FAM91 N-terminus/FAM91 C-terminus, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAM91 N-terminus/FAM91 C-terminus, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I8D6_LEIDO

TriTrypDb:

LdBPK_120900.1 , LdCL_120021100 , LDHU3_12.1700

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I8D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I8D6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.373
CLV_C14_Caspase3-7	376	380	PF00656	0.598
CLV_NRD_NRD_1	473	475	PF00675	0.374
CLV_NRD_NRD_1	651	653	PF00675	0.278
CLV_NRD_NRD_1	834	836	PF00675	0.267
CLV_PCSK_KEX2_1	190	192	PF00082	0.320
CLV_PCSK_KEX2_1	397	399	PF00082	0.240
CLV_PCSK_KEX2_1	423	425	PF00082	0.261
CLV_PCSK_KEX2_1	473	475	PF00082	0.288
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.320
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.319
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.261
CLV_PCSK_SKI1_1	241	245	PF00082	0.435
CLV_PCSK_SKI1_1	398	402	PF00082	0.240
CLV_PCSK_SKI1_1	473	477	PF00082	0.280
CLV_Separin_Metazoa	70	74	PF03568	0.305
DEG_APCC_DBOX_1	297	305	PF00400	0.284
DEG_APCC_DBOX_1	472	480	PF00400	0.259
DEG_SIAH_1	167	175	PF03145	0.207
DOC_CDC14_PxL_1	264	272	PF14671	0.354
DOC_CKS1_1	222	227	PF01111	0.261
DOC_CKS1_1	735	740	PF01111	0.185
DOC_CYCLIN_yCln2_LP_2	760	766	PF00134	0.373
DOC_MAPK_DCC_7	557	567	PF00069	0.259
DOC_MAPK_gen_1	423	430	PF00069	0.261
DOC_MAPK_gen_1	557	567	PF00069	0.373
DOC_MAPK_MEF2A_6	560	569	PF00069	0.377
DOC_MAPK_MEF2A_6	751	760	PF00069	0.239
DOC_MAPK_RevD_3	639	653	PF00069	0.207
DOC_MIT_MIM_1	186	195	PF04212	0.373
DOC_PP1_RVXF_1	146	152	PF00149	0.220
DOC_PP1_RVXF_1	356	363	PF00149	0.396
DOC_PP1_RVXF_1	447	453	PF00149	0.305
DOC_PP2B_LxvP_1	565	568	PF13499	0.283
DOC_PP2B_LxvP_1	760	763	PF13499	0.283
DOC_PP2B_PxIxI_1	527	533	PF00149	0.240
DOC_USP7_MATH_1	13	17	PF00917	0.227
DOC_USP7_MATH_1	388	392	PF00917	0.576
DOC_USP7_MATH_1	393	397	PF00917	0.412
DOC_USP7_MATH_1	594	598	PF00917	0.304
DOC_WW_Pin1_4	193	198	PF00397	0.305
DOC_WW_Pin1_4	221	226	PF00397	0.375
DOC_WW_Pin1_4	257	262	PF00397	0.293
DOC_WW_Pin1_4	29	34	PF00397	0.373
DOC_WW_Pin1_4	329	334	PF00397	0.261
DOC_WW_Pin1_4	519	524	PF00397	0.240
DOC_WW_Pin1_4	544	549	PF00397	0.240
DOC_WW_Pin1_4	734	739	PF00397	0.270
DOC_WW_Pin1_4	94	99	PF00397	0.240
LIG_14-3-3_CanoR_1	278	286	PF00244	0.235
LIG_14-3-3_CanoR_1	290	296	PF00244	0.254
LIG_14-3-3_CanoR_1	298	302	PF00244	0.132
LIG_14-3-3_CanoR_1	507	511	PF00244	0.240
LIG_14-3-3_CanoR_1	608	613	PF00244	0.283
LIG_14-3-3_CanoR_1	718	724	PF00244	0.261
LIG_14-3-3_CanoR_1	806	811	PF00244	0.319
LIG_AP2alpha_2	173	175	PF02296	0.373
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_BIR_III_2	775	779	PF00653	0.320
LIG_BIR_III_2	862	866	PF00653	0.489
LIG_CaM_IQ_9	316	331	PF13499	0.340
LIG_Clathr_ClatBox_1	307	311	PF01394	0.220
LIG_Clathr_ClatBox_1	493	497	PF01394	0.373
LIG_Clathr_ClatBox_1	529	533	PF01394	0.373
LIG_Clathr_ClatBox_1	849	853	PF01394	0.373
LIG_deltaCOP1_diTrp_1	451	458	PF00928	0.305
LIG_eIF4E_1	161	167	PF01652	0.354
LIG_FHA_1	140	146	PF00498	0.240
LIG_FHA_1	182	188	PF00498	0.333
LIG_FHA_1	209	215	PF00498	0.403
LIG_FHA_1	234	240	PF00498	0.239
LIG_FHA_1	36	42	PF00498	0.283
LIG_FHA_1	406	412	PF00498	0.243
LIG_FHA_1	519	525	PF00498	0.259
LIG_FHA_1	596	602	PF00498	0.185
LIG_FHA_1	609	615	PF00498	0.361
LIG_FHA_1	634	640	PF00498	0.281
LIG_FHA_1	709	715	PF00498	0.423
LIG_FHA_1	809	815	PF00498	0.373
LIG_FHA_1	824	830	PF00498	0.305
LIG_FHA_2	121	127	PF00498	0.240
LIG_FHA_2	277	283	PF00498	0.240
LIG_FHA_2	292	298	PF00498	0.240
LIG_FHA_2	30	36	PF00498	0.373
LIG_FHA_2	387	393	PF00498	0.528
LIG_FHA_2	617	623	PF00498	0.185
LIG_FHA_2	696	702	PF00498	0.305
LIG_FHA_2	763	769	PF00498	0.373
LIG_Integrin_RGD_1	702	704	PF01839	0.185
LIG_LIR_Apic_2	236	240	PF02991	0.373
LIG_LIR_Gen_1	103	110	PF02991	0.261
LIG_LIR_Gen_1	113	124	PF02991	0.244
LIG_LIR_Gen_1	262	270	PF02991	0.371
LIG_LIR_Gen_1	408	416	PF02991	0.319
LIG_LIR_Gen_1	505	515	PF02991	0.240
LIG_LIR_Gen_1	546	555	PF02991	0.244
LIG_LIR_Gen_1	617	628	PF02991	0.319
LIG_LIR_Gen_1	65	76	PF02991	0.321
LIG_LIR_Gen_1	660	671	PF02991	0.282
LIG_LIR_Gen_1	704	715	PF02991	0.346
LIG_LIR_Gen_1	722	732	PF02991	0.373
LIG_LIR_Gen_1	745	755	PF02991	0.258
LIG_LIR_Gen_1	805	814	PF02991	0.319
LIG_LIR_Nem_3	100	105	PF02991	0.303
LIG_LIR_Nem_3	113	119	PF02991	0.181
LIG_LIR_Nem_3	173	178	PF02991	0.319
LIG_LIR_Nem_3	262	267	PF02991	0.371
LIG_LIR_Nem_3	505	511	PF02991	0.243
LIG_LIR_Nem_3	546	552	PF02991	0.244
LIG_LIR_Nem_3	617	623	PF02991	0.351
LIG_LIR_Nem_3	660	666	PF02991	0.282
LIG_LIR_Nem_3	704	710	PF02991	0.346
LIG_LIR_Nem_3	722	728	PF02991	0.321
LIG_LIR_Nem_3	729	735	PF02991	0.322
LIG_LIR_Nem_3	745	750	PF02991	0.258
LIG_LIR_Nem_3	799	803	PF02991	0.288
LIG_LIR_Nem_3	805	810	PF02991	0.289
LIG_LIR_Nem_3	851	855	PF02991	0.294
LIG_LYPXL_S_1	81	85	PF13949	0.283
LIG_LYPXL_yS_3	82	85	PF13949	0.261
LIG_NRBOX	303	309	PF00104	0.240
LIG_Pex14_1	549	553	PF04695	0.240
LIG_Rb_pABgroove_1	397	405	PF01858	0.240
LIG_SH2_CRK	102	106	PF00017	0.343
LIG_SH2_CRK	116	120	PF00017	0.167
LIG_SH2_CRK	20	24	PF00017	0.319
LIG_SH2_CRK	203	207	PF00017	0.295
LIG_SH2_CRK	289	293	PF00017	0.240
LIG_SH2_CRK	508	512	PF00017	0.240
LIG_SH2_CRK	555	559	PF00017	0.373
LIG_SH2_CRK	603	607	PF00017	0.373
LIG_SH2_CRK	807	811	PF00017	0.296
LIG_SH2_GRB2like	157	160	PF00017	0.319
LIG_SH2_GRB2like	465	468	PF00017	0.373
LIG_SH2_NCK_1	437	441	PF00017	0.305
LIG_SH2_PTP2	264	267	PF00017	0.373
LIG_SH2_SRC	161	164	PF00017	0.281
LIG_SH2_SRC	465	468	PF00017	0.319
LIG_SH2_STAP1	183	187	PF00017	0.378
LIG_SH2_STAP1	235	239	PF00017	0.263
LIG_SH2_STAP1	403	407	PF00017	0.240
LIG_SH2_STAP1	603	607	PF00017	0.239
LIG_SH2_STAT3	34	37	PF00017	0.312
LIG_SH2_STAT3	365	368	PF00017	0.485
LIG_SH2_STAT3	84	87	PF00017	0.373
LIG_SH2_STAT5	102	105	PF00017	0.175
LIG_SH2_STAT5	138	141	PF00017	0.279
LIG_SH2_STAT5	157	160	PF00017	0.268
LIG_SH2_STAT5	161	164	PF00017	0.249
LIG_SH2_STAT5	183	186	PF00017	0.354
LIG_SH2_STAT5	235	238	PF00017	0.308
LIG_SH2_STAT5	264	267	PF00017	0.394
LIG_SH2_STAT5	465	468	PF00017	0.296
LIG_SH2_STAT5	518	521	PF00017	0.283
LIG_SH2_STAT5	555	558	PF00017	0.292
LIG_SH2_STAT5	620	623	PF00017	0.237
LIG_SH2_STAT5	725	728	PF00017	0.408
LIG_SH2_STAT5	754	757	PF00017	0.351
LIG_SH2_STAT5	84	87	PF00017	0.276
LIG_SH2_STAT5	93	96	PF00017	0.230
LIG_SH3_2	333	338	PF14604	0.185
LIG_SH3_3	262	268	PF00018	0.286
LIG_SH3_3	330	336	PF00018	0.283
LIG_SH3_3	479	485	PF00018	0.292
LIG_SH3_3	665	671	PF00018	0.259
LIG_SUMO_SIM_anti_2	624	632	PF11976	0.262
LIG_SUMO_SIM_anti_2	695	701	PF11976	0.450
LIG_SUMO_SIM_par_1	306	314	PF11976	0.278
LIG_SUMO_SIM_par_1	528	533	PF11976	0.319
LIG_SUMO_SIM_par_1	624	632	PF11976	0.262
LIG_TRAF2_1	350	353	PF00917	0.354
LIG_TRFH_1	20	24	PF08558	0.373
LIG_TYR_ITIM	201	206	PF00017	0.261
LIG_TYR_ITIM	287	292	PF00017	0.259
LIG_TYR_ITIM	601	606	PF00017	0.373
LIG_TYR_ITIM	618	623	PF00017	0.119
LIG_UBA3_1	105	111	PF00899	0.202
LIG_UBA3_1	550	557	PF00899	0.321
LIG_WRC_WIRS_1	254	259	PF05994	0.400
LIG_WRC_WIRS_1	725	730	PF05994	0.305
LIG_WRC_WIRS_1	849	854	PF05994	0.305
MOD_CK1_1	100	106	PF00069	0.254
MOD_CK1_1	177	183	PF00069	0.426
MOD_CK1_1	208	214	PF00069	0.319
MOD_CK1_1	334	340	PF00069	0.185
MOD_CK1_1	522	528	PF00069	0.257
MOD_CK1_1	540	546	PF00069	0.175
MOD_CK1_1	589	595	PF00069	0.436
MOD_CK1_1	708	714	PF00069	0.305
MOD_CK1_1	808	814	PF00069	0.277
MOD_CK1_1	822	828	PF00069	0.376
MOD_CK2_1	347	353	PF00069	0.295
MOD_CK2_1	495	501	PF00069	0.259
MOD_CK2_1	739	745	PF00069	0.329
MOD_CK2_1	762	768	PF00069	0.456
MOD_GlcNHglycan	163	166	PF01048	0.347
MOD_GlcNHglycan	168	171	PF01048	0.331
MOD_GlcNHglycan	524	527	PF01048	0.373
MOD_GlcNHglycan	590	594	PF01048	0.375
MOD_GlcNHglycan	672	675	PF01048	0.305
MOD_GlcNHglycan	692	695	PF01048	0.325
MOD_GSK3_1	177	184	PF00069	0.387
MOD_GSK3_1	253	260	PF00069	0.283
MOD_GSK3_1	414	421	PF00069	0.262
MOD_GSK3_1	502	509	PF00069	0.279
MOD_GSK3_1	518	525	PF00069	0.279
MOD_GSK3_1	540	547	PF00069	0.240
MOD_GSK3_1	618	625	PF00069	0.261
MOD_GSK3_1	666	673	PF00069	0.313
MOD_GSK3_1	724	731	PF00069	0.301
MOD_GSK3_1	779	786	PF00069	0.411
MOD_GSK3_1	816	823	PF00069	0.322
MOD_GSK3_1	853	860	PF00069	0.359
MOD_N-GLC_1	120	125	PF02516	0.240
MOD_N-GLC_1	153	158	PF02516	0.239
MOD_N-GLC_1	276	281	PF02516	0.240
MOD_N-GLC_1	414	419	PF02516	0.240
MOD_NEK2_1	205	210	PF00069	0.373
MOD_NEK2_1	367	372	PF00069	0.449
MOD_NEK2_1	411	416	PF00069	0.258
MOD_NEK2_1	502	507	PF00069	0.382
MOD_NEK2_1	553	558	PF00069	0.373
MOD_NEK2_1	623	628	PF00069	0.319
MOD_NEK2_1	666	671	PF00069	0.256
MOD_NEK2_1	672	677	PF00069	0.276
MOD_NEK2_1	682	687	PF00069	0.235
MOD_NEK2_1	710	715	PF00069	0.332
MOD_NEK2_1	719	724	PF00069	0.213
MOD_NEK2_1	726	731	PF00069	0.178
MOD_NEK2_2	210	215	PF00069	0.359
MOD_NEK2_2	230	235	PF00069	0.278
MOD_PIKK_1	672	678	PF00454	0.340
MOD_PIKK_1	827	833	PF00454	0.288
MOD_PK_1	653	659	PF00069	0.373
MOD_PKA_2	277	283	PF00069	0.252
MOD_PKA_2	297	303	PF00069	0.124
MOD_PKA_2	506	512	PF00069	0.283
MOD_PKA_2	805	811	PF00069	0.299
MOD_Plk_1	112	118	PF00069	0.240
MOD_Plk_1	120	126	PF00069	0.240
MOD_Plk_1	153	159	PF00069	0.239
MOD_Plk_1	296	302	PF00069	0.308
MOD_Plk_1	403	409	PF00069	0.240
MOD_Plk_1	532	538	PF00069	0.293
MOD_Plk_1	616	622	PF00069	0.240
MOD_Plk_1	666	672	PF00069	0.270
MOD_Plk_1	683	689	PF00069	0.361
MOD_Plk_2-3	340	346	PF00069	0.373
MOD_Plk_2-3	739	745	PF00069	0.185
MOD_Plk_4	224	230	PF00069	0.418
MOD_Plk_4	465	471	PF00069	0.305
MOD_Plk_4	506	512	PF00069	0.283
MOD_Plk_4	540	546	PF00069	0.240
MOD_Plk_4	561	567	PF00069	0.282
MOD_Plk_4	568	574	PF00069	0.319
MOD_Plk_4	595	601	PF00069	0.209
MOD_Plk_4	623	629	PF00069	0.258
MOD_Plk_4	695	701	PF00069	0.384
MOD_Plk_4	702	708	PF00069	0.363
MOD_Plk_4	845	851	PF00069	0.322
MOD_Plk_4	86	92	PF00069	0.325
MOD_Plk_4	97	103	PF00069	0.188
MOD_ProDKin_1	193	199	PF00069	0.305
MOD_ProDKin_1	221	227	PF00069	0.375
MOD_ProDKin_1	257	263	PF00069	0.293
MOD_ProDKin_1	29	35	PF00069	0.373
MOD_ProDKin_1	329	335	PF00069	0.261
MOD_ProDKin_1	519	525	PF00069	0.240
MOD_ProDKin_1	544	550	PF00069	0.240
MOD_ProDKin_1	734	740	PF00069	0.270
MOD_ProDKin_1	94	100	PF00069	0.240
MOD_SUMO_for_1	110	113	PF00179	0.214
MOD_SUMO_for_1	494	497	PF00179	0.240
MOD_SUMO_for_1	62	65	PF00179	0.207
MOD_SUMO_rev_2	448	455	PF00179	0.384
TRG_DiLeu_BaEn_1	768	773	PF01217	0.305
TRG_DiLeu_BaEn_2	798	804	PF01217	0.373
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.261
TRG_DiLeu_BaLyEn_6	525	530	PF01217	0.240
TRG_DiLeu_BaLyEn_6	776	781	PF01217	0.373
TRG_ENDOCYTIC_2	102	105	PF00928	0.119
TRG_ENDOCYTIC_2	116	119	PF00928	0.243
TRG_ENDOCYTIC_2	138	141	PF00928	0.288
TRG_ENDOCYTIC_2	20	23	PF00928	0.240
TRG_ENDOCYTIC_2	203	206	PF00928	0.325
TRG_ENDOCYTIC_2	264	267	PF00928	0.373
TRG_ENDOCYTIC_2	289	292	PF00928	0.240
TRG_ENDOCYTIC_2	437	440	PF00928	0.305
TRG_ENDOCYTIC_2	508	511	PF00928	0.240
TRG_ENDOCYTIC_2	51	54	PF00928	0.239
TRG_ENDOCYTIC_2	555	558	PF00928	0.240
TRG_ENDOCYTIC_2	603	606	PF00928	0.373
TRG_ENDOCYTIC_2	620	623	PF00928	0.325
TRG_ENDOCYTIC_2	663	666	PF00928	0.319
TRG_ENDOCYTIC_2	68	71	PF00928	0.240
TRG_ENDOCYTIC_2	725	728	PF00928	0.373
TRG_ENDOCYTIC_2	732	735	PF00928	0.373
TRG_ENDOCYTIC_2	807	810	PF00928	0.283
TRG_ENDOCYTIC_2	82	85	PF00928	0.252
TRG_ER_diArg_1	14	17	PF00400	0.295
TRG_ER_diArg_1	472	474	PF00400	0.267
TRG_Pf-PMV_PEXEL_1	779	783	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY17	Leptomonas seymouri	72%	96%
A0A1X0NP10	Trypanosomatidae	45%	89%
A0A3R7KTC9	Trypanosoma rangeli	44%	99%
C9ZI44	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	82%
E9AGJ4	Leishmania infantum	100%	100%
E9AIN4	Leishmania braziliensis	87%	100%
E9AP31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q3UVG3	Mus musculus	30%	100%
Q4QGF7	Leishmania major	94%	100%
Q658Y4	Homo sapiens	31%	100%
Q6TEP1	Danio rerio	31%	100%
V5AZM4	Trypanosoma cruzi	50%	100%