Exonuclease, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I8M2_LEIDO

TriTrypDb:

LdBPK_100290.1 , LdCL_100008200 , LDHU3_10.0420

Length:

929

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I8M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8M2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	3
GO:0004518	nuclease activity	4	3
GO:0004527	exonuclease activity	5	3
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	499	503	PF00656	0.493
CLV_C14_Caspase3-7	588	592	PF00656	0.466
CLV_C14_Caspase3-7	627	631	PF00656	0.713
CLV_C14_Caspase3-7	890	894	PF00656	0.677
CLV_MEL_PAP_1	70	76	PF00089	0.763
CLV_NRD_NRD_1	2	4	PF00675	0.784
CLV_NRD_NRD_1	259	261	PF00675	0.727
CLV_NRD_NRD_1	29	31	PF00675	0.721
CLV_NRD_NRD_1	579	581	PF00675	0.457
CLV_NRD_NRD_1	710	712	PF00675	0.556
CLV_NRD_NRD_1	719	721	PF00675	0.547
CLV_NRD_NRD_1	808	810	PF00675	0.604
CLV_NRD_NRD_1	815	817	PF00675	0.491
CLV_PCSK_KEX2_1	2	4	PF00082	0.784
CLV_PCSK_KEX2_1	259	261	PF00082	0.733
CLV_PCSK_KEX2_1	28	30	PF00082	0.725
CLV_PCSK_KEX2_1	579	581	PF00082	0.456
CLV_PCSK_KEX2_1	719	721	PF00082	0.562
CLV_PCSK_KEX2_1	808	810	PF00082	0.604
CLV_PCSK_KEX2_1	815	817	PF00082	0.491
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.725
CLV_PCSK_PC7_1	575	581	PF00082	0.456
CLV_PCSK_PC7_1	715	721	PF00082	0.638
CLV_PCSK_SKI1_1	117	121	PF00082	0.658
CLV_PCSK_SKI1_1	362	366	PF00082	0.479
CLV_PCSK_SKI1_1	367	371	PF00082	0.443
CLV_PCSK_SKI1_1	566	570	PF00082	0.498
CLV_PCSK_SKI1_1	815	819	PF00082	0.612
CLV_PCSK_SKI1_1	90	94	PF00082	0.692
DEG_APCC_DBOX_1	467	475	PF00400	0.378
DEG_APCC_DBOX_1	814	822	PF00400	0.607
DEG_MDM2_SWIB_1	747	754	PF02201	0.630
DEG_Nend_UBRbox_1	1	4	PF02207	0.643
DEG_SPOP_SBC_1	266	270	PF00917	0.790
DEG_SPOP_SBC_1	430	434	PF00917	0.656
DEG_SPOP_SBC_1	508	512	PF00917	0.534
DEG_SPOP_SBC_1	688	692	PF00917	0.725
DOC_CKS1_1	8	13	PF01111	0.788
DOC_CKS1_1	920	925	PF01111	0.563
DOC_CYCLIN_yClb1_LxF_4	566	572	PF00134	0.451
DOC_MAPK_gen_1	124	133	PF00069	0.606
DOC_MAPK_gen_1	612	620	PF00069	0.565
DOC_MAPK_MEF2A_6	126	135	PF00069	0.622
DOC_MAPK_MEF2A_6	419	428	PF00069	0.455
DOC_MAPK_MEF2A_6	73	81	PF00069	0.760
DOC_PP1_RVXF_1	115	121	PF00149	0.681
DOC_PP1_RVXF_1	247	254	PF00149	0.660
DOC_PP2B_LxvP_1	238	241	PF13499	0.694
DOC_PP2B_LxvP_1	370	373	PF13499	0.538
DOC_PP2B_LxvP_1	663	666	PF13499	0.694
DOC_PP4_FxxP_1	428	431	PF00568	0.514
DOC_PP4_FxxP_1	557	560	PF00568	0.439
DOC_USP7_MATH_1	16	20	PF00917	0.764
DOC_USP7_MATH_1	167	171	PF00917	0.638
DOC_USP7_MATH_1	183	187	PF00917	0.615
DOC_USP7_MATH_1	205	209	PF00917	0.515
DOC_USP7_MATH_1	261	265	PF00917	0.783
DOC_USP7_MATH_1	266	270	PF00917	0.776
DOC_USP7_MATH_1	277	281	PF00917	0.694
DOC_USP7_MATH_1	318	322	PF00917	0.788
DOC_USP7_MATH_1	389	393	PF00917	0.729
DOC_USP7_MATH_1	429	433	PF00917	0.551
DOC_USP7_MATH_1	443	447	PF00917	0.666
DOC_USP7_MATH_1	592	596	PF00917	0.370
DOC_USP7_MATH_1	613	617	PF00917	0.566
DOC_USP7_MATH_1	624	628	PF00917	0.587
DOC_USP7_MATH_1	65	69	PF00917	0.717
DOC_USP7_MATH_1	677	681	PF00917	0.765
DOC_USP7_MATH_1	688	692	PF00917	0.708
DOC_USP7_MATH_1	769	773	PF00917	0.766
DOC_USP7_MATH_1	88	92	PF00917	0.768
DOC_USP7_MATH_1	883	887	PF00917	0.759
DOC_USP7_UBL2_3	122	126	PF12436	0.580
DOC_USP7_UBL2_3	28	32	PF12436	0.718
DOC_WW_Pin1_4	112	117	PF00397	0.743
DOC_WW_Pin1_4	294	299	PF00397	0.748
DOC_WW_Pin1_4	3	8	PF00397	0.752
DOC_WW_Pin1_4	330	335	PF00397	0.724
DOC_WW_Pin1_4	341	346	PF00397	0.677
DOC_WW_Pin1_4	384	389	PF00397	0.610
DOC_WW_Pin1_4	441	446	PF00397	0.653
DOC_WW_Pin1_4	919	924	PF00397	0.621
LIG_14-3-3_CanoR_1	128	132	PF00244	0.739
LIG_14-3-3_CanoR_1	2	7	PF00244	0.777
LIG_14-3-3_CanoR_1	468	472	PF00244	0.377
LIG_14-3-3_CanoR_1	488	498	PF00244	0.560
LIG_14-3-3_CanoR_1	612	618	PF00244	0.589
LIG_14-3-3_CanoR_1	689	698	PF00244	0.769
LIG_14-3-3_CanoR_1	73	81	PF00244	0.761
LIG_14-3-3_CanoR_1	744	750	PF00244	0.693
LIG_14-3-3_CanoR_1	87	95	PF00244	0.651
LIG_14-3-3_CanoR_1	884	892	PF00244	0.634
LIG_Actin_WH2_2	586	604	PF00022	0.466
LIG_Actin_WH2_2	803	821	PF00022	0.655
LIG_APCC_ABBA_1	650	655	PF00400	0.563
LIG_BIR_III_2	699	703	PF00653	0.789
LIG_BIR_III_4	174	178	PF00653	0.705
LIG_BRCT_BRCA1_1	348	352	PF00533	0.633
LIG_BRCT_BRCA1_1	525	529	PF00533	0.434
LIG_CaM_NSCaTE_8	202	209	PF13499	0.687
LIG_CtBP_PxDLS_1	867	871	PF00389	0.699
LIG_deltaCOP1_diTrp_1	423	428	PF00928	0.489
LIG_deltaCOP1_diTrp_1	552	557	PF00928	0.474
LIG_FHA_1	128	134	PF00498	0.712
LIG_FHA_1	20	26	PF00498	0.720
LIG_FHA_1	391	397	PF00498	0.743
LIG_FHA_1	442	448	PF00498	0.602
LIG_FHA_1	474	480	PF00498	0.459
LIG_FHA_1	526	532	PF00498	0.383
LIG_FHA_1	551	557	PF00498	0.388
LIG_FHA_1	8	14	PF00498	0.758
LIG_FHA_1	826	832	PF00498	0.610
LIG_FHA_1	898	904	PF00498	0.680
LIG_FHA_2	241	247	PF00498	0.724
LIG_FHA_2	468	474	PF00498	0.375
LIG_FHA_2	510	516	PF00498	0.407
LIG_FHA_2	733	739	PF00498	0.665
LIG_FHA_2	888	894	PF00498	0.486
LIG_LIR_Apic_2	427	431	PF02991	0.518
LIG_LIR_Apic_2	552	558	PF02991	0.428
LIG_LIR_Gen_1	139	148	PF02991	0.659
LIG_LIR_Gen_1	423	431	PF02991	0.494
LIG_LIR_Gen_1	748	759	PF02991	0.557
LIG_LIR_Gen_1	852	862	PF02991	0.714
LIG_LIR_Nem_3	423	428	PF02991	0.454
LIG_LIR_Nem_3	496	501	PF02991	0.431
LIG_LIR_Nem_3	748	754	PF02991	0.519
LIG_LIR_Nem_3	852	857	PF02991	0.715
LIG_LYPXL_SIV_4	564	572	PF13949	0.539
LIG_NBox_RRM_1	653	663	PF00076	0.435
LIG_Pex14_2	747	751	PF04695	0.635
LIG_REV1ctd_RIR_1	117	126	PF16727	0.641
LIG_SH2_CRK	235	239	PF00017	0.732
LIG_SH2_GRB2like	134	137	PF00017	0.620
LIG_SH2_NCK_1	669	673	PF00017	0.673
LIG_SH2_SRC	134	137	PF00017	0.620
LIG_SH2_STAP1	140	144	PF00017	0.657
LIG_SH2_STAP1	368	372	PF00017	0.412
LIG_SH2_STAT5	134	137	PF00017	0.620
LIG_SH2_STAT5	235	238	PF00017	0.767
LIG_SH2_STAT5	549	552	PF00017	0.352
LIG_SH2_STAT5	576	579	PF00017	0.441
LIG_SH3_1	46	52	PF00018	0.661
LIG_SH3_3	103	109	PF00018	0.643
LIG_SH3_3	145	151	PF00018	0.715
LIG_SH3_3	255	261	PF00018	0.666
LIG_SH3_3	383	389	PF00018	0.490
LIG_SH3_3	46	52	PF00018	0.757
LIG_SH3_3	5	11	PF00018	0.748
LIG_SH3_3	61	67	PF00018	0.512
LIG_SH3_3	758	764	PF00018	0.761
LIG_SH3_3	917	923	PF00018	0.654
LIG_SUMO_SIM_anti_2	470	476	PF11976	0.486
LIG_SUMO_SIM_anti_2	826	834	PF11976	0.514
LIG_SUMO_SIM_par_1	236	243	PF11976	0.671
LIG_SUMO_SIM_par_1	448	453	PF11976	0.477
LIG_SUMO_SIM_par_1	455	460	PF11976	0.438
LIG_SUMO_SIM_par_1	470	476	PF11976	0.432
LIG_SUMO_SIM_par_1	826	834	PF11976	0.600
LIG_TRAF2_1	388	391	PF00917	0.665
LIG_TRAF2_1	402	405	PF00917	0.785
LIG_TRAF2_1	776	779	PF00917	0.780
LIG_TYR_ITIM	233	238	PF00017	0.729
LIG_UBA3_1	118	126	PF00899	0.677
MOD_CDK_SPK_2	112	117	PF00069	0.743
MOD_CDK_SPK_2	330	335	PF00069	0.750
MOD_CDK_SPxxK_3	294	301	PF00069	0.788
MOD_CDK_SPxxK_3	441	448	PF00069	0.514
MOD_CK1_1	170	176	PF00069	0.811
MOD_CK1_1	19	25	PF00069	0.647
MOD_CK1_1	239	245	PF00069	0.549
MOD_CK1_1	265	271	PF00069	0.762
MOD_CK1_1	585	591	PF00069	0.419
MOD_CK1_1	680	686	PF00069	0.794
MOD_CK1_1	691	697	PF00069	0.680
MOD_CK1_1	795	801	PF00069	0.734
MOD_CK1_1	877	883	PF00069	0.714
MOD_CK2_1	136	142	PF00069	0.584
MOD_CK2_1	240	246	PF00069	0.651
MOD_CK2_1	399	405	PF00069	0.794
MOD_CK2_1	72	78	PF00069	0.692
MOD_CK2_1	732	738	PF00069	0.597
MOD_DYRK1A_RPxSP_1	3	7	PF00069	0.686
MOD_GlcNHglycan	18	21	PF01048	0.692
MOD_GlcNHglycan	185	188	PF01048	0.742
MOD_GlcNHglycan	207	210	PF01048	0.663
MOD_GlcNHglycan	264	267	PF01048	0.811
MOD_GlcNHglycan	269	272	PF01048	0.810
MOD_GlcNHglycan	320	323	PF01048	0.781
MOD_GlcNHglycan	328	331	PF01048	0.767
MOD_GlcNHglycan	337	340	PF01048	0.721
MOD_GlcNHglycan	401	404	PF01048	0.763
MOD_GlcNHglycan	441	444	PF01048	0.746
MOD_GlcNHglycan	463	466	PF01048	0.428
MOD_GlcNHglycan	498	501	PF01048	0.402
MOD_GlcNHglycan	587	590	PF01048	0.406
MOD_GlcNHglycan	594	597	PF01048	0.372
MOD_GlcNHglycan	626	629	PF01048	0.662
MOD_GlcNHglycan	672	675	PF01048	0.715
MOD_GlcNHglycan	679	682	PF01048	0.699
MOD_GlcNHglycan	684	687	PF01048	0.677
MOD_GlcNHglycan	691	694	PF01048	0.497
MOD_GlcNHglycan	771	774	PF01048	0.775
MOD_GlcNHglycan	799	802	PF01048	0.741
MOD_GlcNHglycan	859	863	PF01048	0.682
MOD_GlcNHglycan	879	882	PF01048	0.430
MOD_GlcNHglycan	885	888	PF01048	0.666
MOD_GlcNHglycan	90	93	PF01048	0.751
MOD_GlcNHglycan	900	903	PF01048	0.728
MOD_GSK3_1	15	22	PF00069	0.770
MOD_GSK3_1	201	208	PF00069	0.609
MOD_GSK3_1	236	243	PF00069	0.711
MOD_GSK3_1	261	268	PF00069	0.768
MOD_GSK3_1	3	10	PF00069	0.746
MOD_GSK3_1	326	333	PF00069	0.711
MOD_GSK3_1	429	436	PF00069	0.598
MOD_GSK3_1	437	444	PF00069	0.649
MOD_GSK3_1	489	496	PF00069	0.525
MOD_GSK3_1	592	599	PF00069	0.512
MOD_GSK3_1	687	694	PF00069	0.767
MOD_GSK3_1	732	739	PF00069	0.707
MOD_GSK3_1	871	878	PF00069	0.669
MOD_GSK3_1	883	890	PF00069	0.679
MOD_GSK3_1	898	905	PF00069	0.714
MOD_N-GLC_1	122	127	PF02516	0.620
MOD_N-GLC_1	177	182	PF02516	0.762
MOD_N-GLC_1	277	282	PF02516	0.764
MOD_N-GLC_1	360	365	PF02516	0.426
MOD_N-GLC_1	732	737	PF02516	0.656
MOD_N-GLC_1	745	750	PF02516	0.388
MOD_N-GLC_1	898	903	PF02516	0.595
MOD_NEK2_1	143	148	PF00069	0.614
MOD_NEK2_1	293	298	PF00069	0.728
MOD_NEK2_1	382	387	PF00069	0.583
MOD_NEK2_1	551	556	PF00069	0.433
MOD_NEK2_1	897	902	PF00069	0.517
MOD_NEK2_2	305	310	PF00069	0.695
MOD_NEK2_2	745	750	PF00069	0.683
MOD_NEK2_2	849	854	PF00069	0.716
MOD_PIKK_1	523	529	PF00454	0.421
MOD_PIKK_1	596	602	PF00454	0.515
MOD_PIKK_1	672	678	PF00454	0.729
MOD_PIKK_1	719	725	PF00454	0.681
MOD_PIKK_1	739	745	PF00454	0.687
MOD_PKA_1	2	8	PF00069	0.687
MOD_PKA_1	719	725	PF00069	0.670
MOD_PKA_2	127	133	PF00069	0.735
MOD_PKA_2	2	8	PF00069	0.734
MOD_PKA_2	224	230	PF00069	0.723
MOD_PKA_2	467	473	PF00069	0.380
MOD_PKA_2	489	495	PF00069	0.470
MOD_PKA_2	496	502	PF00069	0.395
MOD_PKA_2	613	619	PF00069	0.590
MOD_PKA_2	688	694	PF00069	0.686
MOD_PKA_2	719	725	PF00069	0.681
MOD_PKA_2	72	78	PF00069	0.726
MOD_PKA_2	795	801	PF00069	0.704
MOD_PKA_2	883	889	PF00069	0.785
MOD_Plk_1	360	366	PF00069	0.529
MOD_Plk_1	373	379	PF00069	0.371
MOD_Plk_1	551	557	PF00069	0.512
MOD_Plk_1	596	602	PF00069	0.474
MOD_Plk_1	745	751	PF00069	0.493
MOD_Plk_1	825	831	PF00069	0.597
MOD_Plk_1	898	904	PF00069	0.663
MOD_Plk_4	127	133	PF00069	0.663
MOD_Plk_4	305	311	PF00069	0.683
MOD_Plk_4	467	473	PF00069	0.405
MOD_Plk_4	525	531	PF00069	0.394
MOD_Plk_4	551	557	PF00069	0.450
MOD_Plk_4	613	619	PF00069	0.547
MOD_Plk_4	65	71	PF00069	0.691
MOD_Plk_4	658	664	PF00069	0.703
MOD_Plk_4	825	831	PF00069	0.502
MOD_ProDKin_1	112	118	PF00069	0.744
MOD_ProDKin_1	294	300	PF00069	0.747
MOD_ProDKin_1	3	9	PF00069	0.754
MOD_ProDKin_1	330	336	PF00069	0.724
MOD_ProDKin_1	341	347	PF00069	0.657
MOD_ProDKin_1	384	390	PF00069	0.626
MOD_ProDKin_1	441	447	PF00069	0.630
MOD_ProDKin_1	919	925	PF00069	0.621
MOD_SUMO_rev_2	402	410	PF00179	0.808
MOD_SUMO_rev_2	534	541	PF00179	0.398
TRG_DiLeu_BaEn_4	868	874	PF01217	0.695
TRG_ENDOCYTIC_2	140	143	PF00928	0.646
TRG_ENDOCYTIC_2	235	238	PF00928	0.735
TRG_ER_diArg_1	1	3	PF00400	0.810
TRG_ER_diArg_1	151	154	PF00400	0.664
TRG_ER_diArg_1	258	260	PF00400	0.768
TRG_ER_diArg_1	487	490	PF00400	0.586
TRG_ER_diArg_1	494	497	PF00400	0.502
TRG_ER_diArg_1	579	581	PF00400	0.457
TRG_ER_diArg_1	611	614	PF00400	0.567
TRG_ER_diArg_1	807	809	PF00400	0.618
TRG_ER_diArg_1	815	817	PF00400	0.485
TRG_NES_CRM1_1	473	489	PF08389	0.510
TRG_NLS_MonoCore_2	25	30	PF00514	0.721
TRG_NLS_MonoExtC_3	25	30	PF00514	0.720
TRG_NLS_MonoExtC_3	31	37	PF00514	0.706
TRG_NLS_MonoExtN_4	26	32	PF00514	0.733
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK4	Leptomonas seymouri	55%	95%
A0A1X0NQ48	Trypanosomatidae	36%	100%
A0A422NRV3	Trypanosoma rangeli	38%	100%
A4H610	Leishmania braziliensis	72%	100%
A4HUD7	Leishmania infantum	99%	100%
C9ZVF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AN37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QHI9	Leishmania major	89%	100%
V5DA05	Trypanosoma cruzi	36%	100%