Nodulin-like/Major Facilitator Superfamily, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I7Y9_LEIDO

TriTrypDb:

LdBPK_110680.1 , LdCL_110012300 , LDHU3_11.0890

Length:

513

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 101
NetGPI	no	yes: 0, no: 101

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	96
GO:0110165	cellular anatomical entity	1	96

Expansion

Sequence features

A0A3Q8I7Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I7Y9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	43
GO:0022857	transmembrane transporter activity	2	43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.359
CLV_NRD_NRD_1	375	377	PF00675	0.398
CLV_PCSK_KEX2_1	116	118	PF00082	0.374
CLV_PCSK_KEX2_1	375	377	PF00082	0.382
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.400
CLV_PCSK_SKI1_1	234	238	PF00082	0.595
CLV_PCSK_SKI1_1	408	412	PF00082	0.524
DEG_Kelch_Keap1_1	279	284	PF01344	0.764
DEG_MDM2_SWIB_1	448	456	PF02201	0.416
DEG_Nend_Nbox_1	1	3	PF02207	0.359
DOC_CKS1_1	144	149	PF01111	0.188
DOC_CYCLIN_yClb5_NLxxxL_5	492	501	PF00134	0.213
DOC_CYCLIN_yCln2_LP_2	144	150	PF00134	0.383
DOC_MAPK_gen_1	116	123	PF00069	0.528
DOC_MAPK_gen_1	375	384	PF00069	0.578
DOC_MAPK_gen_1	470	480	PF00069	0.400
DOC_MAPK_MEF2A_6	208	217	PF00069	0.488
DOC_MAPK_MEF2A_6	377	386	PF00069	0.574
DOC_MAPK_MEF2A_6	482	491	PF00069	0.313
DOC_PP2B_LxvP_1	403	406	PF13499	0.417
DOC_PP4_FxxP_1	388	391	PF00568	0.409
DOC_PP4_FxxP_1	41	44	PF00568	0.326
DOC_SPAK_OSR1_1	86	90	PF12202	0.322
DOC_USP7_MATH_1	224	228	PF00917	0.350
DOC_USP7_MATH_1	4	8	PF00917	0.278
DOC_USP7_MATH_1	406	410	PF00917	0.405
DOC_USP7_MATH_1	415	419	PF00917	0.332
DOC_USP7_UBL2_3	438	442	PF12436	0.540
DOC_WW_Pin1_4	143	148	PF00397	0.337
DOC_WW_Pin1_4	328	333	PF00397	0.399
DOC_WW_Pin1_4	337	342	PF00397	0.387
LIG_14-3-3_CanoR_1	183	191	PF00244	0.558
LIG_14-3-3_CanoR_1	26	34	PF00244	0.334
LIG_14-3-3_CanoR_1	268	274	PF00244	0.591
LIG_14-3-3_CanoR_1	363	369	PF00244	0.308
LIG_14-3-3_CanoR_1	381	387	PF00244	0.407
LIG_BRCT_BRCA1_1	330	334	PF00533	0.374
LIG_BRCT_BRCA1_1	6	10	PF00533	0.307
LIG_BRCT_BRCA1_1	97	101	PF00533	0.414
LIG_FHA_1	224	230	PF00498	0.344
LIG_FHA_1	296	302	PF00498	0.532
LIG_FHA_1	304	310	PF00498	0.459
LIG_FHA_1	338	344	PF00498	0.375
LIG_FHA_1	390	396	PF00498	0.344
LIG_FHA_1	398	404	PF00498	0.334
LIG_FHA_1	426	432	PF00498	0.312
LIG_FHA_1	496	502	PF00498	0.395
LIG_FHA_2	285	291	PF00498	0.626
LIG_FHA_2	45	51	PF00498	0.470
LIG_GBD_Chelix_1	120	128	PF00786	0.431
LIG_GBD_Chelix_1	215	223	PF00786	0.317
LIG_GBD_Chelix_1	453	461	PF00786	0.389
LIG_IRF3_LxIS_1	504	509	PF10401	0.536
LIG_LIR_Apic_2	288	294	PF02991	0.593
LIG_LIR_Apic_2	385	391	PF02991	0.385
LIG_LIR_Apic_2	50	54	PF02991	0.471
LIG_LIR_Gen_1	253	264	PF02991	0.364
LIG_LIR_Gen_1	308	317	PF02991	0.338
LIG_LIR_Gen_1	323	332	PF02991	0.377
LIG_LIR_Gen_1	400	410	PF02991	0.338
LIG_LIR_Gen_1	47	57	PF02991	0.423
LIG_LIR_Gen_1	502	513	PF02991	0.389
LIG_LIR_Gen_1	7	17	PF02991	0.295
LIG_LIR_Nem_3	308	313	PF02991	0.312
LIG_LIR_Nem_3	315	320	PF02991	0.326
LIG_LIR_Nem_3	323	327	PF02991	0.346
LIG_LIR_Nem_3	331	337	PF02991	0.332
LIG_LIR_Nem_3	367	372	PF02991	0.580
LIG_LIR_Nem_3	400	405	PF02991	0.262
LIG_LIR_Nem_3	47	52	PF02991	0.374
LIG_LIR_Nem_3	502	508	PF02991	0.330
LIG_LIR_Nem_3	509	513	PF02991	0.521
LIG_LIR_Nem_3	7	13	PF02991	0.282
LIG_LIR_Nem_3	75	79	PF02991	0.264
LIG_NRBOX	457	463	PF00104	0.303
LIG_NRBOX	496	502	PF00104	0.476
LIG_NRBOX	66	72	PF00104	0.287
LIG_PAM2_1	142	154	PF00658	0.188
LIG_PDZ_Class_1	508	513	PF00595	0.403
LIG_Pex14_2	324	328	PF04695	0.378
LIG_Pex14_2	448	452	PF04695	0.361
LIG_SH2_CRK	45	49	PF00017	0.331
LIG_SH2_PTP2	291	294	PF00017	0.572
LIG_SH2_SRC	505	508	PF00017	0.492
LIG_SH2_STAP1	8	12	PF00017	0.299
LIG_SH2_STAT3	199	202	PF00017	0.535
LIG_SH2_STAT5	150	153	PF00017	0.333
LIG_SH2_STAT5	199	202	PF00017	0.553
LIG_SH2_STAT5	210	213	PF00017	0.309
LIG_SH2_STAT5	222	225	PF00017	0.313
LIG_SH2_STAT5	291	294	PF00017	0.575
LIG_SH2_STAT5	372	375	PF00017	0.588
LIG_SH2_STAT5	40	43	PF00017	0.310
LIG_SH2_STAT5	505	508	PF00017	0.347
LIG_SH2_STAT5	51	54	PF00017	0.492
LIG_SH2_STAT5	58	61	PF00017	0.333
LIG_SH3_3	218	224	PF00018	0.323
LIG_SH3_3	258	264	PF00018	0.368
LIG_SH3_3	482	488	PF00018	0.323
LIG_SUMO_SIM_anti_2	212	217	PF11976	0.380
LIG_SUMO_SIM_anti_2	392	398	PF11976	0.322
LIG_SUMO_SIM_anti_2	426	431	PF11976	0.343
LIG_SUMO_SIM_par_1	156	161	PF11976	0.372
LIG_SUMO_SIM_par_1	392	398	PF11976	0.316
LIG_SUMO_SIM_par_1	428	434	PF11976	0.302
LIG_SUMO_SIM_par_1	92	98	PF11976	0.343
LIG_TRFH_1	40	44	PF08558	0.373
LIG_TYR_ITIM	43	48	PF00017	0.347
LIG_UBA3_1	333	342	PF00899	0.399
MOD_CDK_SPK_2	337	342	PF00069	0.254
MOD_CK1_1	137	143	PF00069	0.386
MOD_CK1_1	182	188	PF00069	0.634
MOD_CK1_1	279	285	PF00069	0.714
MOD_CK1_1	303	309	PF00069	0.524
MOD_CK1_1	335	341	PF00069	0.355
MOD_CK1_1	95	101	PF00069	0.363
MOD_CK2_1	364	370	PF00069	0.408
MOD_GlcNHglycan	13	16	PF01048	0.474
MOD_GlcNHglycan	131	134	PF01048	0.328
MOD_GlcNHglycan	226	229	PF01048	0.345
MOD_GlcNHglycan	276	281	PF01048	0.494
MOD_GlcNHglycan	334	337	PF01048	0.518
MOD_GlcNHglycan	347	350	PF01048	0.328
MOD_GlcNHglycan	358	361	PF01048	0.287
MOD_GSK3_1	108	115	PF00069	0.348
MOD_GSK3_1	170	177	PF00069	0.530
MOD_GSK3_1	22	29	PF00069	0.280
MOD_GSK3_1	296	303	PF00069	0.554
MOD_GSK3_1	328	335	PF00069	0.349
MOD_GSK3_1	345	352	PF00069	0.291
MOD_GSK3_1	495	502	PF00069	0.393
MOD_N-GLC_1	328	333	PF02516	0.556
MOD_N-GLC_1	495	500	PF02516	0.295
MOD_NEK2_1	123	128	PF00069	0.397
MOD_NEK2_1	13	18	PF00069	0.277
MOD_NEK2_1	209	214	PF00069	0.352
MOD_NEK2_1	300	305	PF00069	0.516
MOD_NEK2_1	343	348	PF00069	0.334
MOD_NEK2_1	364	369	PF00069	0.405
MOD_NEK2_1	397	402	PF00069	0.296
MOD_NEK2_1	423	428	PF00069	0.342
MOD_NEK2_1	495	500	PF00069	0.342
MOD_NEK2_1	506	511	PF00069	0.354
MOD_NEK2_1	72	77	PF00069	0.304
MOD_NEK2_2	44	49	PF00069	0.486
MOD_PIKK_1	198	204	PF00454	0.588
MOD_PIKK_1	235	241	PF00454	0.353
MOD_PIKK_1	370	376	PF00454	0.569
MOD_PIKK_1	95	101	PF00454	0.416
MOD_PKA_2	182	188	PF00069	0.534
MOD_PKA_2	267	273	PF00069	0.569
MOD_Plk_1	343	349	PF00069	0.321
MOD_Plk_1	495	501	PF00069	0.316
MOD_Plk_2-3	284	290	PF00069	0.713
MOD_Plk_4	102	108	PF00069	0.322
MOD_Plk_4	123	129	PF00069	0.367
MOD_Plk_4	296	302	PF00069	0.528
MOD_Plk_4	305	311	PF00069	0.477
MOD_Plk_4	349	355	PF00069	0.321
MOD_Plk_4	364	370	PF00069	0.373
MOD_Plk_4	390	396	PF00069	0.335
MOD_Plk_4	397	403	PF00069	0.325
MOD_Plk_4	44	50	PF00069	0.382
MOD_Plk_4	80	86	PF00069	0.279
MOD_ProDKin_1	143	149	PF00069	0.337
MOD_ProDKin_1	328	334	PF00069	0.398
MOD_ProDKin_1	337	343	PF00069	0.384
MOD_SUMO_rev_2	182	191	PF00179	0.572
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.325
TRG_DiLeu_BaLyEn_6	485	490	PF01217	0.344
TRG_ENDOCYTIC_2	150	153	PF00928	0.302
TRG_ENDOCYTIC_2	210	213	PF00928	0.369
TRG_ENDOCYTIC_2	40	43	PF00928	0.319
TRG_ENDOCYTIC_2	45	48	PF00928	0.332
TRG_ENDOCYTIC_2	49	52	PF00928	0.490
TRG_ENDOCYTIC_2	505	508	PF00928	0.391
TRG_ENDOCYTIC_2	510	513	PF00928	0.545
TRG_Pf-PMV_PEXEL_1	460	465	PF00026	0.395
TRG_PTS1	510	513	PF00515	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	40%	81%
A0A0N1HT40	Leptomonas seymouri	75%	90%
A0A0N1HZC2	Leptomonas seymouri	28%	82%
A0A0N1IKC5	Leptomonas seymouri	47%	84%
A0A0N1PAX2	Leptomonas seymouri	22%	100%
A0A0N1PB63	Leptomonas seymouri	26%	78%
A0A0S4IIJ4	Bodo saltans	22%	91%
A0A0S4JR45	Bodo saltans	33%	98%
A0A1X0NKK0	Trypanosomatidae	33%	85%
A0A1X0NL32	Trypanosomatidae	36%	82%
A0A1X0NM09	Trypanosomatidae	31%	84%
A0A1X0NRW5	Trypanosomatidae	40%	74%
A0A1X0NV13	Trypanosomatidae	50%	79%
A0A1X0NV19	Trypanosomatidae	48%	86%
A0A1X0NV27	Trypanosomatidae	49%	86%
A0A1X0NVH8	Trypanosomatidae	47%	78%
A0A1X0NVM7	Trypanosomatidae	54%	80%
A0A1X0NWQ1	Trypanosomatidae	46%	80%
A0A1X0NZE6	Trypanosomatidae	34%	86%
A0A1X0NZU2	Trypanosomatidae	29%	79%
A0A1X0NZU5	Trypanosomatidae	34%	87%
A0A1X0NZW1	Trypanosomatidae	30%	85%
A0A1X0P0M7	Trypanosomatidae	33%	87%
A0A3Q8IF95	Leishmania donovani	28%	81%
A0A3Q8ISY9	Leishmania donovani	38%	81%
A0A3R7JPZ0	Trypanosoma rangeli	26%	100%
A0A3R7JSQ9	Trypanosoma rangeli	29%	100%
A0A3R7KKN8	Trypanosoma rangeli	31%	86%
A0A3R7MAQ7	Trypanosoma rangeli	36%	73%
A0A3R7N415	Trypanosoma rangeli	29%	85%
A0A3R7N921	Trypanosoma rangeli	29%	100%
A0A3R7R443	Trypanosoma rangeli	30%	86%
A0A3R7R6N6	Trypanosoma rangeli	26%	100%
A0A3S7WRJ4	Leishmania donovani	48%	80%
A0A3S7WRJ5	Leishmania donovani	41%	73%
A0A3S7WRL4	Leishmania donovani	100%	82%
A0A3S7WSR4	Leishmania donovani	45%	85%
A0A3S7WWU1	Leishmania donovani	27%	77%
A0A3S7XB11	Leishmania donovani	29%	85%
A0A422MSE4	Trypanosoma rangeli	49%	100%
A0A422MSP6	Trypanosoma rangeli	34%	98%
A0A422MST9	Trypanosoma rangeli	29%	85%
A0A422MU68	Trypanosoma rangeli	27%	100%
A4H6J0	Leishmania braziliensis	47%	100%
A4H6J1	Leishmania braziliensis	45%	100%
A4H6J3	Leishmania braziliensis	88%	100%
A4H7F9	Leishmania braziliensis	43%	100%
A4HC19	Leishmania braziliensis	27%	100%
A4HJW3	Leishmania braziliensis	38%	100%
A4HPE2	Leishmania braziliensis	29%	100%
A4HUX5	Leishmania infantum	48%	100%
A4HUX6	Leishmania infantum	41%	100%
A4HUX7	Leishmania infantum	100%	100%
A4HUX8	Leishmania infantum	99%	100%
A4HZF5	Leishmania infantum	28%	100%
A4HZJ4	Leishmania infantum	27%	100%
A4I7C5	Leishmania infantum	38%	100%
A4ICI3	Leishmania infantum	29%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	86%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	88%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	86%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	88%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	86%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	86%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	85%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	94%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	86%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	88%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	86%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	87%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	94%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	75%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AGK5	Leishmania infantum	45%	100%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9ANL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q4Q1E4	Leishmania major	29%	100%
Q4Q5T8	Leishmania major	37%	100%
Q4QC27	Leishmania major	27%	100%
Q4QC28	Leishmania major	31%	100%
Q4QFY5	Leishmania major	44%	100%
Q4QH10	Leishmania major	97%	100%
Q4QH11	Leishmania major	97%	100%
Q4QH12	Leishmania major	97%	100%
Q4QH13	Leishmania major	98%	100%
Q4QH14	Leishmania major	41%	100%
Q4QH15	Leishmania major	48%	100%
V5B647	Trypanosoma cruzi	47%	81%
V5B983	Trypanosoma cruzi	34%	88%
V5BBB1	Trypanosoma cruzi	45%	87%
V5BFV8	Trypanosoma cruzi	30%	77%
V5BQY6	Trypanosoma cruzi	38%	73%
V5BVP0	Trypanosoma cruzi	49%	87%
V5DT25	Trypanosoma cruzi	57%	83%