Nodulin-like/Major Facilitator Superfamily, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I7Y9_LEIDO

TriTrypDb:

LdBPK_110680.1 , LdCL_110012300 , LDHU3_11.0890

Length:

513

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 101
NetGPI	no	yes: 0, no: 101

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	96
GO:0110165	cellular anatomical entity	1	96

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Expansion

Sequence features

A0A3Q8I7Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I7Y9

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	43
GO:0022857	transmembrane transporter activity	2	43

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.359
CLV_NRD_NRD_1	375	377	PF00675	0.398
CLV_PCSK_KEX2_1	116	118	PF00082	0.374
CLV_PCSK_KEX2_1	375	377	PF00082	0.382
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.400
CLV_PCSK_SKI1_1	234	238	PF00082	0.595
CLV_PCSK_SKI1_1	408	412	PF00082	0.524
DEG_Kelch_Keap1_1	279	284	PF01344	0.764
DEG_MDM2_SWIB_1	448	456	PF02201	0.416
DEG_Nend_Nbox_1	1	3	PF02207	0.359

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	40%	81%
A0A0N1HT40	Leptomonas seymouri	75%	90%
A0A0N1HZC2	Leptomonas seymouri	28%	82%
A0A0N1IKC5	Leptomonas seymouri	47%	84%
A0A0N1PAX2	Leptomonas seymouri	22%	100%
A0A0N1PB63	Leptomonas seymouri	26%	78%
A0A0S4IIJ4	Bodo saltans	22%	91%
A0A0S4JR45	Bodo saltans	33%	98%
A0A1X0NKK0	Trypanosomatidae	33%	85%
A0A1X0NL32	Trypanosomatidae	36%	82%

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