Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I7X8_LEIDO

TriTrypDb:

LdBPK_110570.1 , LdCL_110010600 , LDHU3_11.0640

Length:

132

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3Q8I7X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I7X8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.618
CLV_NRD_NRD_1	24	26	PF00675	0.566
CLV_NRD_NRD_1	8	10	PF00675	0.491
CLV_PCSK_KEX2_1	128	130	PF00082	0.605
CLV_PCSK_KEX2_1	24	26	PF00082	0.393
CLV_PCSK_KEX2_1	8	10	PF00082	0.483
CLV_PCSK_SKI1_1	49	53	PF00082	0.425
DEG_Nend_Nbox_1	1	3	PF02207	0.637
DOC_CKS1_1	94	99	PF01111	0.421
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.587
DOC_PP4_FxxP_1	56	59	PF00568	0.592
DOC_PP4_FxxP_1	82	85	PF00568	0.470
DOC_USP7_MATH_1	122	126	PF00917	0.400
DOC_WW_Pin1_4	105	110	PF00397	0.399
DOC_WW_Pin1_4	93	98	PF00397	0.415
LIG_14-3-3_CanoR_1	24	28	PF00244	0.627
LIG_14-3-3_CanoR_1	3	7	PF00244	0.693
LIG_14-3-3_CanoR_1	66	70	PF00244	0.360
LIG_14-3-3_CanoR_1	9	15	PF00244	0.663
LIG_BRCT_BRCA1_1	67	71	PF00533	0.360
LIG_deltaCOP1_diTrp_1	61	64	PF00928	0.442
LIG_LIR_Apic_2	117	122	PF02991	0.405
LIG_LIR_Apic_2	79	85	PF02991	0.283
LIG_LIR_Nem_3	61	65	PF02991	0.442
LIG_LIR_Nem_3	68	74	PF02991	0.279
LIG_Pex14_2	56	60	PF04695	0.590
LIG_SH2_CRK	20	24	PF00017	0.645
LIG_SH2_CRK	78	82	PF00017	0.395
LIG_SH2_SRC	115	118	PF00017	0.434
LIG_SH2_STAP1	78	82	PF00017	0.279
LIG_SH2_STAT5	46	49	PF00017	0.640
LIG_SH3_3	91	97	PF00018	0.408
LIG_TYR_ITIM	76	81	PF00017	0.410
MOD_CK1_1	4	10	PF00069	0.680
MOD_CK2_1	10	16	PF00069	0.646
MOD_Cter_Amidation	126	129	PF01082	0.703
MOD_GlcNHglycan	124	127	PF01048	0.632
MOD_GlcNHglycan	9	12	PF01048	0.447
MOD_GSK3_1	34	41	PF00069	0.651
MOD_LATS_1	32	38	PF00433	0.633
MOD_N-GLC_1	122	127	PF02516	0.603
MOD_NEK2_1	1	6	PF00069	0.626
MOD_NEK2_1	45	50	PF00069	0.612
MOD_NEK2_1	64	69	PF00069	0.445
MOD_PKA_2	2	8	PF00069	0.658
MOD_PKA_2	23	29	PF00069	0.761
MOD_PKA_2	65	71	PF00069	0.354
MOD_ProDKin_1	105	111	PF00069	0.396
MOD_ProDKin_1	93	99	PF00069	0.418
TRG_ENDOCYTIC_2	78	81	PF00928	0.297
TRG_ER_diArg_1	128	130	PF00400	0.418
TRG_ER_diArg_1	23	25	PF00400	0.731

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJC2	Leptomonas seymouri	92%	100%
A0A0S4JUP5	Bodo saltans	65%	100%
A0A1X0NV45	Trypanosomatidae	79%	100%
A4H6G8	Leishmania braziliensis	98%	100%
A4HUW7	Leishmania infantum	100%	100%
D0A7J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9ANJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QH30	Leishmania major	99%	100%
V5DT78	Trypanosoma cruzi	73%	100%