V-type proton ATPase subunit F

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar ATP synthase subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I866_LEIDO

TriTrypDb:

LdBPK_120480.1 , LdCL_120010500 , LDHU3_12.0740

Length:

137

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	11
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	11
GO:0033180	proton-transporting V-type ATPase, V1 domain	4	11
GO:0098796	membrane protein complex	2	11
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3Q8I866

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I866

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005215	transporter activity	1	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015078	proton transmembrane transporter activity	5	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11
GO:0015399	primary active transmembrane transporter activity	4	11
GO:0016787	hydrolase activity	2	6
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	78	80	PF00675	0.396
DEG_SCF_FBW7_2	62	68	PF00400	0.400
DOC_CKS1_1	59	64	PF01111	0.332
DOC_MAPK_gen_1	79	87	PF00069	0.416
DOC_MAPK_MEF2A_6	79	86	PF00069	0.390
DOC_PP2B_LxvP_1	110	113	PF13499	0.306
DOC_WW_Pin1_4	58	63	PF00397	0.300
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_FHA_1	129	135	PF00498	0.548
LIG_FHA_1	23	29	PF00498	0.289

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I750	Leptomonas seymouri	83%	99%
A0A0S4JD04	Bodo saltans	53%	100%
A0A1X0NNW5	Trypanosomatidae	72%	96%
A0A3R7LS82	Trypanosoma rangeli	67%	100%
A1DH48	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	42%	100%
A4H6W1	Leishmania braziliensis	91%	100%
A6RRW0	Botryotinia fuckeliana (strain B05.10)	44%	100%
A7TMI5	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	38%	100%
C9ZIT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AGE0	Leishmania infantum	99%	100%

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