Ras family protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras family protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8I8G7_LEIDO

TriTrypDb:

LdBPK_090900.1 , LdCL_090014400 , LDHU3_09.1050

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3Q8I8G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8G7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0003924	GTPase activity	7	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	174	176	PF00082	0.690
CLV_PCSK_KEX2_1	37	39	PF00082	0.346
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.725
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.346
CLV_PCSK_SKI1_1	111	115	PF00082	0.385
DEG_APCC_DBOX_1	18	26	PF00400	0.421
DOC_CDC14_PxL_1	1	9	PF14671	0.546
DOC_MAPK_MEF2A_6	47	56	PF00069	0.322
DOC_PP1_RVXF_1	96	102	PF00149	0.322
DOC_PP2B_PxIxI_1	49	55	PF00149	0.322
DOC_USP7_MATH_1	154	158	PF00917	0.558
DOC_USP7_MATH_1	176	180	PF00917	0.692
DOC_USP7_MATH_1	92	96	PF00917	0.359
DOC_WW_Pin1_4	74	79	PF00397	0.698
LIG_14-3-3_CanoR_1	131	137	PF00244	0.455
LIG_14-3-3_CanoR_1	175	182	PF00244	0.750
LIG_14-3-3_CanoR_1	72	76	PF00244	0.622
LIG_eIF4E_1	17	23	PF01652	0.523
LIG_FHA_1	49	55	PF00498	0.322
LIG_FHA_2	11	17	PF00498	0.640
LIG_HP1_1	200	204	PF01393	0.421
LIG_LIR_LC3C_4	258	262	PF02991	0.463
LIG_LIR_Nem_3	107	113	PF02991	0.325
LIG_LIR_Nem_3	135	139	PF02991	0.323
LIG_LIR_Nem_3	14	20	PF02991	0.488
LIG_LYPXL_yS_3	17	20	PF13949	0.544
LIG_MYND_1	5	9	PF01753	0.482
LIG_PTB_Apo_2	112	119	PF02174	0.322
LIG_PTB_Phospho_1	112	118	PF10480	0.322
LIG_Rb_pABgroove_1	122	130	PF01858	0.463
LIG_SH2_NCK_1	118	122	PF00017	0.378
LIG_SH2_STAP1	243	247	PF00017	0.421
LIG_SH2_STAT5	149	152	PF00017	0.421
LIG_SH2_STAT5	39	42	PF00017	0.322
LIG_SH2_STAT5	48	51	PF00017	0.133
LIG_SH3_3	2	8	PF00018	0.593
LIG_SH3_3	73	79	PF00018	0.629
LIG_SUMO_SIM_par_1	21	27	PF11976	0.322
LIG_SxIP_EBH_1	86	98	PF03271	0.563
LIG_TYR_ITIM	15	20	PF00017	0.576
MOD_CK1_1	132	138	PF00069	0.472
MOD_CK1_1	177	183	PF00069	0.531
MOD_CK1_1	246	252	PF00069	0.303
MOD_CK1_1	74	80	PF00069	0.695
MOD_Cter_Amidation	172	175	PF01082	0.732
MOD_GlcNHglycan	103	107	PF01048	0.233
MOD_GlcNHglycan	131	134	PF01048	0.308
MOD_GlcNHglycan	156	159	PF01048	0.648
MOD_GlcNHglycan	176	179	PF01048	0.680
MOD_GlcNHglycan	183	186	PF01048	0.633
MOD_GlcNHglycan	244	248	PF01048	0.322
MOD_GlcNHglycan	84	87	PF01048	0.671
MOD_GlcNHglycan	90	93	PF01048	0.506
MOD_GlcNHglycan	94	97	PF01048	0.407
MOD_GSK3_1	174	181	PF00069	0.708
MOD_GSK3_1	242	249	PF00069	0.304
MOD_GSK3_1	70	77	PF00069	0.535
MOD_GSK3_1	88	95	PF00069	0.634
MOD_PKA_1	174	180	PF00069	0.713
MOD_PKA_2	174	180	PF00069	0.713
MOD_PKA_2	71	77	PF00069	0.677
MOD_PKB_1	221	229	PF00069	0.421
MOD_Plk_1	144	150	PF00069	0.358
MOD_Plk_1	209	215	PF00069	0.402
MOD_Plk_4	144	150	PF00069	0.395
MOD_ProDKin_1	74	80	PF00069	0.703
TRG_ENDOCYTIC_2	110	113	PF00928	0.346
TRG_ENDOCYTIC_2	17	20	PF00928	0.544
TRG_ER_diArg_1	220	223	PF00400	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P8	Leptomonas seymouri	26%	100%
A0A0N1I011	Leptomonas seymouri	25%	100%
A0A0N1I5E3	Leptomonas seymouri	28%	100%
A0A0N1I9K4	Leptomonas seymouri	25%	100%
A0A0N1PE58	Leptomonas seymouri	66%	100%
A0A0S4IRD6	Bodo saltans	25%	100%
A0A0S4KHE5	Bodo saltans	24%	100%
A0A1X0NN55	Trypanosomatidae	42%	100%
A0A1X0NQG4	Trypanosomatidae	29%	100%
A0A1X0NVM5	Trypanosomatidae	25%	100%
A0A3Q8ICX9	Leishmania donovani	26%	100%
A0A3Q8ID64	Leishmania donovani	26%	89%
A0A3Q8IE68	Leishmania donovani	28%	100%
A0A3R7N3U0	Trypanosoma rangeli	45%	100%
A0A3R7N9H9	Trypanosoma rangeli	26%	100%
A0A3R7RHV7	Trypanosoma rangeli	29%	100%
A0A3S5H6H3	Leishmania donovani	28%	100%
A0A3S7WV84	Leishmania donovani	26%	100%
A0A422P0L6	Trypanosoma rangeli	24%	100%
A4H5R6	Leishmania braziliensis	79%	100%
A4H6A5	Leishmania braziliensis	27%	92%
A4H9M3	Leishmania braziliensis	26%	89%
A4HKJ3	Leishmania braziliensis	26%	89%
A4HU06	Leishmania infantum	100%	100%
A4HUM9	Leishmania infantum	28%	92%
A4HXY7	Leishmania infantum	26%	89%
A4I7N3	Leishmania infantum	26%	85%
A4I825	Leishmania infantum	26%	89%
A5D7F5	Bos taurus	33%	99%
D0A5C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A9H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AD53	Leishmania major	28%	100%
E9AHE8	Leishmania infantum	28%	100%
E9AMT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9ANC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	92%
E9ARQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	91%
E9AYX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B2H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	85%
E9B2Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	89%
F1PTE3	Canis lupus familiaris	27%	100%
O00194	Homo sapiens	31%	100%
O14966	Homo sapiens	24%	100%
O24466	Arabidopsis thaliana	27%	100%
O80501	Arabidopsis thaliana	25%	100%
P17609	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P20790	Dictyostelium discoideum	25%	100%
P20791	Dictyostelium discoideum	25%	100%
P23640	Rattus norvegicus	29%	100%
P28186	Arabidopsis thaliana	27%	100%
P35286	Rattus norvegicus	27%	100%
P35293	Mus musculus	26%	100%
P36861	Volvox carteri	28%	100%
P41924	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	100%
P51153	Homo sapiens	27%	100%
P51159	Homo sapiens	28%	100%
Q08DE8	Bos taurus	24%	100%
Q0IIG8	Bos taurus	26%	100%
Q1HE58	Canis lupus familiaris	28%	100%
Q39433	Beta vulgaris	27%	100%
Q4LE85	Sus scrofa	28%	100%
Q4Q573	Leishmania major	26%	89%
Q4Q5N4	Leishmania major	26%	85%
Q4QDS9	Leishmania major	25%	91%
Q4QH97	Leishmania major	28%	92%
Q4QHT9	Leishmania major	88%	100%
Q58DS5	Bos taurus	27%	100%
Q5EB77	Rattus norvegicus	26%	100%
Q5KTJ6	Mesocricetus auratus	27%	100%
Q5M7D1	Xenopus laevis	29%	97%
Q5R5H5	Pongo abelii	26%	100%
Q5R7A4	Pongo abelii	24%	100%
Q5RDE5	Pongo abelii	33%	99%
Q5ZLG1	Gallus gallus	26%	100%
Q63481	Rattus norvegicus	25%	100%
Q6DHC1	Danio rerio	26%	100%
Q6DUB4	Paramecium octaurelia	24%	100%
Q6IMK3	Danio rerio	33%	99%
Q6IML7	Rattus norvegicus	31%	99%
Q6IMM1	Gallus gallus	33%	99%
Q7T3A4	Danio rerio	27%	100%
Q7ZYF1	Xenopus laevis	30%	99%
Q8CFP6	Mus musculus	32%	99%
Q8HZJ5	Bos taurus	30%	100%
Q8VEA8	Mus musculus	22%	100%
Q91YQ1	Mus musculus	25%	100%
Q95UJ0	Paramecium octaurelia	24%	100%
Q99P58	Mus musculus	30%	100%
Q99P74	Rattus norvegicus	29%	100%
Q9DD03	Mus musculus	26%	100%
Q9ERI2	Mus musculus	28%	100%
Q9GP33	Echinococcus multilocularis	24%	100%
Q9LFT9	Arabidopsis thaliana	24%	100%
Q9LV79	Arabidopsis thaliana	26%	100%
Q9LZD4	Arabidopsis thaliana	26%	100%
Q9NP72	Homo sapiens	26%	100%
Q9NZQ0	Homo sapiens	33%	99%
Q9SF91	Arabidopsis thaliana	26%	100%
Q9SID8	Arabidopsis thaliana	24%	100%
Q9SJ11	Arabidopsis thaliana	23%	100%
Q9SMR4	Arabidopsis thaliana	23%	100%
V5BBM5	Trypanosoma cruzi	26%	100%