Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8I8N4_LEIDO

TriTrypDb:

LdBPK_131440.1 , LdCL_130021700 , LDHU3_13.1970

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	15
GO:0042995	cell projection	2	15
GO:0043226	organelle	2	15
GO:0043227	membrane-bounded organelle	3	15
GO:0110165	cellular anatomical entity	1	15
GO:0120025	plasma membrane bounded cell projection	3	15
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8I8N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8N4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	9	11	PF00675	0.520
CLV_PCSK_KEX2_1	9	11	PF00082	0.367
CLV_PCSK_SKI1_1	369	373	PF00082	0.443
CLV_PCSK_SKI1_1	429	433	PF00082	0.427
CLV_PCSK_SKI1_1	78	82	PF00082	0.416
CLV_Separin_Metazoa	406	410	PF03568	0.346
DEG_APCC_DBOX_1	51	59	PF00400	0.596
DEG_Nend_UBRbox_2	1	3	PF02207	0.591
DOC_CDC14_PxL_1	199	207	PF14671	0.429
DOC_CDC14_PxL_1	332	340	PF14671	0.451
DOC_CDC14_PxL_1	377	385	PF14671	0.371
DOC_CDC14_PxL_1	422	430	PF14671	0.500
DOC_CYCLIN_RxL_1	277	286	PF00134	0.398
DOC_CYCLIN_RxL_1	72	85	PF00134	0.400
DOC_MAPK_HePTP_8	69	81	PF00069	0.443
DOC_MAPK_MEF2A_6	112	119	PF00069	0.412
DOC_MAPK_MEF2A_6	139	147	PF00069	0.388
DOC_MAPK_MEF2A_6	72	81	PF00069	0.484
DOC_PP1_RVXF_1	315	321	PF00149	0.341
DOC_USP7_MATH_1	169	173	PF00917	0.492
DOC_USP7_MATH_1	175	179	PF00917	0.513
DOC_USP7_MATH_1	325	329	PF00917	0.367
DOC_USP7_MATH_1	48	52	PF00917	0.456
DOC_USP7_MATH_1	95	99	PF00917	0.595
DOC_WW_Pin1_4	372	377	PF00397	0.493
DOC_WW_Pin1_4	445	450	PF00397	0.364
DOC_WW_Pin1_4	56	61	PF00397	0.510
LIG_14-3-3_CanoR_1	139	144	PF00244	0.494
LIG_14-3-3_CanoR_1	190	199	PF00244	0.501
LIG_14-3-3_CanoR_1	22	28	PF00244	0.566
LIG_14-3-3_CanoR_1	252	261	PF00244	0.425
LIG_14-3-3_CanoR_1	280	285	PF00244	0.477
LIG_14-3-3_CanoR_1	317	321	PF00244	0.500
LIG_14-3-3_CanoR_1	369	377	PF00244	0.467
LIG_14-3-3_CanoR_1	52	56	PF00244	0.558
LIG_14-3-3_CanoR_1	72	78	PF00244	0.287
LIG_14-3-3_CanoR_1	9	15	PF00244	0.490
LIG_Actin_WH2_2	325	341	PF00022	0.487
LIG_BIR_III_4	93	97	PF00653	0.422
LIG_Clathr_ClatBox_1	157	161	PF01394	0.334
LIG_DLG_GKlike_1	139	146	PF00625	0.382
LIG_DLG_GKlike_1	280	287	PF00625	0.380
LIG_FHA_1	205	211	PF00498	0.489
LIG_FHA_1	270	276	PF00498	0.392
LIG_FHA_1	3	9	PF00498	0.453
LIG_FHA_1	360	366	PF00498	0.340
LIG_FHA_1	446	452	PF00498	0.354
LIG_FHA_1	74	80	PF00498	0.534
LIG_GBD_Chelix_1	65	73	PF00786	0.393
LIG_Integrin_RGD_1	120	122	PF01839	0.426
LIG_LIR_Gen_1	168	177	PF02991	0.505
LIG_LIR_Gen_1	387	396	PF02991	0.472
LIG_LIR_Nem_3	168	173	PF02991	0.498
LIG_LIR_Nem_3	297	303	PF02991	0.486
LIG_LIR_Nem_3	387	393	PF02991	0.469
LIG_NRBOX	64	70	PF00104	0.378
LIG_NRBOX	76	82	PF00104	0.335
LIG_RPA_C_Fungi	185	197	PF08784	0.334
LIG_RPA_C_Fungi	5	17	PF08784	0.349
LIG_SH2_CRK	200	204	PF00017	0.408
LIG_SH2_PTP2	430	433	PF00017	0.317
LIG_SH2_STAT5	359	362	PF00017	0.529
LIG_SH2_STAT5	430	433	PF00017	0.526
LIG_SH3_3	171	177	PF00018	0.465
LIG_SUMO_SIM_anti_2	124	132	PF11976	0.577
LIG_SUMO_SIM_anti_2	142	147	PF11976	0.556
LIG_SUMO_SIM_anti_2	272	277	PF11976	0.535
LIG_SUMO_SIM_anti_2	404	409	PF11976	0.346
LIG_SUMO_SIM_par_1	206	212	PF11976	0.363
LIG_SUMO_SIM_par_1	279	286	PF11976	0.495
LIG_TYR_ITIM	428	433	PF00017	0.536
MOD_CDK_SPK_2	445	450	PF00069	0.364
MOD_CDK_SPK_2	56	61	PF00069	0.431
MOD_CDK_SPxxK_3	56	63	PF00069	0.501
MOD_CK1_1	189	195	PF00069	0.470
MOD_CK1_1	204	210	PF00069	0.415
MOD_CK1_1	244	250	PF00069	0.447
MOD_CK1_1	256	262	PF00069	0.354
MOD_CK1_1	269	275	PF00069	0.325
MOD_CK1_1	283	289	PF00069	0.389
MOD_CK1_1	391	397	PF00069	0.385
MOD_CK1_1	445	451	PF00069	0.452
MOD_CK1_1	51	57	PF00069	0.406
MOD_GlcNHglycan	192	195	PF01048	0.510
MOD_GlcNHglycan	23	26	PF01048	0.626
MOD_GlcNHglycan	243	246	PF01048	0.475
MOD_GlcNHglycan	255	258	PF01048	0.307
MOD_GlcNHglycan	261	264	PF01048	0.221
MOD_GlcNHglycan	300	303	PF01048	0.357
MOD_GlcNHglycan	345	348	PF01048	0.400
MOD_GlcNHglycan	390	393	PF01048	0.370
MOD_GSK3_1	124	131	PF00069	0.514
MOD_GSK3_1	17	24	PF00069	0.569
MOD_GSK3_1	186	193	PF00069	0.467
MOD_GSK3_1	240	247	PF00069	0.358
MOD_GSK3_1	252	259	PF00069	0.383
MOD_GSK3_1	292	299	PF00069	0.438
MOD_GSK3_1	359	366	PF00069	0.412
MOD_GSK3_1	68	75	PF00069	0.440
MOD_LATS_1	250	256	PF00433	0.322
MOD_LATS_1	292	298	PF00433	0.302
MOD_NEK2_1	128	133	PF00069	0.559
MOD_NEK2_1	186	191	PF00069	0.514
MOD_NEK2_1	241	246	PF00069	0.430
MOD_NEK2_1	251	256	PF00069	0.460
MOD_NEK2_1	282	287	PF00069	0.446
MOD_NEK2_1	363	368	PF00069	0.317
MOD_NEK2_1	68	73	PF00069	0.591
MOD_PIKK_1	175	181	PF00454	0.564
MOD_PK_1	294	300	PF00069	0.367
MOD_PKA_2	189	195	PF00069	0.527
MOD_PKA_2	21	27	PF00069	0.598
MOD_PKA_2	251	257	PF00069	0.457
MOD_PKA_2	316	322	PF00069	0.354
MOD_PKA_2	51	57	PF00069	0.614
MOD_Plk_1	121	127	PF00069	0.522
MOD_Plk_1	17	23	PF00069	0.445
MOD_Plk_1	386	392	PF00069	0.478
MOD_Plk_1	82	88	PF00069	0.409
MOD_Plk_2-3	316	322	PF00069	0.354
MOD_Plk_4	10	16	PF00069	0.527
MOD_Plk_4	124	130	PF00069	0.427
MOD_Plk_4	141	147	PF00069	0.428
MOD_Plk_4	256	262	PF00069	0.515
MOD_Plk_4	271	277	PF00069	0.213
MOD_Plk_4	82	88	PF00069	0.411
MOD_Plk_4	95	101	PF00069	0.557
MOD_ProDKin_1	372	378	PF00069	0.497
MOD_ProDKin_1	445	451	PF00069	0.357
MOD_ProDKin_1	56	62	PF00069	0.504
MOD_SUMO_rev_2	209	214	PF00179	0.371
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.504
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.536
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.468
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.466
TRG_ENDOCYTIC_2	430	433	PF00928	0.531
TRG_ER_diArg_1	133	136	PF00400	0.523
TRG_ER_diArg_1	336	339	PF00400	0.526
TRG_ER_diArg_1	381	384	PF00400	0.516
TRG_ER_diArg_1	8	10	PF00400	0.365
TRG_NES_CRM1_1	201	211	PF08389	0.362
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F9	Leptomonas seymouri	33%	87%
A0A0N0P8N9	Leptomonas seymouri	31%	69%
A0A0N1HZK9	Leptomonas seymouri	31%	86%
A0A0N1I0W0	Leptomonas seymouri	28%	89%
A0A0N1I1E8	Leptomonas seymouri	26%	100%
A0A1X0NEN5	Trypanosomatidae	26%	78%
A0A1X0NG16	Trypanosomatidae	25%	79%
A4H3R1	Leishmania braziliensis	30%	66%
A4H7G0	Leishmania braziliensis	77%	100%
E9AGK6	Leishmania infantum	99%	100%
E9AKN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9APJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QFY4	Leishmania major	94%	100%