Bromodomain, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bromodomain, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I8I6_LEIDO

TriTrypDb:

LdBPK_091320.1 , LdCL_090019600 , LDHU3_09.1570

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I8I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8I6

PDB structure(s): 5tck_A , 5tck_B , 5tcm_A , 5tcm_B , 5tcm_C , 6bya_A , 6bya_B , 6bya_C , 6bya_D

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.473
CLV_C14_Caspase3-7	196	200	PF00656	0.360
CLV_C14_Caspase3-7	551	555	PF00656	0.501
CLV_NRD_NRD_1	179	181	PF00675	0.475
CLV_NRD_NRD_1	201	203	PF00675	0.421
CLV_NRD_NRD_1	276	278	PF00675	0.467
CLV_NRD_NRD_1	354	356	PF00675	0.680
CLV_NRD_NRD_1	407	409	PF00675	0.421
CLV_NRD_NRD_1	422	424	PF00675	0.390
CLV_NRD_NRD_1	50	52	PF00675	0.403
CLV_PCSK_KEX2_1	179	181	PF00082	0.475
CLV_PCSK_KEX2_1	276	278	PF00082	0.467
CLV_PCSK_KEX2_1	356	358	PF00082	0.747
CLV_PCSK_KEX2_1	406	408	PF00082	0.449
CLV_PCSK_KEX2_1	422	424	PF00082	0.430
CLV_PCSK_KEX2_1	50	52	PF00082	0.379
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.747
CLV_PCSK_PC7_1	418	424	PF00082	0.551
CLV_PCSK_SKI1_1	105	109	PF00082	0.496
CLV_PCSK_SKI1_1	407	411	PF00082	0.529
DEG_APCC_DBOX_1	104	112	PF00400	0.500
DEG_APCC_DBOX_1	417	425	PF00400	0.535
DEG_APCC_DBOX_1	622	630	PF00400	0.516
DEG_SPOP_SBC_1	458	462	PF00917	0.527
DOC_CDC14_PxL_1	34	42	PF14671	0.311
DOC_CYCLIN_yCln2_LP_2	371	377	PF00134	0.611
DOC_MAPK_gen_1	241	250	PF00069	0.403
DOC_MAPK_gen_1	370	377	PF00069	0.615
DOC_MAPK_gen_1	422	428	PF00069	0.594
DOC_MAPK_gen_1	479	488	PF00069	0.436
DOC_MAPK_gen_1	620	628	PF00069	0.542
DOC_MAPK_JIP1_4	207	213	PF00069	0.329
DOC_MAPK_MEF2A_6	241	250	PF00069	0.319
DOC_MAPK_MEF2A_6	507	515	PF00069	0.565
DOC_MAPK_NFAT4_5	243	251	PF00069	0.421
DOC_PP2B_LxvP_1	127	130	PF13499	0.699
DOC_PP2B_LxvP_1	371	374	PF13499	0.647
DOC_PP2B_LxvP_1	399	402	PF13499	0.518
DOC_PP2B_LxvP_1	433	436	PF13499	0.540
DOC_SPAK_OSR1_1	580	584	PF12202	0.457
DOC_USP7_MATH_1	130	134	PF00917	0.637
DOC_USP7_MATH_1	151	155	PF00917	0.702
DOC_USP7_MATH_1	305	309	PF00917	0.686
DOC_USP7_MATH_1	312	316	PF00917	0.764
DOC_USP7_MATH_1	323	327	PF00917	0.672
DOC_USP7_MATH_1	351	355	PF00917	0.749
DOC_USP7_MATH_1	459	463	PF00917	0.655
DOC_USP7_MATH_1	470	474	PF00917	0.520
DOC_USP7_MATH_1	491	495	PF00917	0.540
DOC_USP7_MATH_1	548	552	PF00917	0.511
DOC_USP7_MATH_1	596	600	PF00917	0.536
DOC_USP7_MATH_1	615	619	PF00917	0.680
DOC_WD40_RPTOR_TOS_1	186	192	PF00400	0.514
DOC_WW_Pin1_4	1	6	PF00397	0.666
DOC_WW_Pin1_4	327	332	PF00397	0.815
DOC_WW_Pin1_4	384	389	PF00397	0.631
DOC_WW_Pin1_4	390	395	PF00397	0.518
DOC_WW_Pin1_4	436	441	PF00397	0.578
DOC_WW_Pin1_4	594	599	PF00397	0.482
LIG_14-3-3_CanoR_1	251	257	PF00244	0.382
LIG_14-3-3_CanoR_1	290	295	PF00244	0.522
LIG_14-3-3_CanoR_1	406	412	PF00244	0.611
LIG_14-3-3_CanoR_1	423	429	PF00244	0.354
LIG_Actin_WH2_2	183	200	PF00022	0.435
LIG_Actin_WH2_2	275	292	PF00022	0.399
LIG_AP2alpha_1	498	502	PF02296	0.604
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_deltaCOP1_diTrp_1	261	270	PF00928	0.401
LIG_eIF4E_1	577	583	PF01652	0.441
LIG_FHA_1	2	8	PF00498	0.607
LIG_FHA_1	253	259	PF00498	0.360
LIG_FHA_1	335	341	PF00498	0.563
LIG_FHA_1	385	391	PF00498	0.668
LIG_FHA_1	461	467	PF00498	0.552
LIG_FHA_1	494	500	PF00498	0.662
LIG_LIR_Gen_1	261	270	PF02991	0.420
LIG_LIR_Gen_1	42	49	PF02991	0.312
LIG_LIR_Gen_1	509	520	PF02991	0.444
LIG_LIR_Gen_1	542	549	PF02991	0.507
LIG_LIR_Gen_1	572	583	PF02991	0.441
LIG_LIR_Gen_1	636	646	PF02991	0.490
LIG_LIR_Nem_3	192	197	PF02991	0.454
LIG_LIR_Nem_3	199	204	PF02991	0.312
LIG_LIR_Nem_3	261	266	PF02991	0.429
LIG_LIR_Nem_3	269	273	PF02991	0.350
LIG_LIR_Nem_3	35	40	PF02991	0.441
LIG_LIR_Nem_3	42	47	PF02991	0.285
LIG_LIR_Nem_3	509	515	PF02991	0.385
LIG_LIR_Nem_3	542	546	PF02991	0.501
LIG_LIR_Nem_3	572	578	PF02991	0.439
LIG_LIR_Nem_3	636	642	PF02991	0.484
LIG_LYPXL_yS_3	194	197	PF13949	0.311
LIG_LYPXL_yS_3	37	40	PF13949	0.311
LIG_OCRL_FandH_1	280	292	PF00620	0.382
LIG_PCNA_yPIPBox_3	251	264	PF02747	0.403
LIG_Pex14_2	498	502	PF04695	0.511
LIG_Pex14_2	581	585	PF04695	0.385
LIG_RPA_C_Fungi	604	616	PF08784	0.503
LIG_SH2_CRK	201	205	PF00017	0.360
LIG_SH2_CRK	44	48	PF00017	0.311
LIG_SH2_CRK	89	93	PF00017	0.403
LIG_SH2_NCK_1	8	12	PF00017	0.452
LIG_SH2_STAP1	66	70	PF00017	0.314
LIG_SH2_STAP1	96	100	PF00017	0.346
LIG_SH2_STAT5	223	226	PF00017	0.311
LIG_SH2_STAT5	39	42	PF00017	0.326
LIG_SH2_STAT5	44	47	PF00017	0.294
LIG_SH2_STAT5	512	515	PF00017	0.393
LIG_SH2_STAT5	575	578	PF00017	0.331
LIG_SH3_3	391	397	PF00018	0.623
LIG_SH3_3	580	586	PF00018	0.456
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.312
LIG_SUMO_SIM_anti_2	514	521	PF11976	0.406
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.348
LIG_SUMO_SIM_par_1	336	342	PF11976	0.560
LIG_TRAF2_1	134	137	PF00917	0.694
LIG_TRAF2_1	506	509	PF00917	0.422
LIG_TRAF2_1	645	648	PF00917	0.513
LIG_UBA3_1	211	219	PF00899	0.382
LIG_WRC_WIRS_1	499	504	PF05994	0.524
MOD_CDK_SPK_2	1	6	PF00069	0.644
MOD_CK1_1	150	156	PF00069	0.782
MOD_CK1_1	262	268	PF00069	0.516
MOD_CK1_1	446	452	PF00069	0.641
MOD_CK2_1	163	169	PF00069	0.489
MOD_CK2_1	502	508	PF00069	0.524
MOD_GlcNHglycan	1	4	PF01048	0.577
MOD_GlcNHglycan	132	135	PF01048	0.791
MOD_GlcNHglycan	139	142	PF01048	0.755
MOD_GlcNHglycan	149	152	PF01048	0.674
MOD_GlcNHglycan	153	156	PF01048	0.685
MOD_GlcNHglycan	224	227	PF01048	0.421
MOD_GlcNHglycan	307	310	PF01048	0.773
MOD_GlcNHglycan	314	317	PF01048	0.656
MOD_GlcNHglycan	324	328	PF01048	0.799
MOD_GlcNHglycan	341	344	PF01048	0.623
MOD_GlcNHglycan	347	350	PF01048	0.709
MOD_GlcNHglycan	366	369	PF01048	0.493
MOD_GlcNHglycan	448	452	PF01048	0.784
MOD_GlcNHglycan	472	475	PF01048	0.418
MOD_GlcNHglycan	493	496	PF01048	0.565
MOD_GlcNHglycan	504	507	PF01048	0.409
MOD_GlcNHglycan	536	539	PF01048	0.427
MOD_GlcNHglycan	603	606	PF01048	0.606
MOD_GlcNHglycan	611	614	PF01048	0.483
MOD_GlcNHglycan	93	96	PF01048	0.402
MOD_GSK3_1	137	144	PF00069	0.787
MOD_GSK3_1	147	154	PF00069	0.660
MOD_GSK3_1	222	229	PF00069	0.403
MOD_GSK3_1	231	238	PF00069	0.318
MOD_GSK3_1	262	269	PF00069	0.505
MOD_GSK3_1	310	317	PF00069	0.767
MOD_GSK3_1	323	330	PF00069	0.694
MOD_GSK3_1	334	341	PF00069	0.779
MOD_GSK3_1	443	450	PF00069	0.754
MOD_GSK3_1	468	475	PF00069	0.522
MOD_GSK3_1	498	505	PF00069	0.540
MOD_GSK3_1	587	594	PF00069	0.500
MOD_GSK3_1	597	604	PF00069	0.537
MOD_GSK3_1	615	622	PF00069	0.624
MOD_N-GLC_1	303	308	PF02516	0.676
MOD_NEK2_1	173	178	PF00069	0.387
MOD_NEK2_1	197	202	PF00069	0.403
MOD_NEK2_1	266	271	PF00069	0.464
MOD_NEK2_1	289	294	PF00069	0.429
MOD_NEK2_1	40	45	PF00069	0.346
MOD_NEK2_1	481	486	PF00069	0.428
MOD_NEK2_1	498	503	PF00069	0.423
MOD_NEK2_1	511	516	PF00069	0.398
MOD_NEK2_1	591	596	PF00069	0.518
MOD_NEK2_1	81	86	PF00069	0.403
MOD_NEK2_2	226	231	PF00069	0.390
MOD_NEK2_2	548	553	PF00069	0.502
MOD_NEK2_2	615	620	PF00069	0.571
MOD_PIKK_1	132	138	PF00454	0.707
MOD_PIKK_1	633	639	PF00454	0.454
MOD_PKA_1	147	153	PF00069	0.718
MOD_PKA_1	407	413	PF00069	0.542
MOD_PKA_2	122	128	PF00069	0.580
MOD_PKA_2	130	136	PF00069	0.605
MOD_PKA_2	197	203	PF00069	0.403
MOD_PKA_2	289	295	PF00069	0.454
MOD_PKA_2	407	413	PF00069	0.517
MOD_PKA_2	414	420	PF00069	0.454
MOD_PKA_2	481	487	PF00069	0.446
MOD_PKA_2	619	625	PF00069	0.487
MOD_Plk_4	226	232	PF00069	0.425
MOD_Plk_4	259	265	PF00069	0.506
MOD_Plk_4	424	430	PF00069	0.363
MOD_Plk_4	481	487	PF00069	0.432
MOD_Plk_4	511	517	PF00069	0.451
MOD_ProDKin_1	1	7	PF00069	0.654
MOD_ProDKin_1	327	333	PF00069	0.814
MOD_ProDKin_1	384	390	PF00069	0.627
MOD_ProDKin_1	436	442	PF00069	0.582
MOD_ProDKin_1	594	600	PF00069	0.493
MOD_SUMO_for_1	101	104	PF00179	0.489
MOD_SUMO_for_1	258	261	PF00179	0.464
MOD_SUMO_rev_2	439	446	PF00179	0.702
TRG_DiLeu_BaEn_1	169	174	PF01217	0.409
TRG_DiLeu_BaEn_1	244	249	PF01217	0.403
TRG_DiLeu_BaEn_2	637	643	PF01217	0.471
TRG_DiLeu_BaEn_4	508	514	PF01217	0.484
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.569
TRG_ENDOCYTIC_2	194	197	PF00928	0.311
TRG_ENDOCYTIC_2	201	204	PF00928	0.311
TRG_ENDOCYTIC_2	37	40	PF00928	0.311
TRG_ENDOCYTIC_2	44	47	PF00928	0.311
TRG_ENDOCYTIC_2	512	515	PF00928	0.400
TRG_ENDOCYTIC_2	575	578	PF00928	0.418
TRG_ER_diArg_1	126	129	PF00400	0.632
TRG_ER_diArg_1	214	217	PF00400	0.297
TRG_ER_diArg_1	276	278	PF00400	0.491
TRG_ER_diArg_1	405	408	PF00400	0.428
TRG_ER_diArg_1	421	423	PF00400	0.401
TRG_ER_diArg_1	49	51	PF00400	0.407
TRG_Pf-PMV_PEXEL_1	407	412	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3P5	Leptomonas seymouri	57%	98%
A0A3R7RQU7	Trypanosoma rangeli	36%	92%
A4H5V4	Leishmania braziliensis	82%	100%
A4HU48	Leishmania infantum	100%	100%
D0A9M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	80%
E9AMX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QHP9	Leishmania major	94%	100%