Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I7W7_LEIDO

TriTrypDb:

LdBPK_110390.1 , LdCL_110008800 , LDHU3_11.0490

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I7W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I7W7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.595
CLV_NRD_NRD_1	116	118	PF00675	0.646
CLV_NRD_NRD_1	120	122	PF00675	0.604
CLV_NRD_NRD_1	240	242	PF00675	0.442
CLV_NRD_NRD_1	5	7	PF00675	0.601
CLV_PCSK_KEX2_1	116	118	PF00082	0.597
CLV_PCSK_KEX2_1	120	122	PF00082	0.544
CLV_PCSK_KEX2_1	161	163	PF00082	0.451
CLV_PCSK_KEX2_1	240	242	PF00082	0.442
CLV_PCSK_KEX2_1	369	371	PF00082	0.509
CLV_PCSK_KEX2_1	5	7	PF00082	0.753
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.451
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.420
CLV_PCSK_PC7_1	116	122	PF00082	0.639
CLV_PCSK_SKI1_1	168	172	PF00082	0.451
CLV_PCSK_SKI1_1	225	229	PF00082	0.542
CLV_PCSK_SKI1_1	240	244	PF00082	0.283
CLV_PCSK_SKI1_1	47	51	PF00082	0.592
DEG_Nend_Nbox_1	1	3	PF02207	0.576
DEG_SPOP_SBC_1	227	231	PF00917	0.557
DEG_SPOP_SBC_1	324	328	PF00917	0.546
DEG_SPOP_SBC_1	35	39	PF00917	0.553
DOC_CKS1_1	277	282	PF01111	0.670
DOC_MAPK_gen_1	161	169	PF00069	0.392
DOC_MAPK_gen_1	240	248	PF00069	0.409
DOC_MAPK_gen_1	369	377	PF00069	0.487
DOC_MAPK_gen_1	448	458	PF00069	0.453
DOC_MAPK_JIP1_4	477	483	PF00069	0.381
DOC_MAPK_MEF2A_6	240	248	PF00069	0.397
DOC_MAPK_MEF2A_6	451	458	PF00069	0.520
DOC_PP2B_LxvP_1	481	484	PF13499	0.354
DOC_SPAK_OSR1_1	241	245	PF12202	0.389
DOC_USP7_MATH_1	135	139	PF00917	0.624
DOC_USP7_MATH_1	16	20	PF00917	0.567
DOC_USP7_MATH_1	324	328	PF00917	0.678
DOC_USP7_MATH_1	337	341	PF00917	0.552
DOC_USP7_MATH_1	350	354	PF00917	0.600
DOC_USP7_MATH_1	395	399	PF00917	0.658
DOC_USP7_MATH_1	4	8	PF00917	0.608
DOC_USP7_MATH_1	60	64	PF00917	0.531
DOC_USP7_UBL2_3	219	223	PF12436	0.481
DOC_USP7_UBL2_3	448	452	PF12436	0.474
DOC_WW_Pin1_4	235	240	PF00397	0.513
DOC_WW_Pin1_4	276	281	PF00397	0.632
DOC_WW_Pin1_4	360	365	PF00397	0.546
DOC_WW_Pin1_4	437	442	PF00397	0.516
DOC_WW_Pin1_4	450	455	PF00397	0.627
LIG_14-3-3_CanoR_1	116	122	PF00244	0.604
LIG_14-3-3_CanoR_1	308	313	PF00244	0.493
LIG_14-3-3_CanoR_1	5	9	PF00244	0.578
LIG_BRCT_BRCA1_1	373	377	PF00533	0.462
LIG_BRCT_BRCA1_1	62	66	PF00533	0.505
LIG_Clathr_ClatBox_1	455	459	PF01394	0.450
LIG_FHA_1	178	184	PF00498	0.594
LIG_FHA_1	241	247	PF00498	0.466
LIG_FHA_1	272	278	PF00498	0.674
LIG_FHA_1	317	323	PF00498	0.473
LIG_FHA_1	35	41	PF00498	0.482
LIG_FHA_2	127	133	PF00498	0.626
LIG_FHA_2	143	149	PF00498	0.600
LIG_FHA_2	333	339	PF00498	0.681
LIG_LIR_Gen_1	319	324	PF02991	0.397
LIG_LIR_Nem_3	210	215	PF02991	0.338
LIG_LIR_Nem_3	319	323	PF02991	0.396
LIG_LIR_Nem_3	366	371	PF02991	0.381
LIG_MYND_1	391	395	PF01753	0.586
LIG_PDZ_Class_2	504	509	PF00595	0.416
LIG_SH2_SRC	371	374	PF00017	0.412
LIG_SH2_SRC	42	45	PF00017	0.474
LIG_SH2_STAT5	216	219	PF00017	0.402
LIG_SH2_STAT5	301	304	PF00017	0.417
LIG_SH2_STAT5	371	374	PF00017	0.373
LIG_SH2_STAT5	42	45	PF00017	0.535
LIG_SH2_STAT5	48	51	PF00017	0.504
LIG_SH2_STAT5	55	58	PF00017	0.479
LIG_SH3_3	151	157	PF00018	0.595
LIG_SH3_3	243	249	PF00018	0.457
LIG_SH3_3	279	285	PF00018	0.627
LIG_SH3_3	389	395	PF00018	0.573
LIG_SH3_3	461	467	PF00018	0.422
LIG_Sin3_3	163	170	PF02671	0.492
LIG_SUMO_SIM_anti_2	479	484	PF11976	0.380
LIG_SUMO_SIM_par_1	151	158	PF11976	0.586
LIG_SUMO_SIM_par_1	204	210	PF11976	0.376
LIG_SUMO_SIM_par_1	242	247	PF11976	0.372
LIG_SUMO_SIM_par_1	453	461	PF11976	0.452
LIG_TRAF2_1	265	268	PF00917	0.573
MOD_CDK_SPK_2	235	240	PF00069	0.540
MOD_CDK_SPxK_1	235	241	PF00069	0.501
MOD_CK1_1	138	144	PF00069	0.623
MOD_CK1_1	229	235	PF00069	0.579
MOD_CK1_1	276	282	PF00069	0.617
MOD_CK1_1	340	346	PF00069	0.677
MOD_CK1_1	440	446	PF00069	0.404
MOD_CK1_1	450	456	PF00069	0.450
MOD_CK1_1	457	463	PF00069	0.426
MOD_CK1_1	7	13	PF00069	0.669
MOD_CK2_1	126	132	PF00069	0.625
MOD_CK2_1	142	148	PF00069	0.599
MOD_CK2_1	152	158	PF00069	0.534
MOD_CK2_1	261	267	PF00069	0.616
MOD_CK2_1	330	336	PF00069	0.626
MOD_CK2_1	350	356	PF00069	0.547
MOD_CK2_1	360	366	PF00069	0.466
MOD_CK2_1	457	463	PF00069	0.454
MOD_GlcNHglycan	132	136	PF01048	0.667
MOD_GlcNHglycan	18	21	PF01048	0.520
MOD_GlcNHglycan	255	258	PF01048	0.628
MOD_GlcNHglycan	263	266	PF01048	0.612
MOD_GlcNHglycan	310	313	PF01048	0.496
MOD_GlcNHglycan	341	345	PF01048	0.766
MOD_GlcNHglycan	352	355	PF01048	0.636
MOD_GlcNHglycan	426	430	PF01048	0.665
MOD_GlcNHglycan	9	12	PF01048	0.696
MOD_GlcNHglycan	96	99	PF01048	0.684
MOD_GSK3_1	131	138	PF00069	0.663
MOD_GSK3_1	226	233	PF00069	0.567
MOD_GSK3_1	240	247	PF00069	0.342
MOD_GSK3_1	291	298	PF00069	0.433
MOD_GSK3_1	356	363	PF00069	0.609
MOD_GSK3_1	450	457	PF00069	0.384
MOD_GSK3_1	56	63	PF00069	0.518
MOD_N-GLC_1	138	143	PF02516	0.633
MOD_NEK2_1	228	233	PF00069	0.594
MOD_NEK2_1	36	41	PF00069	0.538
MOD_NEK2_1	447	452	PF00069	0.460
MOD_NEK2_1	496	501	PF00069	0.386
MOD_NEK2_2	61	66	PF00069	0.503
MOD_PIKK_1	120	126	PF00454	0.630
MOD_PIKK_1	325	331	PF00454	0.689
MOD_PKA_1	120	126	PF00069	0.556
MOD_PKA_1	240	246	PF00069	0.409
MOD_PKA_2	115	121	PF00069	0.605
MOD_PKA_2	240	246	PF00069	0.395
MOD_PKA_2	4	10	PF00069	0.711
MOD_Plk_1	71	77	PF00069	0.617
MOD_Plk_2-3	330	336	PF00069	0.637
MOD_Plk_4	483	489	PF00069	0.373
MOD_Plk_4	61	67	PF00069	0.529
MOD_Plk_4	71	77	PF00069	0.548
MOD_ProDKin_1	235	241	PF00069	0.501
MOD_ProDKin_1	276	282	PF00069	0.628
MOD_ProDKin_1	360	366	PF00069	0.537
MOD_ProDKin_1	437	443	PF00069	0.507
MOD_ProDKin_1	450	456	PF00069	0.618
MOD_SUMO_for_1	476	479	PF00179	0.422
MOD_SUMO_rev_2	373	383	PF00179	0.516
TRG_DiLeu_BaEn_2	372	378	PF01217	0.454
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.578
TRG_DiLeu_BaLyEn_6	451	456	PF01217	0.481
TRG_ER_diArg_1	120	122	PF00400	0.618
TRG_ER_diArg_1	239	241	PF00400	0.476
TRG_ER_diArg_1	4	6	PF00400	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH30	Leptomonas seymouri	34%	100%
A4H6K7	Leishmania braziliensis	64%	100%
A4HUV0	Leishmania infantum	100%	100%
E9ANI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QH41	Leishmania major	89%	100%