Mannose-specific lectin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mannose-specific lectin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I8H3_LEIDO

TriTrypDb:

LdBPK_130560.1 , LdCL_130011000 , LDHU3_13.0750

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0000139	Golgi membrane	5	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031090	organelle membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A0A3Q8I8H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8H3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007029	endoplasmic reticulum organization	5	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0030246	carbohydrate binding	2	7
GO:0005537	mannose binding	4	1
GO:0036094	small molecule binding	2	1
GO:0048029	monosaccharide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.517
CLV_NRD_NRD_1	368	370	PF00675	0.671
CLV_NRD_NRD_1	383	385	PF00675	0.533
CLV_NRD_NRD_1	404	406	PF00675	0.769
CLV_NRD_NRD_1	407	409	PF00675	0.750
CLV_NRD_NRD_1	410	412	PF00675	0.725
CLV_PCSK_FUR_1	402	406	PF00082	0.799
CLV_PCSK_FUR_1	408	412	PF00082	0.812
CLV_PCSK_KEX2_1	138	140	PF00082	0.521
CLV_PCSK_KEX2_1	368	370	PF00082	0.667
CLV_PCSK_KEX2_1	383	385	PF00082	0.633
CLV_PCSK_KEX2_1	404	406	PF00082	0.763
CLV_PCSK_KEX2_1	407	409	PF00082	0.744
CLV_PCSK_KEX2_1	410	412	PF00082	0.726
CLV_PCSK_PC7_1	400	406	PF00082	0.696
CLV_PCSK_SKI1_1	17	21	PF00082	0.526
DEG_SCF_FBW7_2	8	15	PF00400	0.525
DOC_MAPK_gen_1	138	146	PF00069	0.355
DOC_MAPK_MEF2A_6	138	146	PF00069	0.355
DOC_MAPK_MEF2A_6	192	199	PF00069	0.318
DOC_PP1_RVXF_1	185	192	PF00149	0.343
DOC_PP2B_LxvP_1	216	219	PF13499	0.355
DOC_PP4_FxxP_1	112	115	PF00568	0.371
DOC_PP4_FxxP_1	117	120	PF00568	0.341
DOC_PP4_FxxP_1	28	31	PF00568	0.317
DOC_USP7_MATH_1	142	146	PF00917	0.332
DOC_WW_Pin1_4	243	248	PF00397	0.474
DOC_WW_Pin1_4	411	416	PF00397	0.814
DOC_WW_Pin1_4	8	13	PF00397	0.499
LIG_14-3-3_CanoR_1	119	124	PF00244	0.343
LIG_14-3-3_CanoR_1	258	263	PF00244	0.629
LIG_14-3-3_CanoR_1	281	287	PF00244	0.701
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BIR_III_3	1	5	PF00653	0.573
LIG_BRCT_BRCA1_1	169	173	PF00533	0.383
LIG_FHA_1	18	24	PF00498	0.451
LIG_FHA_1	206	212	PF00498	0.377
LIG_FHA_1	229	235	PF00498	0.342
LIG_FHA_1	262	268	PF00498	0.808
LIG_FHA_1	281	287	PF00498	0.756
LIG_FHA_1	350	356	PF00498	0.686
LIG_FHA_1	380	386	PF00498	0.702
LIG_FHA_1	66	72	PF00498	0.341
LIG_FHA_2	204	210	PF00498	0.358
LIG_HP1_1	142	146	PF01393	0.405
LIG_LIR_Apic_2	27	31	PF02991	0.317
LIG_LIR_Gen_1	239	249	PF02991	0.452
LIG_LIR_Gen_1	54	62	PF02991	0.322
LIG_LIR_Gen_1	80	90	PF02991	0.318
LIG_LIR_Nem_3	121	126	PF02991	0.357
LIG_LIR_Nem_3	174	178	PF02991	0.339
LIG_LIR_Nem_3	239	245	PF02991	0.340
LIG_LIR_Nem_3	54	60	PF02991	0.322
LIG_LIR_Nem_3	80	85	PF02991	0.293
LIG_MYND_1	8	12	PF01753	0.527
LIG_Pex14_2	126	130	PF04695	0.355
LIG_SH2_GRB2like	133	136	PF00017	0.355
LIG_SH2_GRB2like	273	276	PF00017	0.682
LIG_SH2_PTP2	57	60	PF00017	0.355
LIG_SH2_SRC	309	312	PF00017	0.715
LIG_SH2_SRC	321	324	PF00017	0.566
LIG_SH2_SRC	333	336	PF00017	0.643
LIG_SH2_STAP1	253	257	PF00017	0.578
LIG_SH2_STAP1	273	277	PF00017	0.683
LIG_SH2_STAT5	190	193	PF00017	0.368
LIG_SH2_STAT5	198	201	PF00017	0.328
LIG_SH2_STAT5	224	227	PF00017	0.298
LIG_SH2_STAT5	57	60	PF00017	0.317
LIG_SH3_3	103	109	PF00018	0.218
LIG_SH3_3	87	93	PF00018	0.405
LIG_TRAF2_1	12	15	PF00917	0.618
LIG_WW_3	108	112	PF00397	0.405
MOD_CDK_SPK_2	411	416	PF00069	0.770
MOD_CK1_1	167	173	PF00069	0.328
MOD_CK1_1	200	206	PF00069	0.405
MOD_CK1_1	228	234	PF00069	0.355
MOD_CK1_1	48	54	PF00069	0.353
MOD_CK2_1	203	209	PF00069	0.355
MOD_DYRK1A_RPxSP_1	411	415	PF00069	0.812
MOD_GlcNHglycan	227	230	PF01048	0.555
MOD_GlcNHglycan	347	350	PF01048	0.692
MOD_GlcNHglycan	47	50	PF01048	0.522
MOD_GSK3_1	228	235	PF00069	0.317
MOD_GSK3_1	257	264	PF00069	0.618
MOD_GSK3_1	281	288	PF00069	0.708
MOD_GSK3_1	345	352	PF00069	0.738
MOD_GSK3_1	47	54	PF00069	0.306
MOD_NEK2_1	164	169	PF00069	0.340
MOD_NEK2_1	211	216	PF00069	0.328
MOD_NEK2_1	225	230	PF00069	0.266
MOD_PIKK_1	312	318	PF00454	0.651
MOD_PIKK_1	324	330	PF00454	0.586
MOD_PIKK_1	63	69	PF00454	0.343
MOD_PKA_2	118	124	PF00069	0.343
MOD_PKA_2	200	206	PF00069	0.371
MOD_PKA_2	257	263	PF00069	0.613
MOD_PKA_2	280	286	PF00069	0.720
MOD_PKA_2	379	385	PF00069	0.715
MOD_PKA_2	58	64	PF00069	0.299
MOD_Plk_4	142	148	PF00069	0.355
MOD_Plk_4	291	297	PF00069	0.706
MOD_Plk_4	48	54	PF00069	0.355
MOD_ProDKin_1	243	249	PF00069	0.493
MOD_ProDKin_1	411	417	PF00069	0.814
MOD_ProDKin_1	8	14	PF00069	0.490
MOD_SUMO_for_1	191	194	PF00179	0.405
TRG_DiLeu_BaEn_4	387	393	PF01217	0.569
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.317
TRG_ENDOCYTIC_2	224	227	PF00928	0.298
TRG_ENDOCYTIC_2	57	60	PF00928	0.317
TRG_ENDOCYTIC_2	91	94	PF00928	0.343
TRG_ER_diArg_1	360	363	PF00400	0.711
TRG_ER_diArg_1	368	370	PF00400	0.673
TRG_ER_diArg_1	383	385	PF00400	0.513
TRG_ER_diArg_1	402	405	PF00400	0.765
TRG_ER_diArg_1	406	408	PF00400	0.745
TRG_ER_diArg_1	409	411	PF00400	0.724
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	368	372	PF00026	0.715
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD81	Leptomonas seymouri	62%	100%
A4H756	Leishmania braziliensis	72%	100%
A4HVJ5	Leishmania infantum	100%	100%
D0A6R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	78%
E9AP91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QG87	Leishmania major	96%	89%