Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I8F6_LEIDO

TriTrypDb:

LdBPK_090690.1 , LdCL_090012000 , LDHU3_09.0830

Length:

500

Annotations

Annotations by Jardim et al.

Protein pamitoylation, Palmitoyltransferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	12
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

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Expansion

Sequence features

A0A3Q8I8F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8F6

Function

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Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016409	palmitoyltransferase activity	5	12
GO:0016417	S-acyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	12
GO:0019707	protein-cysteine S-acyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	190	192	PF00675	0.409
CLV_NRD_NRD_1	269	271	PF00675	0.260
CLV_NRD_NRD_1	409	411	PF00675	0.380
CLV_NRD_NRD_1	421	423	PF00675	0.296
CLV_NRD_NRD_1	452	454	PF00675	0.318
CLV_NRD_NRD_1	63	65	PF00675	0.338
CLV_PCSK_KEX2_1	163	165	PF00082	0.405
CLV_PCSK_KEX2_1	190	192	PF00082	0.418
CLV_PCSK_KEX2_1	269	271	PF00082	0.241
CLV_PCSK_KEX2_1	454	456	PF00082	0.407

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD29	Leptomonas seymouri	64%	98%
A0A0S4JKC0	Bodo saltans	37%	100%
A0A1X0NN08	Trypanosomatidae	50%	100%
A0A3R7L7T0	Trypanosoma rangeli	48%	100%
A4H5P5	Leishmania braziliensis	82%	100%
A4HTY5	Leishmania infantum	100%	100%
D0A9E1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AMR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHW0	Leishmania major	94%	100%
V5BSN7	Trypanosoma cruzi	49%	97%

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