RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8I7J7_LEIDO

TriTrypDb:

LdBPK_091350.1 , LdCL_090019900 , LDHU3_09.1600

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I7J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I7J7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.662
CLV_C14_Caspase3-7	356	360	PF00656	0.785
CLV_C14_Caspase3-7	463	467	PF00656	0.635
CLV_C14_Caspase3-7	476	480	PF00656	0.515
CLV_NRD_NRD_1	133	135	PF00675	0.671
CLV_PCSK_KEX2_1	133	135	PF00082	0.671
CLV_PCSK_KEX2_1	351	353	PF00082	0.748
CLV_PCSK_KEX2_1	565	567	PF00082	0.794
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.815
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.754
CLV_PCSK_SKI1_1	438	442	PF00082	0.484
CLV_PCSK_SKI1_1	572	576	PF00082	0.745
DEG_COP1_1	269	278	PF00400	0.831
DEG_SCF_FBW7_1	202	209	PF00400	0.530
DEG_SPOP_SBC_1	212	216	PF00917	0.631
DEG_SPOP_SBC_1	278	282	PF00917	0.818
DOC_ANK_TNKS_1	191	198	PF00023	0.473
DOC_CYCLIN_RxL_1	226	237	PF00134	0.589
DOC_MAPK_gen_1	489	497	PF00069	0.556
DOC_MAPK_MEF2A_6	389	398	PF00069	0.509
DOC_MAPK_MEF2A_6	489	497	PF00069	0.556
DOC_PP1_RVXF_1	227	234	PF00149	0.585
DOC_PP1_RVXF_1	487	493	PF00149	0.556
DOC_PP2B_LxvP_1	289	292	PF13499	0.681
DOC_PP2B_LxvP_1	495	498	PF13499	0.510
DOC_PP2B_LxvP_1	539	542	PF13499	0.514
DOC_PP4_FxxP_1	204	207	PF00568	0.703
DOC_USP7_MATH_1	14	18	PF00917	0.690
DOC_USP7_MATH_1	212	216	PF00917	0.652
DOC_USP7_MATH_1	251	255	PF00917	0.713
DOC_USP7_MATH_1	328	332	PF00917	0.680
DOC_USP7_MATH_1	48	52	PF00917	0.768
DOC_USP7_MATH_1	500	504	PF00917	0.624
DOC_USP7_MATH_1	513	517	PF00917	0.476
DOC_USP7_MATH_1	543	547	PF00917	0.604
DOC_USP7_MATH_1	71	75	PF00917	0.553
DOC_WW_Pin1_4	202	207	PF00397	0.574
DOC_WW_Pin1_4	279	284	PF00397	0.763
DOC_WW_Pin1_4	345	350	PF00397	0.779
DOC_WW_Pin1_4	427	432	PF00397	0.705
DOC_WW_Pin1_4	67	72	PF00397	0.508
LIG_14-3-3_CanoR_1	218	224	PF00244	0.508
LIG_14-3-3_CanoR_1	314	323	PF00244	0.678
LIG_14-3-3_CanoR_1	337	347	PF00244	0.711
LIG_Actin_WH2_2	219	234	PF00022	0.581
LIG_BIR_III_4	447	451	PF00653	0.512
LIG_BIR_III_4	558	562	PF00653	0.791
LIG_CSL_BTD_1	392	395	PF09270	0.483
LIG_deltaCOP1_diTrp_1	150	161	PF00928	0.621
LIG_EABR_CEP55_1	15	24	PF12180	0.722
LIG_FHA_1	222	228	PF00498	0.496
LIG_FHA_1	280	286	PF00498	0.818
LIG_FHA_1	536	542	PF00498	0.503
LIG_FHA_2	316	322	PF00498	0.695
LIG_FHA_2	377	383	PF00498	0.569
LIG_FHA_2	474	480	PF00498	0.739
LIG_LIR_Apic_2	201	207	PF02991	0.724
LIG_LIR_Gen_1	304	311	PF02991	0.520
LIG_LIR_Gen_1	99	108	PF02991	0.632
LIG_LIR_LC3C_4	439	443	PF02991	0.468
LIG_LIR_Nem_3	151	157	PF02991	0.630
LIG_LIR_Nem_3	304	310	PF02991	0.522
LIG_LIR_Nem_3	99	103	PF02991	0.581
LIG_MAD2	397	405	PF02301	0.591
LIG_MYND_1	283	287	PF01753	0.813
LIG_NRBOX	226	232	PF00104	0.541
LIG_PDZ_Class_2	571	576	PF00595	0.742
LIG_Pex14_2	157	161	PF04695	0.584
LIG_SH2_CRK	100	104	PF00017	0.674
LIG_SH2_NCK_1	100	104	PF00017	0.674
LIG_SH2_PTP2	307	310	PF00017	0.420
LIG_SH2_SRC	177	180	PF00017	0.546
LIG_SH2_STAP1	100	104	PF00017	0.499
LIG_SH2_STAP1	386	390	PF00017	0.499
LIG_SH2_STAP1	409	413	PF00017	0.422
LIG_SH2_STAT5	100	103	PF00017	0.667
LIG_SH2_STAT5	307	310	PF00017	0.420
LIG_SH2_STAT5	521	524	PF00017	0.437
LIG_SH3_3	270	276	PF00018	0.820
LIG_SH3_3	288	294	PF00018	0.693
LIG_SH3_3	33	39	PF00018	0.566
LIG_SH3_3	413	419	PF00018	0.475
LIG_SH3_3	561	567	PF00018	0.672
LIG_SUMO_SIM_anti_2	439	444	PF11976	0.467
LIG_SUMO_SIM_par_1	30	35	PF11976	0.593
LIG_TRAF2_1	244	247	PF00917	0.639
LIG_TRAF2_1	52	55	PF00917	0.768
LIG_WW_3	292	296	PF00397	0.554
MOD_CDC14_SPxK_1	348	351	PF00782	0.787
MOD_CDK_SPK_2	279	284	PF00069	0.814
MOD_CDK_SPxK_1	345	351	PF00069	0.784
MOD_CDK_SPxxK_3	345	352	PF00069	0.789
MOD_CK1_1	163	169	PF00069	0.676
MOD_CK1_1	216	222	PF00069	0.478
MOD_CK1_1	40	46	PF00069	0.699
MOD_CK1_1	480	486	PF00069	0.624
MOD_CK2_1	251	257	PF00069	0.727
MOD_CK2_1	48	54	PF00069	0.766
MOD_CK2_1	67	73	PF00069	0.533
MOD_CMANNOS	161	164	PF00535	0.536
MOD_Cter_Amidation	349	352	PF01082	0.779
MOD_DYRK1A_RPxSP_1	345	349	PF00069	0.778
MOD_GlcNHglycan	112	115	PF01048	0.779
MOD_GlcNHglycan	16	19	PF01048	0.658
MOD_GlcNHglycan	165	168	PF01048	0.632
MOD_GlcNHglycan	182	185	PF01048	0.556
MOD_GlcNHglycan	209	212	PF01048	0.734
MOD_GlcNHglycan	25	30	PF01048	0.546
MOD_GlcNHglycan	251	254	PF01048	0.744
MOD_GlcNHglycan	321	326	PF01048	0.737
MOD_GlcNHglycan	330	333	PF01048	0.685
MOD_GlcNHglycan	355	358	PF01048	0.787
MOD_GlcNHglycan	363	366	PF01048	0.706
MOD_GlcNHglycan	373	376	PF01048	0.436
MOD_GlcNHglycan	462	465	PF01048	0.568
MOD_GlcNHglycan	479	482	PF01048	0.655
MOD_GlcNHglycan	545	548	PF01048	0.651
MOD_GlcNHglycan	567	570	PF01048	0.711
MOD_GSK3_1	156	163	PF00069	0.521
MOD_GSK3_1	202	209	PF00069	0.669
MOD_GSK3_1	212	219	PF00069	0.607
MOD_GSK3_1	234	241	PF00069	0.455
MOD_GSK3_1	367	374	PF00069	0.709
MOD_GSK3_1	423	430	PF00069	0.760
MOD_GSK3_1	473	480	PF00069	0.668
MOD_GSK3_1	67	74	PF00069	0.471
MOD_GSK3_1	99	106	PF00069	0.663
MOD_NEK2_1	112	117	PF00069	0.725
MOD_NEK2_1	156	161	PF00069	0.461
MOD_NEK2_1	367	372	PF00069	0.783
MOD_NEK2_1	4	9	PF00069	0.683
MOD_NEK2_1	477	482	PF00069	0.555
MOD_NEK2_2	500	505	PF00069	0.564
MOD_PIKK_1	234	240	PF00454	0.539
MOD_PIKK_1	301	307	PF00454	0.549
MOD_PIKK_1	315	321	PF00454	0.476
MOD_PIKK_1	513	519	PF00454	0.498
MOD_PKA_1	339	345	PF00069	0.772
MOD_PKA_1	565	571	PF00069	0.783
MOD_PKA_2	565	571	PF00069	0.783
MOD_Plk_1	321	327	PF00069	0.601
MOD_Plk_1	367	373	PF00069	0.724
MOD_Plk_1	98	104	PF00069	0.623
MOD_Plk_4	156	162	PF00069	0.568
MOD_Plk_4	37	43	PF00069	0.612
MOD_Plk_4	500	506	PF00069	0.612
MOD_Plk_4	71	77	PF00069	0.497
MOD_ProDKin_1	202	208	PF00069	0.577
MOD_ProDKin_1	279	285	PF00069	0.760
MOD_ProDKin_1	345	351	PF00069	0.784
MOD_ProDKin_1	427	433	PF00069	0.700
MOD_ProDKin_1	67	73	PF00069	0.509
MOD_SUMO_rev_2	356	363	PF00179	0.809
MOD_SUMO_rev_2	382	390	PF00179	0.554
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.597
TRG_ENDOCYTIC_2	100	103	PF00928	0.667
TRG_ENDOCYTIC_2	307	310	PF00928	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D8	Leptomonas seymouri	39%	90%
A0A1X0NIM5	Trypanosomatidae	24%	94%
A4HU51	Leishmania infantum	100%	100%
E9AMY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QHP6	Leishmania major	89%	100%