F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I8N7_LEIDO

TriTrypDb:

LdBPK_091460.1 , LdCL_090021000 , LDHU3_09.1710

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8I8N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8N7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.698
CLV_NRD_NRD_1	195	197	PF00675	0.390
CLV_NRD_NRD_1	206	208	PF00675	0.394
CLV_NRD_NRD_1	40	42	PF00675	0.571
CLV_NRD_NRD_1	488	490	PF00675	0.617
CLV_PCSK_KEX2_1	206	208	PF00082	0.455
CLV_PCSK_KEX2_1	40	42	PF00082	0.548
CLV_PCSK_KEX2_1	488	490	PF00082	0.579
CLV_PCSK_KEX2_1	5	7	PF00082	0.482
CLV_PCSK_KEX2_1	504	506	PF00082	0.476
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.481
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.523
CLV_PCSK_SKI1_1	213	217	PF00082	0.416
CLV_PCSK_SKI1_1	271	275	PF00082	0.637
CLV_PCSK_SKI1_1	348	352	PF00082	0.586
CLV_PCSK_SKI1_1	388	392	PF00082	0.480
CLV_PCSK_SKI1_1	41	45	PF00082	0.470
CLV_PCSK_SKI1_1	447	451	PF00082	0.517
CLV_PCSK_SKI1_1	505	509	PF00082	0.644
CLV_PCSK_SKI1_1	569	573	PF00082	0.273
DEG_SCF_FBW7_1	42	48	PF00400	0.723
DEG_SPOP_SBC_1	77	81	PF00917	0.690
DOC_CKS1_1	42	47	PF01111	0.702
DOC_MAPK_HePTP_8	590	602	PF00069	0.541
DOC_MAPK_MEF2A_6	593	602	PF00069	0.561
DOC_PP1_RVXF_1	239	246	PF00149	0.537
DOC_PP1_RVXF_1	316	323	PF00149	0.436
DOC_USP7_MATH_1	273	277	PF00917	0.391
DOC_USP7_MATH_1	304	308	PF00917	0.636
DOC_USP7_MATH_1	366	370	PF00917	0.452
DOC_USP7_MATH_2	363	369	PF00917	0.362
DOC_WW_Pin1_4	41	46	PF00397	0.716
LIG_14-3-3_CanoR_1	271	280	PF00244	0.391
LIG_14-3-3_CanoR_1	388	393	PF00244	0.294
LIG_14-3-3_CanoR_1	447	453	PF00244	0.401
LIG_14-3-3_CanoR_1	505	510	PF00244	0.352
LIG_14-3-3_CanoR_1	557	561	PF00244	0.383
LIG_14-3-3_CanoR_1	6	11	PF00244	0.645
LIG_14-3-3_CanoR_1	70	78	PF00244	0.715
LIG_Actin_WH2_2	556	571	PF00022	0.250
LIG_AP2alpha_2	453	455	PF02296	0.413
LIG_APCC_ABBA_1	155	160	PF00400	0.644
LIG_APCC_ABBA_1	419	424	PF00400	0.261
LIG_APCC_ABBA_1	452	457	PF00400	0.285
LIG_BIR_III_2	412	416	PF00653	0.278
LIG_BRCT_BRCA1_1	428	432	PF00533	0.300
LIG_BRCT_BRCA1_1	91	95	PF00533	0.667
LIG_Clathr_ClatBox_1	156	160	PF01394	0.667
LIG_Clathr_ClatBox_1	420	424	PF01394	0.318
LIG_deltaCOP1_diTrp_1	533	542	PF00928	0.343
LIG_EH1_1	202	210	PF00400	0.569
LIG_FHA_1	210	216	PF00498	0.674
LIG_FHA_1	281	287	PF00498	0.307
LIG_FHA_1	295	301	PF00498	0.264
LIG_FHA_1	314	320	PF00498	0.525
LIG_FHA_1	353	359	PF00498	0.375
LIG_FHA_1	414	420	PF00498	0.428
LIG_FHA_1	42	48	PF00498	0.757
LIG_FHA_1	476	482	PF00498	0.287
LIG_FHA_1	5	11	PF00498	0.674
LIG_FHA_1	603	609	PF00498	0.271
LIG_FHA_1	613	619	PF00498	0.284
LIG_FHA_1	647	653	PF00498	0.314
LIG_FHA_1	78	84	PF00498	0.792
LIG_FHA_2	110	116	PF00498	0.657
LIG_FHA_2	161	167	PF00498	0.623
LIG_FHA_2	214	220	PF00498	0.568
LIG_FHA_2	290	296	PF00498	0.459
LIG_FHA_2	389	395	PF00498	0.308
LIG_FHA_2	438	444	PF00498	0.286
LIG_FHA_2	448	454	PF00498	0.296
LIG_FHA_2	493	499	PF00498	0.440
LIG_FHA_2	63	69	PF00498	0.655
LIG_GBD_Chelix_1	290	298	PF00786	0.413
LIG_LIR_Apic_2	496	502	PF02991	0.331
LIG_LIR_Gen_1	283	293	PF02991	0.293
LIG_LIR_Gen_1	374	382	PF02991	0.269
LIG_LIR_Gen_1	416	425	PF02991	0.254
LIG_LIR_Gen_1	453	464	PF02991	0.303
LIG_LIR_Gen_1	508	514	PF02991	0.396
LIG_LIR_Gen_1	551	560	PF02991	0.395
LIG_LIR_Gen_1	649	657	PF02991	0.404
LIG_LIR_Nem_3	283	288	PF02991	0.397
LIG_LIR_Nem_3	374	378	PF02991	0.268
LIG_LIR_Nem_3	384	390	PF02991	0.277
LIG_LIR_Nem_3	450	455	PF02991	0.426
LIG_LIR_Nem_3	508	512	PF02991	0.385
LIG_LIR_Nem_3	551	556	PF02991	0.339
LIG_LIR_Nem_3	565	570	PF02991	0.287
LIG_LIR_Nem_3	649	653	PF02991	0.404
LIG_MAD2	41	49	PF02301	0.604
LIG_MYND_1	45	49	PF01753	0.668
LIG_Pex14_1	542	546	PF04695	0.352
LIG_Pex14_2	452	456	PF04695	0.269
LIG_REV1ctd_RIR_1	1	10	PF16727	0.714
LIG_SH2_CRK	180	184	PF00017	0.632
LIG_SH2_CRK	402	406	PF00017	0.387
LIG_SH2_CRK	482	486	PF00017	0.368
LIG_SH2_CRK	553	557	PF00017	0.441
LIG_SH2_CRK	570	574	PF00017	0.335
LIG_SH2_GRB2like	180	183	PF00017	0.592
LIG_SH2_NCK_1	411	415	PF00017	0.342
LIG_SH2_PTP2	546	549	PF00017	0.299
LIG_SH2_SRC	235	238	PF00017	0.543
LIG_SH2_STAP1	180	184	PF00017	0.616
LIG_SH2_STAP1	427	431	PF00017	0.361
LIG_SH2_STAP1	448	452	PF00017	0.428
LIG_SH2_STAP1	72	76	PF00017	0.729
LIG_SH2_STAT5	158	161	PF00017	0.567
LIG_SH2_STAT5	189	192	PF00017	0.651
LIG_SH2_STAT5	204	207	PF00017	0.495
LIG_SH2_STAT5	220	223	PF00017	0.585
LIG_SH2_STAT5	235	238	PF00017	0.530
LIG_SH2_STAT5	265	268	PF00017	0.359
LIG_SH2_STAT5	402	405	PF00017	0.327
LIG_SH2_STAT5	422	425	PF00017	0.186
LIG_SH2_STAT5	546	549	PF00017	0.297
LIG_SH2_STAT5	630	633	PF00017	0.359
LIG_SH2_STAT5	656	659	PF00017	0.314
LIG_SH3_3	296	302	PF00018	0.289
LIG_SH3_3	373	379	PF00018	0.361
LIG_SH3_3	39	45	PF00018	0.746
LIG_SUMO_SIM_anti_2	283	290	PF11976	0.365
LIG_SUMO_SIM_anti_2	295	300	PF11976	0.252
LIG_SUMO_SIM_par_1	286	292	PF11976	0.299
LIG_SUMO_SIM_par_1	354	359	PF11976	0.377
LIG_SUMO_SIM_par_1	388	396	PF11976	0.341
LIG_SUMO_SIM_par_1	473	478	PF11976	0.271
LIG_SUMO_SIM_par_1	6	12	PF11976	0.646
LIG_TRFH_1	375	379	PF08558	0.351
LIG_TYR_ITIM	15	20	PF00017	0.619
LIG_TYR_ITIM	568	573	PF00017	0.404
LIG_TYR_ITSM	549	556	PF00017	0.282
LIG_UBA3_1	586	593	PF00899	0.428
LIG_Vh1_VBS_1	591	609	PF01044	0.290
LIG_WRC_WIRS_1	282	287	PF05994	0.336
LIG_WRC_WIRS_1	372	377	PF05994	0.391
MOD_CK1_1	109	115	PF00069	0.543
MOD_CK1_1	276	282	PF00069	0.435
MOD_CK1_1	306	312	PF00069	0.536
MOD_CK1_1	510	516	PF00069	0.355
MOD_CK1_1	61	67	PF00069	0.649
MOD_CK1_1	9	15	PF00069	0.585
MOD_CK2_1	213	219	PF00069	0.454
MOD_CK2_1	289	295	PF00069	0.361
MOD_CK2_1	388	394	PF00069	0.453
MOD_CK2_1	62	68	PF00069	0.641
MOD_CK2_1	655	661	PF00069	0.336
MOD_DYRK1A_RPxSP_1	41	45	PF00069	0.609
MOD_GlcNHglycan	147	150	PF01048	0.521
MOD_GlcNHglycan	336	339	PF01048	0.327
MOD_GlcNHglycan	360	363	PF01048	0.526
MOD_GlcNHglycan	406	409	PF01048	0.408
MOD_GlcNHglycan	428	431	PF01048	0.406
MOD_GlcNHglycan	435	438	PF01048	0.371
MOD_GlcNHglycan	461	464	PF01048	0.503
MOD_GlcNHglycan	468	471	PF01048	0.555
MOD_GlcNHglycan	517	520	PF01048	0.488
MOD_GlcNHglycan	618	621	PF01048	0.316
MOD_GlcNHglycan	636	639	PF01048	0.406
MOD_GlcNHglycan	90	94	PF01048	0.599
MOD_GSK3_1	141	148	PF00069	0.589
MOD_GSK3_1	209	216	PF00069	0.594
MOD_GSK3_1	269	276	PF00069	0.489
MOD_GSK3_1	303	310	PF00069	0.580
MOD_GSK3_1	352	359	PF00069	0.494
MOD_GSK3_1	388	395	PF00069	0.383
MOD_GSK3_1	41	48	PF00069	0.637
MOD_GSK3_1	433	440	PF00069	0.365
MOD_GSK3_1	443	450	PF00069	0.390
MOD_GSK3_1	455	462	PF00069	0.474
MOD_GSK3_1	510	517	PF00069	0.350
MOD_GSK3_1	58	65	PF00069	0.490
MOD_GSK3_1	612	619	PF00069	0.394
MOD_GSK3_1	651	658	PF00069	0.390
MOD_GSK3_1	66	73	PF00069	0.583
MOD_GSK3_1	89	96	PF00069	0.591
MOD_LATS_1	87	93	PF00433	0.685
MOD_N-GLC_1	425	430	PF02516	0.413
MOD_N-GLC_1	433	438	PF02516	0.361
MOD_N-GLC_1	466	471	PF02516	0.524
MOD_NEK2_1	269	274	PF00069	0.475
MOD_NEK2_1	280	285	PF00069	0.305
MOD_NEK2_1	294	299	PF00069	0.224
MOD_NEK2_1	303	308	PF00069	0.450
MOD_NEK2_1	327	332	PF00069	0.246
MOD_NEK2_1	339	344	PF00069	0.344
MOD_NEK2_1	358	363	PF00069	0.448
MOD_NEK2_1	4	9	PF00069	0.656
MOD_NEK2_1	455	460	PF00069	0.629
MOD_NEK2_1	514	519	PF00069	0.376
MOD_NEK2_1	549	554	PF00069	0.448
MOD_NEK2_1	60	65	PF00069	0.717
MOD_NEK2_1	616	621	PF00069	0.370
MOD_NEK2_1	651	656	PF00069	0.333
MOD_NEK2_1	95	100	PF00069	0.582
MOD_PIKK_1	475	481	PF00454	0.397
MOD_PKA_2	344	350	PF00069	0.285
MOD_PKA_2	514	520	PF00069	0.438
MOD_PKA_2	521	527	PF00069	0.541
MOD_PKA_2	556	562	PF00069	0.393
MOD_PKB_1	386	394	PF00069	0.337
MOD_Plk_1	276	282	PF00069	0.429
MOD_Plk_1	294	300	PF00069	0.322
MOD_Plk_1	356	362	PF00069	0.458
MOD_Plk_1	433	439	PF00069	0.385
MOD_Plk_1	93	99	PF00069	0.630
MOD_Plk_2-3	352	358	PF00069	0.481
MOD_Plk_4	281	287	PF00069	0.345
MOD_Plk_4	289	295	PF00069	0.309
MOD_Plk_4	327	333	PF00069	0.350
MOD_Plk_4	371	377	PF00069	0.497
MOD_Plk_4	612	618	PF00069	0.376
MOD_Plk_4	626	632	PF00069	0.475
MOD_Plk_4	646	652	PF00069	0.341
MOD_ProDKin_1	41	47	PF00069	0.661
MOD_SUMO_for_1	225	228	PF00179	0.559
TRG_ENDOCYTIC_2	17	20	PF00928	0.625
TRG_ENDOCYTIC_2	180	183	PF00928	0.513
TRG_ENDOCYTIC_2	482	485	PF00928	0.341
TRG_ENDOCYTIC_2	546	549	PF00928	0.361
TRG_ENDOCYTIC_2	553	556	PF00928	0.400
TRG_ENDOCYTIC_2	570	573	PF00928	0.313
TRG_ER_diArg_1	117	120	PF00400	0.594
TRG_ER_diArg_1	190	193	PF00400	0.472
TRG_ER_diArg_1	205	207	PF00400	0.481
TRG_ER_diArg_1	40	42	PF00400	0.753
TRG_NES_CRM1_1	150	160	PF08389	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M8	Leptomonas seymouri	64%	100%
A0A1X0NIN6	Trypanosomatidae	42%	100%
A0A3R7N0K0	Trypanosoma rangeli	42%	100%
A4H5W6	Leishmania braziliensis	80%	100%
A4HU61	Leishmania infantum	100%	100%
D0A9P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AMZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4QHN6	Leishmania major	92%	100%
V5BI21	Trypanosoma cruzi	40%	92%