RNA binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8I7R0_LEIDO

TriTrypDb:

LdBPK_100750.1 , LdCL_100014300 , LDHU3_10.1080

Length:

952

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I7R0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I7R0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.682
CLV_C14_Caspase3-7	302	306	PF00656	0.736
CLV_C14_Caspase3-7	321	325	PF00656	0.770
CLV_C14_Caspase3-7	593	597	PF00656	0.552
CLV_MEL_PAP_1	603	609	PF00089	0.506
CLV_NRD_NRD_1	125	127	PF00675	0.594
CLV_NRD_NRD_1	137	139	PF00675	0.667
CLV_NRD_NRD_1	169	171	PF00675	0.756
CLV_NRD_NRD_1	197	199	PF00675	0.541
CLV_NRD_NRD_1	250	252	PF00675	0.699
CLV_NRD_NRD_1	274	276	PF00675	0.599
CLV_NRD_NRD_1	42	44	PF00675	0.538
CLV_NRD_NRD_1	494	496	PF00675	0.560
CLV_NRD_NRD_1	809	811	PF00675	0.697
CLV_NRD_NRD_1	835	837	PF00675	0.627
CLV_NRD_NRD_1	898	900	PF00675	0.251
CLV_PCSK_KEX2_1	171	173	PF00082	0.710
CLV_PCSK_KEX2_1	197	199	PF00082	0.558
CLV_PCSK_KEX2_1	249	251	PF00082	0.761
CLV_PCSK_KEX2_1	274	276	PF00082	0.599
CLV_PCSK_KEX2_1	42	44	PF00082	0.439
CLV_PCSK_KEX2_1	453	455	PF00082	0.549
CLV_PCSK_KEX2_1	494	496	PF00082	0.569
CLV_PCSK_KEX2_1	742	744	PF00082	0.563
CLV_PCSK_KEX2_1	809	811	PF00082	0.697
CLV_PCSK_KEX2_1	834	836	PF00082	0.630
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.710
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.549
CLV_PCSK_PC1ET2_1	742	744	PF00082	0.563
CLV_PCSK_PC7_1	490	496	PF00082	0.645
CLV_PCSK_SKI1_1	274	278	PF00082	0.572
CLV_PCSK_SKI1_1	43	47	PF00082	0.575
CLV_PCSK_SKI1_1	633	637	PF00082	0.360
CLV_PCSK_SKI1_1	642	646	PF00082	0.382
CLV_PCSK_SKI1_1	74	78	PF00082	0.452
CLV_PCSK_SKI1_1	743	747	PF00082	0.328
CLV_PCSK_SKI1_1	752	756	PF00082	0.334
CLV_PCSK_SKI1_1	883	887	PF00082	0.239
DEG_APCC_DBOX_1	369	377	PF00400	0.322
DOC_ANK_TNKS_1	255	262	PF00023	0.652
DOC_CYCLIN_RxL_1	2	12	PF00134	0.415
DOC_CYCLIN_RxL_1	584	593	PF00134	0.523
DOC_CYCLIN_RxL_1	739	749	PF00134	0.476
DOC_CYCLIN_RxL_1	867	879	PF00134	0.376
DOC_CYCLIN_yCln2_LP_2	392	398	PF00134	0.528
DOC_MAPK_gen_1	103	111	PF00069	0.499
DOC_MAPK_gen_1	197	205	PF00069	0.655
DOC_MAPK_gen_1	408	418	PF00069	0.439
DOC_MAPK_gen_1	577	586	PF00069	0.391
DOC_MAPK_gen_1	642	651	PF00069	0.400
DOC_MAPK_gen_1	71	81	PF00069	0.484
DOC_MAPK_MEF2A_6	103	111	PF00069	0.516
DOC_MAPK_MEF2A_6	113	122	PF00069	0.635
DOC_MAPK_MEF2A_6	28	35	PF00069	0.546
DOC_MAPK_MEF2A_6	71	79	PF00069	0.552
DOC_PP1_RVXF_1	631	637	PF00149	0.365
DOC_PP2B_LxvP_1	220	223	PF13499	0.736
DOC_PP2B_LxvP_1	295	298	PF13499	0.505
DOC_PP2B_LxvP_1	7	10	PF13499	0.393
DOC_PP2B_LxvP_1	857	860	PF13499	0.432
DOC_SPAK_OSR1_1	606	610	PF12202	0.493
DOC_USP7_MATH_1	152	156	PF00917	0.743
DOC_USP7_MATH_1	299	303	PF00917	0.685
DOC_USP7_MATH_1	365	369	PF00917	0.569
DOC_USP7_MATH_1	461	465	PF00917	0.586
DOC_USP7_MATH_1	481	485	PF00917	0.507
DOC_USP7_MATH_1	614	618	PF00917	0.396
DOC_USP7_MATH_1	680	684	PF00917	0.625
DOC_USP7_MATH_1	758	762	PF00917	0.376
DOC_USP7_MATH_1	898	902	PF00917	0.451
DOC_USP7_UBL2_3	139	143	PF12436	0.675
DOC_USP7_UBL2_3	769	773	PF12436	0.383
DOC_USP7_UBL2_3	867	871	PF12436	0.287
DOC_WW_Pin1_4	223	228	PF00397	0.750
DOC_WW_Pin1_4	800	805	PF00397	0.672
LIG_14-3-3_CanoR_1	206	215	PF00244	0.577
LIG_14-3-3_CanoR_1	366	373	PF00244	0.536
LIG_14-3-3_CanoR_1	417	425	PF00244	0.512
LIG_14-3-3_CanoR_1	442	450	PF00244	0.437
LIG_14-3-3_CanoR_1	579	586	PF00244	0.387
LIG_14-3-3_CanoR_1	625	629	PF00244	0.431
LIG_14-3-3_CanoR_1	638	642	PF00244	0.307
LIG_14-3-3_CanoR_1	752	758	PF00244	0.311
LIG_14-3-3_CanoR_1	85	93	PF00244	0.459
LIG_14-3-3_CanoR_1	899	905	PF00244	0.528
LIG_BIR_II_1	1	5	PF00653	0.426
LIG_BIR_III_2	728	732	PF00653	0.480
LIG_BRCT_BRCA1_1	482	486	PF00533	0.596
LIG_BRCT_BRCA1_1	900	904	PF00533	0.451
LIG_BRCT_BRCA1_1	98	102	PF00533	0.461
LIG_BRCT_BRCA1_2	482	488	PF00533	0.627
LIG_FHA_1	344	350	PF00498	0.749
LIG_FHA_1	549	555	PF00498	0.355
LIG_FHA_1	580	586	PF00498	0.356
LIG_FHA_1	644	650	PF00498	0.439
LIG_FHA_1	705	711	PF00498	0.343
LIG_FHA_1	786	792	PF00498	0.334
LIG_FHA_1	827	833	PF00498	0.755
LIG_FHA_1	892	898	PF00498	0.522
LIG_FHA_2	160	166	PF00498	0.770
LIG_FHA_2	188	194	PF00498	0.687
LIG_FHA_2	262	268	PF00498	0.661
LIG_FHA_2	44	50	PF00498	0.604
LIG_FHA_2	715	721	PF00498	0.403
LIG_FHA_2	754	760	PF00498	0.302
LIG_FHA_2	812	818	PF00498	0.693
LIG_FHA_2	876	882	PF00498	0.439
LIG_LIR_Gen_1	201	209	PF02991	0.662
LIG_LIR_Gen_1	505	511	PF02991	0.544
LIG_LIR_Gen_1	601	612	PF02991	0.451
LIG_LIR_Gen_1	884	892	PF02991	0.439
LIG_LIR_Nem_3	201	205	PF02991	0.653
LIG_LIR_Nem_3	601	607	PF02991	0.361
LIG_LIR_Nem_3	640	644	PF02991	0.374
LIG_LIR_Nem_3	652	656	PF02991	0.382
LIG_LIR_Nem_3	884	889	PF02991	0.439
LIG_MLH1_MIPbox_1	98	102	PF16413	0.488
LIG_Pex14_1	506	510	PF04695	0.455
LIG_Pex14_2	97	101	PF04695	0.492
LIG_PTB_Apo_2	372	379	PF02174	0.451
LIG_PTB_Apo_2	709	716	PF02174	0.355
LIG_PTB_Apo_2	869	876	PF02174	0.439
LIG_PTB_Apo_2	95	102	PF02174	0.510
LIG_PTB_Phospho_1	372	378	PF10480	0.482
LIG_REV1ctd_RIR_1	99	107	PF16727	0.502
LIG_SH2_CRK	947	951	PF00017	0.348
LIG_SH2_GRB2like	510	513	PF00017	0.464
LIG_SH2_GRB2like	96	99	PF00017	0.507
LIG_SH2_NCK_1	626	630	PF00017	0.472
LIG_SH2_STAP1	706	710	PF00017	0.450
LIG_SH2_STAT5	378	381	PF00017	0.482
LIG_SH2_STAT5	549	552	PF00017	0.396
LIG_SH2_STAT5	626	629	PF00017	0.351
LIG_SH2_STAT5	706	709	PF00017	0.411
LIG_SH2_STAT5	765	768	PF00017	0.287
LIG_SH2_STAT5	96	99	PF00017	0.408
LIG_SH3_3	338	344	PF00018	0.724
LIG_SH3_3	396	402	PF00018	0.439
LIG_SH3_3	892	898	PF00018	0.439
LIG_SUMO_SIM_par_1	31	37	PF11976	0.525
LIG_TRAF2_1	270	273	PF00917	0.630
LIG_TRAF2_1	360	363	PF00917	0.584
LIG_TRAF2_1	380	383	PF00917	0.321
LIG_TRAF2_1	445	448	PF00917	0.546
LIG_TYR_ITIM	945	950	PF00017	0.392
MOD_CK1_1	141	147	PF00069	0.649
MOD_CK1_1	155	161	PF00069	0.609
MOD_CK1_1	207	213	PF00069	0.621
MOD_CK1_1	580	586	PF00069	0.366
MOD_CK1_1	785	791	PF00069	0.302
MOD_CK1_1	824	830	PF00069	0.637
MOD_CK1_1	887	893	PF00069	0.322
MOD_CK2_1	159	165	PF00069	0.758
MOD_CK2_1	416	422	PF00069	0.403
MOD_CK2_1	441	447	PF00069	0.452
MOD_CK2_1	715	721	PF00069	0.407
MOD_CK2_1	903	909	PF00069	0.299
MOD_CK2_1	919	925	PF00069	0.244
MOD_GlcNHglycan	143	146	PF01048	0.742
MOD_GlcNHglycan	154	157	PF01048	0.647
MOD_GlcNHglycan	238	241	PF01048	0.735
MOD_GlcNHglycan	292	295	PF01048	0.609
MOD_GlcNHglycan	301	304	PF01048	0.606
MOD_GlcNHglycan	419	422	PF01048	0.416
MOD_GlcNHglycan	443	446	PF01048	0.394
MOD_GlcNHglycan	611	615	PF01048	0.388
MOD_GlcNHglycan	616	619	PF01048	0.365
MOD_GlcNHglycan	62	65	PF01048	0.713
MOD_GlcNHglycan	666	669	PF01048	0.646
MOD_GlcNHglycan	682	685	PF01048	0.522
MOD_GlcNHglycan	846	849	PF01048	0.733
MOD_GlcNHglycan	86	89	PF01048	0.442
MOD_GlcNHglycan	886	889	PF01048	0.322
MOD_GSK3_1	152	159	PF00069	0.760
MOD_GSK3_1	207	214	PF00069	0.562
MOD_GSK3_1	339	346	PF00069	0.696
MOD_GSK3_1	575	582	PF00069	0.519
MOD_GSK3_1	610	617	PF00069	0.388
MOD_GSK3_1	660	667	PF00069	0.640
MOD_GSK3_1	676	683	PF00069	0.614
MOD_GSK3_1	704	711	PF00069	0.344
MOD_GSK3_1	778	785	PF00069	0.331
MOD_GSK3_1	800	807	PF00069	0.699
MOD_GSK3_1	844	851	PF00069	0.751
MOD_GSK3_1	887	894	PF00069	0.302
MOD_GSK3_1	898	905	PF00069	0.302
MOD_GSK3_1	929	936	PF00069	0.302
MOD_GSK3_1	97	104	PF00069	0.435
MOD_N-GLC_1	139	144	PF02516	0.711
MOD_N-GLC_1	339	344	PF02516	0.712
MOD_N-GLC_1	580	585	PF02516	0.385
MOD_N-GLC_1	97	102	PF02516	0.424
MOD_N-GLC_2	11	13	PF02516	0.513
MOD_NEK2_1	157	162	PF00069	0.758
MOD_NEK2_1	22	27	PF00069	0.451
MOD_NEK2_1	388	393	PF00069	0.289
MOD_NEK2_1	441	446	PF00069	0.402
MOD_NEK2_1	462	467	PF00069	0.605
MOD_NEK2_1	480	485	PF00069	0.426
MOD_NEK2_1	575	580	PF00069	0.525
MOD_NEK2_1	610	615	PF00069	0.367
MOD_NEK2_1	624	629	PF00069	0.353
MOD_NEK2_1	643	648	PF00069	0.491
MOD_NEK2_1	676	681	PF00069	0.615
MOD_NEK2_1	704	709	PF00069	0.363
MOD_NEK2_1	84	89	PF00069	0.450
MOD_NEK2_1	933	938	PF00069	0.287
MOD_NEK2_1	97	102	PF00069	0.306
MOD_NEK2_2	929	934	PF00069	0.322
MOD_PIKK_1	242	248	PF00454	0.722
MOD_PIKK_1	481	487	PF00454	0.615
MOD_PIKK_1	569	575	PF00454	0.591
MOD_PKA_1	138	144	PF00069	0.619
MOD_PKA_2	102	108	PF00069	0.517
MOD_PKA_2	255	261	PF00069	0.684
MOD_PKA_2	365	371	PF00069	0.450
MOD_PKA_2	416	422	PF00069	0.360
MOD_PKA_2	441	447	PF00069	0.409
MOD_PKA_2	624	630	PF00069	0.389
MOD_PKA_2	637	643	PF00069	0.338
MOD_PKA_2	84	90	PF00069	0.500
MOD_PKA_2	898	904	PF00069	0.302
MOD_Plk_1	580	586	PF00069	0.398
MOD_Plk_1	610	616	PF00069	0.360
MOD_Plk_1	758	764	PF00069	0.287
MOD_Plk_1	97	103	PF00069	0.430
MOD_Plk_2-3	318	324	PF00069	0.691
MOD_Plk_2-3	919	925	PF00069	0.287
MOD_Plk_4	388	394	PF00069	0.322
MOD_Plk_4	505	511	PF00069	0.453
MOD_Plk_4	580	586	PF00069	0.366
MOD_Plk_4	704	710	PF00069	0.402
MOD_Plk_4	852	858	PF00069	0.505
MOD_Plk_4	97	103	PF00069	0.359
MOD_ProDKin_1	223	229	PF00069	0.752
MOD_ProDKin_1	800	806	PF00069	0.673
MOD_SUMO_for_1	107	110	PF00179	0.478
MOD_SUMO_rev_2	133	141	PF00179	0.630
MOD_SUMO_rev_2	233	239	PF00179	0.758
TRG_AP2beta_CARGO_1	884	893	PF09066	0.322
TRG_DiLeu_BaEn_1	273	278	PF01217	0.486
TRG_DiLeu_BaEn_2	720	726	PF01217	0.470
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.554
TRG_DiLeu_BaLyEn_6	436	441	PF01217	0.287
TRG_ENDOCYTIC_2	641	644	PF00928	0.377
TRG_ENDOCYTIC_2	706	709	PF00928	0.441
TRG_ENDOCYTIC_2	947	950	PF00928	0.384
TRG_ER_diArg_1	170	173	PF00400	0.673
TRG_ER_diArg_1	197	200	PF00400	0.569
TRG_ER_diArg_1	249	251	PF00400	0.754
TRG_ER_diArg_1	3	6	PF00400	0.377
TRG_ER_diArg_1	370	373	PF00400	0.291
TRG_ER_diArg_1	41	43	PF00400	0.539
TRG_ER_diArg_1	834	836	PF00400	0.744
TRG_NES_CRM1_1	110	124	PF08389	0.614
TRG_NES_CRM1_1	599	611	PF08389	0.510
TRG_NLS_MonoExtC_3	169	174	PF00514	0.745
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	275	280	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	941	946	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY42	Leptomonas seymouri	66%	100%
A0A0S4J8G6	Bodo saltans	40%	100%
A0A1X0NQT4	Trypanosomatidae	47%	100%
A0A3R7NQE9	Trypanosoma rangeli	48%	100%
A4H661	Leishmania braziliensis	80%	99%
A4HUI2	Leishmania infantum	99%	100%
C9ZVK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AN80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q06106	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q4QHE5	Leishmania major	92%	100%
Q4WJT7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q5BGA9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	100%
V5B419	Trypanosoma cruzi	52%	100%