Glucosidase II beta subunit-like, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glucosidase II beta subunit-like, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I8J4_LEIDO

TriTrypDb:

LdBPK_090660.1 , LdCL_090011700 , LDHU3_09.0800

Length:

837

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0017177	glucosidase II complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8I8J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8J4

Function

Biological processes
Term	Name	Level	Count
GO:0006491	N-glycan processing	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009100	glycoprotein metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.545
CLV_C14_Caspase3-7	651	655	PF00656	0.746
CLV_C14_Caspase3-7	67	71	PF00656	0.790
CLV_C14_Caspase3-7	793	797	PF00656	0.523
CLV_MEL_PAP_1	596	602	PF00089	0.383
CLV_NRD_NRD_1	131	133	PF00675	0.408
CLV_NRD_NRD_1	261	263	PF00675	0.495
CLV_NRD_NRD_1	354	356	PF00675	0.470
CLV_NRD_NRD_1	422	424	PF00675	0.354
CLV_NRD_NRD_1	45	47	PF00675	0.466
CLV_NRD_NRD_1	522	524	PF00675	0.404
CLV_NRD_NRD_1	549	551	PF00675	0.453
CLV_NRD_NRD_1	671	673	PF00675	0.349
CLV_PCSK_KEX2_1	131	133	PF00082	0.478
CLV_PCSK_KEX2_1	263	265	PF00082	0.461
CLV_PCSK_KEX2_1	354	356	PF00082	0.473
CLV_PCSK_KEX2_1	421	423	PF00082	0.395
CLV_PCSK_KEX2_1	45	47	PF00082	0.466
CLV_PCSK_KEX2_1	522	524	PF00082	0.404
CLV_PCSK_KEX2_1	549	551	PF00082	0.453
CLV_PCSK_KEX2_1	671	673	PF00082	0.351
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.498
CLV_PCSK_PC7_1	127	133	PF00082	0.363
CLV_PCSK_PC7_1	418	424	PF00082	0.353
CLV_PCSK_SKI1_1	132	136	PF00082	0.384
CLV_PCSK_SKI1_1	166	170	PF00082	0.371
CLV_PCSK_SKI1_1	289	293	PF00082	0.442
CLV_PCSK_SKI1_1	362	366	PF00082	0.387
CLV_PCSK_SKI1_1	381	385	PF00082	0.415
CLV_PCSK_SKI1_1	552	556	PF00082	0.464
CLV_PCSK_SKI1_1	711	715	PF00082	0.444
CLV_PCSK_SKI1_1	825	829	PF00082	0.431
CLV_Separin_Metazoa	145	149	PF03568	0.664
CLV_Separin_Metazoa	589	593	PF03568	0.565
DEG_APCC_DBOX_1	188	196	PF00400	0.580
DEG_SCF_FBW7_1	731	737	PF00400	0.635
DEG_SPOP_SBC_1	759	763	PF00917	0.664
DEG_SPOP_SBC_1	84	88	PF00917	0.740
DOC_ANK_TNKS_1	410	417	PF00023	0.509
DOC_CKS1_1	168	173	PF01111	0.623
DOC_CKS1_1	219	224	PF01111	0.698
DOC_CKS1_1	314	319	PF01111	0.677
DOC_CKS1_1	553	558	PF01111	0.769
DOC_CKS1_1	731	736	PF01111	0.729
DOC_CKS1_1	813	818	PF01111	0.537
DOC_CYCLIN_RxL_1	286	295	PF00134	0.646
DOC_MAPK_gen_1	439	446	PF00069	0.674
DOC_MAPK_MEF2A_6	439	446	PF00069	0.567
DOC_MAPK_NFAT4_5	439	447	PF00069	0.566
DOC_MAPK_RevD_3	407	423	PF00069	0.537
DOC_PP2B_LxvP_1	291	294	PF13499	0.646
DOC_PP2B_LxvP_1	38	41	PF13499	0.651
DOC_PP4_FxxP_1	104	107	PF00568	0.540
DOC_USP7_MATH_1	364	368	PF00917	0.709
DOC_USP7_MATH_1	475	479	PF00917	0.555
DOC_USP7_MATH_1	494	498	PF00917	0.455
DOC_USP7_MATH_1	642	646	PF00917	0.676
DOC_USP7_MATH_1	648	652	PF00917	0.699
DOC_USP7_MATH_1	726	730	PF00917	0.707
DOC_USP7_MATH_1	759	763	PF00917	0.664
DOC_USP7_MATH_1	77	81	PF00917	0.787
DOC_USP7_MATH_1	83	87	PF00917	0.754
DOC_USP7_UBL2_3	710	714	PF12436	0.700
DOC_USP7_UBL2_3	832	836	PF12436	0.655
DOC_WW_Pin1_4	167	172	PF00397	0.621
DOC_WW_Pin1_4	218	223	PF00397	0.666
DOC_WW_Pin1_4	313	318	PF00397	0.719
DOC_WW_Pin1_4	319	324	PF00397	0.731
DOC_WW_Pin1_4	362	367	PF00397	0.645
DOC_WW_Pin1_4	44	49	PF00397	0.648
DOC_WW_Pin1_4	534	539	PF00397	0.654
DOC_WW_Pin1_4	552	557	PF00397	0.663
DOC_WW_Pin1_4	621	626	PF00397	0.695
DOC_WW_Pin1_4	630	635	PF00397	0.660
DOC_WW_Pin1_4	730	735	PF00397	0.726
DOC_WW_Pin1_4	773	778	PF00397	0.728
DOC_WW_Pin1_4	78	83	PF00397	0.770
DOC_WW_Pin1_4	812	817	PF00397	0.527
LIG_14-3-3_CanoR_1	227	232	PF00244	0.656
LIG_14-3-3_CanoR_1	270	280	PF00244	0.676
LIG_14-3-3_CanoR_1	325	333	PF00244	0.590
LIG_14-3-3_CanoR_1	354	361	PF00244	0.673
LIG_14-3-3_CanoR_1	536	542	PF00244	0.659
LIG_14-3-3_CanoR_1	592	596	PF00244	0.698
LIG_14-3-3_CanoR_1	630	634	PF00244	0.614
LIG_14-3-3_CanoR_1	676	682	PF00244	0.695
LIG_14-3-3_CanoR_1	780	785	PF00244	0.618
LIG_APCC_ABBA_1	105	110	PF00400	0.541
LIG_BIR_II_1	1	5	PF00653	0.413
LIG_BRCT_BRCA1_1	100	104	PF00533	0.510
LIG_BRCT_BRCA1_1	678	682	PF00533	0.671
LIG_CaM_IQ_9	346	362	PF13499	0.579
LIG_CSL_BTD_1	692	695	PF09270	0.572
LIG_deltaCOP1_diTrp_1	7	12	PF00928	0.281
LIG_eIF4E_1	515	521	PF01652	0.609
LIG_FHA_1	119	125	PF00498	0.603
LIG_FHA_1	162	168	PF00498	0.552
LIG_FHA_1	204	210	PF00498	0.567
LIG_FHA_1	219	225	PF00498	0.605
LIG_FHA_1	241	247	PF00498	0.624
LIG_FHA_1	363	369	PF00498	0.686
LIG_FHA_1	448	454	PF00498	0.597
LIG_FHA_1	622	628	PF00498	0.633
LIG_FHA_1	723	729	PF00498	0.710
LIG_FHA_1	747	753	PF00498	0.717
LIG_FHA_2	168	174	PF00498	0.585
LIG_FHA_2	392	398	PF00498	0.675
LIG_FHA_2	537	543	PF00498	0.703
LIG_FHA_2	553	559	PF00498	0.628
LIG_FHA_2	65	71	PF00498	0.735
LIG_FHA_2	710	716	PF00498	0.726
LIG_Integrin_RGD_1	264	266	PF01839	0.494
LIG_LIR_Apic_2	101	107	PF02991	0.537
LIG_LIR_Gen_1	173	183	PF02991	0.622
LIG_LIR_Gen_1	391	398	PF02991	0.660
LIG_LIR_Nem_3	173	179	PF02991	0.589
LIG_LIR_Nem_3	226	231	PF02991	0.655
LIG_LIR_Nem_3	386	392	PF02991	0.603
LIG_LIR_Nem_3	457	462	PF02991	0.564
LIG_LIR_Nem_3	513	518	PF02991	0.553
LIG_LIR_Nem_3	643	649	PF02991	0.661
LIG_LIR_Nem_3	7	11	PF02991	0.303
LIG_LIR_Nem_3	729	735	PF02991	0.775
LIG_LYPXL_yS_3	518	521	PF13949	0.613
LIG_Pex14_1	12	16	PF04695	0.373
LIG_SH2_SRC	16	19	PF00017	0.172
LIG_SH2_SRC	413	416	PF00017	0.542
LIG_SH2_STAP1	100	104	PF00017	0.496
LIG_SH2_STAP1	369	373	PF00017	0.659
LIG_SH2_STAP1	95	99	PF00017	0.500
LIG_SH2_STAT3	257	260	PF00017	0.793
LIG_SH2_STAT3	567	570	PF00017	0.648
LIG_SH2_STAT5	16	19	PF00017	0.235
LIG_SH2_STAT5	199	202	PF00017	0.544
LIG_SH2_STAT5	231	234	PF00017	0.604
LIG_SH2_STAT5	272	275	PF00017	0.718
LIG_SH2_STAT5	393	396	PF00017	0.711
LIG_SH2_STAT5	459	462	PF00017	0.566
LIG_SH2_STAT5	623	626	PF00017	0.704
LIG_SH2_STAT5	732	735	PF00017	0.776
LIG_SH2_STAT5	748	751	PF00017	0.561
LIG_SH2_STAT5	790	793	PF00017	0.562
LIG_SH2_STAT5	95	98	PF00017	0.501
LIG_SH3_1	255	261	PF00018	0.707
LIG_SH3_1	45	51	PF00018	0.649
LIG_SH3_2	258	263	PF14604	0.729
LIG_SH3_3	165	171	PF00018	0.617
LIG_SH3_3	216	222	PF00018	0.668
LIG_SH3_3	255	261	PF00018	0.721
LIG_SH3_3	274	280	PF00018	0.556
LIG_SH3_3	45	51	PF00018	0.716
LIG_SH3_3	569	575	PF00018	0.650
LIG_SH3_3	58	64	PF00018	0.614
LIG_SH3_3	636	642	PF00018	0.630
LIG_SH3_3	692	698	PF00018	0.797
LIG_SH3_3	728	734	PF00018	0.642
LIG_SH3_3	810	816	PF00018	0.598
LIG_SUMO_SIM_par_1	121	130	PF11976	0.658
LIG_SUMO_SIM_par_1	699	704	PF11976	0.705
LIG_TRAF2_1	170	173	PF00917	0.561
LIG_TRAF2_1	455	458	PF00917	0.558
LIG_TRFH_1	257	261	PF08558	0.667
MOD_CDC14_SPxK_1	322	325	PF00782	0.678
MOD_CDK_SPK_2	773	778	PF00069	0.728
MOD_CDK_SPxK_1	319	325	PF00069	0.681
MOD_CDK_SPxxK_3	630	637	PF00069	0.613
MOD_CDK_SPxxK_3	773	780	PF00069	0.624
MOD_CK1_1	118	124	PF00069	0.626
MOD_CK1_1	19	25	PF00069	0.296
MOD_CK1_1	391	397	PF00069	0.586
MOD_CK1_1	447	453	PF00069	0.527
MOD_CK1_1	503	509	PF00069	0.593
MOD_CK1_1	621	627	PF00069	0.650
MOD_CK1_1	783	789	PF00069	0.573
MOD_CK1_1	817	823	PF00069	0.554
MOD_CK1_1	86	92	PF00069	0.676
MOD_CK2_1	139	145	PF00069	0.649
MOD_CK2_1	167	173	PF00069	0.531
MOD_CK2_1	364	370	PF00069	0.658
MOD_CK2_1	391	397	PF00069	0.684
MOD_CK2_1	452	458	PF00069	0.623
MOD_CK2_1	552	558	PF00069	0.678
MOD_CK2_1	718	724	PF00069	0.690
MOD_CMANNOS	690	693	PF00535	0.355
MOD_GlcNHglycan	110	113	PF01048	0.445
MOD_GlcNHglycan	141	144	PF01048	0.426
MOD_GlcNHglycan	149	153	PF01048	0.486
MOD_GlcNHglycan	216	219	PF01048	0.419
MOD_GlcNHglycan	274	277	PF01048	0.374
MOD_GlcNHglycan	28	33	PF01048	0.443
MOD_GlcNHglycan	356	359	PF01048	0.435
MOD_GlcNHglycan	378	381	PF01048	0.395
MOD_GlcNHglycan	57	60	PF01048	0.644
MOD_GlcNHglycan	620	623	PF01048	0.468
MOD_GlcNHglycan	72	75	PF01048	0.487
MOD_GlcNHglycan	720	723	PF01048	0.520
MOD_GlcNHglycan	816	819	PF01048	0.308
MOD_GSK3_1	157	164	PF00069	0.608
MOD_GSK3_1	17	24	PF00069	0.386
MOD_GSK3_1	208	215	PF00069	0.574
MOD_GSK3_1	223	230	PF00069	0.614
MOD_GSK3_1	360	367	PF00069	0.620
MOD_GSK3_1	388	395	PF00069	0.609
MOD_GSK3_1	51	58	PF00069	0.794
MOD_GSK3_1	532	539	PF00069	0.636
MOD_GSK3_1	66	73	PF00069	0.646
MOD_GSK3_1	718	725	PF00069	0.709
MOD_GSK3_1	726	733	PF00069	0.692
MOD_GSK3_1	734	741	PF00069	0.630
MOD_GSK3_1	760	767	PF00069	0.796
MOD_GSK3_1	776	783	PF00069	0.599
MOD_GSK3_1	83	90	PF00069	0.587
MOD_N-GLC_1	437	442	PF02516	0.396
MOD_N-GLC_1	447	452	PF02516	0.339
MOD_N-GLC_1	579	584	PF02516	0.407
MOD_N-GLC_1	618	623	PF02516	0.399
MOD_N-GLC_1	628	633	PF02516	0.417
MOD_N-GLC_1	78	83	PF02516	0.424
MOD_N-GLC_2	212	214	PF02516	0.411
MOD_NEK2_1	17	22	PF00069	0.284
MOD_NEK2_1	271	276	PF00069	0.717
MOD_NEK2_1	340	345	PF00069	0.584
MOD_NEK2_1	444	449	PF00069	0.611
MOD_NEK2_1	527	532	PF00069	0.707
MOD_NEK2_1	53	58	PF00069	0.706
MOD_NEK2_1	591	596	PF00069	0.599
MOD_NEK2_1	628	633	PF00069	0.686
MOD_NEK2_1	701	706	PF00069	0.690
MOD_NEK2_1	760	765	PF00069	0.749
MOD_NEK2_2	388	393	PF00069	0.644
MOD_NEK2_2	677	682	PF00069	0.665
MOD_PIKK_1	184	190	PF00454	0.649
MOD_PIKK_1	726	732	PF00454	0.612
MOD_PIKK_1	760	766	PF00454	0.686
MOD_PK_1	780	786	PF00069	0.557
MOD_PKA_1	354	360	PF00069	0.614
MOD_PKA_2	108	114	PF00069	0.689
MOD_PKA_2	324	330	PF00069	0.723
MOD_PKA_2	354	360	PF00069	0.668
MOD_PKA_2	591	597	PF00069	0.602
MOD_PKA_2	629	635	PF00069	0.629
MOD_PKB_1	778	786	PF00069	0.586
MOD_Plk_1	28	34	PF00069	0.702
MOD_Plk_1	527	533	PF00069	0.712
MOD_Plk_1	579	585	PF00069	0.593
MOD_Plk_1	618	624	PF00069	0.650
MOD_Plk_2-3	125	131	PF00069	0.656
MOD_Plk_2-3	452	458	PF00069	0.553
MOD_Plk_2-3	579	585	PF00069	0.639
MOD_Plk_4	100	106	PF00069	0.607
MOD_Plk_4	157	163	PF00069	0.628
MOD_Plk_4	227	233	PF00069	0.691
MOD_Plk_4	292	298	PF00069	0.590
MOD_Plk_4	364	370	PF00069	0.682
MOD_Plk_4	388	394	PF00069	0.563
MOD_Plk_4	591	597	PF00069	0.713
MOD_Plk_4	677	683	PF00069	0.743
MOD_Plk_4	738	744	PF00069	0.680
MOD_Plk_4	786	792	PF00069	0.589
MOD_Plk_4	794	800	PF00069	0.608
MOD_ProDKin_1	167	173	PF00069	0.620
MOD_ProDKin_1	218	224	PF00069	0.662
MOD_ProDKin_1	313	319	PF00069	0.722
MOD_ProDKin_1	362	368	PF00069	0.649
MOD_ProDKin_1	44	50	PF00069	0.646
MOD_ProDKin_1	534	540	PF00069	0.655
MOD_ProDKin_1	552	558	PF00069	0.658
MOD_ProDKin_1	621	627	PF00069	0.691
MOD_ProDKin_1	630	636	PF00069	0.659
MOD_ProDKin_1	730	736	PF00069	0.727
MOD_ProDKin_1	773	779	PF00069	0.723
MOD_ProDKin_1	78	84	PF00069	0.771
MOD_ProDKin_1	812	818	PF00069	0.528
MOD_SUMO_rev_2	327	333	PF00179	0.565
MOD_SUMO_rev_2	367	373	PF00179	0.592
MOD_SUMO_rev_2	702	712	PF00179	0.664
TRG_DiLeu_BaEn_1	157	162	PF01217	0.621
TRG_DiLeu_BaEn_1	528	533	PF01217	0.633
TRG_ENDOCYTIC_2	389	392	PF00928	0.655
TRG_ENDOCYTIC_2	393	396	PF00928	0.638
TRG_ENDOCYTIC_2	517	520	PF00928	0.530
TRG_ER_diArg_1	261	264	PF00400	0.651
TRG_ER_diArg_1	421	423	PF00400	0.620
TRG_ER_diArg_1	521	523	PF00400	0.588
TRG_ER_diArg_1	777	780	PF00400	0.671
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	806	810	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJC1	Leptomonas seymouri	54%	89%
A0A1X0NMP0	Trypanosomatidae	29%	99%
A0A422NV59	Trypanosoma rangeli	30%	100%
A4HTY2	Leishmania infantum	99%	100%
D0A9D8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AI37	Leishmania braziliensis	81%	98%
E9AMR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHW3	Leishmania major	93%	100%
V5B314	Trypanosoma cruzi	29%	100%