Histidine_phosphatase_superfamily_(Branch_1)_puta tive/Pfam:PF00300

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine phosphatase superfamily (branch 1), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I8G2_LEIDO

TriTrypDb:

LdBPK_130380.1 , LdCL_130009200 , LDHU3_13.0540

Length:

512

Annotations

Annotations by Jardim et al.

Transporters, Plasma-membrane choline transporter

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I8G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8G2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.623
CLV_NRD_NRD_1	121	123	PF00675	0.375
CLV_NRD_NRD_1	288	290	PF00675	0.692
CLV_NRD_NRD_1	322	324	PF00675	0.389
CLV_NRD_NRD_1	355	357	PF00675	0.516
CLV_NRD_NRD_1	443	445	PF00675	0.559
CLV_PCSK_FUR_1	441	445	PF00082	0.516
CLV_PCSK_KEX2_1	126	128	PF00082	0.421
CLV_PCSK_KEX2_1	288	290	PF00082	0.724
CLV_PCSK_KEX2_1	322	324	PF00082	0.389
CLV_PCSK_KEX2_1	427	429	PF00082	0.338
CLV_PCSK_KEX2_1	441	443	PF00082	0.578
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.438
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.289
CLV_PCSK_PC7_1	122	128	PF00082	0.306
CLV_PCSK_PC7_1	284	290	PF00082	0.603
CLV_PCSK_SKI1_1	201	205	PF00082	0.577
CLV_PCSK_SKI1_1	289	293	PF00082	0.646
DEG_SCF_FBW7_1	475	481	PF00400	0.581
DEG_SPOP_SBC_1	263	267	PF00917	0.311
DOC_CDC14_PxL_1	176	184	PF14671	0.439
DOC_CKS1_1	475	480	PF01111	0.637
DOC_CYCLIN_yCln2_LP_2	383	386	PF00134	0.354
DOC_MAPK_DCC_7	480	489	PF00069	0.589
DOC_MAPK_gen_1	126	136	PF00069	0.372
DOC_MAPK_gen_1	480	489	PF00069	0.504
DOC_MAPK_gen_1	85	95	PF00069	0.347
DOC_PP1_RVXF_1	199	205	PF00149	0.448
DOC_PP2B_LxvP_1	383	386	PF13499	0.354
DOC_PP2B_LxvP_1	44	47	PF13499	0.486
DOC_USP7_MATH_1	17	21	PF00917	0.673
DOC_USP7_MATH_1	264	268	PF00917	0.421
DOC_USP7_MATH_1	274	278	PF00917	0.487
DOC_USP7_MATH_1	290	294	PF00917	0.642
DOC_USP7_MATH_1	337	341	PF00917	0.457
DOC_USP7_MATH_1	419	423	PF00917	0.355
DOC_USP7_MATH_1	446	450	PF00917	0.612
DOC_USP7_MATH_1	495	499	PF00917	0.462
DOC_USP7_UBL2_3	408	412	PF12436	0.544
DOC_USP7_UBL2_3	459	463	PF12436	0.701
DOC_WW_Pin1_4	135	140	PF00397	0.279
DOC_WW_Pin1_4	294	299	PF00397	0.660
DOC_WW_Pin1_4	465	470	PF00397	0.564
DOC_WW_Pin1_4	474	479	PF00397	0.756
DOC_WW_Pin1_4	482	487	PF00397	0.688
LIG_14-3-3_CanoR_1	105	110	PF00244	0.417
LIG_14-3-3_CanoR_1	129	135	PF00244	0.445
LIG_14-3-3_CanoR_1	212	216	PF00244	0.493
LIG_14-3-3_CanoR_1	289	298	PF00244	0.787
LIG_14-3-3_CanoR_1	34	41	PF00244	0.504
LIG_APCC_ABBA_1	159	164	PF00400	0.279
LIG_APCC_ABBAyCdc20_2	158	164	PF00400	0.279
LIG_BIR_II_1	1	5	PF00653	0.604
LIG_BRCT_BRCA1_1	328	332	PF00533	0.355
LIG_BRCT_BRCA1_1	67	71	PF00533	0.385
LIG_deltaCOP1_diTrp_1	169	176	PF00928	0.370
LIG_DLG_GKlike_1	105	113	PF00625	0.402
LIG_FHA_1	129	135	PF00498	0.385
LIG_FHA_1	144	150	PF00498	0.255
LIG_FHA_1	176	182	PF00498	0.500
LIG_FHA_1	225	231	PF00498	0.490
LIG_FHA_1	264	270	PF00498	0.435
LIG_FHA_1	328	334	PF00498	0.424
LIG_FHA_1	474	480	PF00498	0.697
LIG_FHA_1	502	508	PF00498	0.510
LIG_FHA_2	243	249	PF00498	0.514
LIG_FHA_2	310	316	PF00498	0.484
LIG_FHA_2	391	397	PF00498	0.328
LIG_FHA_2	398	404	PF00498	0.337
LIG_FHA_2	435	441	PF00498	0.477
LIG_LIR_Gen_1	131	140	PF02991	0.391
LIG_LIR_Gen_1	417	426	PF02991	0.382
LIG_LIR_Gen_1	68	78	PF02991	0.270
LIG_LIR_Nem_3	131	135	PF02991	0.381
LIG_LIR_Nem_3	241	246	PF02991	0.407
LIG_LIR_Nem_3	417	423	PF02991	0.391
LIG_LIR_Nem_3	68	74	PF02991	0.393
LIG_MYND_1	381	385	PF01753	0.502
LIG_Rb_pABgroove_1	90	98	PF01858	0.378
LIG_SH2_CRK	416	420	PF00017	0.447
LIG_SH2_CRK	433	437	PF00017	0.470
LIG_SH2_CRK	96	100	PF00017	0.402
LIG_SH2_NCK_1	416	420	PF00017	0.536
LIG_SH2_PTP2	162	165	PF00017	0.410
LIG_SH2_SRC	162	165	PF00017	0.410
LIG_SH2_SRC	96	99	PF00017	0.402
LIG_SH2_STAT5	115	118	PF00017	0.355
LIG_SH2_STAT5	162	165	PF00017	0.410
LIG_SH2_STAT5	186	189	PF00017	0.436
LIG_SH2_STAT5	363	366	PF00017	0.452
LIG_SH2_STAT5	420	423	PF00017	0.353
LIG_SH3_1	480	486	PF00018	0.525
LIG_SH3_2	14	19	PF14604	0.619
LIG_SH3_3	11	17	PF00018	0.613
LIG_SH3_3	189	195	PF00018	0.708
LIG_SH3_3	308	314	PF00018	0.432
LIG_SH3_3	401	407	PF00018	0.453
LIG_SH3_3	480	486	PF00018	0.640
LIG_SUMO_SIM_anti_2	39	45	PF11976	0.511
LIG_SUMO_SIM_anti_2	498	504	PF11976	0.398
LIG_SUMO_SIM_par_1	344	350	PF11976	0.447
LIG_SxIP_EBH_1	212	222	PF03271	0.425
LIG_TRAF2_1	223	226	PF00917	0.505
LIG_TRAF2_1	437	440	PF00917	0.496
LIG_TYR_ITIM	113	118	PF00017	0.410
LIG_TYR_ITIM	418	423	PF00017	0.376
LIG_UBA3_1	215	220	PF00899	0.420
LIG_WRC_WIRS_1	106	111	PF05994	0.306
MOD_CDK_SPK_2	294	299	PF00069	0.612
MOD_CDK_SPxK_1	474	480	PF00069	0.591
MOD_CDK_SPxxK_3	135	142	PF00069	0.279
MOD_CDK_SPxxK_3	465	472	PF00069	0.566
MOD_CK1_1	108	114	PF00069	0.410
MOD_CK1_1	185	191	PF00069	0.619
MOD_CK1_1	294	300	PF00069	0.790
MOD_CK1_1	422	428	PF00069	0.431
MOD_CK1_1	447	453	PF00069	0.633
MOD_CK2_1	18	24	PF00069	0.620
MOD_CK2_1	242	248	PF00069	0.408
MOD_CK2_1	264	270	PF00069	0.487
MOD_CK2_1	309	315	PF00069	0.431
MOD_CK2_1	397	403	PF00069	0.394
MOD_CK2_1	434	440	PF00069	0.586
MOD_DYRK1A_RPxSP_1	482	486	PF00069	0.562
MOD_GlcNHglycan	188	191	PF01048	0.566
MOD_GlcNHglycan	240	243	PF01048	0.497
MOD_GlcNHglycan	266	269	PF01048	0.382
MOD_GlcNHglycan	35	38	PF01048	0.691
MOD_GlcNHglycan	376	379	PF01048	0.538
MOD_GlcNHglycan	58	61	PF01048	0.468
MOD_GSK3_1	18	25	PF00069	0.620
MOD_GSK3_1	182	189	PF00069	0.495
MOD_GSK3_1	238	245	PF00069	0.441
MOD_GSK3_1	258	265	PF00069	0.365
MOD_GSK3_1	274	281	PF00069	0.543
MOD_GSK3_1	290	297	PF00069	0.773
MOD_GSK3_1	4	11	PF00069	0.621
MOD_GSK3_1	474	481	PF00069	0.725
MOD_GSK3_1	49	56	PF00069	0.567
MOD_N-GLC_1	17	22	PF02516	0.618
MOD_N-GLC_1	30	35	PF02516	0.595
MOD_NEK2_1	182	187	PF00069	0.491
MOD_NEK2_1	211	216	PF00069	0.337
MOD_NEK2_1	218	223	PF00069	0.343
MOD_NEK2_1	390	395	PF00069	0.326
MOD_NEK2_1	49	54	PF00069	0.558
MOD_NEK2_1	501	506	PF00069	0.600
MOD_NEK2_2	130	135	PF00069	0.410
MOD_PIKK_1	291	297	PF00454	0.790
MOD_PK_1	444	450	PF00069	0.449
MOD_PKA_2	128	134	PF00069	0.421
MOD_PKA_2	18	24	PF00069	0.620
MOD_PKA_2	211	217	PF00069	0.496
MOD_PKA_2	283	289	PF00069	0.726
MOD_PKA_2	33	39	PF00069	0.544
MOD_PKA_2	355	361	PF00069	0.502
MOD_PKA_2	374	380	PF00069	0.520
MOD_PKA_2	56	62	PF00069	0.460
MOD_PKB_1	442	450	PF00069	0.598
MOD_Plk_1	17	23	PF00069	0.617
MOD_Plk_1	39	45	PF00069	0.409
MOD_Plk_1	444	450	PF00069	0.454
MOD_Plk_4	211	217	PF00069	0.349
MOD_Plk_4	339	345	PF00069	0.493
MOD_Plk_4	39	45	PF00069	0.538
MOD_Plk_4	397	403	PF00069	0.482
MOD_ProDKin_1	135	141	PF00069	0.279
MOD_ProDKin_1	294	300	PF00069	0.659
MOD_ProDKin_1	465	471	PF00069	0.564
MOD_ProDKin_1	474	480	PF00069	0.753
MOD_ProDKin_1	482	488	PF00069	0.687
MOD_SUMO_rev_2	267	274	PF00179	0.408
TRG_DiLeu_BaEn_1	225	230	PF01217	0.534
TRG_DiLeu_BaEn_4	225	231	PF01217	0.536
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.260
TRG_DiLeu_BaLyEn_6	198	203	PF01217	0.421
TRG_ENDOCYTIC_2	115	118	PF00928	0.410
TRG_ENDOCYTIC_2	363	366	PF00928	0.440
TRG_ENDOCYTIC_2	420	423	PF00928	0.409
TRG_ENDOCYTIC_2	432	435	PF00928	0.474
TRG_ER_diArg_1	321	323	PF00400	0.432
TRG_ER_diArg_1	441	444	PF00400	0.582
TRG_ER_diArg_1	479	482	PF00400	0.663
TRG_ER_diArg_1	502	505	PF00400	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P925	Leptomonas seymouri	65%	100%
A0A1X0NN77	Trypanosomatidae	33%	100%
A0A3R7KJL2	Trypanosoma rangeli	35%	100%
A4H738	Leishmania braziliensis	83%	100%
A4HVH8	Leishmania infantum	100%	100%
D0A6T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AP73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QGA5	Leishmania major	94%	100%
V5BFH7	Trypanosoma cruzi	38%	100%