SH3 domain/Variant SH3 domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Variant SH3 domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I836_LEIDO

TriTrypDb:

LdBPK_111370.1 , LdCL_110019700 , LDHU3_11.1710

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I836

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I836

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.373
CLV_C14_Caspase3-7	34	38	PF00656	0.312
CLV_MEL_PAP_1	80	86	PF00089	0.460
CLV_NRD_NRD_1	117	119	PF00675	0.669
CLV_NRD_NRD_1	190	192	PF00675	0.603
CLV_NRD_NRD_1	311	313	PF00675	0.366
CLV_NRD_NRD_1	342	344	PF00675	0.567
CLV_NRD_NRD_1	352	354	PF00675	0.369
CLV_NRD_NRD_1	379	381	PF00675	0.570
CLV_NRD_NRD_1	82	84	PF00675	0.394
CLV_PCSK_FUR_1	377	381	PF00082	0.514
CLV_PCSK_KEX2_1	242	244	PF00082	0.567
CLV_PCSK_KEX2_1	311	313	PF00082	0.368
CLV_PCSK_KEX2_1	341	343	PF00082	0.467
CLV_PCSK_KEX2_1	379	381	PF00082	0.572
CLV_PCSK_KEX2_1	82	84	PF00082	0.501
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.442
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.455
CLV_PCSK_PC7_1	338	344	PF00082	0.396
CLV_PCSK_SKI1_1	192	196	PF00082	0.517
CLV_PCSK_SKI1_1	231	235	PF00082	0.481
CLV_PCSK_SKI1_1	292	296	PF00082	0.364
CLV_PCSK_SKI1_1	329	333	PF00082	0.481
CLV_PCSK_SKI1_1	338	342	PF00082	0.430
CLV_PCSK_SKI1_1	354	358	PF00082	0.292
CLV_PCSK_SKI1_1	51	55	PF00082	0.340
CLV_PCSK_SKI1_1	76	80	PF00082	0.515
DEG_APCC_DBOX_1	230	238	PF00400	0.576
DOC_MAPK_gen_1	24	33	PF00069	0.381
DOC_MAPK_gen_1	341	349	PF00069	0.504
DOC_MAPK_gen_1	82	88	PF00069	0.435
DOC_MAPK_MEF2A_6	342	351	PF00069	0.498
DOC_PP1_RVXF_1	270	276	PF00149	0.528
DOC_PP4_FxxP_1	64	67	PF00568	0.522
DOC_SPAK_OSR1_1	83	87	PF12202	0.498
DOC_USP7_MATH_1	216	220	PF00917	0.603
DOC_USP7_MATH_1	229	233	PF00917	0.466
DOC_USP7_MATH_1	307	311	PF00917	0.492
DOC_USP7_MATH_1	36	40	PF00917	0.413
DOC_USP7_UBL2_3	238	242	PF12436	0.537
DOC_WW_Pin1_4	106	111	PF00397	0.595
LIG_14-3-3_CanoR_1	118	122	PF00244	0.663
LIG_14-3-3_CanoR_1	170	177	PF00244	0.386
LIG_14-3-3_CanoR_1	178	182	PF00244	0.362
LIG_14-3-3_CanoR_1	209	214	PF00244	0.460
LIG_14-3-3_CanoR_1	264	269	PF00244	0.558
LIG_BIR_III_4	37	41	PF00653	0.312
LIG_FHA_1	55	61	PF00498	0.413
LIG_FHA_2	118	124	PF00498	0.548
LIG_FHA_2	203	209	PF00498	0.392
LIG_FHA_2	299	305	PF00498	0.427
LIG_FHA_2	371	377	PF00498	0.524
LIG_KLC1_Yacidic_2	29	34	PF13176	0.224
LIG_LIR_Apic_2	14	18	PF02991	0.396
LIG_LIR_Apic_2	56	61	PF02991	0.371
LIG_LIR_Gen_1	20	30	PF02991	0.377
LIG_LIR_Gen_1	205	215	PF02991	0.612
LIG_LIR_Nem_3	20	25	PF02991	0.436
LIG_LIR_Nem_3	203	207	PF02991	0.599
LIG_LIR_Nem_3	335	340	PF02991	0.525
LIG_MYND_3	94	98	PF01753	0.525
LIG_SH2_CRK	15	19	PF00017	0.362
LIG_SH2_CRK	337	341	PF00017	0.491
LIG_SH2_CRK	58	62	PF00017	0.514
LIG_SH2_NCK_1	15	19	PF00017	0.413
LIG_SH2_NCK_1	186	190	PF00017	0.340
LIG_SH2_NCK_1	58	62	PF00017	0.514
LIG_SH2_PTP2	62	65	PF00017	0.555
LIG_SH2_SRC	10	13	PF00017	0.371
LIG_SH2_SRC	15	18	PF00017	0.347
LIG_SH2_STAP1	186	190	PF00017	0.340
LIG_SH2_STAT5	298	301	PF00017	0.422
LIG_SH2_STAT5	32	35	PF00017	0.320
LIG_SH2_STAT5	359	362	PF00017	0.326
LIG_SH2_STAT5	58	61	PF00017	0.491
LIG_SH2_STAT5	62	65	PF00017	0.535
LIG_SH3_3	107	113	PF00018	0.635
LIG_SH3_3	60	66	PF00018	0.446
LIG_TRAF2_1	256	259	PF00917	0.512
LIG_TRAF2_1	373	376	PF00917	0.538
LIG_WRC_WIRS_1	201	206	PF05994	0.417
MOD_CK1_1	220	226	PF00069	0.641
MOD_CK1_1	56	62	PF00069	0.413
MOD_CK2_1	117	123	PF00069	0.542
MOD_CK2_1	202	208	PF00069	0.586
MOD_CK2_1	298	304	PF00069	0.436
MOD_CK2_1	370	376	PF00069	0.516
MOD_Cter_Amidation	80	83	PF01082	0.364
MOD_GlcNHglycan	19	22	PF01048	0.312
MOD_GlcNHglycan	219	222	PF01048	0.599
MOD_GlcNHglycan	231	234	PF01048	0.651
MOD_GlcNHglycan	37	41	PF01048	0.285
MOD_GlcNHglycan	89	92	PF01048	0.557
MOD_GSK3_1	177	184	PF00069	0.434
MOD_GSK3_1	216	223	PF00069	0.694
MOD_GSK3_1	246	253	PF00069	0.460
MOD_NEK2_1	181	186	PF00069	0.554
MOD_NEK2_1	251	256	PF00069	0.493
MOD_PIKK_1	137	143	PF00454	0.480
MOD_PKA_2	117	123	PF00069	0.553
MOD_PKA_2	154	160	PF00069	0.582
MOD_PKA_2	169	175	PF00069	0.579
MOD_PKA_2	177	183	PF00069	0.497
MOD_PKA_2	249	255	PF00069	0.561
MOD_Plk_1	181	187	PF00069	0.550
MOD_Plk_1	246	252	PF00069	0.501
MOD_Plk_4	181	187	PF00069	0.416
MOD_Plk_4	264	270	PF00069	0.436
MOD_ProDKin_1	106	112	PF00069	0.589
MOD_SUMO_rev_2	232	240	PF00179	0.538
TRG_DiLeu_BaEn_4	246	252	PF01217	0.499
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.498
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.368
TRG_ENDOCYTIC_2	207	210	PF00928	0.582
TRG_ENDOCYTIC_2	337	340	PF00928	0.505
TRG_ER_diArg_1	132	135	PF00400	0.554
TRG_ER_diArg_1	319	322	PF00400	0.445
TRG_ER_diArg_1	377	380	PF00400	0.587
TRG_ER_diArg_1	82	84	PF00400	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ47	Leptomonas seymouri	46%	100%
A0A1X0NUT5	Trypanosomatidae	27%	100%
A0A3R7RDU1	Trypanosoma rangeli	29%	98%
A4H6R1	Leishmania braziliensis	65%	100%
A4HV44	Leishmania infantum	99%	100%
D0A7A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9ANS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QGU4	Leishmania major	84%	100%
V5DT68	Trypanosoma cruzi	29%	98%