RNA-binding protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8I7S8_LEIDO

TriTrypDb:

LdBPK_101110.1 , LdCL_100018000 , LDHU3_10.1460

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I7S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I7S8

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.370
CLV_NRD_NRD_1	18	20	PF00675	0.623
CLV_NRD_NRD_1	253	255	PF00675	0.483
CLV_NRD_NRD_1	264	266	PF00675	0.399
CLV_NRD_NRD_1	284	286	PF00675	0.663
CLV_NRD_NRD_1	374	376	PF00675	0.671
CLV_NRD_NRD_1	59	61	PF00675	0.752
CLV_PCSK_FUR_1	206	210	PF00082	0.263
CLV_PCSK_KEX2_1	18	20	PF00082	0.691
CLV_PCSK_KEX2_1	208	210	PF00082	0.263
CLV_PCSK_KEX2_1	252	254	PF00082	0.544
CLV_PCSK_KEX2_1	263	265	PF00082	0.385
CLV_PCSK_KEX2_1	284	286	PF00082	0.657
CLV_PCSK_KEX2_1	333	335	PF00082	0.565
CLV_PCSK_KEX2_1	370	372	PF00082	0.650
CLV_PCSK_KEX2_1	374	376	PF00082	0.633
CLV_PCSK_KEX2_1	59	61	PF00082	0.667
CLV_PCSK_KEX2_1	85	87	PF00082	0.689
CLV_PCSK_KEX2_1	93	95	PF00082	0.661
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.640
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.306
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.565
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.639
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.678
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.590
CLV_PCSK_SKI1_1	247	251	PF00082	0.506
CLV_PCSK_SKI1_1	264	268	PF00082	0.491
CLV_PCSK_SKI1_1	370	374	PF00082	0.664
CLV_PCSK_SKI1_1	79	83	PF00082	0.649
DEG_SPOP_SBC_1	70	74	PF00917	0.647
DOC_CYCLIN_RxL_1	17	28	PF00134	0.580
DOC_MAPK_gen_1	18	24	PF00069	0.597
DOC_MAPK_gen_1	212	221	PF00069	0.506
DOC_MAPK_gen_1	284	293	PF00069	0.497
DOC_MAPK_MEF2A_6	223	231	PF00069	0.506
DOC_MAPK_MEF2A_6	284	293	PF00069	0.535
DOC_PP1_RVXF_1	173	179	PF00149	0.300
DOC_PP1_RVXF_1	18	25	PF00149	0.591
DOC_PP4_FxxP_1	178	181	PF00568	0.460
DOC_PP4_FxxP_1	183	186	PF00568	0.468
DOC_USP7_MATH_1	103	107	PF00917	0.653
DOC_USP7_MATH_1	124	128	PF00917	0.731
DOC_USP7_MATH_1	154	158	PF00917	0.806
DOC_USP7_UBL2_3	352	356	PF12436	0.704
DOC_USP7_UBL2_3	366	370	PF12436	0.632
DOC_USP7_UBL2_3	4	8	PF12436	0.675
DOC_USP7_UBL2_3	46	50	PF12436	0.582
DOC_WW_Pin1_4	365	370	PF00397	0.684
LIG_14-3-3_CanoR_1	175	179	PF00244	0.359
LIG_14-3-3_CanoR_1	19	25	PF00244	0.601
LIG_14-3-3_CanoR_1	206	216	PF00244	0.484
LIG_14-3-3_CanoR_1	247	252	PF00244	0.516
LIG_14-3-3_CanoR_1	336	345	PF00244	0.704
LIG_FHA_1	355	361	PF00498	0.739
LIG_FHA_1	36	42	PF00498	0.574
LIG_FHA_2	296	302	PF00498	0.420
LIG_FHA_2	93	99	PF00498	0.562
LIG_LIR_Apic_2	177	181	PF02991	0.468
LIG_LIR_Apic_2	182	186	PF02991	0.458
LIG_LIR_Nem_3	169	174	PF02991	0.433
LIG_Pex14_2	191	195	PF04695	0.463
LIG_Pex14_2	313	317	PF04695	0.436
LIG_SH2_CRK	171	175	PF00017	0.459
LIG_SH2_CRK	189	193	PF00017	0.506
LIG_SH2_SRC	305	308	PF00017	0.427
LIG_SH2_STAT3	271	274	PF00017	0.380
LIG_SH2_STAT5	218	221	PF00017	0.463
LIG_SH2_STAT5	305	308	PF00017	0.489
LIG_SH3_3	38	44	PF00018	0.690
LIG_SH3_3	96	102	PF00018	0.775
LIG_SUMO_SIM_par_1	227	233	PF11976	0.506
LIG_TRAF2_1	106	109	PF00917	0.695
LIG_TRAF2_1	95	98	PF00917	0.646
MOD_CDC14_SPxK_1	368	371	PF00782	0.625
MOD_CDK_SPK_2	365	370	PF00069	0.625
MOD_CDK_SPxK_1	365	371	PF00069	0.715
MOD_CK1_1	156	162	PF00069	0.630
MOD_CK1_1	164	170	PF00069	0.571
MOD_CK1_1	207	213	PF00069	0.463
MOD_CK1_1	337	343	PF00069	0.605
MOD_CK2_1	103	109	PF00069	0.671
MOD_CK2_1	138	144	PF00069	0.604
MOD_CK2_1	20	26	PF00069	0.534
MOD_CK2_1	92	98	PF00069	0.558
MOD_Cter_Amidation	16	19	PF01082	0.629
MOD_GlcNHglycan	11	14	PF01048	0.598
MOD_GlcNHglycan	156	159	PF01048	0.631
MOD_GlcNHglycan	224	227	PF01048	0.289
MOD_GlcNHglycan	362	365	PF01048	0.555
MOD_GlcNHglycan	73	76	PF01048	0.747
MOD_GlcNHglycan	86	89	PF01048	0.557
MOD_GSK3_1	152	159	PF00069	0.644
MOD_GSK3_1	20	27	PF00069	0.563
MOD_GSK3_1	317	324	PF00069	0.591
MOD_GSK3_1	337	344	PF00069	0.712
MOD_GSK3_1	355	362	PF00069	0.638
MOD_GSK3_1	65	72	PF00069	0.726
MOD_GSK3_1	9	16	PF00069	0.661
MOD_N-GLC_1	109	114	PF02516	0.655
MOD_N-GLC_1	164	169	PF02516	0.563
MOD_N-GLC_1	341	346	PF02516	0.553
MOD_N-GLC_1	70	75	PF02516	0.626
MOD_NEK2_1	195	200	PF00069	0.506
MOD_NEK2_1	24	29	PF00069	0.550
MOD_NEK2_1	317	322	PF00069	0.478
MOD_NEK2_1	84	89	PF00069	0.642
MOD_NEK2_2	25	30	PF00069	0.549
MOD_NEK2_2	3	8	PF00069	0.587
MOD_PIKK_1	270	276	PF00454	0.375
MOD_PIKK_1	317	323	PF00454	0.525
MOD_PKA_1	20	26	PF00069	0.594
MOD_PKA_1	332	338	PF00069	0.668
MOD_PKA_1	370	376	PF00069	0.636
MOD_PKA_1	66	72	PF00069	0.658
MOD_PKA_2	161	167	PF00069	0.601
MOD_PKA_2	174	180	PF00069	0.260
MOD_PKA_2	370	376	PF00069	0.682
MOD_PKB_1	245	253	PF00069	0.495
MOD_Plk_1	25	31	PF00069	0.522
MOD_Plk_1	341	347	PF00069	0.530
MOD_Plk_2-3	109	115	PF00069	0.622
MOD_Plk_4	174	180	PF00069	0.360
MOD_Plk_4	195	201	PF00069	0.517
MOD_ProDKin_1	365	371	PF00069	0.689
MOD_SUMO_rev_2	307	315	PF00179	0.381
TRG_ENDOCYTIC_2	171	174	PF00928	0.398
TRG_ENDOCYTIC_2	189	192	PF00928	0.463
TRG_ENDOCYTIC_2	218	221	PF00928	0.463
TRG_ER_diArg_1	244	247	PF00400	0.468
TRG_ER_diArg_1	251	254	PF00400	0.528
TRG_ER_diArg_1	263	265	PF00400	0.421
TRG_ER_diArg_1	283	285	PF00400	0.386
TRG_ER_diArg_1	58	60	PF00400	0.656
TRG_NLS_Bipartite_1	8	23	PF00514	0.646
TRG_NLS_MonoCore_2	17	22	PF00514	0.613
TRG_NLS_MonoCore_2	330	335	PF00514	0.609
TRG_NLS_MonoExtC_3	331	336	PF00514	0.618
TRG_NLS_MonoExtN_4	18	23	PF00514	0.598
TRG_NLS_MonoExtN_4	331	337	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9B0	Leptomonas seymouri	59%	92%
A0A3R7KMG8	Trypanosoma rangeli	47%	91%
A4H691	Leishmania braziliensis	73%	100%
A4HUL4	Leishmania infantum	99%	100%
E9ANB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QHB1	Leishmania major	90%	99%