Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8I855_LEIDO

TriTrypDb:

LdBPK_120280.1 , LdCL_120008400 , LDHU3_12.0450

Length:

866

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I855

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I855

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.671
CLV_NRD_NRD_1	253	255	PF00675	0.733
CLV_NRD_NRD_1	311	313	PF00675	0.642
CLV_NRD_NRD_1	456	458	PF00675	0.660
CLV_NRD_NRD_1	461	463	PF00675	0.608
CLV_NRD_NRD_1	646	648	PF00675	0.644
CLV_NRD_NRD_1	850	852	PF00675	0.576
CLV_PCSK_KEX2_1	122	124	PF00082	0.671
CLV_PCSK_KEX2_1	253	255	PF00082	0.730
CLV_PCSK_KEX2_1	311	313	PF00082	0.642
CLV_PCSK_KEX2_1	456	458	PF00082	0.748
CLV_PCSK_KEX2_1	460	462	PF00082	0.689
CLV_PCSK_KEX2_1	646	648	PF00082	0.644
CLV_PCSK_KEX2_1	850	852	PF00082	0.576
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.679
CLV_PCSK_PC7_1	456	462	PF00082	0.643
CLV_PCSK_SKI1_1	243	247	PF00082	0.663
CLV_PCSK_SKI1_1	425	429	PF00082	0.584
CLV_PCSK_SKI1_1	592	596	PF00082	0.643
CLV_PCSK_SKI1_1	821	825	PF00082	0.611
CLV_PCSK_SKI1_1	843	847	PF00082	0.593
CLV_Separin_Metazoa	745	749	PF03568	0.570
DEG_APCC_DBOX_1	424	432	PF00400	0.568
DEG_APCC_DBOX_1	820	828	PF00400	0.554
DEG_APCC_DBOX_1	842	850	PF00400	0.580
DEG_Nend_UBRbox_2	1	3	PF02207	0.545
DEG_SPOP_SBC_1	229	233	PF00917	0.688
DEG_SPOP_SBC_1	545	549	PF00917	0.624
DOC_CYCLIN_RxL_1	422	432	PF00134	0.569
DOC_CYCLIN_yCln2_LP_2	212	218	PF00134	0.634
DOC_CYCLIN_yCln2_LP_2	757	763	PF00134	0.628
DOC_MAPK_DCC_7	89	97	PF00069	0.499
DOC_MAPK_gen_1	592	600	PF00069	0.659
DOC_MAPK_gen_1	841	849	PF00069	0.586
DOC_MAPK_gen_1	850	858	PF00069	0.481
DOC_MAPK_MEF2A_6	151	159	PF00069	0.567
DOC_MAPK_MEF2A_6	841	849	PF00069	0.586
DOC_PP2B_LxvP_1	136	139	PF13499	0.657
DOC_PP2B_LxvP_1	757	760	PF13499	0.597
DOC_PP2B_LxvP_1	822	825	PF13499	0.569
DOC_PP4_FxxP_1	576	579	PF00568	0.614
DOC_USP7_MATH_1	104	108	PF00917	0.732
DOC_USP7_MATH_1	181	185	PF00917	0.708
DOC_USP7_MATH_1	188	192	PF00917	0.630
DOC_USP7_MATH_1	229	233	PF00917	0.771
DOC_USP7_MATH_1	237	241	PF00917	0.632
DOC_USP7_MATH_1	255	259	PF00917	0.642
DOC_USP7_MATH_1	260	264	PF00917	0.737
DOC_USP7_MATH_1	267	271	PF00917	0.573
DOC_USP7_MATH_1	284	288	PF00917	0.530
DOC_USP7_MATH_1	346	350	PF00917	0.707
DOC_USP7_MATH_1	434	438	PF00917	0.619
DOC_USP7_MATH_1	478	482	PF00917	0.663
DOC_USP7_MATH_1	524	528	PF00917	0.719
DOC_USP7_MATH_1	533	537	PF00917	0.633
DOC_USP7_MATH_1	594	598	PF00917	0.603
DOC_USP7_MATH_1	641	645	PF00917	0.796
DOC_USP7_MATH_1	667	671	PF00917	0.682
DOC_USP7_MATH_1	690	694	PF00917	0.768
DOC_USP7_MATH_1	785	789	PF00917	0.728
DOC_USP7_MATH_1	810	814	PF00917	0.671
DOC_USP7_MATH_2	356	362	PF00917	0.733
DOC_WW_Pin1_4	248	253	PF00397	0.662
DOC_WW_Pin1_4	256	261	PF00397	0.680
DOC_WW_Pin1_4	265	270	PF00397	0.590
DOC_WW_Pin1_4	430	435	PF00397	0.602
DOC_WW_Pin1_4	470	475	PF00397	0.764
DOC_WW_Pin1_4	546	551	PF00397	0.632
DOC_WW_Pin1_4	575	580	PF00397	0.632
DOC_WW_Pin1_4	59	64	PF00397	0.660
DOC_WW_Pin1_4	602	607	PF00397	0.732
DOC_WW_Pin1_4	617	622	PF00397	0.633
DOC_WW_Pin1_4	681	686	PF00397	0.774
DOC_WW_Pin1_4	766	771	PF00397	0.726
DOC_WW_Pin1_4	778	783	PF00397	0.611
LIG_14-3-3_CanoR_1	193	203	PF00244	0.647
LIG_14-3-3_CanoR_1	461	467	PF00244	0.677
LIG_14-3-3_CanoR_1	532	541	PF00244	0.614
LIG_14-3-3_CanoR_1	544	550	PF00244	0.557
LIG_14-3-3_CanoR_1	633	638	PF00244	0.665
LIG_14-3-3_CanoR_1	646	652	PF00244	0.636
LIG_14-3-3_CanoR_1	732	741	PF00244	0.516
LIG_14-3-3_CanoR_1	762	771	PF00244	0.700
LIG_14-3-3_CanoR_1	850	859	PF00244	0.586
LIG_Actin_WH2_2	579	594	PF00022	0.647
LIG_Actin_WH2_2	746	764	PF00022	0.593
LIG_BRCT_BRCA1_1	29	33	PF00533	0.583
LIG_Clathr_ClatBox_1	327	331	PF01394	0.627
LIG_FHA_1	101	107	PF00498	0.649
LIG_FHA_1	172	178	PF00498	0.538
LIG_FHA_1	197	203	PF00498	0.617
LIG_FHA_1	260	266	PF00498	0.555
LIG_FHA_1	300	306	PF00498	0.652
LIG_FHA_1	392	398	PF00498	0.720
LIG_FHA_1	403	409	PF00498	0.614
LIG_FHA_1	509	515	PF00498	0.592
LIG_FHA_1	536	542	PF00498	0.697
LIG_FHA_1	606	612	PF00498	0.628
LIG_FHA_1	620	626	PF00498	0.617
LIG_FHA_1	66	72	PF00498	0.597
LIG_FHA_1	736	742	PF00498	0.549
LIG_FHA_1	756	762	PF00498	0.506
LIG_FHA_1	778	784	PF00498	0.554
LIG_FHA_1	842	848	PF00498	0.585
LIG_FHA_2	112	118	PF00498	0.506
LIG_FHA_2	597	603	PF00498	0.716
LIG_FHA_2	83	89	PF00498	0.611
LIG_GBD_Chelix_1	496	504	PF00786	0.588
LIG_Integrin_RGD_1	123	125	PF01839	0.583
LIG_LIR_Apic_2	247	252	PF02991	0.690
LIG_LIR_Apic_2	568	574	PF02991	0.627
LIG_LIR_Apic_2	575	579	PF02991	0.582
LIG_LIR_Gen_1	150	160	PF02991	0.568
LIG_LIR_Gen_1	518	528	PF02991	0.569
LIG_LIR_Gen_1	658	668	PF02991	0.664
LIG_LIR_Gen_1	749	759	PF02991	0.567
LIG_LIR_Nem_3	150	156	PF02991	0.564
LIG_LIR_Nem_3	244	249	PF02991	0.669
LIG_LIR_Nem_3	377	382	PF02991	0.671
LIG_LIR_Nem_3	518	523	PF02991	0.547
LIG_LIR_Nem_3	658	664	PF02991	0.665
LIG_LIR_Nem_3	749	754	PF02991	0.560
LIG_LIR_Nem_3	798	804	PF02991	0.555
LIG_LIR_Nem_3	855	861	PF02991	0.607
LIG_NRBOX	423	429	PF00104	0.564
LIG_PCNA_PIPBox_1	20	29	PF02747	0.598
LIG_RPA_C_Fungi	316	328	PF08784	0.554
LIG_SH2_CRK	129	133	PF00017	0.665
LIG_SH2_CRK	249	253	PF00017	0.701
LIG_SH2_CRK	379	383	PF00017	0.678
LIG_SH2_CRK	661	665	PF00017	0.657
LIG_SH2_PTP2	520	523	PF00017	0.559
LIG_SH2_SRC	323	326	PF00017	0.621
LIG_SH2_STAP1	323	327	PF00017	0.664
LIG_SH2_STAP1	637	641	PF00017	0.727
LIG_SH2_STAT5	129	132	PF00017	0.580
LIG_SH2_STAT5	26	29	PF00017	0.581
LIG_SH2_STAT5	414	417	PF00017	0.618
LIG_SH2_STAT5	520	523	PF00017	0.559
LIG_SH2_STAT5	571	574	PF00017	0.606
LIG_SH3_1	254	260	PF00018	0.668
LIG_SH3_1	571	577	PF00018	0.601
LIG_SH3_3	125	131	PF00018	0.794
LIG_SH3_3	165	171	PF00018	0.602
LIG_SH3_3	254	260	PF00018	0.668
LIG_SH3_3	357	363	PF00018	0.608
LIG_SH3_3	380	386	PF00018	0.758
LIG_SH3_3	518	524	PF00018	0.674
LIG_SH3_3	52	58	PF00018	0.691
LIG_SH3_3	571	577	PF00018	0.688
LIG_SH3_3	682	688	PF00018	0.715
LIG_SH3_3	858	864	PF00018	0.632
LIG_SH3_3	88	94	PF00018	0.702
LIG_SUMO_SIM_anti_2	844	850	PF11976	0.574
LIG_SUMO_SIM_par_1	103	112	PF11976	0.664
LIG_SUMO_SIM_par_1	325	331	PF11976	0.590
LIG_SUMO_SIM_par_1	61	68	PF11976	0.610
LIG_SUMO_SIM_par_1	737	745	PF11976	0.574
LIG_TRAF2_1	356	359	PF00917	0.735
LIG_TRAF2_1	37	40	PF00917	0.584
LIG_TRAF2_1	566	569	PF00917	0.690
LIG_Vh1_VBS_1	408	426	PF01044	0.573
LIG_WRC_WIRS_1	159	164	PF05994	0.561
MOD_CDC14_SPxK_1	251	254	PF00782	0.624
MOD_CDK_SPK_2	248	253	PF00069	0.610
MOD_CDK_SPxK_1	248	254	PF00069	0.615
MOD_CDK_SPxK_1	546	552	PF00069	0.746
MOD_CDK_SPxxK_3	575	582	PF00069	0.629
MOD_CK1_1	107	113	PF00069	0.674
MOD_CK1_1	191	197	PF00069	0.645
MOD_CK1_1	230	236	PF00069	0.693
MOD_CK1_1	259	265	PF00069	0.736
MOD_CK1_1	268	274	PF00069	0.570
MOD_CK1_1	401	407	PF00069	0.740
MOD_CK1_1	410	416	PF00069	0.560
MOD_CK1_1	465	471	PF00069	0.733
MOD_CK1_1	472	478	PF00069	0.700
MOD_CK1_1	499	505	PF00069	0.589
MOD_CK1_1	535	541	PF00069	0.732
MOD_CK1_1	575	581	PF00069	0.629
MOD_CK1_1	648	654	PF00069	0.684
MOD_CK1_1	731	737	PF00069	0.526
MOD_CK1_1	765	771	PF00069	0.734
MOD_CK1_1	793	799	PF00069	0.710
MOD_CK1_1	813	819	PF00069	0.400
MOD_CK2_1	111	117	PF00069	0.501
MOD_CK2_1	158	164	PF00069	0.586
MOD_CK2_1	562	568	PF00069	0.694
MOD_CK2_1	785	791	PF00069	0.639
MOD_CK2_1	806	812	PF00069	0.626
MOD_CK2_1	813	819	PF00069	0.556
MOD_CK2_1	82	88	PF00069	0.549
MOD_DYRK1A_RPxSP_1	256	260	PF00069	0.597
MOD_GlcNHglycan	205	209	PF01048	0.665
MOD_GlcNHglycan	262	265	PF01048	0.725
MOD_GlcNHglycan	271	274	PF01048	0.578
MOD_GlcNHglycan	286	289	PF01048	0.551
MOD_GlcNHglycan	409	412	PF01048	0.611
MOD_GlcNHglycan	436	439	PF01048	0.605
MOD_GlcNHglycan	468	471	PF01048	0.752
MOD_GlcNHglycan	474	477	PF01048	0.692
MOD_GlcNHglycan	501	504	PF01048	0.674
MOD_GlcNHglycan	526	529	PF01048	0.688
MOD_GlcNHglycan	564	567	PF01048	0.611
MOD_GlcNHglycan	657	660	PF01048	0.686
MOD_GlcNHglycan	680	684	PF01048	0.762
MOD_GlcNHglycan	720	725	PF01048	0.635
MOD_GlcNHglycan	808	811	PF01048	0.580
MOD_GlcNHglycan	812	815	PF01048	0.527
MOD_GSK3_1	100	107	PF00069	0.650
MOD_GSK3_1	171	178	PF00069	0.541
MOD_GSK3_1	191	198	PF00069	0.563
MOD_GSK3_1	227	234	PF00069	0.667
MOD_GSK3_1	244	251	PF00069	0.516
MOD_GSK3_1	255	262	PF00069	0.716
MOD_GSK3_1	265	272	PF00069	0.654
MOD_GSK3_1	284	291	PF00069	0.620
MOD_GSK3_1	370	377	PF00069	0.596
MOD_GSK3_1	397	404	PF00069	0.726
MOD_GSK3_1	430	437	PF00069	0.600
MOD_GSK3_1	462	469	PF00069	0.748
MOD_GSK3_1	499	506	PF00069	0.590
MOD_GSK3_1	524	531	PF00069	0.727
MOD_GSK3_1	532	539	PF00069	0.644
MOD_GSK3_1	641	648	PF00069	0.745
MOD_GSK3_1	65	72	PF00069	0.623
MOD_GSK3_1	651	658	PF00069	0.579
MOD_GSK3_1	679	686	PF00069	0.800
MOD_GSK3_1	728	735	PF00069	0.642
MOD_GSK3_1	762	769	PF00069	0.742
MOD_GSK3_1	791	798	PF00069	0.562
MOD_GSK3_1	806	813	PF00069	0.512
MOD_N-GLC_1	539	544	PF02516	0.615
MOD_NEK2_1	118	123	PF00069	0.708
MOD_NEK2_1	27	32	PF00069	0.588
MOD_NEK2_1	397	402	PF00069	0.611
MOD_NEK2_1	466	471	PF00069	0.671
MOD_NEK2_1	645	650	PF00069	0.710
MOD_NEK2_1	65	70	PF00069	0.582
MOD_NEK2_1	655	660	PF00069	0.618
MOD_NEK2_1	790	795	PF00069	0.714
MOD_NEK2_1	82	87	PF00069	0.433
MOD_NEK2_2	188	193	PF00069	0.645
MOD_NEK2_2	306	311	PF00069	0.641
MOD_NEK2_2	641	646	PF00069	0.605
MOD_PIKK_1	197	203	PF00454	0.603
MOD_PIKK_1	27	33	PF00454	0.586
MOD_PIKK_1	291	297	PF00454	0.697
MOD_PIKK_1	391	397	PF00454	0.649
MOD_PIKK_1	732	738	PF00454	0.640
MOD_PKA_1	456	462	PF00069	0.608
MOD_PKA_1	646	652	PF00069	0.609
MOD_PKA_2	194	200	PF00069	0.654
MOD_PKA_2	255	261	PF00069	0.636
MOD_PKA_2	456	462	PF00069	0.637
MOD_PKA_2	632	638	PF00069	0.704
MOD_PKA_2	645	651	PF00069	0.669
MOD_PKA_2	731	737	PF00069	0.526
MOD_PKA_2	804	810	PF00069	0.698
MOD_PKB_1	193	201	PF00069	0.653
MOD_Plk_1	188	194	PF00069	0.588
MOD_Plk_1	841	847	PF00069	0.596
MOD_Plk_4	104	110	PF00069	0.535
MOD_Plk_4	158	164	PF00069	0.568
MOD_Plk_4	182	188	PF00069	0.625
MOD_Plk_4	288	294	PF00069	0.576
MOD_Plk_4	410	416	PF00069	0.615
MOD_Plk_4	419	425	PF00069	0.518
MOD_Plk_4	450	456	PF00069	0.734
MOD_Plk_4	785	791	PF00069	0.726
MOD_Plk_4	82	88	PF00069	0.611
MOD_Plk_4	93	99	PF00069	0.529
MOD_ProDKin_1	248	254	PF00069	0.666
MOD_ProDKin_1	256	262	PF00069	0.683
MOD_ProDKin_1	265	271	PF00069	0.590
MOD_ProDKin_1	430	436	PF00069	0.602
MOD_ProDKin_1	470	476	PF00069	0.764
MOD_ProDKin_1	546	552	PF00069	0.635
MOD_ProDKin_1	575	581	PF00069	0.629
MOD_ProDKin_1	59	65	PF00069	0.656
MOD_ProDKin_1	602	608	PF00069	0.733
MOD_ProDKin_1	617	623	PF00069	0.635
MOD_ProDKin_1	681	687	PF00069	0.773
MOD_ProDKin_1	766	772	PF00069	0.726
MOD_ProDKin_1	778	784	PF00069	0.612
MOD_SUMO_for_1	717	720	PF00179	0.672
MOD_SUMO_rev_2	712	719	PF00179	0.665
TRG_DiLeu_BaEn_1	568	573	PF01217	0.694
TRG_DiLeu_BaEn_4	568	574	PF01217	0.692
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.660
TRG_ENDOCYTIC_2	129	132	PF00928	0.667
TRG_ENDOCYTIC_2	379	382	PF00928	0.676
TRG_ENDOCYTIC_2	520	523	PF00928	0.559
TRG_ENDOCYTIC_2	661	664	PF00928	0.664
TRG_ER_diArg_1	192	195	PF00400	0.616
TRG_ER_diArg_1	252	254	PF00400	0.738
TRG_ER_diArg_1	310	312	PF00400	0.644
TRG_ER_diArg_1	318	321	PF00400	0.533
TRG_ER_diArg_1	455	457	PF00400	0.670
TRG_ER_diArg_1	645	647	PF00400	0.643
TRG_ER_diArg_1	668	671	PF00400	0.704
TRG_ER_diArg_1	849	851	PF00400	0.577
TRG_NES_CRM1_1	325	339	PF08389	0.639
TRG_NES_CRM1_1	505	518	PF08389	0.611
TRG_NLS_MonoExtN_4	457	464	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	16	21	PF00026	0.690
TRG_Pf-PMV_PEXEL_1	243	248	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	850	855	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AGC0	Leishmania infantum	99%	100%
E9ANW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QGR0	Leishmania major	89%	99%