Elongation factor-1 gamma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

elongation factor-1 gamma

Species:

Leishmania donovani

UniProt:

A0A3Q8I8H5_LEIDO

TriTrypDb:

LdBPK_091020.1 , LdCL_090015800 , LDHU3_09.1190

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I8H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8H5

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003746	translation elongation factor activity	4	13
GO:0005488	binding	1	13
GO:0008135	translation factor activity, RNA binding	3	13
GO:0045182	translation regulator activity	1	13
GO:0090079	translation regulator activity, nucleic acid binding	2	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.411
CLV_NRD_NRD_1	325	327	PF00675	0.312
CLV_PCSK_KEX2_1	267	269	PF00082	0.312
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.312
CLV_PCSK_SKI1_1	148	152	PF00082	0.312
CLV_PCSK_SKI1_1	327	331	PF00082	0.312
CLV_PCSK_SKI1_1	396	400	PF00082	0.420
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.458
DOC_MAPK_gen_1	326	334	PF00069	0.312
DOC_MAPK_MEF2A_6	327	336	PF00069	0.312
DOC_PP2B_LxvP_1	6	9	PF13499	0.431
DOC_USP7_MATH_1	126	130	PF00917	0.341
DOC_USP7_MATH_1	92	96	PF00917	0.526
DOC_USP7_UBL2_3	216	220	PF12436	0.623
DOC_USP7_UBL2_3	227	231	PF12436	0.605
DOC_USP7_UBL2_3	245	249	PF12436	0.689
DOC_USP7_UBL2_3	82	86	PF12436	0.545
DOC_WW_Pin1_4	41	46	PF00397	0.372
DOC_WW_Pin1_4	49	54	PF00397	0.286
DOC_WW_Pin1_4	88	93	PF00397	0.419
LIG_14-3-3_CanoR_1	155	159	PF00244	0.331
LIG_14-3-3_CanoR_1	190	196	PF00244	0.312
LIG_BIR_III_2	254	258	PF00653	0.425
LIG_BRCT_BRCA1_1	161	165	PF00533	0.447
LIG_CtBP_PxDLS_1	178	183	PF00389	0.447
LIG_deltaCOP1_diTrp_1	142	150	PF00928	0.312
LIG_deltaCOP1_diTrp_1	99	104	PF00928	0.371
LIG_EH1_1	329	337	PF00400	0.312
LIG_EVH1_2	257	261	PF00568	0.312
LIG_FHA_1	1	7	PF00498	0.521
LIG_FHA_1	147	153	PF00498	0.312
LIG_FHA_1	199	205	PF00498	0.389
LIG_FHA_1	273	279	PF00498	0.312
LIG_FHA_1	309	315	PF00498	0.312
LIG_FHA_1	382	388	PF00498	0.356
LIG_FHA_2	131	137	PF00498	0.404
LIG_FHA_2	155	161	PF00498	0.357
LIG_FHA_2	89	95	PF00498	0.412
LIG_LIR_Gen_1	289	299	PF02991	0.424
LIG_LIR_Gen_1	369	378	PF02991	0.402
LIG_LIR_Gen_1	99	109	PF02991	0.355
LIG_LIR_Nem_3	119	124	PF02991	0.129
LIG_LIR_Nem_3	289	295	PF02991	0.325
LIG_LIR_Nem_3	3	7	PF02991	0.441
LIG_LIR_Nem_3	346	350	PF02991	0.352
LIG_LIR_Nem_3	369	373	PF02991	0.395
LIG_LIR_Nem_3	99	104	PF02991	0.357
LIG_LYPXL_SIV_4	25	33	PF13949	0.447
LIG_Pex14_1	208	212	PF04695	0.554
LIG_Pex14_2	165	169	PF04695	0.296
LIG_SH2_CRK	192	196	PF00017	0.312
LIG_SH2_CRK	4	8	PF00017	0.433
LIG_SH2_GRB2like	26	29	PF00017	0.447
LIG_SH2_GRB2like	270	273	PF00017	0.312
LIG_SH2_NCK_1	26	30	PF00017	0.447
LIG_SH2_SRC	26	29	PF00017	0.447
LIG_SH2_STAP1	292	296	PF00017	0.312
LIG_SH2_STAT5	116	119	PF00017	0.447
LIG_SH2_STAT5	282	285	PF00017	0.312
LIG_SH2_STAT5	292	295	PF00017	0.312
LIG_SH2_STAT5	386	389	PF00017	0.368
LIG_SH2_STAT5	66	69	PF00017	0.437
LIG_SH3_3	275	281	PF00018	0.312
LIG_SH3_3	389	395	PF00018	0.398
LIG_SH3_3	6	12	PF00018	0.488
LIG_SUMO_SIM_anti_2	201	206	PF11976	0.398
LIG_TRAF2_1	133	136	PF00917	0.425
LIG_TRAF2_1	244	247	PF00917	0.716
LIG_UBA3_1	73	82	PF00899	0.425
LIG_WRC_WIRS_1	118	123	PF05994	0.352
LIG_WRC_WIRS_1	344	349	PF05994	0.352
MOD_CDK_SPxxK_3	49	56	PF00069	0.331
MOD_CK1_1	59	65	PF00069	0.434
MOD_CK2_1	130	136	PF00069	0.369
MOD_CK2_1	240	246	PF00069	0.591
MOD_CK2_1	88	94	PF00069	0.395
MOD_GlcNHglycan	128	131	PF01048	0.384
MOD_GlcNHglycan	13	16	PF01048	0.431
MOD_GlcNHglycan	239	245	PF01048	0.693
MOD_GlcNHglycan	81	85	PF01048	0.419
MOD_GSK3_1	126	133	PF00069	0.428
MOD_GSK3_1	268	275	PF00069	0.312
MOD_GSK3_1	286	293	PF00069	0.312
MOD_GSK3_1	88	95	PF00069	0.487
MOD_N-GLC_1	41	46	PF02516	0.331
MOD_N-GLC_1	49	54	PF02516	0.331
MOD_NEK2_1	117	122	PF00069	0.469
MOD_NEK2_1	134	139	PF00069	0.326
MOD_NEK2_1	191	196	PF00069	0.308
MOD_NEK2_1	67	72	PF00069	0.377
MOD_NEK2_1	93	98	PF00069	0.410
MOD_PIKK_1	93	99	PF00454	0.368
MOD_PKA_2	154	160	PF00069	0.312
MOD_Plk_1	134	140	PF00069	0.425
MOD_Plk_1	159	165	PF00069	0.447
MOD_Plk_1	93	99	PF00069	0.504
MOD_Plk_2-3	154	160	PF00069	0.312
MOD_Plk_4	191	197	PF00069	0.302
MOD_Plk_4	257	263	PF00069	0.414
MOD_Plk_4	343	349	PF00069	0.384
MOD_ProDKin_1	41	47	PF00069	0.372
MOD_ProDKin_1	49	55	PF00069	0.286
MOD_ProDKin_1	88	94	PF00069	0.414
MOD_SUMO_for_1	226	229	PF00179	0.639
MOD_SUMO_for_1	244	247	PF00179	0.729
MOD_SUMO_rev_2	223	232	PF00179	0.745
MOD_SUMO_rev_2	240	250	PF00179	0.630
MOD_SUMO_rev_2	30	35	PF00179	0.352
MOD_SUMO_rev_2	366	376	PF00179	0.509
TRG_DiLeu_BaEn_2	145	151	PF01217	0.312
TRG_ENDOCYTIC_2	192	195	PF00928	0.305
TRG_ENDOCYTIC_2	26	29	PF00928	0.447
TRG_ENDOCYTIC_2	292	295	PF00928	0.312
TRG_ENDOCYTIC_2	4	7	PF00928	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSJ4	Leptomonas seymouri	80%	100%
A0A1X0NID9	Trypanosomatidae	68%	99%
A0A3R7LEF5	Trypanosoma rangeli	60%	89%
A0A3S7WQR4	Leishmania donovani	100%	100%
A2Q127	Equus caballus	32%	93%
A4H5S5	Leishmania braziliensis	91%	100%
A4HU18	Leishmania infantum	100%	100%
A4HU19	Leishmania infantum	100%	100%
D0A9I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	87%
D0A9K2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AMU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O04487	Arabidopsis thaliana	36%	98%
P12261	Artemia salina	29%	94%
P26641	Homo sapiens	32%	93%
P26642	Xenopus laevis	31%	93%
P29547	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	98%
P29694	Oryctolagus cuniculus	32%	93%
P34715	Trypanosoma cruzi	65%	99%
P36008	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	98%
P40921	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	99%
P54412	Caenorhabditis elegans	30%	100%
Q29387	Sus scrofa	32%	94%
Q3SZV3	Bos taurus	31%	92%
Q4R7H5	Macaca fascicularis	32%	93%
Q5Z627	Oryza sativa subsp. japonica	35%	97%
Q66NE0	Leishmania major	98%	100%
Q68FR6	Rattus norvegicus	32%	93%
Q6PE25	Danio rerio	32%	92%
Q6YW46	Oryza sativa subsp. japonica	36%	97%
Q90YC0	Carassius auratus	32%	92%
Q91375	Xenopus laevis	30%	93%
Q9D8N0	Mus musculus	33%	93%
Q9FUM1	Prunus avium	33%	96%
Q9FVT2	Arabidopsis thaliana	36%	98%
Q9NJH0	Drosophila melanogaster	30%	94%
Q9ZRI7	Oryza sativa subsp. japonica	36%	97%