LeishMANIAdb
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4a-hydroxytetrahydrobiopterin dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
4a-hydroxytetrahydrobiopterin dehydratase
Gene product:
pterin-4-alpha-carbinolamine dehydratase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8I7V7_LEIDO
TriTrypDb:
LdBPK_110220.1 , LdCL_110007100 , LDHU3_11.0280
Length:
111

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I7V7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I7V7

Function

Biological processes
Term Name Level Count
GO:0006066 alcohol metabolic process 3 7
GO:0006725 cellular aromatic compound metabolic process 3 7
GO:0006729 tetrahydrobiopterin biosynthetic process 6 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009058 biosynthetic process 2 7
GO:0009987 cellular process 1 7
GO:0018130 heterocycle biosynthetic process 4 7
GO:0019438 aromatic compound biosynthetic process 4 7
GO:0019751 polyol metabolic process 4 7
GO:0034311 diol metabolic process 5 7
GO:0034312 diol biosynthetic process 6 7
GO:0034641 cellular nitrogen compound metabolic process 3 7
GO:0042558 pteridine-containing compound metabolic process 4 7
GO:0042559 pteridine-containing compound biosynthetic process 5 7
GO:0044237 cellular metabolic process 2 7
GO:0044249 cellular biosynthetic process 3 7
GO:0044271 cellular nitrogen compound biosynthetic process 4 7
GO:0044281 small molecule metabolic process 2 7
GO:0044283 small molecule biosynthetic process 3 7
GO:0046146 tetrahydrobiopterin metabolic process 5 7
GO:0046165 alcohol biosynthetic process 4 7
GO:0046173 polyol biosynthetic process 5 7
GO:0046483 heterocycle metabolic process 3 7
GO:0071704 organic substance metabolic process 2 7
GO:1901360 organic cyclic compound metabolic process 3 7
GO:1901362 organic cyclic compound biosynthetic process 4 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:1901566 organonitrogen compound biosynthetic process 4 7
GO:1901576 organic substance biosynthetic process 3 7
GO:1901615 organic hydroxy compound metabolic process 3 7
GO:1901617 organic hydroxy compound biosynthetic process 4 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity 5 7
GO:0016829 lyase activity 2 7
GO:0016835 carbon-oxygen lyase activity 3 7
GO:0016836 hydro-lyase activity 4 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 2 4 PF00675 0.718
CLV_PCSK_KEX2_1 2 4 PF00082 0.718
CLV_PCSK_SKI1_1 3 7 PF00082 0.608
DEG_Nend_UBRbox_1 1 4 PF02207 0.645
DOC_PP2B_LxvP_1 7 10 PF13499 0.628
DOC_PP4_FxxP_1 13 16 PF00568 0.274
DOC_USP7_MATH_1 21 25 PF00917 0.364
LIG_14-3-3_CanoR_1 52 58 PF00244 0.357
LIG_APCC_ABBAyCdc20_2 40 46 PF00400 0.410
LIG_FHA_1 17 23 PF00498 0.319
LIG_FHA_2 80 86 PF00498 0.487
LIG_FHA_2 89 95 PF00498 0.386
LIG_LIR_Gen_1 41 51 PF02991 0.487
LIG_LIR_Gen_1 71 81 PF02991 0.386
LIG_LIR_Nem_3 41 47 PF02991 0.378
LIG_LIR_Nem_3 71 77 PF02991 0.329
LIG_Pex14_1 70 74 PF04695 0.386
LIG_SH2_CRK 74 78 PF00017 0.364
LIG_SH2_GRB2like 53 56 PF00017 0.487
LIG_SH2_STAT5 42 45 PF00017 0.349
MOD_GlcNHglycan 13 16 PF01048 0.497
MOD_PIKK_1 16 22 PF00454 0.364
MOD_PIKK_1 88 94 PF00454 0.487
MOD_PKA_2 68 74 PF00069 0.334
TRG_ENDOCYTIC_2 105 108 PF00928 0.380
TRG_ENDOCYTIC_2 74 77 PF00928 0.364
TRG_ER_diArg_1 1 3 PF00400 0.735

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HV76 Leptomonas seymouri 69% 99%
A0A0S4KHT1 Bodo saltans 43% 84%
A0A1X0NV87 Trypanosomatidae 52% 83%
A0A3R7MSR6 Trypanosoma rangeli 56% 100%
A0K2V4 Burkholderia cenocepacia (strain HI2424) 45% 100%
A0M1H4 Gramella forsetii (strain KT0803) 35% 100%
A1B3I3 Paracoccus denitrificans (strain Pd 1222) 31% 100%
A1SSU3 Psychromonas ingrahamii (strain 37) 36% 100%
A1TND7 Acidovorax citrulli (strain AAC00-1) 33% 96%
A2BPX4 Prochlorococcus marinus (strain AS9601) 35% 100%
A2BVF3 Prochlorococcus marinus (strain MIT 9515) 35% 100%
A2C7K4 Prochlorococcus marinus (strain MIT 9303) 39% 100%
A3PBL6 Prochlorococcus marinus (strain MIT 9301) 35% 100%
A4H9T6 Leishmania braziliensis 85% 100%
A4HUT4 Leishmania infantum 99% 100%
A4JA07 Burkholderia vietnamiensis (strain G4 / LMG 22486) 46% 100%
A4YEM3 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) 40% 100%
A4YJY8 Bradyrhizobium sp. (strain ORS 278) 46% 100%
A5E8P9 Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) 49% 100%
A5FWK8 Acidiphilium cryptum (strain JF-5) 48% 100%
A5GMR6 Synechococcus sp. (strain WH7803) 46% 100%
A5V667 Rhizorhabdus wittichii (strain DSM 6014 / CCUG 31198 / JCM 15750 / NBRC 105917 / EY 4224 / RW1) 45% 100%
A5VN26 Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512) 41% 100%
A6UE17 Sinorhizobium medicae (strain WSM419) 38% 100%
A6VSD2 Marinomonas sp. (strain MWYL1) 37% 100%
A6WV21 Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37) 44% 100%
A7HSX5 Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) 49% 100%
A8G3K7 Prochlorococcus marinus (strain MIT 9215) 35% 100%
A8LKP0 Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12) 43% 100%
A9AJD5 Burkholderia multivorans (strain ATCC 17616 / 249) 47% 100%
A9AXS2 Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785 / 114-95) 31% 100%
A9M6T4 Brucella canis (strain ATCC 23365 / NCTC 10854) 41% 100%
A9WI69 Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) 34% 100%
B0CIJ4 Brucella suis (strain ATCC 23445 / NCTC 10510) 41% 100%
B0RTH5 Xanthomonas campestris pv. campestris (strain B100) 30% 94%
B0T207 Caulobacter sp. (strain K31) 47% 100%
B1K1I7 Burkholderia cenocepacia (strain MC0-3) 43% 100%
B1XN71 Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) 38% 100%
B1YQ64 Burkholderia ambifaria (strain MC40-6) 44% 100%
B1ZY08 Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1) 43% 100%
B2FM88 Stenotrophomonas maltophilia (strain K279a) 28% 96%
B2IVV2 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) 36% 100%
B2S7X9 Brucella abortus (strain S19) 41% 100%
B2T7M8 Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) 43% 100%
B2UGY6 Ralstonia pickettii (strain 12J) 41% 100%
B3Q9E4 Rhodopseudomonas palustris (strain TIE-1) 51% 100%
B4E566 Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) 46% 100%
B4RBN1 Phenylobacterium zucineum (strain HLK1) 42% 100%
B4RXT2 Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype) 42% 100%
B5ZTF5 Rhizobium leguminosarum bv. trifolii (strain WSM2304) 44% 100%
B6JAT9 Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) 47% 100%
B8G3F7 Chloroflexus aggregans (strain MD-66 / DSM 9485) 37% 100%
B8GYB5 Caulobacter vibrioides (strain NA1000 / CB15N) 44% 100%
B8HU56 Cyanothece sp. (strain PCC 7425 / ATCC 29141) 33% 100%
B9JCJ2 Agrobacterium radiobacter (strain K84 / ATCC BAA-868) 45% 100%
B9JUA0 Agrobacterium vitis (strain S4 / ATCC BAA-846) 44% 100%
B9L1Y8 Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2) 43% 100%
B9LCC8 Chloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl) 34% 100%
C0RGE2 Brucella melitensis biotype 2 (strain ATCC 23457) 41% 100%
C1F425 Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161) 43% 100%
C3MAI8 Sinorhizobium fredii (strain NBRC 101917 / NGR234) 38% 100%
D0A7M7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 90%
E9ANG8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O66462 Aquifex aeolicus (strain VF5) 26% 100%
O73930 Gallus gallus 40% 100%
P0C8L6 Hypsibius exemplaris 38% 100%
P61457 Homo sapiens 40% 100%
P61458 Mus musculus 40% 100%
P61459 Rattus norvegicus 40% 100%
P61734 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 51% 100%
P65722 Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) 41% 100%
P65723 Brucella suis biovar 1 (strain 1330) 41% 100%
P73790 Synechocystis sp. (strain PCC 6803 / Kazusa) 41% 100%
Q01VX3 Solibacter usitatus (strain Ellin6076) 44% 100%
Q0BJP4 Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) 44% 100%
Q0I8H5 Synechococcus sp. (strain CC9311) 41% 100%
Q116J2 Trichodesmium erythraeum (strain IMS101) 29% 100%
Q11D07 Chelativorans sp. (strain BNC1) 43% 100%
Q13D98 Rhodopseudomonas palustris (strain BisB5) 53% 100%
Q13SM2 Paraburkholderia xenovorans (strain LB400) 40% 100%
Q16BN1 Roseobacter denitrificans (strain ATCC 33942 / OCh 114) 42% 100%
Q1GDR0 Ruegeria sp. (strain TM1040) 47% 100%
Q1IP68 Koribacter versatilis (strain Ellin345) 46% 100%
Q1MAM8 Rhizobium leguminosarum bv. viciae (strain 3841) 46% 100%
Q1QHE0 Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14) 49% 100%
Q214W1 Rhodopseudomonas palustris (strain BisB18) 54% 100%
Q28VA7 Jannaschia sp. (strain CCS1) 44% 100%
Q2G9B0 Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199) 48% 100%
Q2J3Z9 Rhodopseudomonas palustris (strain HaA2) 59% 100%
Q2K3A7 Rhizobium etli (strain CFN 42 / ATCC 51251) 43% 100%
Q2KXB6 Bordetella avium (strain 197N) 47% 100%
Q2RNC0 Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) 39% 100%
Q2YB52 Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71) 27% 98%
Q2YNV0 Brucella abortus (strain 2308) 41% 100%
Q31C42 Prochlorococcus marinus (strain MIT 9312) 34% 100%
Q39L06 Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383) 45% 100%
Q3JXT0 Burkholderia pseudomallei (strain 1710b) 48% 100%
Q3MA60 Trichormus variabilis (strain ATCC 29413 / PCC 7937) 37% 100%
Q3SNS9 Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255) 52% 100%
Q3ZBD3 Bos taurus 41% 100%
Q46GT1 Prochlorococcus marinus (strain NATL2A) 39% 100%
Q46VT8 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) 45% 100%
Q4FVF3 Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4) 49% 100%
Q4J6J6 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 31% 100%
Q4QH58 Leishmania major 92% 100%
Q54RY8 Dictyostelium discoideum 39% 100%
Q57FT6 Brucella abortus biovar 1 (strain 9-941) 41% 100%
Q5R7K1 Pongo abelii 41% 95%
Q62FU4 Burkholderia mallei (strain ATCC 23344) 48% 100%
Q63PF1 Burkholderia pseudomallei (strain K96243) 48% 100%
Q7NK35 Gloeobacter violaceus (strain ATCC 29082 / PCC 7421) 39% 100%
Q7NVH7 Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757) 35% 100%
Q7U5B3 Parasynechococcus marenigrum (strain WH8102) 40% 100%
Q7V2I5 Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 / MED4) 41% 100%
Q7V689 Prochlorococcus marinus (strain MIT 9313) 39% 100%
Q7VD93 Prochlorococcus marinus (strain SARG / CCMP1375 / SS120) 33% 100%
Q7VU17 Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 50% 98%
Q7W4J0 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) 50% 98%
Q7WG14 Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 50% 98%
Q89WZ6 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) 49% 100%
Q8DHW8 Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1) 39% 100%
Q8UC22 Agrobacterium fabrum (strain C58 / ATCC 33970) 47% 100%
Q8XU38 Ralstonia solanacearum (strain GMI1000) 43% 100%
Q8YNL6 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 37% 100%
Q91901 Xenopus laevis 40% 100%
Q92L66 Rhizobium meliloti (strain 1021) 38% 100%
Q96YL0 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 40% 100%
Q97WM6 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 32% 100%
Q98E92 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 48% 100%
Q9ABI2 Caulobacter vibrioides (strain ATCC 19089 / CB15) 44% 100%
Q9CZL5 Mus musculus 40% 82%
Q9DG45 Gallus gallus 37% 100%
Q9H0N5 Homo sapiens 38% 85%
Q9TZH6 Caenorhabditis elegans 39% 78%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS