Leucine-rich repeat protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8I844_LEIDO

TriTrypDb:

LdBPK_120150.1 , LdCL_120006600 , LDHU3_12.0220

Length:

1071

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A0A3Q8I844

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I844

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1024	1028	PF00656	0.688
CLV_C14_Caspase3-7	160	164	PF00656	0.542
CLV_C14_Caspase3-7	295	299	PF00656	0.705
CLV_NRD_NRD_1	207	209	PF00675	0.692
CLV_NRD_NRD_1	223	225	PF00675	0.572
CLV_NRD_NRD_1	309	311	PF00675	0.722
CLV_NRD_NRD_1	362	364	PF00675	0.807
CLV_NRD_NRD_1	411	413	PF00675	0.605
CLV_NRD_NRD_1	418	420	PF00675	0.608
CLV_NRD_NRD_1	465	467	PF00675	0.707
CLV_NRD_NRD_1	495	497	PF00675	0.507
CLV_NRD_NRD_1	656	658	PF00675	0.677
CLV_NRD_NRD_1	851	853	PF00675	0.603
CLV_PCSK_FUR_1	462	466	PF00082	0.743
CLV_PCSK_KEX2_1	206	208	PF00082	0.695
CLV_PCSK_KEX2_1	223	225	PF00082	0.563
CLV_PCSK_KEX2_1	309	311	PF00082	0.722
CLV_PCSK_KEX2_1	410	412	PF00082	0.615
CLV_PCSK_KEX2_1	418	420	PF00082	0.595
CLV_PCSK_KEX2_1	464	466	PF00082	0.730
CLV_PCSK_KEX2_1	495	497	PF00082	0.507
CLV_PCSK_KEX2_1	656	658	PF00082	0.668
CLV_PCSK_KEX2_1	761	763	PF00082	0.706
CLV_PCSK_KEX2_1	851	853	PF00082	0.603
CLV_PCSK_KEX2_1	92	94	PF00082	0.490
CLV_PCSK_PC1ET2_1	761	763	PF00082	0.706
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.490
CLV_PCSK_SKI1_1	363	367	PF00082	0.743
CLV_PCSK_SKI1_1	48	52	PF00082	0.518
CLV_PCSK_SKI1_1	851	855	PF00082	0.661
CLV_PCSK_SKI1_1	97	101	PF00082	0.617
CLV_PCSK_SKI1_1	974	978	PF00082	0.623
CLV_Separin_Metazoa	415	419	PF03568	0.546
DEG_APCC_DBOX_1	167	175	PF00400	0.588
DEG_APCC_DBOX_1	327	335	PF00400	0.721
DEG_APCC_DBOX_1	409	417	PF00400	0.579
DEG_APCC_DBOX_1	495	503	PF00400	0.450
DEG_APCC_KENBOX_2	286	290	PF00400	0.657
DEG_SPOP_SBC_1	244	248	PF00917	0.666
DOC_CKS1_1	819	824	PF01111	0.739
DOC_MAPK_gen_1	42	51	PF00069	0.529
DOC_MAPK_gen_1	495	502	PF00069	0.453
DOC_MAPK_gen_1	92	98	PF00069	0.485
DOC_MAPK_MEF2A_6	42	51	PF00069	0.529
DOC_MAPK_MEF2A_6	495	502	PF00069	0.628
DOC_PP1_RVXF_1	46	52	PF00149	0.513
DOC_PP1_RVXF_1	607	614	PF00149	0.744
DOC_PP1_RVXF_1	850	857	PF00149	0.692
DOC_PP2B_LxvP_1	8	11	PF13499	0.650
DOC_PP4_FxxP_1	613	616	PF00568	0.691
DOC_USP7_MATH_1	20	24	PF00917	0.599
DOC_USP7_MATH_1	227	231	PF00917	0.697
DOC_USP7_MATH_1	244	248	PF00917	0.576
DOC_USP7_MATH_1	272	276	PF00917	0.721
DOC_USP7_MATH_1	31	35	PF00917	0.467
DOC_USP7_MATH_1	355	359	PF00917	0.759
DOC_USP7_MATH_1	365	369	PF00917	0.715
DOC_USP7_MATH_1	377	381	PF00917	0.596
DOC_USP7_MATH_1	482	486	PF00917	0.554
DOC_USP7_MATH_1	511	515	PF00917	0.608
DOC_USP7_MATH_1	554	558	PF00917	0.581
DOC_USP7_MATH_1	632	636	PF00917	0.612
DOC_USP7_MATH_1	651	655	PF00917	0.687
DOC_USP7_MATH_1	659	663	PF00917	0.632
DOC_USP7_MATH_1	680	684	PF00917	0.710
DOC_USP7_MATH_1	692	696	PF00917	0.627
DOC_USP7_MATH_1	827	831	PF00917	0.700
DOC_USP7_MATH_1	927	931	PF00917	0.675
DOC_USP7_MATH_1	964	968	PF00917	0.772
DOC_USP7_MATH_1	970	974	PF00917	0.674
DOC_USP7_UBL2_3	757	761	PF12436	0.700
DOC_WW_Pin1_4	1054	1059	PF00397	0.605
DOC_WW_Pin1_4	11	16	PF00397	0.631
DOC_WW_Pin1_4	199	204	PF00397	0.651
DOC_WW_Pin1_4	210	215	PF00397	0.595
DOC_WW_Pin1_4	338	343	PF00397	0.725
DOC_WW_Pin1_4	356	361	PF00397	0.548
DOC_WW_Pin1_4	417	422	PF00397	0.593
DOC_WW_Pin1_4	539	544	PF00397	0.728
DOC_WW_Pin1_4	595	600	PF00397	0.774
DOC_WW_Pin1_4	628	633	PF00397	0.647
DOC_WW_Pin1_4	713	718	PF00397	0.656
DOC_WW_Pin1_4	782	787	PF00397	0.625
DOC_WW_Pin1_4	803	808	PF00397	0.681
DOC_WW_Pin1_4	811	816	PF00397	0.687
DOC_WW_Pin1_4	818	823	PF00397	0.613
DOC_WW_Pin1_4	902	907	PF00397	0.675
DOC_WW_Pin1_4	990	995	PF00397	0.651
LIG_14-3-3_CanoR_1	206	216	PF00244	0.634
LIG_14-3-3_CanoR_1	309	318	PF00244	0.702
LIG_14-3-3_CanoR_1	363	371	PF00244	0.776
LIG_14-3-3_CanoR_1	42	48	PF00244	0.534
LIG_14-3-3_CanoR_1	466	474	PF00244	0.644
LIG_14-3-3_CanoR_1	53	58	PF00244	0.392
LIG_14-3-3_CanoR_1	553	562	PF00244	0.594
LIG_14-3-3_CanoR_1	731	736	PF00244	0.682
LIG_14-3-3_CanoR_1	857	864	PF00244	0.657
LIG_14-3-3_CanoR_1	97	102	PF00244	0.614
LIG_Actin_WH2_2	34	50	PF00022	0.535
LIG_Actin_WH2_2	768	785	PF00022	0.673
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_BIR_III_4	1011	1015	PF00653	0.761
LIG_BIR_III_4	424	428	PF00653	0.711
LIG_BRCT_BRCA1_1	212	216	PF00533	0.627
LIG_CtBP_PxDLS_1	786	790	PF00389	0.688
LIG_EH1_1	434	442	PF00400	0.434
LIG_FHA_1	1055	1061	PF00498	0.600
LIG_FHA_1	240	246	PF00498	0.704
LIG_FHA_1	364	370	PF00498	0.779
LIG_FHA_1	476	482	PF00498	0.427
LIG_FHA_1	617	623	PF00498	0.490
LIG_FHA_1	78	84	PF00498	0.555
LIG_FHA_1	811	817	PF00498	0.692
LIG_FHA_1	834	840	PF00498	0.714
LIG_FHA_1	991	997	PF00498	0.685
LIG_FHA_2	173	179	PF00498	0.573
LIG_FHA_2	346	352	PF00498	0.737
LIG_FHA_2	975	981	PF00498	0.783
LIG_Integrin_isoDGR_2	289	291	PF01839	0.748
LIG_LIR_Gen_1	144	153	PF02991	0.398
LIG_LIR_Gen_1	213	222	PF02991	0.630
LIG_LIR_Gen_1	403	413	PF02991	0.522
LIG_LIR_Gen_1	734	741	PF02991	0.687
LIG_LIR_Gen_1	743	754	PF02991	0.577
LIG_LIR_Nem_3	144	148	PF02991	0.458
LIG_LIR_Nem_3	213	219	PF02991	0.631
LIG_LIR_Nem_3	403	408	PF02991	0.516
LIG_LIR_Nem_3	637	643	PF02991	0.645
LIG_LIR_Nem_3	734	738	PF02991	0.667
LIG_LIR_Nem_3	743	749	PF02991	0.525
LIG_MYND_1	592	596	PF01753	0.715
LIG_NRBOX	744	750	PF00104	0.687
LIG_NRBOX	78	84	PF00104	0.555
LIG_Pex14_1	61	65	PF04695	0.469
LIG_Pex14_1	726	730	PF04695	0.593
LIG_Pex14_1	742	746	PF04695	0.596
LIG_PTAP_UEV_1	370	375	PF05743	0.670
LIG_RPA_C_Fungi	891	903	PF08784	0.524
LIG_SH2_CRK	735	739	PF00017	0.694
LIG_SH2_CRK	746	750	PF00017	0.544
LIG_SH2_GRB2like	568	571	PF00017	0.639
LIG_SH2_NCK_1	19	23	PF00017	0.586
LIG_SH2_SRC	19	22	PF00017	0.588
LIG_SH2_SRC	568	571	PF00017	0.639
LIG_SH2_STAP1	398	402	PF00017	0.561
LIG_SH2_STAP1	519	523	PF00017	0.540
LIG_SH2_STAP1	746	750	PF00017	0.693
LIG_SH2_STAT3	65	68	PF00017	0.400
LIG_SH2_STAT5	143	146	PF00017	0.476
LIG_SH2_STAT5	642	645	PF00017	0.591
LIG_SH2_STAT5	65	68	PF00017	0.515
LIG_SH2_STAT5	664	667	PF00017	0.752
LIG_SH2_STAT5	735	738	PF00017	0.700
LIG_SH3_2	342	347	PF14604	0.721
LIG_SH3_3	1055	1061	PF00018	0.600
LIG_SH3_3	339	345	PF00018	0.718
LIG_SH3_3	368	374	PF00018	0.787
LIG_SH3_3	491	497	PF00018	0.555
LIG_SH3_3	538	544	PF00018	0.747
LIG_SH3_3	590	596	PF00018	0.785
LIG_SH3_3	705	711	PF00018	0.693
LIG_SH3_3	734	740	PF00018	0.546
LIG_SH3_3	760	766	PF00018	0.694
LIG_SH3_3	809	815	PF00018	0.747
LIG_SH3_3	96	102	PF00018	0.606
LIG_SH3_4	950	957	PF00018	0.733
LIG_SUMO_SIM_par_1	439	447	PF11976	0.598
LIG_SUMO_SIM_par_1	497	503	PF11976	0.603
LIG_SUMO_SIM_par_1	70	76	PF11976	0.520
LIG_TRAF2_1	260	263	PF00917	0.790
LIG_TRAF2_1	293	296	PF00917	0.731
LIG_TRAF2_1	721	724	PF00917	0.564
LIG_TRAF2_1	888	891	PF00917	0.673
LIG_TRAF2_1	933	936	PF00917	0.625
LIG_TYR_ITIM	517	522	PF00017	0.542
LIG_TYR_ITIM	744	749	PF00017	0.686
LIG_UBA3_1	331	335	PF00899	0.614
LIG_WRC_WIRS_1	142	147	PF05994	0.541
MOD_CDK_SPxxK_3	199	206	PF00069	0.668
MOD_CDK_SPxxK_3	356	363	PF00069	0.736
MOD_CDK_SPxxK_3	713	720	PF00069	0.705
MOD_CDK_SPxxK_3	811	818	PF00069	0.680
MOD_CK1_1	1046	1052	PF00069	0.609
MOD_CK1_1	210	216	PF00069	0.599
MOD_CK1_1	247	253	PF00069	0.693
MOD_CK1_1	311	317	PF00069	0.732
MOD_CK1_1	324	330	PF00069	0.574
MOD_CK1_1	358	364	PF00069	0.733
MOD_CK1_1	4	10	PF00069	0.653
MOD_CK1_1	420	426	PF00069	0.738
MOD_CK1_1	433	439	PF00069	0.471
MOD_CK1_1	548	554	PF00069	0.691
MOD_CK1_1	598	604	PF00069	0.682
MOD_CK1_1	634	640	PF00069	0.680
MOD_CK1_1	687	693	PF00069	0.701
MOD_CK1_1	811	817	PF00069	0.663
MOD_CK2_1	257	263	PF00069	0.789
MOD_CK2_1	345	351	PF00069	0.729
MOD_CK2_1	433	439	PF00069	0.635
MOD_CK2_1	484	490	PF00069	0.560
MOD_CK2_1	584	590	PF00069	0.684
MOD_CK2_1	750	756	PF00069	0.728
MOD_CK2_1	862	868	PF00069	0.637
MOD_CK2_1	885	891	PF00069	0.701
MOD_CK2_1	931	937	PF00069	0.562
MOD_DYRK1A_RPxSP_1	595	599	PF00069	0.793
MOD_GlcNHglycan	1003	1006	PF01048	0.597
MOD_GlcNHglycan	1045	1048	PF01048	0.635
MOD_GlcNHglycan	106	109	PF01048	0.619
MOD_GlcNHglycan	130	133	PF01048	0.362
MOD_GlcNHglycan	139	142	PF01048	0.528
MOD_GlcNHglycan	225	228	PF01048	0.753
MOD_GlcNHglycan	235	239	PF01048	0.673
MOD_GlcNHglycan	250	253	PF01048	0.567
MOD_GlcNHglycan	265	268	PF01048	0.577
MOD_GlcNHglycan	300	303	PF01048	0.727
MOD_GlcNHglycan	305	308	PF01048	0.680
MOD_GlcNHglycan	311	314	PF01048	0.622
MOD_GlcNHglycan	351	354	PF01048	0.800
MOD_GlcNHglycan	379	382	PF01048	0.741
MOD_GlcNHglycan	424	428	PF01048	0.755
MOD_GlcNHglycan	451	454	PF01048	0.655
MOD_GlcNHglycan	505	508	PF01048	0.551
MOD_GlcNHglycan	535	538	PF01048	0.667
MOD_GlcNHglycan	556	559	PF01048	0.574
MOD_GlcNHglycan	586	589	PF01048	0.730
MOD_GlcNHglycan	600	603	PF01048	0.607
MOD_GlcNHglycan	636	639	PF01048	0.649
MOD_GlcNHglycan	694	697	PF01048	0.614
MOD_GlcNHglycan	752	755	PF01048	0.636
MOD_GlcNHglycan	798	802	PF01048	0.644
MOD_GlcNHglycan	829	832	PF01048	0.758
MOD_GlcNHglycan	83	86	PF01048	0.561
MOD_GlcNHglycan	887	890	PF01048	0.700
MOD_GlcNHglycan	929	932	PF01048	0.763
MOD_GlcNHglycan	957	960	PF01048	0.672
MOD_GlcNHglycan	966	969	PF01048	0.615
MOD_GSK3_1	100	107	PF00069	0.655
MOD_GSK3_1	1046	1053	PF00069	0.682
MOD_GSK3_1	137	144	PF00069	0.604
MOD_GSK3_1	206	213	PF00069	0.713
MOD_GSK3_1	21	28	PF00069	0.482
MOD_GSK3_1	223	230	PF00069	0.556
MOD_GSK3_1	239	246	PF00069	0.668
MOD_GSK3_1	345	352	PF00069	0.732
MOD_GSK3_1	355	362	PF00069	0.665
MOD_GSK3_1	365	372	PF00069	0.586
MOD_GSK3_1	377	384	PF00069	0.567
MOD_GSK3_1	396	403	PF00069	0.346
MOD_GSK3_1	440	447	PF00069	0.464
MOD_GSK3_1	480	487	PF00069	0.574
MOD_GSK3_1	545	552	PF00069	0.728
MOD_GSK3_1	628	635	PF00069	0.724
MOD_GSK3_1	675	682	PF00069	0.744
MOD_GSK3_1	73	80	PF00069	0.530
MOD_GSK3_1	833	840	PF00069	0.697
MOD_GSK3_1	927	934	PF00069	0.784
MOD_GSK3_1	955	962	PF00069	0.701
MOD_GSK3_1	970	977	PF00069	0.593
MOD_GSK3_1	978	985	PF00069	0.609
MOD_LATS_1	205	211	PF00433	0.716
MOD_N-GLC_1	303	308	PF02516	0.729
MOD_N-GLC_1	324	329	PF02516	0.674
MOD_N-GLC_1	569	574	PF02516	0.715
MOD_N-GLC_1	692	697	PF02516	0.728
MOD_N-GLC_1	833	838	PF02516	0.691
MOD_NEK2_1	1	6	PF00069	0.656
MOD_NEK2_1	128	133	PF00069	0.341
MOD_NEK2_1	151	156	PF00069	0.486
MOD_NEK2_1	177	182	PF00069	0.511
MOD_NEK2_1	245	250	PF00069	0.667
MOD_NEK2_1	25	30	PF00069	0.551
MOD_NEK2_1	440	445	PF00069	0.581
MOD_NEK2_1	500	505	PF00069	0.589
MOD_NEK2_1	60	65	PF00069	0.436
MOD_NEK2_1	72	77	PF00069	0.458
MOD_NEK2_1	755	760	PF00069	0.626
MOD_NEK2_1	955	960	PF00069	0.613
MOD_NEK2_2	43	48	PF00069	0.526
MOD_NEK2_2	616	621	PF00069	0.495
MOD_NEK2_2	651	656	PF00069	0.557
MOD_PIKK_1	1	7	PF00454	0.627
MOD_PIKK_1	100	106	PF00454	0.650
MOD_PIKK_1	143	149	PF00454	0.540
MOD_PIKK_1	381	387	PF00454	0.606
MOD_PIKK_1	475	481	PF00454	0.456
MOD_PIKK_1	857	863	PF00454	0.698
MOD_PIKK_1	936	942	PF00454	0.649
MOD_PIKK_1	950	956	PF00454	0.664
MOD_PKA_1	206	212	PF00069	0.687
MOD_PKA_1	223	229	PF00069	0.572
MOD_PKA_1	309	315	PF00069	0.727
MOD_PKA_1	363	369	PF00069	0.741
MOD_PKA_2	151	157	PF00069	0.490
MOD_PKA_2	206	212	PF00069	0.687
MOD_PKA_2	223	229	PF00069	0.572
MOD_PKA_2	308	314	PF00069	0.727
MOD_PKA_2	327	333	PF00069	0.523
MOD_PKA_2	52	58	PF00069	0.503
MOD_PKA_2	584	590	PF00069	0.747
MOD_PKA_2	750	756	PF00069	0.728
MOD_PKB_1	206	214	PF00069	0.603
MOD_Plk_1	177	183	PF00069	0.580
MOD_Plk_1	400	406	PF00069	0.501
MOD_Plk_1	755	761	PF00069	0.694
MOD_Plk_1	979	985	PF00069	0.674
MOD_Plk_2-3	258	264	PF00069	0.614
MOD_Plk_4	327	333	PF00069	0.719
MOD_Plk_4	4	10	PF00069	0.643
MOD_Plk_4	400	406	PF00069	0.469
MOD_ProDKin_1	1054	1060	PF00069	0.603
MOD_ProDKin_1	11	17	PF00069	0.627
MOD_ProDKin_1	199	205	PF00069	0.659
MOD_ProDKin_1	210	216	PF00069	0.596
MOD_ProDKin_1	338	344	PF00069	0.723
MOD_ProDKin_1	356	362	PF00069	0.548
MOD_ProDKin_1	417	423	PF00069	0.599
MOD_ProDKin_1	539	545	PF00069	0.730
MOD_ProDKin_1	595	601	PF00069	0.776
MOD_ProDKin_1	628	634	PF00069	0.639
MOD_ProDKin_1	713	719	PF00069	0.655
MOD_ProDKin_1	782	788	PF00069	0.616
MOD_ProDKin_1	803	809	PF00069	0.683
MOD_ProDKin_1	811	817	PF00069	0.692
MOD_ProDKin_1	818	824	PF00069	0.614
MOD_ProDKin_1	902	908	PF00069	0.673
MOD_ProDKin_1	990	996	PF00069	0.651
MOD_SUMO_rev_2	967	976	PF00179	0.595
TRG_DiLeu_BaEn_1	513	518	PF01217	0.504
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.640
TRG_DiLeu_BaLyEn_6	571	576	PF01217	0.603
TRG_DiLeu_BaLyEn_6	767	772	PF01217	0.688
TRG_ENDOCYTIC_2	120	123	PF00928	0.579
TRG_ENDOCYTIC_2	19	22	PF00928	0.588
TRG_ENDOCYTIC_2	519	522	PF00928	0.540
TRG_ENDOCYTIC_2	735	738	PF00928	0.700
TRG_ENDOCYTIC_2	746	749	PF00928	0.543
TRG_ER_diArg_1	206	208	PF00400	0.690
TRG_ER_diArg_1	222	224	PF00400	0.542
TRG_ER_diArg_1	409	412	PF00400	0.600
TRG_ER_diArg_1	417	419	PF00400	0.571
TRG_ER_diArg_1	463	466	PF00400	0.776
TRG_ER_diArg_1	494	496	PF00400	0.530
TRG_ER_diArg_1	645	648	PF00400	0.598
TRG_ER_diArg_1	656	658	PF00400	0.528
TRG_ER_diArg_1	719	722	PF00400	0.692
TRG_ER_diArg_1	850	852	PF00400	0.601
TRG_ER_diArg_1	983	986	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H6T1	Leishmania braziliensis	60%	100%
A4HV59	Leishmania infantum	99%	100%
E9ANU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QGS8	Leishmania major	84%	98%