Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I7M1_LEIDO

TriTrypDb:

LdBPK_100110.1 , LdCL_100006300 , LDHU3_10.0190

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8I7M1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I7M1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	642	646	PF00656	0.576
CLV_NRD_NRD_1	184	186	PF00675	0.486
CLV_NRD_NRD_1	209	211	PF00675	0.510
CLV_NRD_NRD_1	240	242	PF00675	0.504
CLV_NRD_NRD_1	352	354	PF00675	0.442
CLV_NRD_NRD_1	449	451	PF00675	0.618
CLV_NRD_NRD_1	515	517	PF00675	0.625
CLV_NRD_NRD_1	717	719	PF00675	0.554
CLV_NRD_NRD_1	90	92	PF00675	0.438
CLV_PCSK_KEX2_1	183	185	PF00082	0.484
CLV_PCSK_KEX2_1	208	210	PF00082	0.483
CLV_PCSK_KEX2_1	437	439	PF00082	0.661
CLV_PCSK_KEX2_1	515	517	PF00082	0.748
CLV_PCSK_KEX2_1	625	627	PF00082	0.526
CLV_PCSK_KEX2_1	717	719	PF00082	0.755
CLV_PCSK_KEX2_1	90	92	PF00082	0.514
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.601
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.543
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.748
CLV_PCSK_PC1ET2_1	625	627	PF00082	0.526
CLV_PCSK_PC7_1	86	92	PF00082	0.529
CLV_PCSK_SKI1_1	11	15	PF00082	0.361
CLV_PCSK_SKI1_1	185	189	PF00082	0.522
CLV_PCSK_SKI1_1	210	214	PF00082	0.536
CLV_PCSK_SKI1_1	334	338	PF00082	0.428
CLV_PCSK_SKI1_1	340	344	PF00082	0.440
CLV_PCSK_SKI1_1	458	462	PF00082	0.699
CLV_PCSK_SKI1_1	488	492	PF00082	0.652
DEG_SPOP_SBC_1	478	482	PF00917	0.744
DOC_CKS1_1	460	465	PF01111	0.530
DOC_MAPK_DCC_7	399	408	PF00069	0.466
DOC_MAPK_gen_1	127	134	PF00069	0.454
DOC_MAPK_gen_1	225	234	PF00069	0.611
DOC_MAPK_gen_1	399	408	PF00069	0.650
DOC_MAPK_JIP1_4	531	537	PF00069	0.675
DOC_MAPK_MEF2A_6	127	134	PF00069	0.388
DOC_MAPK_MEF2A_6	167	175	PF00069	0.446
DOC_MAPK_MEF2A_6	399	408	PF00069	0.685
DOC_MAPK_MEF2A_6	531	539	PF00069	0.776
DOC_MAPK_RevD_3	171	185	PF00069	0.450
DOC_PP1_RVXF_1	73	80	PF00149	0.362
DOC_PP4_FxxP_1	637	640	PF00568	0.609
DOC_SPAK_OSR1_1	78	82	PF12202	0.383
DOC_SPAK_OSR1_1	9	13	PF12202	0.347
DOC_USP7_MATH_1	109	113	PF00917	0.369
DOC_USP7_MATH_1	436	440	PF00917	0.697
DOC_USP7_MATH_1	478	482	PF00917	0.755
DOC_USP7_MATH_1	547	551	PF00917	0.686
DOC_USP7_MATH_1	601	605	PF00917	0.651
DOC_USP7_MATH_1	606	610	PF00917	0.619
DOC_USP7_MATH_1	614	618	PF00917	0.558
DOC_USP7_MATH_2	698	704	PF00917	0.660
DOC_WW_Pin1_4	353	358	PF00397	0.514
DOC_WW_Pin1_4	36	41	PF00397	0.427
DOC_WW_Pin1_4	459	464	PF00397	0.715
DOC_WW_Pin1_4	468	473	PF00397	0.659
DOC_WW_Pin1_4	483	488	PF00397	0.666
DOC_WW_Pin1_4	587	592	PF00397	0.738
DOC_WW_Pin1_4	664	669	PF00397	0.617
LIG_14-3-3_CanoR_1	183	188	PF00244	0.589
LIG_14-3-3_CanoR_1	717	725	PF00244	0.731
LIG_Actin_WH2_2	322	339	PF00022	0.431
LIG_APCC_ABBA_1	132	137	PF00400	0.402
LIG_BIR_III_2	573	577	PF00653	0.539
LIG_CaM_IQ_9	326	342	PF13499	0.293
LIG_Clathr_ClatBox_1	174	178	PF01394	0.420
LIG_EVH1_2	140	144	PF00568	0.444
LIG_FHA_1	219	225	PF00498	0.523
LIG_FHA_1	3	9	PF00498	0.433
LIG_FHA_1	462	468	PF00498	0.686
LIG_FHA_1	653	659	PF00498	0.760
LIG_FHA_1	99	105	PF00498	0.523
LIG_FHA_2	177	183	PF00498	0.508
LIG_FHA_2	224	230	PF00498	0.596
LIG_FHA_2	275	281	PF00498	0.540
LIG_FHA_2	412	418	PF00498	0.625
LIG_FHA_2	484	490	PF00498	0.692
LIG_FHA_2	496	502	PF00498	0.698
LIG_FHA_2	706	712	PF00498	0.785
LIG_FHA_2	94	100	PF00498	0.364
LIG_Integrin_isoDGR_2	421	423	PF01839	0.524
LIG_LIR_Apic_2	635	640	PF02991	0.629
LIG_LIR_Gen_1	628	639	PF02991	0.673
LIG_LIR_Nem_3	116	122	PF02991	0.451
LIG_LIR_Nem_3	143	147	PF02991	0.450
LIG_LIR_Nem_3	577	583	PF02991	0.635
LIG_LIR_Nem_3	722	728	PF02991	0.687
LIG_NRBOX	176	182	PF00104	0.557
LIG_PTAP_UEV_1	462	467	PF05743	0.663
LIG_SH2_CRK	236	240	PF00017	0.471
LIG_SH2_CRK	725	729	PF00017	0.715
LIG_SH2_STAP1	236	240	PF00017	0.636
LIG_SH2_STAP1	26	30	PF00017	0.384
LIG_SH2_STAT3	42	45	PF00017	0.512
LIG_SH2_STAT5	236	239	PF00017	0.566
LIG_SH2_STAT5	254	257	PF00017	0.470
LIG_SH2_STAT5	26	29	PF00017	0.444
LIG_SH2_STAT5	42	45	PF00017	0.384
LIG_SH2_STAT5	670	673	PF00017	0.731
LIG_SH2_STAT5	725	728	PF00017	0.605
LIG_SH2_STAT5	76	79	PF00017	0.403
LIG_SH2_STAT5	84	87	PF00017	0.425
LIG_SH3_3	153	159	PF00018	0.643
LIG_SH3_3	460	466	PF00018	0.591
LIG_SH3_3	469	475	PF00018	0.588
LIG_SH3_3	526	532	PF00018	0.596
LIG_SH3_3	595	601	PF00018	0.700
LIG_SH3_3	691	697	PF00018	0.536
LIG_SUMO_SIM_par_1	11	16	PF11976	0.427
LIG_TRAF2_1	197	200	PF00917	0.649
LIG_TRAF2_1	288	291	PF00917	0.494
LIG_TRFH_1	597	601	PF08558	0.723
LIG_TYR_ITIM	234	239	PF00017	0.496
MOD_CDK_SPK_2	483	488	PF00069	0.683
MOD_CDK_SPxxK_3	353	360	PF00069	0.531
MOD_CK1_1	274	280	PF00069	0.621
MOD_CK1_1	415	421	PF00069	0.515
MOD_CK1_1	471	477	PF00069	0.656
MOD_CK1_1	479	485	PF00069	0.597
MOD_CK1_1	565	571	PF00069	0.808
MOD_CK1_1	587	593	PF00069	0.621
MOD_CK1_1	673	679	PF00069	0.592
MOD_CK2_1	176	182	PF00069	0.497
MOD_CK2_1	194	200	PF00069	0.486
MOD_CK2_1	223	229	PF00069	0.596
MOD_CK2_1	274	280	PF00069	0.530
MOD_CK2_1	285	291	PF00069	0.368
MOD_CK2_1	411	417	PF00069	0.699
MOD_CK2_1	50	56	PF00069	0.463
MOD_CK2_1	705	711	PF00069	0.567
MOD_GlcNHglycan	109	112	PF01048	0.413
MOD_GlcNHglycan	273	276	PF01048	0.615
MOD_GlcNHglycan	318	322	PF01048	0.474
MOD_GlcNHglycan	476	479	PF01048	0.721
MOD_GlcNHglycan	481	484	PF01048	0.733
MOD_GlcNHglycan	532	535	PF01048	0.636
MOD_GlcNHglycan	540	543	PF01048	0.579
MOD_GlcNHglycan	565	568	PF01048	0.792
MOD_GlcNHglycan	616	619	PF01048	0.692
MOD_GlcNHglycan	681	684	PF01048	0.655
MOD_GlcNHglycan	689	692	PF01048	0.627
MOD_GSK3_1	109	116	PF00069	0.432
MOD_GSK3_1	190	197	PF00069	0.669
MOD_GSK3_1	270	277	PF00069	0.559
MOD_GSK3_1	32	39	PF00069	0.447
MOD_GSK3_1	385	392	PF00069	0.445
MOD_GSK3_1	407	414	PF00069	0.642
MOD_GSK3_1	466	473	PF00069	0.625
MOD_GSK3_1	474	481	PF00069	0.646
MOD_GSK3_1	562	569	PF00069	0.807
MOD_GSK3_1	726	733	PF00069	0.635
MOD_N-GLC_1	271	276	PF02516	0.684
MOD_N-GLC_1	285	290	PF02516	0.514
MOD_N-GLC_1	35	40	PF02516	0.547
MOD_N-GLC_1	718	723	PF02516	0.763
MOD_NEK2_1	121	126	PF00069	0.466
MOD_NEK2_1	336	341	PF00069	0.451
MOD_NEK2_1	502	507	PF00069	0.697
MOD_NEK2_1	562	567	PF00069	0.748
MOD_NEK2_1	584	589	PF00069	0.693
MOD_PIKK_1	98	104	PF00454	0.453
MOD_PKA_1	183	189	PF00069	0.595
MOD_PKA_1	717	723	PF00069	0.745
MOD_PKA_2	183	189	PF00069	0.595
MOD_PKA_2	2	8	PF00069	0.521
MOD_PKA_2	415	421	PF00069	0.714
MOD_PKA_2	563	569	PF00069	0.719
MOD_PKA_2	673	679	PF00069	0.696
MOD_PKA_2	717	723	PF00069	0.642
MOD_Plk_1	285	291	PF00069	0.523
MOD_Plk_1	301	307	PF00069	0.371
MOD_Plk_1	517	523	PF00069	0.697
MOD_Plk_1	635	641	PF00069	0.678
MOD_Plk_1	98	104	PF00069	0.445
MOD_Plk_2-3	428	434	PF00069	0.544
MOD_Plk_4	113	119	PF00069	0.375
MOD_Plk_4	176	182	PF00069	0.508
MOD_Plk_4	24	30	PF00069	0.501
MOD_Plk_4	274	280	PF00069	0.662
MOD_Plk_4	579	585	PF00069	0.755
MOD_ProDKin_1	353	359	PF00069	0.508
MOD_ProDKin_1	36	42	PF00069	0.420
MOD_ProDKin_1	459	465	PF00069	0.716
MOD_ProDKin_1	468	474	PF00069	0.660
MOD_ProDKin_1	483	489	PF00069	0.663
MOD_ProDKin_1	587	593	PF00069	0.742
MOD_ProDKin_1	664	670	PF00069	0.622
MOD_SUMO_for_1	187	190	PF00179	0.649
MOD_SUMO_rev_2	193	203	PF00179	0.666
MOD_SUMO_rev_2	405	410	PF00179	0.578
MOD_SUMO_rev_2	427	436	PF00179	0.527
TRG_DiLeu_BaEn_4	301	307	PF01217	0.445
TRG_ENDOCYTIC_2	236	239	PF00928	0.594
TRG_ENDOCYTIC_2	26	29	PF00928	0.493
TRG_ENDOCYTIC_2	631	634	PF00928	0.694
TRG_ENDOCYTIC_2	649	652	PF00928	0.503
TRG_ENDOCYTIC_2	725	728	PF00928	0.720
TRG_ENDOCYTIC_2	76	79	PF00928	0.458
TRG_ER_diArg_1	183	185	PF00400	0.484
TRG_ER_diArg_1	89	91	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	90	95	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD89	Leptomonas seymouri	64%	98%
A0A0S4J8X4	Bodo saltans	23%	91%
A0A1X0NRK9	Trypanosomatidae	38%	100%
A0A422NRU0	Trypanosoma rangeli	37%	100%
A4H5Z4	Leishmania braziliensis	64%	99%
A4HUC0	Leishmania infantum	100%	100%
C9ZVH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AN19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QHK7	Leishmania major	90%	100%
V5B9H5	Trypanosoma cruzi	37%	100%