Succinyl-diaminopimelate desuccinylase-like protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidase m20/m25/m40 family-like protein

Species:

Leishmania infantum

UniProt:

A0A381MQ29_LEIIN

TriTrypDb:

LINF_310026700

Length:

471

Annotations

Annotations by Jardim et al.

Hydrolase, Succinyl-diaminopimelate desuccinylase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 33

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Previous1Next

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A381MQ29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A381MQ29

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0019538	protein metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Previous1Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	24
GO:0005488	binding	1	1
GO:0005506	iron ion binding	6	1
GO:0008233	peptidase activity	3	3
GO:0016491	oxidoreductase activity	2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0016787	hydrolase activity	2	24
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Previous1 2Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	354	356	PF00082	0.368
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.368
CLV_PCSK_SKI1_1	242	246	PF00082	0.309
CLV_PCSK_SKI1_1	354	358	PF00082	0.293
CLV_PCSK_SKI1_1	388	392	PF00082	0.285
CLV_PCSK_SKI1_1	452	456	PF00082	0.318
DEG_APCC_DBOX_1	241	249	PF00400	0.319
DOC_ANK_TNKS_1	106	113	PF00023	0.406
DOC_ANK_TNKS_1	208	215	PF00023	0.318
DOC_MAPK_gen_1	180	188	PF00069	0.367

Previous1 2 3 4 5…13Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q9	Leptomonas seymouri	75%	100%
A0A0N1PBD8	Leptomonas seymouri	77%	100%
A0A0S4JJE7	Bodo saltans	60%	100%
A0A1X0P1Q0	Trypanosomatidae	64%	99%
A0A3Q8IFP2	Leishmania donovani	100%	83%
A0A3R7KSZ4	Trypanosoma rangeli	63%	100%
A0A3S7X4P6	Leishmania donovani	100%	100%
A0A3S7X6U2	Leishmania donovani	75%	100%
A4HJG9	Leishmania braziliensis	92%	100%
A4HJH1	Leishmania braziliensis	93%	100%

Previous1 2 3 4Next