	655	661	PF00018	0.705
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.578
LIG_SUMO_SIM_anti_2	415	421	PF11976	0.616
LIG_SUMO_SIM_par_1	67	73	PF11976	0.688
LIG_SxIP_EBH_1	549	563	PF03271	0.509
MOD_CDC14_SPxK_1	660	663	PF00782	0.678
MOD_CDK_SPK_2	300	305	PF00069	0.635
MOD_CDK_SPxK_1	657	663	PF00069	0.788
MOD_CDK_SPxxK_3	35	42	PF00069	0.716
MOD_CDK_SPxxK_3	657	664	PF00069	0.678
MOD_CK1_1	149	155	PF00069	0.636
MOD_CK1_1	220	226	PF00069	0.752
MOD_CK1_1	268	274	PF00069	0.705
MOD_CK1_1	29	35	PF00069	0.715
MOD_CK1_1	394	400	PF00069	0.595
MOD_CK1_1	448	454	PF00069	0.575
MOD_CK1_1	506	512	PF00069	0.590
MOD_CK1_1	562	568	PF00069	0.595
MOD_CK1_1	70	76	PF00069	0.695
MOD_CK2_1	149	155	PF00069	0.580
MOD_CK2_1	159	165	PF00069	0.580
MOD_CK2_1	300	306	PF00069	0.676
MOD_CK2_1	340	346	PF00069	0.572
MOD_CK2_1	469	475	PF00069	0.501
MOD_CK2_1	494	500	PF00069	0.487
MOD_CK2_1	56	62	PF00069	0.692
MOD_CK2_1	662	668	PF00069	0.724
MOD_Cter_Amidation	288	291	PF01082	0.677
MOD_GlcNHglycan	139	142	PF01048	0.620
MOD_GlcNHglycan	14	17	PF01048	0.750
MOD_GlcNHglycan	199	202	PF01048	0.760
MOD_GlcNHglycan	217	220	PF01048	0.662
MOD_GlcNHglycan	224	227	PF01048	0.727
MOD_GlcNHglycan	238	241	PF01048	0.750
MOD_GlcNHglycan	251	254	PF01048	0.494
MOD_GlcNHglycan	270	273	PF01048	0.731
MOD_GlcNHglycan	396	399	PF01048	0.570
MOD_GlcNHglycan	561	564	PF01048	0.618
MOD_GlcNHglycan	576	579	PF01048	0.613
MOD_GlcNHglycan	58	61	PF01048	0.693
MOD_GSK3_1	144	151	PF00069	0.584
MOD_GSK3_1	217	224	PF00069	0.742
MOD_GSK3_1	230	237	PF00069	0.694
MOD_GSK3_1	261	268	PF00069	0.818
MOD_GSK3_1	336	343	PF00069	0.583
MOD_GSK3_1	490	497	PF00069	0.639
MOD_GSK3_1	503	510	PF00069	0.466
MOD_GSK3_1	558	565	PF00069	0.626
MOD_GSK3_1	645	652	PF00069	0.718
MOD_GSK3_1	662	669	PF00069	0.607
MOD_GSK3_1	675	682	PF00069	0.663
MOD_GSK3_1	79	86	PF00069	0.616
MOD_N-GLC_1	507	512	PF02516	0.545
MOD_NEK2_1	196	201	PF00069	0.753
MOD_NEK2_1	373	378	PF00069	0.644
MOD_NEK2_1	420	425	PF00069	0.499
MOD_NEK2_1	45	50	PF00069	0.670
MOD_NEK2_1	487	492	PF00069	0.562
MOD_NEK2_1	527	532	PF00069	0.675
MOD_NEK2_1	559	564	PF00069	0.625
MOD_NEK2_1	606	611	PF00069	0.812
MOD_NEK2_1	633	638	PF00069	0.696
MOD_NEK2_2	67	72	PF00069	0.653
MOD_NEK2_2	91	96	PF00069	0.677
MOD_PIKK_1	224	230	PF00454	0.855
MOD_PKA_1	215	221	PF00069	0.647
MOD_PKA_2	215	221	PF00069	0.841
MOD_PKA_2	229	235	PF00069	0.696
MOD_PKA_2	574	580	PF00069	0.693
MOD_PKA_2	633	639	PF00069	0.676
MOD_PKA_2	645	651	PF00069	0.808
MOD_PKA_2	662	668	PF00069	0.560
MOD_Plk_4	111	117	PF00069	0.667
MOD_Plk_4	171	177	PF00069	0.631
MOD_Plk_4	340	346	PF00069	0.520
MOD_Plk_4	391	397	PF00069	0.661
MOD_Plk_4	487	493	PF00069	0.585
MOD_Plk_4	625	631	PF00069	0.681
MOD_Plk_4	67	73	PF00069	0.698
MOD_ProDKin_1	144	150	PF00069	0.586
MOD_ProDKin_1	191	197	PF00069	0.632
MOD_ProDKin_1	261	267	PF00069	0.780
MOD_ProDKin_1	300	306	PF00069	0.735
MOD_ProDKin_1	35	41	PF00069	0.714
MOD_ProDKin_1	445	451	PF00069	0.678
MOD_ProDKin_1	657	663	PF00069	0.788
MOD_ProDKin_1	675	681	PF00069	0.672
TRG_DiLeu_BaEn_1	566	571	PF01217	0.596
TRG_DiLeu_BaEn_2	154	160	PF01217	0.582
TRG_ENDOCYTIC_2	54	57	PF00928	0.623
TRG_ENDOCYTIC_2	567	570	PF00928	0.576
TRG_ER_diArg_1	214	216	PF00400	0.650
TRG_ER_diArg_1	295	298	PF00400	0.703
TRG_ER_diArg_1	375	378	PF00400	0.567
TRG_ER_diArg_1	424	427	PF00400	0.497
TRG_ER_diArg_1	524	527	PF00400	0.532
TRG_ER_diArg_1	633	635	PF00400	0.664
TRG_ER_diArg_1	662	664	PF00400	0.716
TRG_ER_diArg_1	74	76	PF00400	0.635
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B4	Leptomonas seymouri	45%	100%
A4H7H8	Leishmania braziliensis	78%	100%
A4HVV9	Leishmania infantum	99%	100%
E9APL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QFW8	Leishmania major	95%	100%