Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I7N0_LEIDO

TriTrypDb:

LdBPK_100350.1 , LdCL_100008800 , LDHU3_10.0500

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I7N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I7N0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.680
CLV_C14_Caspase3-7	203	207	PF00656	0.696
CLV_C14_Caspase3-7	263	267	PF00656	0.657
CLV_NRD_NRD_1	252	254	PF00675	0.538
CLV_NRD_NRD_1	384	386	PF00675	0.532
CLV_NRD_NRD_1	97	99	PF00675	0.450
CLV_PCSK_FUR_1	419	423	PF00082	0.723
CLV_PCSK_KEX2_1	252	254	PF00082	0.538
CLV_PCSK_KEX2_1	384	386	PF00082	0.532
CLV_PCSK_KEX2_1	421	423	PF00082	0.705
CLV_PCSK_KEX2_1	97	99	PF00082	0.450
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.755
CLV_PCSK_SKI1_1	122	126	PF00082	0.796
CLV_PCSK_SKI1_1	167	171	PF00082	0.630
CLV_PCSK_SKI1_1	22	26	PF00082	0.629
CLV_Separin_Metazoa	320	324	PF03568	0.515
DEG_APCC_DBOX_1	73	81	PF00400	0.604
DEG_SPOP_SBC_1	10	14	PF00917	0.705
DEG_SPOP_SBC_1	239	243	PF00917	0.575
DOC_MAPK_MEF2A_6	295	304	PF00069	0.611
DOC_PP2B_LxvP_1	197	200	PF13499	0.502
DOC_PP4_FxxP_1	32	35	PF00568	0.457
DOC_USP7_MATH_1	10	14	PF00917	0.595
DOC_USP7_MATH_1	239	243	PF00917	0.730
DOC_USP7_MATH_1	390	394	PF00917	0.669
DOC_WW_Pin1_4	183	188	PF00397	0.644
DOC_WW_Pin1_4	305	310	PF00397	0.578
DOC_WW_Pin1_4	394	399	PF00397	0.640
LIG_14-3-3_CanoR_1	114	118	PF00244	0.613
LIG_14-3-3_CanoR_1	147	153	PF00244	0.543
LIG_14-3-3_CanoR_1	22	32	PF00244	0.587
LIG_14-3-3_CanoR_1	252	260	PF00244	0.636
LIG_14-3-3_CanoR_1	323	333	PF00244	0.517
LIG_14-3-3_CanoR_1	369	374	PF00244	0.453
LIG_14-3-3_CanoR_1	37	46	PF00244	0.615
LIG_14-3-3_CanoR_1	384	391	PF00244	0.427
LIG_Actin_WH2_2	131	149	PF00022	0.583
LIG_Actin_WH2_2	315	332	PF00022	0.642
LIG_BIR_III_2	206	210	PF00653	0.626
LIG_CaM_IQ_9	361	377	PF13499	0.454
LIG_DLG_GKlike_1	369	377	PF00625	0.462
LIG_FHA_1	147	153	PF00498	0.562
LIG_FHA_1	155	161	PF00498	0.462
LIG_FHA_1	208	214	PF00498	0.657
LIG_FHA_1	23	29	PF00498	0.532
LIG_FHA_1	39	45	PF00498	0.691
LIG_FHA_2	201	207	PF00498	0.563
LIG_FHA_2	312	318	PF00498	0.640
LIG_GBD_Chelix_1	290	298	PF00786	0.597
LIG_LIR_Apic_2	31	35	PF02991	0.467
LIG_LIR_Gen_1	157	165	PF02991	0.426
LIG_LIR_Gen_1	219	230	PF02991	0.650
LIG_LIR_Nem_3	157	162	PF02991	0.428
LIG_LIR_Nem_3	219	225	PF02991	0.536
LIG_PROFILIN_1	403	409	PF00235	0.579
LIG_RPA_C_Fungi	379	391	PF08784	0.503
LIG_SH2_SRC	198	201	PF00017	0.511
LIG_SH2_STAP1	165	169	PF00017	0.597
LIG_SH2_STAT5	198	201	PF00017	0.574
LIG_SH2_STAT5	259	262	PF00017	0.675
LIG_SH2_STAT5	90	93	PF00017	0.462
LIG_SH3_3	177	183	PF00018	0.657
LIG_SH3_3	331	337	PF00018	0.697
LIG_SH3_3	338	344	PF00018	0.657
LIG_SH3_3	400	406	PF00018	0.726
LIG_SUMO_SIM_anti_2	317	324	PF11976	0.643
LIG_SUMO_SIM_par_1	160	166	PF11976	0.429
LIG_SUMO_SIM_par_1	357	363	PF11976	0.498
LIG_TRAF2_1	209	212	PF00917	0.691
LIG_TRAF2_1	286	289	PF00917	0.631
LIG_TRAF2_1	351	354	PF00917	0.622
MOD_CDK_SPK_2	394	399	PF00069	0.753
MOD_CK1_1	113	119	PF00069	0.525
MOD_CK1_1	154	160	PF00069	0.521
MOD_CK1_1	238	244	PF00069	0.616
MOD_CK1_1	272	278	PF00069	0.573
MOD_CK1_1	307	313	PF00069	0.703
MOD_CK1_1	335	341	PF00069	0.630
MOD_CK1_1	383	389	PF00069	0.648
MOD_CK1_1	96	102	PF00069	0.696
MOD_CK2_1	412	418	PF00069	0.720
MOD_GlcNHglycan	104	107	PF01048	0.641
MOD_GlcNHglycan	170	173	PF01048	0.680
MOD_GlcNHglycan	18	21	PF01048	0.690
MOD_GlcNHglycan	237	240	PF01048	0.610
MOD_GlcNHglycan	242	245	PF01048	0.669
MOD_GlcNHglycan	255	258	PF01048	0.584
MOD_GlcNHglycan	347	350	PF01048	0.675
MOD_GlcNHglycan	356	359	PF01048	0.574
MOD_GlcNHglycan	385	388	PF01048	0.551
MOD_GlcNHglycan	422	425	PF01048	0.695
MOD_GlcNHglycan	50	53	PF01048	0.587
MOD_GlcNHglycan	6	9	PF01048	0.637
MOD_GlcNHglycan	77	80	PF01048	0.539
MOD_GSK3_1	147	154	PF00069	0.591
MOD_GSK3_1	207	214	PF00069	0.649
MOD_GSK3_1	235	242	PF00069	0.634
MOD_GSK3_1	24	31	PF00069	0.599
MOD_GSK3_1	269	276	PF00069	0.699
MOD_GSK3_1	305	312	PF00069	0.616
MOD_GSK3_1	379	386	PF00069	0.598
MOD_GSK3_1	390	397	PF00069	0.627
MOD_GSK3_1	420	427	PF00069	0.745
MOD_GSK3_1	93	100	PF00069	0.558
MOD_N-GLC_1	147	152	PF02516	0.402
MOD_NEK2_1	1	6	PF00069	0.546
MOD_NEK2_1	146	151	PF00069	0.541
MOD_NEK2_1	278	283	PF00069	0.615
MOD_NEK2_1	290	295	PF00069	0.424
MOD_NEK2_1	304	309	PF00069	0.563
MOD_NEK2_1	321	326	PF00069	0.572
MOD_NEK2_1	380	385	PF00069	0.697
MOD_NMyristoyl	1	7	PF02799	0.561
MOD_PIKK_1	270	276	PF00454	0.652
MOD_PIKK_1	278	284	PF00454	0.525
MOD_PIKK_1	335	341	PF00454	0.680
MOD_PK_1	147	153	PF00069	0.511
MOD_PKA_1	97	103	PF00069	0.498
MOD_PKA_2	113	119	PF00069	0.525
MOD_PKA_2	146	152	PF00069	0.539
MOD_PKA_2	335	341	PF00069	0.583
MOD_PKA_2	383	389	PF00069	0.505
MOD_PKA_2	96	102	PF00069	0.696
MOD_PKB_1	369	377	PF00069	0.462
MOD_Plk_1	147	153	PF00069	0.400
MOD_Plk_1	211	217	PF00069	0.573
MOD_Plk_4	147	153	PF00069	0.511
MOD_ProDKin_1	183	189	PF00069	0.639
MOD_ProDKin_1	305	311	PF00069	0.583
MOD_ProDKin_1	394	400	PF00069	0.642
MOD_SUMO_for_1	124	127	PF00179	0.788
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.475
TRG_ER_diArg_1	251	253	PF00400	0.531
TRG_ER_diArg_1	368	371	PF00400	0.462
TRG_NES_CRM1_1	288	303	PF08389	0.544
TRG_NES_CRM1_1	354	365	PF08389	0.626
TRG_NLS_MonoExtC_3	121	127	PF00514	0.614
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC0	Leptomonas seymouri	36%	80%
A4H616	Leishmania braziliensis	69%	100%
A4HUE3	Leishmania infantum	99%	100%
E9AN43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QHI3	Leishmania major	91%	100%