Glycosyl hydrolase family 47, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8I8J9_LEIDO

TriTrypDb:

LdBPK_091470.1 , LdCL_090021100 , LDHU3_09.1720

Length:

658

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3Q8I8J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8J9

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	7
GO:0004559	alpha-mannosidase activity	6	7
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	8	7
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0015923	mannosidase activity	5	7
GO:0015924	mannosyl-oligosaccharide mannosidase activity	7	7
GO:0016787	hydrolase activity	2	7
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.410
CLV_NRD_NRD_1	17	19	PF00675	0.382
CLV_NRD_NRD_1	356	358	PF00675	0.583
CLV_NRD_NRD_1	408	410	PF00675	0.632
CLV_NRD_NRD_1	515	517	PF00675	0.603
CLV_NRD_NRD_1	590	592	PF00675	0.672
CLV_NRD_NRD_1	602	604	PF00675	0.634
CLV_NRD_NRD_1	630	632	PF00675	0.552
CLV_NRD_NRD_1	87	89	PF00675	0.437
CLV_PCSK_KEX2_1	131	133	PF00082	0.415
CLV_PCSK_KEX2_1	17	19	PF00082	0.382
CLV_PCSK_KEX2_1	408	410	PF00082	0.584
CLV_PCSK_KEX2_1	602	604	PF00082	0.630
CLV_PCSK_KEX2_1	630	632	PF00082	0.552
CLV_PCSK_KEX2_1	86	88	PF00082	0.434
CLV_PCSK_SKI1_1	106	110	PF00082	0.361
CLV_PCSK_SKI1_1	18	22	PF00082	0.378
CLV_PCSK_SKI1_1	184	188	PF00082	0.623
CLV_PCSK_SKI1_1	257	261	PF00082	0.600
CLV_PCSK_SKI1_1	283	287	PF00082	0.523
CLV_PCSK_SKI1_1	306	310	PF00082	0.610
CLV_PCSK_SKI1_1	397	401	PF00082	0.498
CLV_PCSK_SKI1_1	434	438	PF00082	0.580
DEG_APCC_DBOX_1	305	313	PF00400	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.609
DOC_CKS1_1	458	463	PF01111	0.345
DOC_CKS1_1	652	657	PF01111	0.437
DOC_MAPK_gen_1	25	32	PF00069	0.572
DOC_MAPK_gen_1	516	524	PF00069	0.383
DOC_MAPK_gen_1	602	613	PF00069	0.319
DOC_MAPK_gen_1	86	98	PF00069	0.588
DOC_MAPK_MEF2A_6	397	404	PF00069	0.300
DOC_MAPK_MEF2A_6	606	615	PF00069	0.306
DOC_MAPK_MEF2A_6	91	100	PF00069	0.581
DOC_MAPK_NFAT4_5	397	405	PF00069	0.301
DOC_PP1_RVXF_1	141	148	PF00149	0.495
DOC_PP4_FxxP_1	110	113	PF00568	0.559
DOC_PP4_FxxP_1	363	366	PF00568	0.411
DOC_USP7_MATH_1	176	180	PF00917	0.475
DOC_USP7_MATH_1	186	190	PF00917	0.408
DOC_USP7_MATH_1	285	289	PF00917	0.282
DOC_USP7_MATH_1	319	323	PF00917	0.397
DOC_USP7_MATH_1	359	363	PF00917	0.415
DOC_USP7_MATH_1	383	387	PF00917	0.394
DOC_USP7_MATH_1	422	426	PF00917	0.357
DOC_USP7_MATH_1	483	487	PF00917	0.410
DOC_WW_Pin1_4	250	255	PF00397	0.402
DOC_WW_Pin1_4	457	462	PF00397	0.350
DOC_WW_Pin1_4	596	601	PF00397	0.354
DOC_WW_Pin1_4	639	644	PF00397	0.321
DOC_WW_Pin1_4	651	656	PF00397	0.403
DOC_WW_Pin1_4	79	84	PF00397	0.591
LIG_14-3-3_CanoR_1	115	121	PF00244	0.562
LIG_14-3-3_CanoR_1	135	144	PF00244	0.503
LIG_14-3-3_CanoR_1	357	366	PF00244	0.457
LIG_14-3-3_CanoR_1	434	443	PF00244	0.390
LIG_14-3-3_CanoR_1	489	496	PF00244	0.365
LIG_14-3-3_CanoR_1	516	524	PF00244	0.408
LIG_14-3-3_CanoR_1	546	550	PF00244	0.389
LIG_14-3-3_CanoR_1	58	62	PF00244	0.575
LIG_14-3-3_CanoR_1	95	99	PF00244	0.583
LIG_APCC_ABBA_1	225	230	PF00400	0.289
LIG_APCC_ABBA_1	507	512	PF00400	0.348
LIG_BRCT_BRCA1_1	359	363	PF00533	0.385
LIG_BRCT_BRCA1_1	65	69	PF00533	0.578
LIG_CSL_BTD_1	363	366	PF09270	0.411
LIG_deltaCOP1_diTrp_1	192	200	PF00928	0.454
LIG_EH1_1	615	623	PF00400	0.360
LIG_FHA_1	185	191	PF00498	0.437
LIG_FHA_1	217	223	PF00498	0.349
LIG_FHA_1	227	233	PF00498	0.412
LIG_FHA_1	34	40	PF00498	0.574
LIG_FHA_1	344	350	PF00498	0.411
LIG_FHA_1	431	437	PF00498	0.353
LIG_FHA_1	608	614	PF00498	0.340
LIG_FHA_1	635	641	PF00498	0.356
LIG_FHA_1	643	649	PF00498	0.398
LIG_FHA_2	253	259	PF00498	0.408
LIG_FHA_2	535	541	PF00498	0.485
LIG_FHA_2	564	570	PF00498	0.449
LIG_GBD_Chelix_1	153	161	PF00786	0.277
LIG_HP1_1	26	30	PF01393	0.567
LIG_LIR_Apic_2	360	366	PF02991	0.406
LIG_LIR_Gen_1	142	152	PF02991	0.465
LIG_LIR_Gen_1	325	333	PF02991	0.365
LIG_LIR_Gen_1	386	396	PF02991	0.349
LIG_LIR_Gen_1	547	557	PF02991	0.406
LIG_LIR_Gen_1	610	618	PF02991	0.294
LIG_LIR_Gen_1	67	77	PF02991	0.579
LIG_LIR_Nem_3	142	147	PF02991	0.471
LIG_LIR_Nem_3	325	329	PF02991	0.355
LIG_LIR_Nem_3	332	337	PF02991	0.357
LIG_LIR_Nem_3	386	392	PF02991	0.400
LIG_LIR_Nem_3	504	510	PF02991	0.321
LIG_LIR_Nem_3	547	552	PF02991	0.429
LIG_LIR_Nem_3	558	564	PF02991	0.299
LIG_LIR_Nem_3	610	615	PF02991	0.290
LIG_LIR_Nem_3	67	73	PF02991	0.578
LIG_MLH1_MIPbox_1	66	70	PF16413	0.577
LIG_PCNA_PIPBox_1	424	433	PF02747	0.343
LIG_Pex14_2	69	73	PF04695	0.581
LIG_SH2_CRK	389	393	PF00017	0.339
LIG_SH2_NCK_1	510	514	PF00017	0.368
LIG_SH2_NCK_1	533	537	PF00017	0.525
LIG_SH2_PTP2	155	158	PF00017	0.369
LIG_SH2_SRC	510	513	PF00017	0.357
LIG_SH2_STAP1	389	393	PF00017	0.339
LIG_SH2_STAP1	419	423	PF00017	0.311
LIG_SH2_STAP1	432	436	PF00017	0.344
LIG_SH2_STAT5	144	147	PF00017	0.304
LIG_SH2_STAT5	155	158	PF00017	0.320
LIG_SH2_STAT5	217	220	PF00017	0.326
LIG_SH2_STAT5	432	435	PF00017	0.494
LIG_SH2_STAT5	523	526	PF00017	0.394
LIG_SH2_STAT5	533	536	PF00017	0.479
LIG_SH2_STAT5	549	552	PF00017	0.440
LIG_SH3_1	310	316	PF00018	0.343
LIG_SH3_3	191	197	PF00018	0.423
LIG_SH3_3	198	204	PF00018	0.416
LIG_SH3_3	2	8	PF00018	0.570
LIG_SH3_3	310	316	PF00018	0.387
LIG_SH3_3	455	461	PF00018	0.360
LIG_SH3_3	479	485	PF00018	0.436
LIG_SH3_3	646	652	PF00018	0.380
LIG_SH3_CIN85_PxpxPR_1	457	462	PF14604	0.395
LIG_Sin3_3	452	459	PF02671	0.424
LIG_SUMO_SIM_anti_2	241	246	PF11976	0.301
LIG_SUMO_SIM_anti_2	576	581	PF11976	0.310
LIG_SUMO_SIM_par_1	155	160	PF11976	0.323
LIG_SUMO_SIM_par_1	241	246	PF11976	0.286
LIG_TYR_ITIM	153	158	PF00017	0.311
LIG_WRC_WIRS_1	557	562	PF05994	0.335
MOD_CDK_SPK_2	457	462	PF00069	0.414
MOD_CDK_SPxK_1	596	602	PF00069	0.419
MOD_CDK_SPxxK_3	250	257	PF00069	0.473
MOD_CDK_SPxxK_3	596	603	PF00069	0.417
MOD_CDK_SPxxK_3	79	86	PF00069	0.477
MOD_CK1_1	165	171	PF00069	0.423
MOD_CK1_1	322	328	PF00069	0.495
MOD_CK1_1	335	341	PF00069	0.486
MOD_CK1_1	343	349	PF00069	0.494
MOD_CK1_1	544	550	PF00069	0.492
MOD_CK1_1	57	63	PF00069	0.487
MOD_CK1_1	626	632	PF00069	0.476
MOD_CK1_1	64	70	PF00069	0.505
MOD_CK1_1	642	648	PF00069	0.386
MOD_CK2_1	176	182	PF00069	0.595
MOD_CK2_1	186	192	PF00069	0.497
MOD_CK2_1	252	258	PF00069	0.384
MOD_CK2_1	447	453	PF00069	0.577
MOD_CK2_1	556	562	PF00069	0.371
MOD_CK2_1	9	15	PF00069	0.463
MOD_Cter_Amidation	406	409	PF01082	0.410
MOD_Cter_Amidation	514	517	PF01082	0.468
MOD_GlcNHglycan	178	181	PF01048	0.558
MOD_GlcNHglycan	287	290	PF01048	0.502
MOD_GlcNHglycan	321	324	PF01048	0.498
MOD_GlcNHglycan	326	329	PF01048	0.431
MOD_GlcNHglycan	385	388	PF01048	0.492
MOD_GlcNHglycan	486	489	PF01048	0.490
MOD_GlcNHglycan	519	522	PF01048	0.559
MOD_GlcNHglycan	526	529	PF01048	0.496
MOD_GlcNHglycan	539	544	PF01048	0.581
MOD_GlcNHglycan	596	599	PF01048	0.509
MOD_GSK3_1	216	223	PF00069	0.475
MOD_GSK3_1	243	250	PF00069	0.450
MOD_GSK3_1	265	272	PF00069	0.554
MOD_GSK3_1	318	325	PF00069	0.549
MOD_GSK3_1	33	40	PF00069	0.454
MOD_GSK3_1	343	350	PF00069	0.618
MOD_GSK3_1	430	437	PF00069	0.409
MOD_GSK3_1	443	450	PF00069	0.403
MOD_GSK3_1	484	491	PF00069	0.479
MOD_GSK3_1	534	541	PF00069	0.709
MOD_GSK3_1	57	64	PF00069	0.492
MOD_GSK3_1	590	597	PF00069	0.538
MOD_GSK3_1	635	642	PF00069	0.355
MOD_GSK3_1	9	16	PF00069	0.464
MOD_N-GLC_1	443	448	PF02516	0.391
MOD_N-GLC_2	124	126	PF02516	0.492
MOD_NEK2_1	157	162	PF00069	0.323
MOD_NEK2_1	33	38	PF00069	0.453
MOD_NEK2_1	376	381	PF00069	0.686
MOD_NEK2_1	430	435	PF00069	0.449
MOD_NEK2_1	443	448	PF00069	0.443
MOD_NEK2_1	502	507	PF00069	0.382
MOD_NEK2_1	54	59	PF00069	0.457
MOD_NEK2_1	545	550	PF00069	0.554
MOD_NEK2_1	556	561	PF00069	0.283
MOD_NEK2_1	563	568	PF00069	0.258
MOD_NEK2_1	635	640	PF00069	0.363
MOD_NEK2_2	352	357	PF00069	0.459
MOD_NEK2_2	94	99	PF00069	0.459
MOD_PIKK_1	124	130	PF00454	0.500
MOD_PIKK_1	57	63	PF00454	0.475
MOD_PKA_1	357	363	PF00069	0.479
MOD_PKA_1	408	414	PF00069	0.450
MOD_PKA_2	408	414	PF00069	0.450
MOD_PKA_2	483	489	PF00069	0.627
MOD_PKA_2	534	540	PF00069	0.670
MOD_PKA_2	545	551	PF00069	0.455
MOD_PKA_2	57	63	PF00069	0.449
MOD_PKA_2	590	596	PF00069	0.543
MOD_PKA_2	623	629	PF00069	0.470
MOD_PKA_2	94	100	PF00069	0.461
MOD_PKB_1	133	141	PF00069	0.419
MOD_Plk_1	443	449	PF00069	0.392
MOD_Plk_4	157	163	PF00069	0.411
MOD_Plk_4	359	365	PF00069	0.574
MOD_Plk_4	422	428	PF00069	0.371
MOD_Plk_4	556	562	PF00069	0.377
MOD_Plk_4	636	642	PF00069	0.449
MOD_Plk_4	65	71	PF00069	0.456
MOD_Plk_4	9	15	PF00069	0.463
MOD_ProDKin_1	250	256	PF00069	0.482
MOD_ProDKin_1	457	463	PF00069	0.411
MOD_ProDKin_1	596	602	PF00069	0.419
MOD_ProDKin_1	639	645	PF00069	0.378
MOD_ProDKin_1	651	657	PF00069	0.503
MOD_ProDKin_1	79	85	PF00069	0.477
MOD_SUMO_rev_2	179	186	PF00179	0.499
TRG_DiLeu_BaEn_2	303	309	PF01217	0.417
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.336
TRG_ENDOCYTIC_2	105	108	PF00928	0.432
TRG_ENDOCYTIC_2	144	147	PF00928	0.304
TRG_ENDOCYTIC_2	155	158	PF00928	0.304
TRG_ENDOCYTIC_2	389	392	PF00928	0.412
TRG_ENDOCYTIC_2	549	552	PF00928	0.537
TRG_ER_diArg_1	131	133	PF00400	0.508
TRG_ER_diArg_1	601	603	PF00400	0.535
TRG_ER_diArg_1	630	632	PF00400	0.424
TRG_ER_diArg_1	85	88	PF00400	0.543
TRG_NES_CRM1_1	569	583	PF08389	0.382
TRG_NLS_MonoExtN_4	513	520	PF00514	0.488
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	413	417	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A3	Leptomonas seymouri	51%	100%
A4H5W7	Leishmania braziliensis	74%	100%
A4HU62	Leishmania infantum	99%	100%
E9AMZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHN5	Leishmania major	92%	100%