ATP-dependent helicase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent helicase, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8I8M7_LEIDO

TriTrypDb:

LdBPK_091300.1 , LdCL_090019400 , LDHU3_09.1540

Length:

2283

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I8M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	7
GO:0004386	helicase activity	2	7
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0140657	ATP-dependent activity	1	7
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1039	1043	PF00656	0.641
CLV_C14_Caspase3-7	11	15	PF00656	0.577
CLV_C14_Caspase3-7	1260	1264	PF00656	0.507
CLV_C14_Caspase3-7	164	168	PF00656	0.522
CLV_C14_Caspase3-7	1816	1820	PF00656	0.509
CLV_C14_Caspase3-7	2002	2006	PF00656	0.368
CLV_C14_Caspase3-7	2116	2120	PF00656	0.471
CLV_C14_Caspase3-7	2184	2188	PF00656	0.626
CLV_C14_Caspase3-7	2239	2243	PF00656	0.618
CLV_C14_Caspase3-7	436	440	PF00656	0.679

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I514	Leptomonas seymouri	50%	92%
A4H5V2	Leishmania braziliensis	76%	100%
A4HU46	Leishmania infantum	100%	100%
E9AMX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHQ1	Leishmania major	93%	100%

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