40S ribosomal protein S4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S4, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I8K3_LEIDO

TriTrypDb:

LdBPK_131120.1 , LdCL_130016500 , LdCL_130016600 , LDHU3_13.1380 , LDHU3_13.1390

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0015935	small ribosomal subunit	4	1
GO:0022627	cytosolic small ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

A0A3Q8I8K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8K3

PDB structure(s): 6az1_E

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	12
GO:0019843	rRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	259	261	PF00675	0.544
CLV_NRD_NRD_1	268	270	PF00675	0.685
CLV_NRD_NRD_1	271	273	PF00675	0.690
CLV_NRD_NRD_1	74	76	PF00675	0.342
CLV_PCSK_KEX2_1	7	9	PF00082	0.339
CLV_PCSK_KEX2_1	74	76	PF00082	0.394
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.339
CLV_PCSK_SKI1_1	105	109	PF00082	0.375
CLV_PCSK_SKI1_1	119	123	PF00082	0.328
CLV_PCSK_SKI1_1	4	8	PF00082	0.346
CLV_PCSK_SKI1_1	50	54	PF00082	0.334
DEG_APCC_DBOX_1	104	112	PF00400	0.581
DEG_APCC_DBOX_1	35	43	PF00400	0.571
DEG_APCC_DBOX_1	62	70	PF00400	0.528
DOC_MAPK_DCC_7	34	44	PF00069	0.626
DOC_MAPK_gen_1	103	111	PF00069	0.528
DOC_MAPK_gen_1	162	169	PF00069	0.621
DOC_MAPK_gen_1	171	180	PF00069	0.447
DOC_MAPK_gen_1	186	195	PF00069	0.377
DOC_MAPK_gen_1	34	43	PF00069	0.528
DOC_MAPK_HePTP_8	224	236	PF00069	0.553
DOC_MAPK_MEF2A_6	227	236	PF00069	0.540
DOC_MAPK_MEF2A_6	34	43	PF00069	0.528
DOC_MAPK_NFAT4_5	36	44	PF00069	0.370
DOC_PP2B_LxvP_1	9	12	PF13499	0.539
DOC_USP7_MATH_1	107	111	PF00917	0.541
DOC_USP7_MATH_1	149	153	PF00917	0.634
DOC_USP7_UBL2_3	3	7	PF12436	0.539
LIG_Actin_WH2_2	37	52	PF00022	0.376
LIG_BIR_II_1	1	5	PF00653	0.430
LIG_BIR_III_4	209	213	PF00653	0.539
LIG_Clathr_ClatBox_1	66	70	PF01394	0.528
LIG_FHA_1	128	134	PF00498	0.528
LIG_SH2_STAP1	51	55	PF00017	0.528
LIG_SH2_STAT5	127	130	PF00017	0.528
LIG_SH3_3	20	26	PF00018	0.533
LIG_SH3_3	231	237	PF00018	0.528
LIG_SH3_3	84	90	PF00018	0.512
LIG_SUMO_SIM_par_1	107	113	PF11976	0.527
LIG_SUMO_SIM_par_1	133	138	PF11976	0.528
LIG_UBA3_1	222	227	PF00899	0.553
LIG_UBA3_1	41	50	PF00899	0.528
MOD_CK1_1	18	24	PF00069	0.539
MOD_CK2_1	107	113	PF00069	0.527
MOD_CK2_1	208	214	PF00069	0.462
MOD_GlcNHglycan	209	213	PF01048	0.394
MOD_GSK3_1	149	156	PF00069	0.626
MOD_LATS_1	206	212	PF00433	0.507
MOD_NEK2_1	232	237	PF00069	0.634
MOD_Plk_4	153	159	PF00069	0.528
MOD_SUMO_for_1	193	196	PF00179	0.606
MOD_SUMO_rev_2	70	80	PF00179	0.530
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.626
TRG_DiLeu_LyEn_5	37	42	PF01217	0.550
TRG_ER_diArg_1	143	146	PF00400	0.528
TRG_ER_diArg_1	186	189	PF00400	0.423
TRG_ER_diArg_1	26	29	PF00400	0.538
TRG_ER_diArg_1	45	48	PF00400	0.460
TRG_ER_diArg_1	73	75	PF00400	0.604
TRG_NLS_MonoExtC_3	268	273	PF00514	0.632
TRG_NLS_MonoExtN_4	266	273	PF00514	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAK8	Leptomonas seymouri	89%	100%
A0A0S4JC93	Bodo saltans	72%	99%
A0A1D8PCI6	Candida albicans (strain SC5314 / ATCC MYA-2876)	51%	100%
A0A1X0NNJ3	Trypanosomatidae	79%	100%
A0A1X0NPF5	Trypanosomatidae	79%	100%
A0A381MCU2	Leishmania infantum	100%	100%
A0A3R7RAV9	Trypanosoma rangeli	78%	100%
A1RS06	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	37%	100%
A2BMD1	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	33%	100%
A3DNB9	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	35%	100%
A3MWZ7	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	35%	100%
A4FWA9	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	35%	100%
A4H7A6	Leishmania braziliensis	97%	100%
A4WLL4	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	35%	100%
A4YCX8	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	28%	100%
A5UL76	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	33%	100%
A6UQ56	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	33%	100%
A6UWV0	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	33%	100%
A6VGZ7	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	35%	100%
A8ACD4	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	33%	100%
A8MB20	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	30%	100%
A9A9Q2	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	34%	100%
B0R668	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	28%	100%
B1L778	Korarchaeum cryptofilum (strain OPF8)	32%	100%
B1Y9S4	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	36%	100%
B8D5V8	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	32%	100%
B9LSR5	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	30%	100%
C3MQ71	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	29%	100%
C3MVJ0	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	29%	100%
C3N5T9	Sulfolobus islandicus (strain M.16.27)	29%	100%
C3NEF5	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	29%	100%
C3NH97	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	29%	100%
C4KHG8	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	29%	100%
D0A6J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
E9APE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O05634	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	29%	100%
O22424	Zea mays	51%	100%
O26123	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	38%	100%
O28366	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	33%	100%
O59430	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	38%	100%
O59950	Yarrowia lipolytica (strain CLIB 122 / E 150)	50%	100%
O62738	Monodelphis domestica	53%	100%
O62739	Monodelphis domestica	53%	100%
O81363	Prunus armeniaca	49%	100%
P0C233	Tetrahymena thermophila	47%	100%
P0CX35	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	100%
P0CX36	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	100%
P14023	Methanococcus vannielii	33%	100%
P22090	Homo sapiens	51%	100%
P22510	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	28%	100%
P41042	Drosophila melanogaster	52%	100%
P46299	Gossypium hirsutum	52%	100%
P46300	Solanum tuberosum	52%	100%
P47836	Gallus gallus	53%	100%
P47837	Candida albicans	49%	100%
P47961	Cricetulus griseus	53%	100%
P49204	Arabidopsis thaliana	52%	100%
P49398	Oryza sativa subsp. japonica	53%	100%
P49401	Xenopus laevis	53%	100%
P51405	Dictyostelium discoideum	48%	100%
P54039	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	36%	100%
P55832	Equus caballus	54%	100%
P62428	Methanococcus maripaludis (strain S2 / LL)	33%	100%
P62429	Nanoarchaeum equitans (strain Kin4-M)	31%	100%
P62701	Homo sapiens	53%	100%
P62702	Mus musculus	53%	100%
P62703	Rattus norvegicus	53%	100%
P62704	Mesocricetus auratus	53%	100%
P62705	Felis catus	53%	100%
P79103	Bos taurus	53%	100%
P79183	Macaca fuscata fuscata	51%	100%
P87158	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	100%
Q0W1X6	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	31%	100%
Q2FT37	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	30%	100%
Q2NFW9	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	34%	100%
Q3IMX6	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	27%	100%
Q40941	Bigelowiella natans	22%	100%
Q46GA7	Methanosarcina barkeri (strain Fusaro / DSM 804)	33%	100%
Q4GXU6	Carabus granulatus	51%	100%
Q4PMB3	Ixodes scapularis	52%	100%
Q4QG31	Leishmania major	99%	100%
Q56230	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	33%	100%
Q56FH2	Lysiphlebus testaceipes	53%	100%
Q5JJG0	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	37%	100%
Q5UAP0	Bombyx mori	52%	100%
Q642H9	Danio rerio	53%	100%
Q6GVM7	Pan troglodytes	51%	100%
Q6L1B5	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	28%	100%
Q6PBC4	Xenopus tropicalis	53%	100%
Q76MY1	Macaca fuscata fuscata	53%	100%
Q76N24	Chlorocebus aethiops	53%	100%
Q861U7	Pongo pygmaeus	51%	100%
Q861U8	Gorilla gorilla gorilla	51%	100%
Q861U9	Pan troglodytes	51%	100%
Q861V0	Pan paniscus	51%	100%
Q8PV38	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	32%	100%
Q8SRB9	Encephalitozoon cuniculi (strain GB-M1)	35%	100%
Q8TD47	Homo sapiens	49%	100%
Q8TRT5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	33%	100%
Q8TW18	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	36%	100%
Q8U011	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	37%	100%
Q8VYK6	Arabidopsis thaliana	52%	100%
Q8ZTD3	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	34%	100%
Q90YS0	Ictalurus punctatus	53%	100%
Q93VH9	Arabidopsis thaliana	53%	100%
Q95V34	Spodoptera frugiperda	51%	100%
Q975J2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	29%	100%
Q97BW4	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	34%	100%
Q9HPC2	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	28%	100%
Q9N3X2	Caenorhabditis elegans	52%	100%
Q9P4W9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	100%
Q9USW5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	100%
Q9UX94	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	29%	100%
Q9V1U8	Pyrococcus abyssi (strain GE5 / Orsay)	37%	100%
Q9YF85	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	37%	100%