LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8I7G4_LEIDO
TriTrypDb:
LdBPK_090730.1 * , LdCL_090012400 , LDHU3_09.0870
Length:
370

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8I7G4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8I7G4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 215 219 PF00656 0.617
CLV_C14_Caspase3-7 285 289 PF00656 0.611
CLV_NRD_NRD_1 18 20 PF00675 0.518
CLV_NRD_NRD_1 197 199 PF00675 0.626
CLV_NRD_NRD_1 24 26 PF00675 0.570
CLV_NRD_NRD_1 243 245 PF00675 0.535
CLV_NRD_NRD_1 261 263 PF00675 0.732
CLV_NRD_NRD_1 326 328 PF00675 0.651
CLV_NRD_NRD_1 357 359 PF00675 0.548
CLV_PCSK_KEX2_1 18 20 PF00082 0.527
CLV_PCSK_KEX2_1 196 198 PF00082 0.593
CLV_PCSK_KEX2_1 243 245 PF00082 0.535
CLV_PCSK_KEX2_1 261 263 PF00082 0.737
CLV_PCSK_KEX2_1 274 276 PF00082 0.621
CLV_PCSK_PC1ET2_1 274 276 PF00082 0.646
CLV_PCSK_PC7_1 193 199 PF00082 0.590
CLV_PCSK_SKI1_1 187 191 PF00082 0.552
CLV_PCSK_SKI1_1 25 29 PF00082 0.559
CLV_PCSK_SKI1_1 358 362 PF00082 0.485
DEG_APCC_DBOX_1 120 128 PF00400 0.523
DEG_APCC_DBOX_1 357 365 PF00400 0.570
DOC_MAPK_gen_1 193 203 PF00069 0.584
DOC_MAPK_MEF2A_6 196 203 PF00069 0.532
DOC_MAPK_NFAT4_5 196 204 PF00069 0.535
DOC_PP1_RVXF_1 349 356 PF00149 0.531
DOC_PP2B_LxvP_1 310 313 PF13499 0.621
DOC_USP7_MATH_1 140 144 PF00917 0.617
DOC_USP7_MATH_1 64 68 PF00917 0.510
DOC_USP7_MATH_1 87 91 PF00917 0.646
DOC_WW_Pin1_4 25 30 PF00397 0.552
DOC_WW_Pin1_4 330 335 PF00397 0.673
DOC_WW_Pin1_4 85 90 PF00397 0.660
LIG_14-3-3_CanoR_1 114 118 PF00244 0.608
LIG_14-3-3_CanoR_1 18 22 PF00244 0.460
LIG_14-3-3_CanoR_1 243 252 PF00244 0.585
LIG_14-3-3_CanoR_1 327 334 PF00244 0.642
LIG_EVH1_1 310 314 PF00568 0.620
LIG_EVH1_2 78 82 PF00568 0.695
LIG_FHA_1 222 228 PF00498 0.719
LIG_FHA_1 26 32 PF00498 0.525
LIG_FHA_1 281 287 PF00498 0.710
LIG_FHA_1 317 323 PF00498 0.721
LIG_GBD_Chelix_1 127 135 PF00786 0.489
LIG_LIR_Gen_1 159 169 PF02991 0.488
LIG_LIR_Gen_1 251 257 PF02991 0.647
LIG_LIR_Gen_1 290 301 PF02991 0.569
LIG_LIR_Gen_1 44 55 PF02991 0.513
LIG_LIR_Nem_3 159 164 PF02991 0.489
LIG_LIR_Nem_3 241 245 PF02991 0.665
LIG_LIR_Nem_3 251 256 PF02991 0.567
LIG_LIR_Nem_3 290 296 PF02991 0.587
LIG_LIR_Nem_3 44 50 PF02991 0.517
LIG_NRBOX 251 257 PF00104 0.551
LIG_PCNA_yPIPBox_3 4 18 PF02747 0.507
LIG_SH2_CRK 242 246 PF00017 0.622
LIG_SH2_SRC 107 110 PF00017 0.566
LIG_SH2_STAT5 134 137 PF00017 0.533
LIG_SH2_STAT5 347 350 PF00017 0.562
LIG_SH2_STAT5 41 44 PF00017 0.448
LIG_SH3_1 308 314 PF00018 0.658
LIG_SH3_3 232 238 PF00018 0.630
LIG_SH3_3 308 314 PF00018 0.678
LIG_SH3_3 331 337 PF00018 0.645
LIG_SH3_3 83 89 PF00018 0.602
LIG_SH3_5 238 242 PF00018 0.584
LIG_SUMO_SIM_anti_2 231 237 PF11976 0.616
MOD_CK1_1 113 119 PF00069 0.665
MOD_CK1_1 143 149 PF00069 0.579
MOD_CK1_1 152 158 PF00069 0.397
MOD_CK1_1 251 257 PF00069 0.530
MOD_CK1_1 276 282 PF00069 0.673
MOD_CK1_1 90 96 PF00069 0.665
MOD_CK2_1 17 23 PF00069 0.662
MOD_Cter_Amidation 16 19 PF01082 0.538
MOD_GlcNHglycan 137 140 PF01048 0.653
MOD_GlcNHglycan 143 146 PF01048 0.629
MOD_GlcNHglycan 89 92 PF01048 0.646
MOD_GSK3_1 269 276 PF00069 0.694
MOD_GSK3_1 322 329 PF00069 0.707
MOD_GSK3_1 87 94 PF00069 0.663
MOD_NEK2_1 135 140 PF00069 0.554
MOD_NEK2_1 216 221 PF00069 0.607
MOD_NEK2_1 316 321 PF00069 0.703
MOD_NEK2_1 322 327 PF00069 0.795
MOD_NEK2_1 50 55 PF00069 0.511
MOD_NEK2_1 82 87 PF00069 0.672
MOD_NEK2_2 17 22 PF00069 0.536
MOD_PIKK_1 149 155 PF00454 0.592
MOD_PIKK_1 243 249 PF00454 0.593
MOD_PIKK_1 322 328 PF00454 0.646
MOD_PKA_1 243 249 PF00069 0.593
MOD_PKA_1 273 279 PF00069 0.585
MOD_PKA_2 113 119 PF00069 0.635
MOD_PKA_2 141 147 PF00069 0.623
MOD_PKA_2 17 23 PF00069 0.480
MOD_PKA_2 192 198 PF00069 0.553
MOD_PKA_2 243 249 PF00069 0.593
MOD_PKA_2 276 282 PF00069 0.684
MOD_PKA_2 326 332 PF00069 0.669
MOD_PKB_1 275 283 PF00069 0.673
MOD_Plk_1 277 283 PF00069 0.577
MOD_Plk_2-3 282 288 PF00069 0.598
MOD_Plk_4 152 158 PF00069 0.496
MOD_Plk_4 231 237 PF00069 0.624
MOD_Plk_4 248 254 PF00069 0.569
MOD_ProDKin_1 25 31 PF00069 0.549
MOD_ProDKin_1 330 336 PF00069 0.672
MOD_ProDKin_1 85 91 PF00069 0.662
MOD_SUMO_rev_2 20 28 PF00179 0.541
MOD_SUMO_rev_2 212 222 PF00179 0.599
TRG_ENDOCYTIC_2 242 245 PF00928 0.667
TRG_ENDOCYTIC_2 47 50 PF00928 0.519
TRG_ER_diArg_1 196 198 PF00400 0.600
TRG_ER_diArg_1 242 244 PF00400 0.549
TRG_ER_diArg_1 295 298 PF00400 0.622
TRG_NLS_Bipartite_1 261 277 PF00514 0.589
TRG_NLS_MonoExtC_3 272 277 PF00514 0.584
TRG_NLS_MonoExtN_4 270 277 PF00514 0.591
TRG_Pf-PMV_PEXEL_1 237 241 PF00026 0.672
TRG_Pf-PMV_PEXEL_1 243 247 PF00026 0.695

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDE5 Leptomonas seymouri 43% 94%
A4H5P9 Leishmania braziliensis 75% 100%
A4HTY9 Leishmania infantum 99% 100%
E9AMR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QHV6 Leishmania major 95% 100%
V5BN47 Trypanosoma cruzi 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS